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PLDN
Pallidin is a protein that in humans is encoded by the ''PLDN'' gene. Function The protein encoded by this gene may play a role in intracellular vesicle trafficking. It interacts with Syntaxin 13 which mediates intracellular membrane fusion. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. Interactions PLDN has been shown to interact with: * BLOC1S1, * BLOC1S2, * CNO, * Dysbindin, * MUTED, * SNAPAP, and * STX12 Syntaxin-12 is a protein that in humans is encoded by the ''STX12'' gene In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed .... References Further reading * * * * * * * * * * * * {{gene-15-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
BLOC1S1
Biogenesis of lysosome-related organelles complex 1 subunit 1 is a protein that in humans is encoded by the ''BLOC1S1'' gene. BLOC1S1 is a component of the ubiquitously expressed BLOC1 multisubunit protein complex. BLOC1 is required for normal biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules (Starcevic and Dell'Angelica, 2004). upplied by OMIMref name="entrez" /> Interactions BLOC1S1 has been shown to interact with BLOC1S2, SNAPAP SNARE-associated protein Snapin is a protein that in humans is encoded by the ''SNAPIN'' gene. Function SNAPAP is a component of the SNARE complex of proteins that is required for synaptic vesicle docking and fusion. SNAPAP is also a componen ... and PLDN. References External links * Further reading * * * * * * * {{gene-12-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
BLOC1S2
Biogenesis of lysosome-related organelles complex 1 subunit 2 is a protein that in humans is encoded by the ''BLOC1S2'' gene In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei .... Interactions BLOC1S2 has been shown to interact with BLOC1S1, SNAPAP, MUTED, CNO and PLDN. References External links * Further reading * * * * * * * * {{gene-10-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CNO (gene)
Protein cappuccino homolog is a protein that in humans is encoded by the ''CNO'' gene. This intronless gene encodes a protein that may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. A similar protein in mouse is a component of a protein complex termed biogenesis of lysosome-related organelles complex 1 ( BLOC-1), and is a model for Hermansky–Pudlak syndrome. The encoded protein may play a role in intracellular vesicular trafficking. Interactions CNO (gene) has been shown to interact with BLOC1S2 and PLDN Pallidin is a protein that in humans is encoded by the ''PLDN'' gene. Function The protein encoded by this gene may play a role in intracellular vesicle trafficking. It interacts with Syntaxin 13 which mediates intracellular membrane fusion. S .... References External links * Further reading * * * * * * {{gene-4-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dysbindin
Dysbindin, short for dystrobrevin-binding protein 1, is a protein constituent of the dystrophin-associated protein complex (DPC) of skeletal muscle cells. It is also a part of BLOC-1, or biogenesis of lysosome-related organelles complex 1.In humans, dysbindin is encoded by the ''DTNBP1'' gene. Discovery Dysbindin was discovered by the research group of Derek Blake via yeast two-hybrid screening for binding partners of α-dystrobrevin. Tissue distribution Dysbindin is found in neural tissue of the brain, particularly in axon bundles and especially in certain axon terminals, notably mossy fiber synaptic terminals in the cerebellum and hippocampus. Structure Dysbindin is a coiled-coil-containing protein that serves as a core, stable component of the biogenesis of lysosome-related organelles complex 1 (BLOC-1), a multisubunit complex involved in intracellular protein trafficking and synaptic function. Structurally, dysbindin engages in direct interactions with other ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
SNAPAP
SNARE-associated protein Snapin is a protein that in humans is encoded by the ''SNAPIN'' gene. Function SNAPAP is a component of the SNARE complex of proteins that is required for synaptic vesicle docking and fusion. SNAPAP is also a component of the ubiquitously expressed BLOC1 multisubunit protein complex. BLOC1 is required for normal biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. Snapin has been established to be a promoter of vesicle docking, as it plays a role in binding to SNAP-25, which together stabilize and favor SNARE complex assembly and vesicle docking. Specifically, the degree to which snapin is necessary for proper synaptic release varies across species. The functions of snapin have been reported to be independent of synaptotagmin, and works through the SNAP-25 pathway to stabilize, prime, and dock vesicles. Interactions SNAPAP has been shown to interact with: * BLOC1S1, * BLOC1S ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metabolic reactions, DNA replication, Cell signaling, responding to stimuli, providing Cytoskeleton, structure to cells and Fibrous protein, organisms, and Intracellular transport, transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the Nucleic acid sequence, nucleotide sequence of their genes, and which usually results in protein folding into a specific Protein structure, 3D structure that determines its activity. A linear chain of amino acid residues is called a polypeptide. A protein contains at least one long polypeptide. Short polypeptides, containing less than 20–30 residues, are rarely considered to be proteins and are commonly called pep ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protein-coding genes and non-coding genes. During gene expression (the synthesis of Gene product, RNA or protein from a gene), DNA is first transcription (biology), copied into RNA. RNA can be non-coding RNA, directly functional or be the intermediate protein biosynthesis, template for the synthesis of a protein. The transmission of genes to an organism's offspring, is the basis of the inheritance of phenotypic traits from one generation to the next. These genes make up different DNA sequences, together called a genotype, that is specific to every given individual, within the gene pool of the population (biology), population of a given species. The genotype, along with environmental and developmental factors, ultimately determines the phenotype ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
MUTED
Muteness is a speech disorder in which a person lacks the ability to speak. Mute, Mutes or the Mute may also refer to: Arts and entertainment Film and television * ''Mute'' (2005 film), a short film by Melissa Joan Hart * ''Mute'' (2018 film), a science-fiction thriller directed by Duncan Jones * "Mute" (''The Twilight Zone''), a 1963 episode of ''The Twilight Zone'' * ''Muted'' (TV series), a 2023 Spanish Netflix series * Mutes, anthropomorphic animals in the American animated television series ''Kipo and the Age of Wonderbeasts'' Music * Mute (music), a device used to alter the sound of a musical instrument * Left-hand muting or palm mute, guitar muting techniques * Mute Records, a record label in the United Kingdom * ''Mute'' (album), a 2000 indie rock compilation album from Hush Records * ''Muted'' (album), a 2003 album from hip hop artist Alias In print * ''Mute'' (novel), a 1981 novel by Piers Anthony * "Mute" (short story), by Stephen King * Mute, a character in ' ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
