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Otto Folin
Otto Knut Olof Folin (April 4, 1867 – October 25, 1934) was a Swedish-born American chemist who is best known for his groundbreaking work at Harvard University on practical micromethods for the determination of the constituents of protein-free blood filtrates and the discovery of creatine phosphate in muscles. Background Folin was born in Åseda, Småland in Sweden. He was the seventh of twelve children of Nils Magnus Folin and Eva Olson. He moved to America at the age of fifteen following two brothers and an aunt who had already settled there. He carried on his schooling in Stillwater, Minnesota. He moved to Minneapolis, Minnesota entering the University of Minnesota and completed his B.S in 1892. Career In 1896, Folin returned to Sweden and began his research in the laboratory of Prof. Olof Hammarsten (1841-1932) at Uppsala University. In 1897, he left to work in the laboratory of the chemist, Ernst Leopold Salkowski at the Pathological Institute of Charité (''Char ...
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Augustine H
Augustine of Hippo ( , ; ; 13 November 354 – 28 August 430) was a theologian and philosopher of Berbers, Berber origin and the bishop of Hippo Regius in Numidia (Roman province), Numidia, Roman North Africa. His writings deeply influenced the development of Western philosophy and Western Christianity, and he is viewed as one of the most important Latin Church Fathers, Church Fathers of the Latin Church in the Patristic Period. His many important works include ''The City of God'', ''De Doctrina Christiana, On Christian Doctrine'', and ''Confessions (Augustine), Confessions''. According to his contemporary, Jerome, Jerome of Stridon, Augustine "established anew the ancient Faith". In his youth he was drawn to the Manichaeism, Manichaean faith, and later to the Hellenistic philosophy of Neoplatonism. After his conversion to Christianity and baptism in 386, Augustine developed his own approach to philosophy and theology, accommodating a variety of methods and perspectives. Believ ...
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United States
The United States of America (USA), also known as the United States (U.S.) or America, is a country primarily located in North America. It is a federal republic of 50 U.S. state, states and a federal capital district, Washington, D.C. The 48 contiguous states border Canada to the north and Mexico to the south, with the semi-exclave of Alaska in the northwest and the archipelago of Hawaii in the Pacific Ocean. The United States asserts sovereignty over five Territories of the United States, major island territories and United States Minor Outlying Islands, various uninhabited islands in Oceania and the Caribbean. It is a megadiverse country, with the world's List of countries and dependencies by area, third-largest land area and List of countries and dependencies by population, third-largest population, exceeding 340 million. Its three Metropolitan statistical areas by population, largest metropolitan areas are New York metropolitan area, New York, Greater Los Angeles, Los Angel ...
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Journal Of Biological Chemistry
The ''Journal of Biological Chemistry'' (''JBC'') is a weekly peer-reviewed scientific journal that was established in 1905., jbc.org Since 1925, it is published by the American Society for Biochemistry and Molecular Biology. It covers research in areas of biochemistry and molecular biology. The editor is Alex Toker. the journal is fully open access. In press articles are available free on its website immediately after acceptance. Editors The following individuals have served as editors of the journal: * 1906–1909: John Jacob Abel and Christian Archibald Herter * 1909–1910: Christian Archibald Herter * 1910–1914: Alfred Newton Richards * 1914–1925: Donald D. Van Slyke * 1925–1936: Stanley R. Benedict. After Benedict died, John T. Edsall served as temporary editor until the next editor was appointed. * 1937–1958: Rudolph J. Anderson * 1958–1967: John T. Edsall * 1968–1971: William Howard Stein * 1971–2011: Herbert Tabor * 2011–2015: Martha Fedor * ...
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American Society For Biochemistry And Molecular Biology
The American Society for Biochemistry and Molecular Biology (ASBMB) is a learned society that was founded on December 26, 1906, at a meeting organized by John Jacob Abel (Johns Hopkins University). The roots of the society were in the American Physiological Society, which had been formed some 20 years earlier. ASBMB is the US member of the International Union of Biochemistry and Molecular Biology. The ASBMB was originally called the American Society of Biological Chemists, before obtaining its current name in 1987. The society is based in Rockville, Maryland. ASBMB's mission is to advance the science of biochemistry and molecular biology through publication of scientific journal, scientific and educational journals, the organization of scientific meetings, advocacy for funding of basic research and education, support of science education at all levels, and by promoting the diversity of individuals entering the scientific workforce. The organization currently has over 12,000 member ...
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Folin-Wu Method
The blood sugar level, blood sugar concentration, blood glucose level, or glycemia is the measure of glucose concentrated in the blood. The body tightly regulates blood glucose levels as a part of metabolic homeostasis. For a 70 kg (154 lb) human, approximately four grams of dissolved glucose (also called "blood glucose") is maintained in the blood plasma at all times. Glucose that is not circulating in the blood is stored in skeletal muscle and liver cells in the form of glycogen; in fasting individuals, blood glucose is maintained at a constant level by releasing just enough glucose from these glycogen stores in the liver and skeletal muscle in order to maintain homeostasis. Glucose can be transported from the intestines or liver to other tissues in the body via the bloodstream. Cellular glucose uptake is primarily regulated by insulin, a hormone produced in the pancreas. Once inside the cell, the glucose can now act as an energy source as it undergoes the proces ...
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Hsien Wu
Hsien Wu (; 24 November 1893 – 8 August 1959) was a Chinese biochemist and geneticist. He was the first to propose that protein denaturation was a purely conformational change, i.e., corresponded to protein unfolding and not to some chemical alteration of the protein. This crucial idea was popularized later by Linus Pauling and Alfred Mirsky. Wu was born in Fuzhou, Fujian, China. He studied at the Massachusetts Institute of Technology (undergraduate), and then trained at Harvard University (graduate) under Otto Folin, developing the first small-volume (≥ 0.1-mL sample) assay for blood sugar ( Folin-Wu method). Wu then returned to China to a position at Peking Union Medical College, becoming head of the biochemistry department in 1924. At the end of that year, he married his research assistant Daisy Yen and would continue collaborating with her until his death in 1959. Wu left China in 1947 to reside in the United States; his wife and children joined him in 1949. Wu ...
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Vintilă Ciocâlteu
Vintilă Ciocâlteu (; April 12, 1890 – February 3, 1947) was a Romanian physician, researcher, professor, and author. Biography He was born in Plenița, Dolj County, Romania, the son of the teacher Mihai Ciocâlteu. He attended high school in Craiova, and he graduated the Faculty of Medicine of Bucharest in 1920. Ciocâlteu distinguished himself throughout medical school and was active in the leadership of the student association. Due to his brilliant academic results, he was selected as the recipient of a Rockefeller grant to further his studies at Harvard Medical School in the United States. There, in collaboration with Otto Folin he co-developed the chemical reactive known as the Folin-Ciocalteu reagent (FCR). He returned to Romania as a professor at the Carol Davila University of Medicine and Pharmacy in Bucharest, where he laid the foundation of the biochemistry lab. He also set up his own additional private research lab in the vacant former Royal Stables. His credenti ...
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Boston
Boston is the capital and most populous city in the Commonwealth (U.S. state), Commonwealth of Massachusetts in the United States. The city serves as the cultural and Financial centre, financial center of New England, a region of the Northeastern United States. It has an area of and a population of 675,647 as of the 2020 United States census, 2020 census, making it the third-largest city in the Northeastern United States after New York City and Philadelphia. The larger Greater Boston metropolitan statistical area has a population of 4.9 million as of 2023, making it the largest metropolitan area in New England and the Metropolitan statistical area, eleventh-largest in the United States. Boston was founded on Shawmut Peninsula in 1630 by English Puritans, Puritan settlers, who named the city after the market town of Boston, Lincolnshire in England. During the American Revolution and American Revolutionary War, Revolutionary War, Boston was home to several seminal events, incl ...
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Berlin, Germany
Berlin ( ; ) is the capital and largest city of Germany, by both area and population. With 3.7 million inhabitants, it has the highest population within its city limits of any city in the European Union. The city is also one of the states of Germany, being the third smallest state in the country by area. Berlin is surrounded by the state of Brandenburg, and Brandenburg's capital Potsdam is nearby. The urban area of Berlin has a population of over 4.6 million and is therefore the most populous urban area in Germany. The Berlin-Brandenburg capital region has around 6.2 million inhabitants and is Germany's second-largest metropolitan region after the Rhine-Ruhr region, as well as the fifth-biggest metropolitan region by GDP in the European Union. Berlin was built along the banks of the Spree river, which flows into the Havel in the western borough of Spandau. The city includes lakes in the western and southeastern boroughs, the largest of which is Müggelsee. About on ...
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Ernst Leopold Salkowski
Ernst Leopold Salkowski (October 11, 1844 – March 8, 1923) was a German biochemist who was a native of Königsberg. He received his education at the University of Königsberg, later working in Berlin as an assistant in the chemical laboratory of Rudolf Virchow's institute of pathology (1872). In 1874 he became an associate professor of medicinal chemistry in Berlin, followed by an assignment as departmental head (1880). In 1909 he was honored with the title of "full professor". Salkowski specialized in the fields of physiological and pathological chemistry, also making contributions in the related fields of pharmacology, analytical chemistry and hygiene. In 1890 he was the first to describe tissue autolysis, of which he referred to as "auto-digestion". He is remembered for developing tests for detection of various compounds and substances, such as cholesterol ( Salkowski's test), creatinine, glucose, carbon monoxide, and indole. In 1892 (with Jastrowitz) he was the first ...
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Minneapolis, Minnesota
Minneapolis is a city in Hennepin County, Minnesota, United States, and its county seat. With a population of 429,954 as of the 2020 United States census, 2020 census, it is the state's List of cities in Minnesota, most populous city. Located in the state's center near the eastern border, it occupies both banks of the Upper Mississippi River and adjoins Saint Paul, Minnesota, Saint Paul, the state capital of Minnesota. Minneapolis, Saint Paul, and the surrounding area are collectively known as the Minneapolis–Saint Paul, Twin Cities, a metropolitan area with 3.69 million residents. Minneapolis is built on an artesian aquifer on flat terrain and is known for cold, snowy winters and hot, humid summers. Nicknamed the "City of Lakes", Minneapolis is abundant in water, with list of lakes in Minneapolis, thirteen lakes, wetlands, the Mississippi River, creeks, and waterfalls. The city's public park system is connected by the Grand Rounds National Scenic Byway. Dakota people orig ...
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Stillwater (Minnesota)
Stillwater is a city in the U.S. state of Minnesota and the county seat of Washington County, Minnesota, Washington County. It is in the Minneapolis–Saint Paul metropolitan area, on the west bank of the St. Croix River (Wisconsin-Minnesota), St. Croix River, across from Houlton, Wisconsin. Stillwater's population was 19,394 at the 2020 United States census, 2020 census. Stillwater is often called "the birthplace of Minnesota" due to its role in the establishment of the state. Geography According to the United States Census Bureau, the city has an area of ; is land and is water. State Highways Minnesota State Highway 36, 36, Minnesota State Highway 95, 95, and Minnesota State Highway 96, 96 are three of the community's main routes. Climate Stillwater receives an average annual snowfall of . Average annual rainfall is . Each year has an average of 14 days above . Name The name "Stillwater" was proposed in 1843 by John McKusick, who built the settlement's first sawmill. M ...
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