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Mütter Museum
The Mütter Museum is a medical history and science museum located in the Center City, Philadelphia, Center City area of Philadelphia, Pennsylvania. It contains a collection of anatomy, anatomical and pathology, pathological Biological specimen, specimens, wax sculpture, wax models, and antique medical equipment. The museum is part of College of Physicians of Philadelphia, The College of Physicians of Philadelphia. The original purpose of the museum, founded with a gift from Dr. Thomas Dent Mütter on December 11, 1858, was for the education of medical professionals, medical students, and invited guests of College Fellows, and did not become open to non-Fellows until the mid-1970s. The College of Physicians of Philadelphia is itself not a teaching organization, but rather a member organization or "scientific body dedicated to the advancement of science and medicine". The museum has a collection of over 37,000 specimens, of which about 10% were on display as of 2023. This does ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
College Of Physicians Of Philadelphia
The College of Physicians of Philadelphia is the oldest private medical society in the United States. Founded in 1787 by 24 Philadelphia physicians "to advance the Science of Medicine, and thereby lessen human misery, by investigating the diseases and remedies which are peculiar to our country" and to promote "order and uniformity in the practice of Physick," it has made important contributions to medical education and research. The College hosts the Mütter Museum, a gallery of 19th-century specimens, teaching models, instruments, and photographs, as well as the Historical Medical Library, which is one of the country's oldest medical libraries. The College of Physicians of Philadelphia Building, designed by the firm of Cope & Stewardson and built in 1909, was designated a U.S. National Historic Landmark in October, 2008. It was also then listed on the National Register of Historic Places. Current programs The College remains a private membership organization of physicians, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Harry Raymond Eastlack
Harry Raymond Eastlack, Jr. (17 November 1933 – 11 November 1973) was the subject of the most recognized case of fibrodysplasia ossificans progressiva (FOP) from the 20th century. His case is also particularly acknowledged, by scientists and researchers, for his contribution to medical advancement. After living with a rare, disabling, and currently incurable genetic disease, Eastlack decided to have his skeleton and medical history donated to the Mütter Museum of the College of Physicians of Philadelphia in support of FOP research. His skeleton is one of the few FOP-presenting, fully articulated ones in existence, and it has proved valuable to the study of the disease. As is characteristic of FOP patients, Eastlack did not demonstrate any possible sign of a disease at birth except for a malformation of the big toes. At the time it was not recognized as the first clinical sign of FOP. It was not until 1937 when the first heterotopic ossification symptom surfaced. By the time of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chang And Eng Bunker
Chang Bunker (จัน บังเกอร์) and Eng Bunker (อิน บังเกอร์) (May 11, 1811 – January 17, 1874) were Siamese (Thai)-American conjoined twins, conjoined twin brothers whose fame propelled the expression "Siamese twins" to become synonymous for conjoined twins in general. They were widely exhibited as curiosities and were "two of the nineteenth century's most studied human beings". The brothers were born in Rattanakosin Kingdom (1782–1932), Siam (now known as Thailand) to a family of Thai Chinese, Chinese descent and were brought to the United States in 1829. They became known to American and European audiences in "freak shows". Newspapers and the public were initially sympathetic to them, and within three years they left the control of their managers, who they thought were cheating them, and toured on their own. In early exhibitions, they were exoticized and displayed their athleticism; they later held conversations in English in a more ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Conjoined
Conjoined twins, popularly referred to as Siamese twins, are twins joined '' in utero''. It is a very rare phenomenon, estimated to occur in anywhere between one in 50,000 births to one in 200,000 births, with a somewhat higher incidence in southwest Asia and Africa. Approximately half are stillborn, and an additional one-third die within 24 hours. Most live births are female, with a ratio of 3:1. Two possible explanations of the cause of conjoined twins have been proposed. The one that is generally accepted is ''fission'', in which the fertilized egg splits partially. The other explanation, no longer believed to be accurate, is ''fusion'', in which the fertilized egg completely separates, but stem cells (that search for similar cells) find similar stem cells on the other twin and fuse the twins together. Conjoined twins and some monozygotic, but not conjoined, twins share a single common chorion, placenta, and amniotic sac '' in utero''. Chang and Eng Bunker (1811–1874) ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Liver
The liver is a major metabolic organ (anatomy), organ exclusively found in vertebrates, which performs many essential biological Function (biology), functions such as detoxification of the organism, and the Protein biosynthesis, synthesis of various proteins and various other Biochemistry, biochemicals necessary for digestion and growth. In humans, it is located in the quadrants and regions of abdomen, right upper quadrant of the abdomen, below the thoracic diaphragm, diaphragm and mostly shielded by the lower right rib cage. Its other metabolic roles include carbohydrate metabolism, the production of a number of hormones, conversion and storage of nutrients such as glucose and glycogen, and the decomposition of red blood cells. Anatomical and medical terminology often use the prefix List of medical roots, suffixes and prefixes#H, ''hepat-'' from ἡπατο-, from the Greek language, Greek word for liver, such as hepatology, and hepatitis The liver is also an accessory digestive ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hard Palate
The hard palate is a thin horizontal bony plate made up of two bones of the facial skeleton, located in the roof of the mouth. The bones are the palatine process of the maxilla and the horizontal plate of palatine bone. The hard palate spans the alveolar arch formed by the alveolar process that holds the upper teeth (when these are developed). Structure The hard palate is formed by the palatine process of the maxilla and horizontal plate of palatine bone. It forms a partition between the nasal passages and the mouth. On the anterior portion of the hard palate are the ''plicae'', irregular ridges in the mucous membrane that help hold food while the teeth are biting into it while also facilitating the movement of food backward towards the larynx once pieces have been bitten off. This partition is continued deeper into the mouth by a fleshy extension called the soft palate. On the ventral surface of the hard palate, some projections or transverse ridges are present which ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Grover Cleveland
Stephen Grover Cleveland (March 18, 1837June 24, 1908) was the 22nd and 24th president of the United States, serving from 1885 to 1889 and from 1893 to 1897. He was the first U.S. president to serve nonconsecutive terms and the first History of the Democratic Party (United States), Democrat elected president after the American Civil War, Civil War. Born in Caldwell, New Jersey, Cleveland was elected mayor of Buffalo in 1881 and governor of New York in 1882. While governor, he closely cooperated with New York State Assembly, state assembly minority leader Theodore Roosevelt to pass reform measures, winning national attention. He led the Bourbon Democrats, a pro-business movement opposed to History of tariffs in the United States#Civil War, high tariffs, free silver, inflation, imperialism, and subsidies to businesses, farmers, or Social history of soldiers and veterans in the United States, veterans. His crusade for political reform and fiscal conservatism made him an icon ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neoplasm
A neoplasm () is a type of abnormal and excessive growth of tissue. The process that occurs to form or produce a neoplasm is called neoplasia. The growth of a neoplasm is uncoordinated with that of the normal surrounding tissue, and persists in growing abnormally, even if the original trigger is removed. This abnormal growth usually forms a mass, which may be called a tumour or tumor.'' ICD-10 classifies neoplasms into four main groups: benign neoplasms, in situ neoplasms, malignant neoplasms, and neoplasms of uncertain or unknown behavior. Malignant neoplasms are also simply known as cancers and are the focus of oncology. Prior to the abnormal growth of tissue, such as neoplasia, cells often undergo an abnormal pattern of growth, such as metaplasia or dysplasia. However, metaplasia or dysplasia does not always progress to neoplasia and can occur in other conditions as well. The word neoplasm is from Ancient Greek 'new' and 'formation, creation'. Types A neoplasm ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Malignancy
Malignancy () is the tendency of a medical condition to become progressively worse; the term is most familiar as a characterization of cancer. A ''malignant'' tumor contrasts with a non-cancerous ''benign'' tumor in that a malignancy is not self-limited in its growth, is capable of invading into adjacent tissues, and may be capable of spreading to distant tissues. A benign tumor has none of those properties, but may still be harmful to health. The term benign in more general medical use characterizes a condition or growth that is not cancerous, i.e. does not spread to other parts of the body or invade nearby tissue. Sometimes the term is used to suggest that a condition is not dangerous or serious. Malignancy in cancers is characterized by anaplasia, invasiveness, and metastasis. Malignant tumors are also characterized by genome instability, so that cancers, as assessed by whole genome sequencing, frequently have between 10,000 and 100,000 mutations in their entire genomes. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cutaneous Horn
Cutaneous horns, also known by the Latin name ''cornu cutaneum'', are unusual keratinous skin tumors with the appearance of horns, or sometimes of wood or coral. Formally, this is a clinical diagnosis for a "conical projection above the surface of the skin." They are usually small and localized but can, in very rare cases, be much larger. Although often benign, they can also be malignant or premalignant. Signs and symptoms The lesion at the base of the keratin mound is benign in the majority of cases. Malignancy is present in up to 20% of cases, with squamous-cell carcinoma being the most common type. The incidence of squamous-cell carcinoma increases to 37% when the cutaneous horn is present on the penis. Cause The cause of cutaneous horns is still unknown, but it is believed that exposure to radiation can trigger the condition. This is evidenced by a higher rate of cases occurring on the face and hands, areas that are often exposed to sunlight. Moreover, there is a higher pr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Teratology
Teratology is the study of abnormalities of physiological development in organisms during their life span. It is a sub-discipline in medical genetics which focuses on the classification of congenital abnormalities in dysmorphology caused by teratogens and also in pharmacology and toxicology. Teratogens are substances that may cause non-heritable birth defects via a toxic effect on an embryo or fetus. Defects include malformations, disruptions, deformations, and dysplasia that may cause stunted growth, delayed mental development, or other congenital disorders that lack structural malformations. These defects can be recognized prior to or at birth as well as later during early childhood. The related term developmental toxicity includes all manifestations of abnormal development that are caused by environmental insult. The extent to which teratogens will impact an embryo is dependent on several factors, such as how long the embryo has been exposed, the stage of development the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Achondroplasia
Achondroplasia is a genetic disorder with an autosomal dominant pattern of inheritance whose primary feature is dwarfism. It is the most common cause of dwarfism and affects about 1 in 27,500 people. In those with the condition, the Rhizomelia, arms and legs are short, while the torso is typically of normal length. Those affected have an average adult height of for males and for females. Other features can include an Macrocephaly, enlarged head with Skull bossing, prominent forehead (frontal bossing) and underdevelopment of the midface (midface hypoplasia). Complications can include sleep apnea or recurrent ear infections. Achondroplasia includes the extremely rare short-limb skeletal dysplasia with severe combined immunodeficiency. Achondroplasia is caused by a mutation in the fibroblast growth factor receptor 3 (''FGFR3'') gene that results in its protein being Gain-of-function, overactive. Achondroplasia results in impaired endochondral bone growth (bone growth within car ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
