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Muscle Strain
A strain is an acute or Chronic condition, chronic soft tissue injury that occurs to a muscle, tendon, or both. The equivalent injury to a ligament is a sprain. Generally, the muscle or tendon overstretches and partially tears, under more physical stress than it can withstand, often from a sudden increase in duration, intensity, or frequency of an activity. Strains most commonly occur in the foot, leg, or back. Immediate treatment typically used to include four steps abbreviated as R.I.C.E. (rest, ice, compression, elevation) before the role of inflammation was found to be helpful. Signs and symptoms Typical Medical sign, signs and symptoms of a strain include pain, functional loss of the involved structure, muscle weakness, bruising, contusion, and localized inflammation. A strain can range from mild overstretching to severe tears, depending on the extent of injury. Cause A strain can occur as a result of improper body mechanics with any activity (e.g., contact sports, lifti ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hamstring
A hamstring () is any one of the three posterior thigh muscles in human anatomy between the hip and the knee: from medial to lateral, the semimembranosus, semitendinosus and biceps femoris. Etymology The word " ham" is derived from the Old English “ham” or “hom” meaning the hollow or bend of the knee, from a Germanic base where it meant "crooked". It gained the meaning of the leg of an animal around the 15th century. ''String'' refers to tendons, and thus the hamstrings' string-like tendons felt on either side of the back of the knee. Criteria The common criteria of any hamstring muscles are: # Muscles should originate from ischial tuberosity. # Muscles should be inserted over the knee joint, in the tibia or in the fibula. # Muscles will be innervated by the tibial branch of the sciatic nerve. # Muscle will participate in flexion of the knee joint and extension of the hip joint. Those muscles which fulfill all of the four criteria are called true hamstrings. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Foot
The foot (: feet) is an anatomical structure found in many vertebrates. It is the terminal portion of a limb which bears weight and allows locomotion. In many animals with feet, the foot is an organ at the terminal part of the leg made up of one or more segments or bones, generally including claws and/or nails. Etymology The word "foot", in the sense of meaning the "terminal part of the leg of a vertebrate animal" comes from Old English ''fot'', from Proto-Germanic *''fot'' (source also of Old Frisian ''fot'', Old Saxon ''fot'', Old Norse ''fotr'', Danish ''fod'', Swedish ''fot'', Dutch ''voet'', Old High German ''fuoz'', German ''Fuß'', Gothic ''fotus'', all meaning "foot"), from PIE root *''ped-'' "foot". The plural form ''feet'' is an instance of i-mutation. Structure The human foot is a strong and complex mechanical structure containing 26 bones, 33 joints (20 of which are actively articulated), and more than a hundred muscles, tendons, and ligaments.Podiatry Chan ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cyclooxygenase-2 Inhibition
Cyclooxygenase-2 inhibitors (COX-2 inhibitors), also known as coxibs, are a type of nonsteroidal anti-inflammatory drug (NSAID) that directly target cyclooxygenase-2 (COX-2), an enzyme responsible for inflammation and pain. Targeting selectivity for COX-2 reduces the risk of peptic ulceration and is the main feature of celecoxib, rofecoxib, and other members of this drug class. After several COX-2–inhibiting drugs were approved for marketing, data from clinical trials revealed that COX-2 inhibitors caused a significant increase in heart attacks and strokes, with some drugs in the class having worse risks than others. Rofecoxib (sold under the brand name Vioxx) was taken off the market in 2004 because of these concerns, while celecoxib (sold under the brand name Celebrex) and traditional NSAIDs received boxed warnings on their labels. Many COX-2–specific inhibitors have been removed from the US market. As of December 2011, only Celebrex (celecoxib) is still available for p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cyclooxygenase-1
Cyclooxygenase 1 (COX-1), also known as prostaglandin-endoperoxide synthase 1 (Human Genome Organisation, HUGO PTGS1), is an enzyme that in humans is encoded by the ''PTGS1'' gene. In humans it is one of Cyclooxygenase-3, three cyclooxygenases. History Cyclooxygenase (COX) is the central enzyme in the biosynthetic pathway to prostaglandins from arachidonic acid. This protein was isolated more than 40 years ago and Clone (genetics), cloned in 1988. Gene and isozymes There are two isozymes of COX encoded by distinct gene products: a constitutive COX-1 (this enzyme) and an inducible COX-2, which differ in their regulation of expression and tissue distribution. The expression of these two transcripts is differentially regulated by relevant cytokines and growth factors. This gene encodes COX-1, which regulates angiogenesis in endothelial cells. COX-1 is also involved in cell signaling and maintaining tissue Homeostasis#Overview, homeostasis. A splice variant of COX-1 termed COX-3 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ibuprofen/paracetamol
Ibuprofen/paracetamol, sold under the brand name Combogesic among others, is a fixed-dose combination of two medications, ibuprofen, a non-steroidal anti-inflammatory drug (NSAID); and paracetamol (acetaminophen), an analgesic and antipyretic. It is available as a generic medication. Medical uses Ibuprofen/paracetamol is indicated In medicine, an indication is a valid reason to use a certain test, medication, procedure, or surgery. There can be multiple indications to use a procedure or medication. An indication can commonly be confused with the term diagnosis. A diagnosis ... for the short term management of mild to moderate acute pain. There is evidence that paracetamol combined with ibuprofen provides pain relief better than either medication used alone. Adverse effects Society and culture Brand names The combination is available as Combiflam, Advil Dual Action with Acetaminophen, Ibupane, Nuromol and Combogesic. References {{DEFAULTSORT:Ibuprofen Para ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Leukocyte Extravasation
In immunology, leukocyte extravasation (also commonly known as leukocyte adhesion cascade or diapedesis – the passage of cells through the intact vessel wall) is the movement of leukocytes (white blood cells) out of the circulatory system (extravasation) and towards the site of tissue damage or infection. This process forms part of the innate immune response, involving the recruitment of non-specific leukocytes. Monocytes also use this process in the absence of infection or tissue damage during their development into macrophages. Overview Leukocyte extravasation occurs mainly in post-capillary venules, where haemodynamic shear stress, shear forces are minimised. This process can be understood in several steps: # Chemotaxis#Chemoattractants and chemorepellents, Chemoattraction # Rolling adhesion # Tight adhesion # (Endothelial) Transmigration It has been demonstrated that leukocyte recruitment is halted whenever any of these steps is suppressed. White blood cells (leukocytes) ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cold Compression Therapy
Cold compression therapy, also known as hilotherapy, combines two of the principles of rest, ice, compression, elevation to reduce pain and swelling from a sports or activity injury to soft tissues and is recommended by orthopedic surgeons following surgery. The therapy is especially useful for sprains, strains, pulled muscles and pulled ligaments. Cold compression Cold compression is a combination of cryotherapy and static compression, commonly used for the treatment of pain and inflammation after acute injury or surgical procedures. Cryotherapy, the use of ice or cold in a therapeutic setting, has become one of the most common treatments in orthopedic medicine. The primary reason for using cryotherapy in acute injury management is to lower the temperature of the injured tissue, which reduces the tissue's metabolic rate and helps the tissue to survive the period following the injury. It is well documented that metabolic rate decreases by application of cryotherapy. A stud ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
NSAID
Non-steroidal anti-inflammatory drugs (NSAID) are members of a therapeutic drug class which reduces pain, decreases inflammation, decreases fever, and prevents blood clots. Side effects depend on the specific drug, its dose and duration of use, but largely include an increased risk of gastrointestinal ulcers and bleeds, heart attack, and kidney disease. The term ''non-steroidal'', common from around 1960, distinguishes these drugs from corticosteroids, another class of anti-inflammatory drugs, which during the 1950s had acquired a bad reputation due to overuse and side-effect problems after their introduction in 1948. NSAIDs work by inhibiting the activity of cyclooxygenase enzymes (the COX-1 and COX-2 isoenzymes). In cells, these enzymes are involved in the synthesis of key biological mediators, namely prostaglandins, which are involved in inflammation, and thromboxanes, which are involved in blood clotting. There are two general types of NSAIDs available: non-sele ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Diapedesis
In immunology, leukocyte extravasation (also commonly known as leukocyte adhesion cascade or diapedesis – the passage of cells through the intact vessel wall) is the movement of leukocytes (white blood cells) out of the circulatory system ( extravasation) and towards the site of tissue damage or infection. This process forms part of the innate immune response, involving the recruitment of non-specific leukocytes. Monocytes also use this process in the absence of infection or tissue damage during their development into macrophages. Overview Leukocyte extravasation occurs mainly in post-capillary venules, where haemodynamic shear forces are minimised. This process can be understood in several steps: # Chemoattraction # Rolling adhesion # Tight adhesion # (Endothelial) Transmigration It has been demonstrated that leukocyte recruitment is halted whenever any of these steps is suppressed. White blood cells (leukocytes) perform most of their functions in tissues. Functions incl ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Elastic Bandage
An elastic bandage is a "stretchable bandage used to create localized pressure". Elastic bandages are commonly used to treat muscle sprains and strains by reducing the flow of blood to a particular area by the application of even stable pressure which can restrict swelling at the place of injury. Elastic bandages are also used to treat bone fractures. Padding is applied to the fractured limb, then a splint (usually plaster) is applied. The elastic bandage is then applied to hold the splint in place and to protect it. This is a common technique for fractures which may swell, which would cause a cast to function improperly. These types of splints are usually removed after swelling has decreased and then a fiberglass or plaster cast can be applied. Due to the risk of latex allergies among users, the original composition of elastic bandages has changed. While some bandages are still manufactured with latex, many woven and knitted elastic bandages provide adequate compression with ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Vasoconstriction
Vasoconstriction is the narrowing of the blood vessels resulting from contraction of the muscular wall of the vessels, in particular the large arteries and small arterioles. The process is the opposite of vasodilation, the widening of blood vessels. The process is particularly important in controlling hemorrhage and reducing acute blood loss. When blood vessels constrict, the flow of blood is restricted or decreased, thus retaining body heat or increasing vascular resistance. This makes the skin turn paler because less blood reaches the surface, reducing the radiation of heat. On a larger level, vasoconstriction is one mechanism by which the body regulates and maintains mean arterial pressure. Medications causing vasoconstriction, also known as vasoconstrictors, are one type of medicine used to raise blood pressure. Generalized vasoconstriction usually results in an increase in systemic blood pressure, but it may also occur in specific tissues, causing a localized reduction in b ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Acute Phase
Acute may refer to: Language * Acute accent, a diacritic used in many modern written languages * Acute (phonetic), a perceptual classification Science and mathematics * Acute angle ** Acute triangle ** Acute, a leaf shape in the glossary of leaf morphology * Acute (medicine), a disease that it is of short duration and of recent onset. ** Acute toxicity, the adverse effects of a substance from a single exposure or in a short period of time See also * Acutance In photography, acutance describes a subjective perception of visual acuity that is related to the edge contrast of an image. Acutance is related to the magnitude of the gradient of brightness. Due to the nature of the human visual system, an ..., in photography, subjective perception of sharpness related to the edge contrast of an image * Acuity (other) {{disambiguation ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
