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Muzlifah Haniffa
Muzlifah Haniffa is a Malaysian dermatologist and immunologist who focuses on the development of the immune system and the use of single-cell techniques to understand biology. Haniffa is a professor and Wellcome Trust Senior Research Fellow in the Faculty of Medical Sciences at Newcastle University. Early life and education Haniffa was born in Penang, Malaysia. Her interests in science as a child were piqued initially by space, but later she decided to pursue a career as a clinical scientist. Haniffa studied at Tunku Kurshiah College, Seremban and moved to the UK in the 1990s. Haniffa graduated BSc, MBBCh from the University of Wales College of Medicine in 1999. She became a member of the Royal College of Physicians in 2002. In 2007, she earned a diploma in epidemiology from the London School of Hygiene & Tropical Medicine. She completed her PhD from Newcastle University in 2009 and completed her clinical dermatology training in 2010. She was runner-up for the 2009 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tunku Kurshiah College
Kolej Tunku Kurshiah ( en, Tunku Kurshiah College; abbreviated TKC; formerly known as ''Malay Girls College; abbreviated MGC''), is a premier boarding school located in Seremban, Negeri Sembilan. TKC is one of the best all-girls residential school (Sekolah Berasrama Penuh) and the first fully residential girls' school in Malaysia. In 2010, the school was awarded with the Sekolah Berprestasi Tinggi or High Performance School title, a title awarded to the 20 schools in Malaysia that have met stringent criteria including academic achievement, strength of alumni, international recognition, network and linkages. The school is specialised in leadership, innovation and invention. In the 2013 PMR examination, the school managed to produce 96 out of 112 (85.7%) of straight A students with GPS 1.03 to the best school in Negeri Sembilan while for Sijil Pelajaran Malaysia (SPM), the school GPS is 1.5. History Tunku Kurshiah College was established as Malay Girls College in 1947. It was i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Malaysia
Malaysia ( ; ) is a country in Southeast Asia. The federation, federal constitutional monarchy consists of States and federal territories of Malaysia, thirteen states and three federal territories, separated by the South China Sea into two regions: Peninsular Malaysia and Borneo's East Malaysia. Peninsular Malaysia shares a land and maritime Malaysia–Thailand border, border with Thailand and Maritime boundary, maritime borders with Singapore, Vietnam, and Indonesia. East Malaysia shares land and maritime borders with Brunei and Indonesia, and a maritime border with the Philippines and Vietnam. Kuala Lumpur is the national capital, the country's largest city, and the seat of the Parliament of Malaysia, legislative branch of the Government of Malaysia, federal government. The nearby Planned community#Planned capitals, planned capital of Putrajaya is the administrative capital, which represents the seat of both the Government of Malaysia#Executive, executive branch (the Cabine ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
White Blood Cell
White blood cells, also called leukocytes or leucocytes, are the cells of the immune system that are involved in protecting the body against both infectious disease and foreign invaders. All white blood cells are produced and derived from multipotent cells in the bone marrow known as hematopoietic stem cells. Leukocytes are found throughout the body, including the blood and lymphatic system. All white blood cells have nuclei, which distinguishes them from the other blood cells, the anucleated red blood cells (RBCs) and platelets. The different white blood cells are usually classified by cell lineage ( myeloid cells or lymphoid cells). White blood cells are part of the body's immune system. They help the body fight infection and other diseases. Types of white blood cells are granulocytes (neutrophils, eosinophils, and basophils), and agranulocytes (monocytes, and lymphocytes (T cells and B cells)). Myeloid cells ( myelocytes) include neutrophils, eosinophils, mast cells, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ashley Moffett
Ashley is a place name derived from the Old English words '' æsc'' (“ash”) and '' lēah'' (“meadow”). It may refer to: People and fictional characters * Ashley (given name), a list of people and fictional characters with the given name * Ashley (surname), a list of people * Ashley (singer) (born 1975), Puerto Rican singer * Ashley, South Korean singer and leader of Ladies' Code Places Australia * Ashley, New South Wales England * Ashley, Cambridgeshire * Ashley, Cheshire * Ashley, Gloucestershire * Ashley, East Hampshire * Ashley, New Forest, Hampshire * Ashley, Test Valley, Hampshire * Ashley, Kent * Ashley, Northamptonshire * Ashley, Staffordshire * Ashley, Wiltshire * Ashley (Bristol ward) New Zealand * Ashley, New Zealand ** Ashley (New Zealand electorate), a former electorate 1866–1902 United States * Ashley County, Arkansas * Ashley, Illinois * Ashley, Indiana * Ashley, Michigan * Ashley, Missouri * Ashley, North Dakota * Ashley, Ohio * Ashley, P ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fiona Powrie
Dame Fiona Magaret Powrie (born 1963) is currently the head of the Kennedy Institute of Rheumatology at the University of Oxford. Formerly she was the inaugural Sidney Truelove Professor of Gastroenterology at the University of Oxford. She is also head of the Experimental Medicine Division of the Nuffield Department of Clinical Medicine. Career Powrie studied biochemistry at the University of Bath, before completing a D. Phil. in Don Mason's lab at the Sir William Dunn School of Pathology, the University of Oxford. Notable work Regulatory T cells Powrie worked with Don Mason at the Sir William Dunn School of Pathology studying the interactions of different subsets of CD4+ T cells in rats. This work identified that CD4+OX22hi (OX22 is CD45RC in rats and the equivalent of CD45RB in mice, both isoforms of CD45) T cells contained pathogenic activity while CD4+OX22lo T cells contained regulatory activity and could prevent the pathogenic activity of CD4+OX22hi T cells These were f ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sarah Teichmann
Sarah Amalia Teichmann (born 1975) is a German scientist who is head of cellular genetics at the Wellcome Sanger Institute and a visiting research group leader at the European Bioinformatics Institute (EMBL-EBI). She serves as director of research (equivalent to Professor) in the Cavendish Laboratory, at the University of Cambridge and a senior research fellow at Churchill College, Cambridge. Education Teichmann was educated at the European School, Karlsruhe in Germany from 1981 to 1993 where she completed the European Baccalaureate in 1993. Teichmann went on to study the Natural Sciences Tripos at Trinity College, Cambridge and was awarded a first class Bachelor of Arts degree in 1996. In 1999, she completed her PhD supervised by Cyrus Chothia at the Laboratory of Molecular Biology (LMB) on genome evolution. Career and research Following her PhD, Teichmann did postdoctoral research supervised by Janet Thornton at University College London and funded by the Beit Memorial Fellow ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Single-cell Transcriptomics
Single-cell transcriptomics examines the gene expression level of individual cells in a given population by simultaneously measuring the RNA concentration (conventionally only messenger RNA (mRNA)) of hundreds to thousands of genes. Single-cell transcriptomics makes it possible to unravel heterogeneous cell populations, reconstruct cellular developmental pathways, and model transcriptional dynamics — all previously masked in bulk RNA sequencing. Background The development of high-throughput RNA sequencing (RNA-seq) and microarrays has made gene expression analysis a routine. RNA analysis was previously limited to tracing individual transcripts by Northern blots or quantitative PCR. Higher throughput and speed allow researchers to frequently characterize the expression profiles of populations of thousands of cells. The data from bulk assays has led to identifying genes differentially expressed in distinct cell populations, and biomarker discovery. These studies are limite ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Human Cell Atlas
The Human Cell Atlas is a project to describe all cell types in the human body. The initiative was announced by a consortium after its inaugural meeting in London in October 2016, which established the first phase of the project. Aviv Regev and Sarah Teichmann defined the goals of the project at that meeting, which was convened by the Broad Institute, the Wellcome Trust Sanger Institute and Wellcome Trust. Regev and Teichmann lead the project. Description The Human Cell Atlas will catalogue a cell based on several criteria, specifically the cell type, its state, its location in the body, the transitions it undergoes, and its lineage. It will gather data from existing research, and integrate it with data collected in future research projects. Among the data it will collect is the fluxome, genome, metabolome, proteome, and transcriptome. Its scope is to categorize the 37 trillion cells of the human body to determine which genes each cell expresses by sampling cells fro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Allergology
Allergies, also known as allergic diseases, refer a number of conditions caused by the hypersensitivity of the immune system to typically harmless substances in the environment. These diseases include hay fever, food allergies, atopic dermatitis, allergic asthma, and anaphylaxis. Symptoms may include red eyes, an itchy rash, sneezing, coughing, a runny nose, shortness of breath, or swelling. Note: food intolerances and food poisoning are separate conditions. Common allergens include pollen and certain foods. Metals and other substances may also cause such problems. Food, insect stings, and medications are common causes of severe reactions. Their development is due to both genetic and environmental factors. The underlying mechanism involves immunoglobulin E antibodies (IgE), part of the body's immune system, binding to an allergen and then to a receptor on mast cells or basophils where it triggers the release of inflammatory chemicals such as histamine. Diagnos ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fungus
A fungus (plural, : fungi or funguses) is any member of the group of Eukaryote, eukaryotic organisms that includes microorganisms such as yeasts and Mold (fungus), molds, as well as the more familiar mushrooms. These organisms are classified as a Kingdom (biology), kingdom, separately from the other eukaryotic kingdoms, which by one traditional classification include Plantae, Animalia, Protozoa, and Chromista. A characteristic that places fungi in a different kingdom from plants, bacteria, and some protists is chitin in their cell walls. Fungi, like animals, are heterotrophs; they acquire their food by absorbing dissolved molecules, typically by secreting digestive enzymes into their environment. Fungi do not photosynthesize. Growth is their means of motility, mobility, except for spores (a few of which are flagellated), which may travel through the air or water. Fungi are the principal decomposers in ecological systems. These and other differences place fungi in a single gro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
T Helper 17 Cell
T helper 17 cells (Th17) are a subset of pro-inflammatory T helper cells defined by their production of interleukin 17 (IL-17). They are related to T regulatory cells and the signals that cause Th17s to differentiate actually inhibit Treg differentiation. However, Th17s are developmentally distinct from Th1 and Th2 lineages. Th17 cells play an important role in maintaining mucosal barriers and contributing to pathogen clearance at mucosal surfaces; such protective and non-pathogenic Th17 cells have been termed as Treg17 cells. They have also been implicated in autoimmune and inflammatory disorders. The loss of Th17 cell populations at mucosal surfaces has been linked to chronic inflammation and microbial translocation. These regulatory Th17 cells can be generated by TGF-beta plus IL-6 in vitro. Differentiation Like conventional regulatory T cells (Treg), induction of regulatory Treg17 cells could play an important role in modulating and preventing certain autoimmune diseases. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Macrophage
Macrophages (abbreviated as M φ, MΦ or MP) ( el, large eaters, from Greek ''μακρός'' (') = large, ''φαγεῖν'' (') = to eat) are a type of white blood cell of the immune system that engulfs and digests pathogens, such as cancer cells, microbe A microorganism, or microbe,, ''mikros'', "small") and ''organism'' from the el, ὀργανισμός, ''organismós'', "organism"). It is usually written as a single word but is sometimes hyphenated (''micro-organism''), especially in olde ...s, cellular debris, and foreign substances, which do not have proteins that are specific to healthy body cells on their surface. The process is called phagocytosis, which acts to defend the host against infection and injury. These large phagocytes are found in essentially all tissues, where they patrol for potential pathogens by amoeboid movement. They take various forms (with various names) throughout the body (e.g., histiocytes, Kupffer cells, alveolar macrophages, microg ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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