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Oral Polio Vaccine AIDS Hypothesis
The Oral polio vaccine AIDS hypothesis (OPV AIDS) is a largely discredited hypothesis which argued the AIDS pandemic originated from live polio vaccines prepared in chimpanzee tissue cultures, accidentally contaminated with simian immunodeficiency virus and then administered to up to one million Africans between 1957 and 1960 in experimental mass vaccination campaigns. Though a small number of experts initially thought this hypothesis was plausible, later data analyses in molecular biology and phylogenetic studies contradict the OPV AIDS hypothesis. Scientific consensus regards the hypothesis as lacking evidence or disproven. A 2004 ''Nature'' article has described the hypothesis as "refuted". Background: polio vaccines Two vaccines are used throughout the world to combat poliomyelitis. The first, a polio vaccine developed by Jonas Salk, is an ''inactivated poliovirus vaccine'' (IPV), consisting of a mixture of three wild, virulent strains of poliovirus, grown in a type of mo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hypothesis
A hypothesis (: hypotheses) is a proposed explanation for a phenomenon. A scientific hypothesis must be based on observations and make a testable and reproducible prediction about reality, in a process beginning with an educated guess or thought. If a hypothesis is repeatedly independently demonstrated by experiment to be true, it becomes a scientific theory. In colloquial usage, the words "hypothesis" and "theory" are often used interchangeably, but this is incorrect in the context of science. A working hypothesis is a provisionally-accepted hypothesis used for the purpose of pursuing further progress in research. Working hypotheses are frequently discarded, and often proposed with knowledge (and warning) that they are incomplete and thus false, with the intent of moving research in at least somewhat the right direction, especially when scientists are stuck on an issue and brainstorming ideas. A different meaning of the term ''hypothesis'' is used in formal l ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Attenuated Vaccine
An attenuated vaccine (or a live attenuated vaccine, LAV) is a vaccine created by reducing the virulence of a pathogen, but still keeping it viable (or "live"). Attenuation takes an infectious agent and alters it so that it becomes harmless or less virulent. These vaccines contrast to those produced by "killing" the pathogen ( inactivated vaccine). Attenuated vaccines stimulate a strong and effective immune response that is long-lasting. In comparison to inactivated vaccines, attenuated vaccines produce a stronger and more durable immune response with a quick immunity onset. They are generally avoided in pregnancy and in patients with severe immunodeficiencies. Attenuated vaccines function by encouraging the body to create antibodies and memory immune cells in response to the specific pathogen which the vaccine protects against. Common examples of live attenuated vaccines are measles, mumps, rubella, yellow fever, varicella, and some influenza vaccines. Development Attenua ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
French West Africa
French West Africa (, ) was a federation of eight French colonial empires#Second French colonial empire, French colonial territories in West Africa: Colonial Mauritania, Mauritania, French Senegal, Senegal, French Sudan (now Mali), French Guinea (now Guinea), French Ivory Coast, Ivory Coast, French Upper Volta, Upper Volta (now Burkina Faso), French Dahomey, Dahomey (now Benin) and Colony of Niger, Niger. The federation existed from 1895 until 1958. Its capital was Saint-Louis, Senegal, Saint-Louis in Senegal until 1902, and then Dakar until the federation's collapse in 1960. With an area of 4,689,000 km2, French West Africa was eight times the size of Metropolitan France. French Equatorial Africa had an additional area of 2,500,000 km2. History Until after World War II, almost none of the Africans living in the colonies of France were citizens of France. Rather, they were "French subjects," lacking rights before the law, property ownership rights, rights to travel, dissen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
African Green Monkey
''Chlorocebus'' is a genus of medium-sized primates from the family of Old World monkeys. Six species are currently recognized, although some people classify them all as a single species with numerous subspecies. Either way, they make up the entirety of the genus ''Chlorocebus''. Confusingly, the terms "vervet monkey" and "green monkey" are sometimes used to refer to the whole genus ''Chlorocebus'', though they also refer more precisely to species '' Chlorocebus pygerythrus'' and ''Chlorocebus sabaeus'', respectively, neither of which is the type species for ''Chlorocebus''. This article uses the term ''Chlorocebus'' consistently for the genus and the common names only for the species. The native range of these monkeys is sub-Saharan Africa from Senegal and Ethiopia south to South Africa. However, in previous centuries, a number of them were taken as pets by early Caribbean settlers and slave traders, and were transported across the Atlantic Ocean to the Caribbean islands. The mo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tissue Culture
Tissue culture is the growth of tissue (biology), tissues or cell (biology), cells in an artificial medium separate from the parent organism. This technique is also called micropropagation. This is typically facilitated via use of a liquid, semi-solid, or solid growth medium, such as broth or agar. Tissue culture commonly refers to the culture of animal cells and tissues, with the more specific term plant tissue culture being used for plants. The term "tissue culture" was coined by American pathologist Montrose Thomas Burrows. Historical use In 1885 Wilhelm Roux removed a section of the medullary plate of an embryonic chicken and maintained it in a warm saline solution for several days, establishing the basic principle of tissue culture. In 1907 the zoologist Ross Granville Harrison demonstrated the growth of frog embryonic cells that would give rise to nerve cells in a medium of clotted lymph. In 1913, E. Steinhardt, C. Israeli, and R. A. Lambert grew vaccinia virus in fragme ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Kinshasa
Kinshasa (; ; ), formerly named Léopoldville from 1881–1966 (), is the Capital city, capital and Cities of the Democratic Republic of the Congo, largest city of the Democratic Republic of the Congo. Kinshasa is one of the world's fastest-growing Megacity, megacities, with an estimated population of 17 million in 2024. It is the List of cities and towns in the Democratic Republic of the Congo, most densely populated city in the DRC, the List of cities in Africa by population, most populous city and List of urban areas in Africa by population, third-largest metropolitan area in Africa, and the world's List of largest cities, twenty-second most populous city and List of national capitals by population, fourth-most populous capital city. It is the leading Economy, economic, Politics, political, and cultural center of the DRC, housing several industries including manufacturing, telecommunications, List of banks in the Democratic Republic of the Congo, banking, and entertainment. The ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Burundi
Burundi, officially the Republic of Burundi, is a landlocked country in East Africa. It is located in the Great Rift Valley at the junction between the African Great Lakes region and Southeast Africa, with a population of over 14 million people. It is bordered by Rwanda to the north, Tanzania to the east and southeast, and the Democratic Republic of the Congo to the west; Lake Tanganyika lies along its southwestern border. The political capital city is Gitega and the economic capital city is Bujumbura. The Great Lakes Twa, Twa, Hutu and Tutsi peoples have lived in Burundi for at least 500 years. For more than 200 of those years, Burundi was an independent Kingdom of Burundi, kingdom. In 1885, it became part of the German colony of German East Africa. After the First World War and German Revolution of 1918–19, Germany's defeat, the League of Nations mandated the territories of Burundi and neighboring Rwanda to Belgium in a combined territory called Rwanda-Urundi. After the Se ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rwanda
Rwanda, officially the Republic of Rwanda, is a landlocked country in the Great Rift Valley of East Africa, where the African Great Lakes region and Southeast Africa converge. Located a few degrees south of the Equator, Rwanda is bordered by Uganda, Tanzania, Burundi, and the Democratic Republic of the Congo. With a comparatively high elevation, Rwanda has been given the sobriquet "land of a thousand hills" (), with its geography dominated by mountains in the west and savanna to the southeast, with numerous lakes throughout the country. The climate is temperate to subtropical, with two rainy seasons and two dry seasons each year. It is the most densely populated mainland African country; among countries larger than 10,000 km2, it is the third-most densely populated country in the world. Its Capital city, capital and largest city is Kigali. Hunter-gatherers settled the territory in the Stone Age, Stone and Iron Ages, followed later by Bantu peoples. The population coalesce ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Democratic Republic Of The Congo
The Democratic Republic of the Congo (DRC), also known as the DR Congo, Congo-Kinshasa, or simply the Congo (the last ambiguously also referring to the neighbouring Republic of the Congo), is a country in Central Africa. By land area, it is the List of African countries by area, second-largest country in Africa and the List of countries and dependencies by area, 11th-largest in the world. With a population of around 112 million, the DR Congo is the most populous nominally List of countries and territories where French is an official language, Francophone country in the world. Belgian French, French is the official and most widely spoken language, though there are Languages of the Democratic Republic of the Congo, over 200 indigenous languages. The national capital and largest city is Kinshasa, which is also the economic center. The country is bordered by the Republic of the Congo, the Cabinda Province, Cabinda exclave of Angola, and the South Atlantic Ocean to the west; the Cen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hilary Koprowski
Hilary Koprowski (5 December 191611 April 2013) was a Polish virologist and immunologist active in the United States who demonstrated the world's first effective live polio vaccine. He authored or co-authored over 875 scientific papers and co-edited several scientific journals. Koprowski received many academic honors and national decorations, including the Belgian Order of the Lion, the French Order of Merit and Legion of Honour, Finland's Order of the Lion, and the Order of Merit of the Republic of Poland. Koprowski was the target of accusations in the press related to the " oral polio vaccine AIDS hypothesis", which posited that the AIDS pandemic originated from live polio vaccines developed by Koprowski in the Belgian Congo. This hypothesis was challenged on numerous grounds, and scientists largely rejected it. Life Hilary Koprowski was born in Warsaw to an educated, assimilated Jewish family. His parents met in 1906 when Paweł Koprowski (1882–1957) was serving in t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Albert Sabin
Albert Bruce Sabin ( ; born Abram Saperstejn; August 26, 1906 – March 3, 1993) was a Polish-American medical researcher, best known for developing the oral polio vaccine, which has played a key role in nearly Poliomyelitis eradication, eradicating the disease. In 1969–72, he served as the president of the Weizmann Institute of Science in Israel. Biography Abram Saperstejn was born in Białystok, Russian Empire (before and since 1918 in Poland), to History of the Jews in Poland, Polish-Jewish parents, Jacob Saperstejn and Tillie Krugman. In 1921, he emigrated with his family on the SS Lapland, SS ''Lapland'' which sailed from Antwerp to the Port of New York and New Jersey, Port of New York. In 1930, he became a naturalized citizen of the United States and changed his name to Albert Bruce Sabin. He graduated from high school in Paterson, New Jersey. Sabin began university in a dentistry program, but was interested in virology and changed majors. He received a bachelor's deg ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pharynx
The pharynx (: pharynges) is the part of the throat behind the human mouth, mouth and nasal cavity, and above the esophagus and trachea (the tubes going down to the stomach and the lungs respectively). It is found in vertebrates and invertebrates, though its structure varies across species. The pharynx carries food to the esophagus and air to the larynx. The flap of cartilage called the epiglottis stops food from entering the larynx. In humans, the pharynx is part of the Digestion, digestive system and the conducting zone of the respiratory system. (The conducting zone—which also includes the nostrils of the Human nose, nose, the larynx, trachea, bronchus, bronchi, and bronchioles—filters, warms, and moistens air and conducts it into the lungs). The human pharynx is conventionally divided into three sections: the nasopharynx, oropharynx, and laryngopharynx (hypopharynx). In humans, two sets of pharyngeal muscles form the pharynx and determine the shape of its lumen (anatomy), ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
