PAR1 Vorapaxar 3
PAR1 may refer to: * PAR1 (gene), Prader–Willi/Angelman region-1 gene * PAR-1, a serine/threonine-protein kinase of the KIN2/PAR-1/MARK kinase family * Coagulation factor II receptor * Parchive, a data archive format * PAR1, one of the pseudoautosomal region The pseudoautosomal regions or PARs are Homology (biology), homologous sequences of Nucleotide, nucleotides found within the Sex chromosome, sex chromosomes of species with an XY sex-determination system, XY or ZW sex-determination system, ZW mech ...

Coagulation Factor II Receptor
Proteinase-activated receptor 1 (PAR1) also known as protease-activated receptor 1, coagulation factor II receptor and thrombin receptor is a protein that in humans is encoded by the ''F2R'' gene. PAR1 is a G protein-coupled receptor and one of four protease-activated receptors involved in the regulation of thrombotic response. Highly expressed in platelets and endothelial cells, PAR1 plays a key role in mediating the interplay between coagulation and inflammation, which is important in the pathogenesis of inflammatory and fibrotic lung diseases." It is also involved both in disruption and maintenance of endothelial barrier integrity, through interaction with either thrombin or activated protein C, respectively. Structure PAR1 is a transmembrane G-protein-coupled receptor (GPCR) that shares much of its structure with the other protease-activated receptors. These characteristics include having seven transmembrane alpha helices, four extracellular loops and three intracellular l ...
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KIN2/PAR-1/MARK Kinase Family
In molecular biology, members of the KIN2/PAR-1/MARK kinase family of proteins are kinases that are conserved from yeast to human and share the same domain organisation: an N-terminal kinase domain and a C-terminal kinase associated domain 1 (KA1). Some members of this family also contain an UBA domain (ubiquitin-associated domain). Members of this kinase family are involved in various biological processes such as cell polarity, cell cycle control, intracellular signalling, microtubule stability and protein stability. The function of the KA1 domain is not yet known. Some proteins known to contain a KA1 domain are listed below: *Mammalian MAP/microtubule affinity-regulating kinases (MARK 1, 2, 3). They regulate polarity in neuronal cell models and appear to function redundantly in phosphorylating microtubule-associated proteins and in regulating microtubule stability. *Mammalian maternal embryonic leucine zipper kinase (MELK). It phosphorylates ZNF622 and may contribute to its r ...
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Parchive
Parchive (a portmanteau of parity archive, and formally known as Parity Volume Set Specification) is an erasure code system that produces par files for checksum verification of data integrity, with the capability to perform data recovery operations that can repair or regenerate corrupted or missing data. Parchive was originally written to solve the problem of reliable file sharing on Usenet, but it can be used for protecting any kind of data from data corruption, disc rot, bit rot, and accidental or malicious damage. Despite the name, Parchive uses more advanced techniques (specifically error correction codes) than simplistic parity methods of error detection. As of 2014, PAR1 is obsolete, PAR2 is mature for widespread use, and PAR3 is a discontinued experimental version developed by MultiPar author Yutaka Sawada. The original SourceForge Parchive project has been inactive since April 30, 2015. A new PAR3 specification has been worked on since April 28, 2019 by PAR2 specifi ...
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