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ORF9b
ORF9b (formerly sometimes called ORF13) is a gene that encodes a viral accessory protein in coronavirus Coronaviruses are a group of related RNA viruses that cause diseases in mammals and birds. In humans and birds, they cause respiratory tract infections that can range from mild to lethal. Mild illnesses in humans include some cases of the comm ...es of the subgenus ''Sarbecovirus'', including SARS-CoV and SARS-CoV-2. It is an overlapping gene whose open reading frame is entirely contained within the N gene, which encodes coronavirus nucleocapsid protein. The encoded protein is 97 amino acid residues long in SARS-CoV and 98 in SARS-CoV-2, in both cases forming a protein dimer. Nomenclature There has been inconsistency in the nomenclature used for this gene in the scientific literature. In some work on SARS-CoV, it has been referred to as ORF13. It has also sometimes been referred to as ORF9a, resulting in a downstream ORF of 76 codons in SARS-CoV, also overlapping with th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
ORF9c
ORF9c (formerly also called ORF14) is an open reading frame (ORF) in coronavirus genomes of the subgenus ''Sarbecovirus''. It is 73 codons long in the SARS-CoV-2 genome. Although it is often included in lists of ''Sarbecovirus'' viral accessory protein genes, experimental and bioinformatics evidence suggests ORF9c may not be a functional protein-coding gene. Nomenclature There has been inconsistency in the nomenclature used for this gene in the scientific literature. In some work on SARS-CoV, it has been referred to as ORF14. It has sometimes been referred to as ORF9b, while its longer upstream neighbor ORF9b was given the name ORF9a. The current recommended nomenclature refers to this gene as ORF9c, and the upstream gene as ORF9b. Expression and interactions ORF9c is one of two overlapping genes fully contained within the open reading frame of the N gene encoding coronavirus nucleocapsid protein, the other being ORF9b. It is unclear if ORF9c is functionally expressed during SAR ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |