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NIMML
The Biocomplexity Institute of Virginia Tech (formerly the Virginia Bioinformatics Institute) was a research institute specializing in bioinformatics, computational biology, and systems biology. The institute had more than 250 personnel, including over 50 tenured and research faculty. Research at the institute involved collaboration in diverse disciplines such as mathematics, computer science, biology, plant pathology, biochemistry, systems biology, statistics, economics, synthetic biology and medicine. The institute developed -omic and bioinformatic tools and databases that can be applied to the study of human, animal and plant diseases as well as the discovery of new vaccine, drug and diagnostic targets. The institute's programs were supported by a variety of government and private agencies including the National Institutes of Health, National Science Foundation, U.S. Department of Defense, U.S. Department of Agriculture, and U.S. Department of Energy. Since inception, the Bioc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Seal (emblem)
A seal is a device for making an impression in Sealing wax, wax, clay, paper, or some other medium, including an Paper embossing, embossment on paper, and is also the impression thus made. The original purpose was to authenticate a document, or to prevent interference with a package or envelope by applying a seal which had to be broken to open the container (hence the modern English verb "to seal", which implies secure closing without an actual wax seal). The seal-making device is also referred to as the seal ''matrix'' or ''die''; the imprint it creates as the seal impression (or, more rarely, the ''sealing''). If the impression is made purely as a relief resulting from the greater pressure on the paper where the high parts of the matrix touch, the seal is known as a ''dry seal''; in other cases ink or another liquid or liquefied medium is used, in another color than the paper. In most traditional forms of dry seal the design on the seal matrix is in Intaglio (sculpture), intag ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Infectious Diseases
infection is the invasion of tissues by pathogens, their multiplication, and the reaction of host tissues to the infectious agent and the toxins they produce. An infectious disease, also known as a transmissible disease or communicable disease, is an illness resulting from an infection. Infections can be caused by a wide range of pathogens, most prominently bacteria and viruses. Hosts can fight infections using their immune systems. Mammalian hosts react to infections with an innate response, often involving inflammation, followed by an adaptive response. Treatment for infections depends on the type of pathogen involved. Common medications include: * Antibiotics for bacterial infections. * Antivirals for viral infections. * Antifungals for fungal infections. * Antiprotozoals for protozoan infections. * Antihelminthics for infections caused by parasitic worms. Infectious diseases remain a significant global health concern, causing approximately 9.2 million deaths ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Affymetrix
Affymetrix is now Applied Biosystems, a brand of DNA microarray products sold by Thermo Fisher Scientific that originated with an American biotechnology research and development and manufacturing company of the same name. The Santa Clara, California-based Affymetrix, Inc. now a part of Thermo Fisher Scientific was co-founded by Alex Zaffaroni and Stephen Fodor. Stephen Fodor and his group, based on their earlier development of methods to fabricate DNA microarrays using semiconductor manufacturing techniques. In 1994, the company's first product under the "GeneChip" Affymetrix trademark, an HIV genotyping chip was introduced, and the company went public in 1996. After incorporation, Affymetrix grew in part by acquiring technologies from other companies, including Genetic MicroSystems (slide-based Microarrays and scanners) and Neomorphic (for bioinformatics) in 2000, ParAllele Bioscience (custom SNP genotyping), USB/Anatrace (biochemical reagents) in 2008, Panomics (low to mi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
454 Life Sciences
454 Life Sciences was a biotechnology company based in Branford, Connecticut that specialized in high-throughput DNA sequencing. It was acquired by Roche in 2007 and shut down by Roche in 2013 when its technology became noncompetitive, although production continued until mid-2016. History 454 Life Sciences was founded by Jonathan Rothberg and was originally known as 454 Corporation, a subsidiary of CuraGen. For their method for low-cost gene sequencing, 454 Life Sciences was awarded the Wall Street Journal's Gold Medal for Innovation in the Biotech-Medical category in 2005. The name 454 was the code name by which the project was referred to at CuraGen, and the numbers have no known special meaning. In November 2006, Rothberg, Michael Egholm, and colleagues at 454 published a cover article with Svante Pääbo in Nature describing the first million base pairs of the Neanderthal genome, and initiated the Neanderthal Genome Project to complete the sequence of the Neanderthal ge ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Virginia Tech National Capital Region
Virginia, officially the Commonwealth of Virginia, is a state in the Southeastern and Mid-Atlantic regions of the United States between the Atlantic Coast and the Appalachian Mountains. The state's capital is Richmond and its most populous city is Virginia Beach. Its most populous subdivision is Fairfax County, part of Northern Virginia, where slightly over a third of Virginia's population of more than 8.8million live. Eastern Virginia is part of the Atlantic Plain, and the Middle Peninsula forms the mouth of the Chesapeake Bay. Central Virginia lies predominantly in the Piedmont, the foothill region of the Blue Ridge Mountains, which cross the western and southwestern parts of the state. The fertile Shenandoah Valley fosters the state's most productive agricultural counties, while the economy in Northern Virginia is driven by technology companies and U.S. federal government agencies. Hampton Roads is also the site of the region's main seaport and Naval Station Norfolk, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alexandria, Virginia
Alexandria is an independent city (United States), independent city in Northern Virginia, United States. It lies on the western bank of the Potomac River approximately south of Washington, D.C., D.C. The city's population of 159,467 at the 2020 census made it the List of cities in Virginia, sixth-most populous city in Virginia and List of United States cities by population, 169th-most populous city in the U.S. Alexandria is a principal city of the Washington metropolitan area, which is part of the larger Washington–Baltimore combined statistical area. Like the rest of Northern Virginia and Central Maryland, present-day Alexandria has been influenced by its proximity to the U.S. capital. It is largely populated by professionals working in the United States federal civil service, federal civil service, in the United States Armed Forces, U.S. military, or for one of the many private companies which contract to Government contractor, provide services to the Federal government of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Abscisic Acid
Abscisic acid (ABA or abscisin II) is a plant hormone. ABA functions in many plant developmental processes, including seed and bud dormancy, the control of organ size and stomatal closure. It is especially important for plants in the response to environmental stresses, including drought, soil salinity, cold tolerance, freezing tolerance, heat stress and heavy metal ion tolerance. Discovery In the 1940s, Torsten Hemberg, while working at the University of Stockholm, found evidence that a positive correlation exists between the rest period and the occurrence of an acidic ether soluble growth inhibitor in potato tubers. In 1963, abscisic acid was first identified and characterized as a plant hormone by Frederick T. Addicott and Larry A. Davis. They were studying compounds that cause abscission (shedding) of cotton fruits (bolls). Two compounds were isolated and called abscisin I and abscisin II. Abscisin II is presently called abscisic acid (ABA). In plants Function ABA was ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Conjugated Linoleic Acid
Conjugated linoleic acids (CLA) are a family of isomers of linoleic acid. In principle, 28 isomers are possible. CLA is found mostly in the meat and dairy products derived from ruminants. The two C=C double bonds are conjugated (i.e., separated by a single bond) as opposed by "typical" polyunsaturated fatty acids where double bonds are separated by two single bonds. CLAs are simultaneously both cis-fats and trans-fats, as one of the two C=C bonds is ''cis'' and the other ''trans''. CLA is naturally present in milkfat and beef, has shown some potentially beneficial effects on rodent models of cardiometabolic disease, and is also available as a dietary supplement. Biochemistry CLA describes a variety of isomers of octadecadienoic fatty acids. Commonly, CLAs are studied as some mixture of isomers wherein the isomers c9,t11-CLA (rumenic acid) and t10,c12-CLA were the most abundant. Studies show however that individual isomers have distinct health effects. Conjugated linoleic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Virginia Tech Carilion School Of Medicine And Research Institute
Virginia, officially the Commonwealth of Virginia, is a state in the Southeastern and Mid-Atlantic regions of the United States between the Atlantic Coast and the Appalachian Mountains. The state's capital is Richmond and its most populous city is Virginia Beach. Its most populous subdivision is Fairfax County, part of Northern Virginia, where slightly over a third of Virginia's population of more than 8.8million live. Eastern Virginia is part of the Atlantic Plain, and the Middle Peninsula forms the mouth of the Chesapeake Bay. Central Virginia lies predominantly in the Piedmont, the foothill region of the Blue Ridge Mountains, which cross the western and southwestern parts of the state. The fertile Shenandoah Valley fosters the state's most productive agricultural counties, while the economy in Northern Virginia is driven by technology companies and U.S. federal government agencies. Hampton Roads is also the site of the region's main seaport and Naval Station Norfolk, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
COPASI
COPASI (COmplex PAthway SImulator) is an open-source software application for creating and solving mathematical models of biological processes such as metabolic networks, cell-signaling pathways, regulatory networks, infectious diseases, and many others. History COPASI is based on the Gepasi simulation software that was developed in the early 1990s by Pedro Mendes. The initial development of COPASI was funded by the Virginia Bioinformatics Institute, and the Klaus Tschira Foundation. Current development efforts are supported by grants from the National Institutes of Health, the BBSRC, and the German Ministry of Education. Development team COPASI is the result of an international collaboration between the University of Manchester (UK), the University of Heidelberg (Germany), and the Virginia Bioinformatics Institute (USA). The project principal investigators are Pedro Mendes and Ursula Kummer. The chief software architects are Stefan Hoops and Sven Sahle. Features COP ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Georgetown University
Georgetown University is a private university, private Jesuit research university in Washington, D.C., United States. Founded by Bishop John Carroll (archbishop of Baltimore), John Carroll in 1789, it is the oldest Catholic higher education, Catholic institution of higher education in the United States, the oldest university in Washington, D.C., and the nation's first University charter#Federal, federally chartered university. The university has eleven Undergraduate education, undergraduate and Postgraduate education, graduate schools. Its main campus, located in the Georgetown (Washington, D.C.), Georgetown historic neighborhood, is on a hill above the Potomac River and identifiable by Healy Hall, a National Historic Landmark. It is Carnegie Classification of Institutions of Higher Education, classified among List_of_research_universities_in_the_United_States#Universities_classified_as_"R1:_Doctoral_Universities_–_Very_high_research_activity", "R1: Doctoral Universities – V ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cryptosporidiosis
Cryptosporidiosis, sometimes informally called crypto, is a parasitic disease caused by ''Cryptosporidium'', a genus of protozoan parasites in the phylum Apicomplexa. It affects the ileum, distal small intestine and can affect the respiratory tract in both immunocompetent (i.e., individuals with a normal functioning immune system) and immunocompromised (e.g., persons with HIV/AIDS or autoimmune disorders) individuals, resulting in diarrhea, watery diarrhea with or without an unexplained cough. In immunosuppressed individuals, the symptoms are particularly severe and can be fatal. It is primarily spread through the fecal-oral route, often through contaminated water; recent evidence suggests that it can also be transmitted via fomites contaminated with respiratory secretions. ''Cryptosporidium'' is commonly isolated in HIV-positive patients presenting with diarrhea. The organism was first described in 1907 by Tyzzer, who recognised it was a coccidian. On January 8, 2025, a group o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
