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Organoids
An organoid is a miniaturised and simplified version of an Organ (anatomy), organ produced ''in vitro'' in three dimensions that mimics the key functional, structural, and biological complexity of that organ. It is derived from one or a few Cell (biology), cells from a Tissue (biology), tissue, embryonic stem cells, or induced pluripotent stem cells, which can Self-organization, self-organize in three-dimensional culture owing to their Stem cell, self-renewal and Cellular differentiation, differentiation capacities. The technique for growing organoids has rapidly improved since the early 2010s, and ''The Scientist (magazine), The Scientist'' named it one of the biggest scientific advancements of 2013. Scientists and engineers use organoids to study development and disease in the laboratory, for drug discovery and development in industry, personalized diagnostics and medicine, gene and cell therapies, tissue engineering, and regenerative medicine.Verstegen, Monique M. A.; Coppes, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hans Clevers
Johannes (Hans) Carolus Clevers (born 27 March 1957) is a Dutch Molecular genetics, molecular geneticist, Cell biology, cell biologist and stem cell researcher. He became the Head of Pharma, Research and Early Development, and a member of the Corporate Executive Committee, of the Switzerland, Swiss healthcare company Roche in 2022. Previously, he headed a research group at the Royal Netherlands Academy of Arts and Sciences#Research institutes, Hubrecht Institute for Developmental Biology and Stem Cell Research and at the ; he remained as an advisor and guest scientist or visiting researcher to both groups. He is also a Professor in Molecular Genetics at Utrecht University. Early life and education Hans Clevers was born in Eindhoven, the Netherlands in 1957. He began studying biology at Utrecht University in 1975, but also started taking medicine in 1978, in part due to his interest and in part because his friends and brothers were in the medical profession. He spent 1 year in N ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Stem Cell
In multicellular organisms, stem cells are undifferentiated or partially differentiated cells that can change into various types of cells and proliferate indefinitely to produce more of the same stem cell. They are the earliest type of cell in a cell lineage. They are found in both embryonic and adult organisms, but they have slightly different properties in each. They are usually distinguished from progenitor cells, which cannot divide indefinitely, and precursor or blast cells, which are usually committed to differentiating into one cell type. In mammals, roughly 50 to 150 cells make up the inner cell mass during the blastocyst stage of embryonic development, around days 5–14. These have stem-cell capability. '' In vivo'', they eventually differentiate into all of the body's cell types (making them pluripotent). This process starts with the differentiation into the three germ layers – the ectoderm, mesoderm and endoderm – at the gastrulation stage. However, whe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Embryoid Body
Embryoid bodies (EBs) are three-dimensional aggregates formed by pluripotent stem cells. These include embryonic stem cells (ESC) and induced pluripotent stem cells (iPSC) EBs are differentiation of human embryonic stem cells into embryoid bodies comprising the three embryonic germ layers. They mimic the characteristics seen in early-stage embryos. They are often used as a model system to conduct research on various aspects of developmental biology. They can also contribute to research focused on tissue engineering and regenerative medicine. Background The pluripotent cell types that comprise embryoid bodies include embryonic stem cells (ESCs) derived from the blastocyst stage of embryos from mouse (mESC), primate, and human (hESC) sources. Additionally, EBs can be formed from embryonic stem cells derived through alternative techniques, including somatic cell nuclear transfer or the reprogramming of somatic cells to yield induced pluripotent stem cells (iPS). Similar to ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Intestinal Organoid
The gastrointestinal tract (GI tract, digestive tract, alimentary canal) is the tract or passageway of the digestive system that leads from the mouth to the anus. The tract is the largest of the body's systems, after the cardiovascular system. The GI tract contains all the major organs of the digestive system, in humans and other animals, including the esophagus, stomach, and intestines. Food taken in through the mouth is digested to extract nutrients and absorb energy, and the waste expelled at the anus as feces. ''Gastrointestinal'' is an adjective meaning of or pertaining to the stomach and intestines. Most animals have a "through-gut" or complete digestive tract. Exceptions are more primitive ones: sponges have small pores ( ostia) throughout their body for digestion and a larger dorsal pore (osculum) for excretion, comb jellies have both a ventral mouth and dorsal anal pores, while cnidarians and acoels have a single pore for both digestion and excretion. The human gastroi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
UMC Utrecht
The University Medical Center Utrecht (UMCU; Dutch: ''Universitair Medisch Centrum Utrecht'') is the University hospital of the city of Utrecht, Netherlands. It is affiliated with the Utrecht University. Since the foundation of the university in 1636 an academic hospital has existed in various forms. Nowadays the UMC Utrecht comprises the academic hospital, the faculty of Medicine as well as the Wilhelmina Children's hospital. In total approximately 10,000 people work at the UMCU including medical staff, nursing staff, residents, support personnel and researchers, making it one of the largest hospitals in the Netherlands. __TOC__ Special units * Neurosurgery * Cardiothoracic surgery *Radiation oncology unit * Neonatal and pediatric surgery and intensive care * Pediatric oncology * Level I trauma center Adjacent to the UMCU lies the Central Military Hospital, or CMH, for military personnel. The UMCU also features a Major Incident Hospital (Dutch: ''Calamiteitenhospitaal''). Thi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hubrecht Institute
The Royal Netherlands Academy of Arts and Sciences (, KNAW) is an organization dedicated to the advancement of science and literature in the Netherlands. The academy is housed in the Trippenhuis in Amsterdam. In addition to various advisory and administrative functions it operates a number of research institutes and awards many prizes, including the Lorentz Medal in theoretical physics, the Dr Hendrik Muller Prize for Behavioural and Social Science and the Dr. A.H. Heineken Prize, Heineken Prizes. Main functions The academy advises the Dutch government on scientific matters. While its advice often pertains to genuine scientific concerns, it also counsels the government on such topics as policy on careers for researchers or the Netherlands' contribution to major international projects. The academy offers solicited and unsolicited advice to parliament, ministries, universities and research institutes, funding agencies and international organizations. * Advising the government ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neuron
A neuron (American English), neurone (British English), or nerve cell, is an membrane potential#Cell excitability, excitable cell (biology), cell that fires electric signals called action potentials across a neural network (biology), neural network in the nervous system. They are located in the nervous system and help to receive and conduct impulses. Neurons communicate with other cells via synapses, which are specialized connections that commonly use minute amounts of chemical neurotransmitters to pass the electric signal from the presynaptic neuron to the target cell through the synaptic gap. Neurons are the main components of nervous tissue in all Animalia, animals except sponges and placozoans. Plants and fungi do not have nerve cells. Molecular evidence suggests that the ability to generate electric signals first appeared in evolution some 700 to 800 million years ago, during the Tonian period. Predecessors of neurons were the peptidergic secretory cells. They eventually ga ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
RIKEN
is a national scientific research institute in Japan. Founded in 1917, it now has about 3,000 scientists on seven campuses across Japan, including the main site at Wakō, Saitama, Wakō, Saitama Prefecture, on the outskirts of Tokyo. Riken is a Japanese National Research and Development Agencies, Designated National Research and Development Institute, and was formerly an Independent Administrative Institution. Riken conducts research in various fields of science, including physics, chemistry, biology, genomics, medical science, engineering, high-performance computing and computer science, computational science, and ranging from basic research to applied research, practical applications with 485 partners worldwide. It is almost entirely funded by the Japanese government, with an annual budget of ¥100 billion (US$750 million) in FY2023. Name "Riken" is an acronym of the formal name , and its full name in Japanese is and in English is the Institute of Physical and Chemical Resear ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Yoshiki Sasai
was a Japanese stem cell biologist. He developed methods to guide human embryonic stem cells (hESCs) into forming brain cortex, eyes (optic cups), and other organs in tissue culture. Sasai worked at the Riken Center for Developmental Biology (CDB) in Kobe, and was Director of the Laboratory for Organogenesis and Neurogenesis. Following his involvement in the 2014 STAP cell controversy, Sasai was found dead at Riken from an apparent suicide. Early life and education Yoshiki Sasai was born in 1962 in Hyogo, Japan. He received his medical degree from Kyoto University's School of Medicine in 1986. In 1993 Sasai was awarded a PhD from the Kyoto University School of Medicine, and served a residency at Kobe Municipal General Hospital. Career Sasai worked as a research fellow at Edward M. De Robertis's laboratory at UCLA School of Medicine until 1996. Sasai became an associate professor at Kyoto University in 1996, and a full professor in 1998. In 2003 he moved to the RIKEN Center ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Liver
The liver is a major metabolic organ (anatomy), organ exclusively found in vertebrates, which performs many essential biological Function (biology), functions such as detoxification of the organism, and the Protein biosynthesis, synthesis of various proteins and various other Biochemistry, biochemicals necessary for digestion and growth. In humans, it is located in the quadrants and regions of abdomen, right upper quadrant of the abdomen, below the thoracic diaphragm, diaphragm and mostly shielded by the lower right rib cage. Its other metabolic roles include carbohydrate metabolism, the production of a number of hormones, conversion and storage of nutrients such as glucose and glycogen, and the decomposition of red blood cells. Anatomical and medical terminology often use the prefix List of medical roots, suffixes and prefixes#H, ''hepat-'' from ἡπατο-, from the Greek language, Greek word for liver, such as hepatology, and hepatitis The liver is also an accessory digestive ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
