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PCLO
Protein piccolo is a protein that in humans is encoded by the ''PCLO'' gene. Function Synaptic vesicles dock and fuse in the active zone of the plasma membrane at chemical synapses. The presynaptic cytoskeletal matrix (PCM), which is associated with the active zone and is situated between synaptic vesicles, is thought to be involved in maintaining the neurotransmitter release site in register with the postsynaptic reception apparatus. The cycling of synaptic vesicles is a multistep process involving a number of proteins (see MIM 603215). Among the components of the PCM that orchestrate these events are Bassoon (BSN; MIM 604020), RIM (RIMS1; MIM 606629), Oboe (RIMS2; MIM 606630), and Piccolo (PCLO). upplied by OMIMref name="entrez"/> Interactions The protein product of ''PCLO'' called Piccolo has been shown to interact with number of proteins including GIT1, the F-actin-binding protein Abp1, PRA1, TRIO, DAAM1, and Profilin. Clinical relevance Recurrent mutations in th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
GIT1 ARF GTPase-activating protein GIT1 is an enzyme that in humans is encoded by the ''GIT1'' gene. GIT1 contains an ARFGAP domain, Anykrin repeats, and a GRK-interacting domain. The Arf-GAP domain, which enables it to act as a GTPase activating protein (GAP) for the Arf family of GTPases, has been shown to be involved in phosphorylation and inhibition of the ADRB2. If synaptic localization of GIT1 is disturbed, then this is known to affect dendritic spine morphology and formation---this is thought to occur through the Rac1/PAK1/LIMK/CFL1 pathway. Interactions GIT1 has been shown to interact with: * ARHGEF7, * Beta adrenergic receptor kinase, * GIT2, * PCLO, * PLCG1, * PPFIA4 * PTK2, and * liprin-alpha-1 Liprin-alpha-1 is a protein that in humans is encoded by the ''PPFIA1'' gene. Function The protein encoded by this gene is a member of the LAR protein tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LA .... References Further ... [...More Info...] [...Related Items...] OR: [Wikipedia] |