Mucometrocolpos
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Mucometrocolpos
Mucometrocolpos is the abnormal accumulation of genital secretions (mucus) that occur as a result of an imperforate hymen and the buildup of these secretions behind the hymen. The secretions originate from uterine and cervical glands. It is a rare, congenital condition and usually occurs independent of other abnormal structures though inheritance can play a part in its occurrence. It also occurs with McKusick–Kaufman syndrome (MKS). Polydactyly and heart disease are associated with this condition. Diagnosis is challenging because symptoms also occur in a variety of other syndromes. Secretions can build up and extend as far as the uterus and abdomen. Mucometrocolpos can sometimes cause abdominal distention. The build up of mucous secretions can occur prior to adolescence unrelated to menstruation Menstruation (also known as a period, among other colloquial terms) is the regular discharge of blood and Mucous membrane, mucosal tissue from the endometrium, inner lining of the ute ...
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Imperforate Hymen
An imperforate hymen is a congenital disorder where a hymen without an opening completely obstructs the vagina. It is caused by a failure of the hymen to perforate during fetal development. It is most often diagnosed in adolescent girls when menstrual blood accumulates in the vagina and sometimes also in the uterus. It is treated by surgical incision of the hymen. Signs and symptoms Affected newborns may present with acute urinary retention. In adolescent females, the most common symptoms of an imperforate hymen are cyclic pelvic pain and amenorrhea; other symptoms associated with hematocolpos include urinary retention, constipation, low back pain, nausea, and diarrhea. Other vaginal anomalies can have similar symptoms to an imperforate hymen. Vaginal atresia and a transverse vaginal septum require differentiation. A strong urge to defecate has been observed in a few women. Complications If untreated or unrecognized before puberty, an imperforate hymen can lead to peritonitis ...
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Mucous Gland
Mucous glands, also known as muciparous glands, are found in several different parts of the body, and they typically stain lighter than serous glands during standard histological preparation. Most are multicellular, but goblet cells are single-celled glands. Mucous salivary glands The mucous salivary glands are similar in structure to the buccal and labial glands. They are found especially at the back part behind the vallate papillae, but are also present at the apex and marginal parts. In this connection, the anterior lingual glands require special notice. They are situated on the under surface of the apex of the tongue, one on either side of the frenulum, where they are covered by a fascicle of muscular fibers derived from the styloglossus and inferior longitudinal muscles. They produce a glycoprotein, mucin that absorbs water to form a sticky secretion called mucus. They are from 12 to 25 mm. long, and about 8 mm. broad, and each opens by three or four ...
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Hymen
The hymen is a thin piece of mucosal tissue that surrounds or partially covers the vaginal opening. A small percentage of females are born with hymens that are imperforate and completely obstruct the vaginal canal. It forms part of the vulva and is similar in structure to the vagina. The word is from the Greek ''ὑμήν'' meaning a thin skin or membrane. In children, a common appearance of the hymen is crescent-shaped, although many shapes are possible. Each shape in the natural range has a Latinate name. During puberty, estrogen causes the hymen to change in appearance and become very elastic. Normal variations of the post-pubertal hymen range from thin and stretchy to thick and somewhat rigid. Very rarely, it may be completely absent. The hymen can rip or tear during first penetrative intercourse, which usually results in pain and, sometimes, mild temporary bleeding or spotting. Minor injuries to the hymen may heal on their own, and not require surgical intervention. His ...
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Uterus
The uterus (from Latin ''uterus'', : uteri or uteruses) or womb () is the hollow organ, organ in the reproductive system of most female mammals, including humans, that accommodates the embryonic development, embryonic and prenatal development, fetal development of one or more Fertilized egg, fertilized eggs until birth. The uterus is a hormone-responsive sex organ that contains uterine gland, glands in its endometrium, lining that secrete uterine milk for embryonic nourishment. (The term ''uterus'' is also applied to analogous structures in some non-mammalian animals.) In humans, the lower end of the uterus is a narrow part known as the Uterine isthmus, isthmus that connects to the cervix, the anterior gateway leading to the vagina. The upper end, the body of the uterus, is connected to the fallopian tubes at the uterine horns; the rounded part, the fundus, is above the openings to the fallopian tubes. The connection of the uterine cavity with a fallopian tube is called the utero ...
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Cervix
The cervix (: cervices) or cervix uteri is a dynamic fibromuscular sexual organ of the female reproductive system that connects the vagina with the uterine cavity. The human female cervix has been documented anatomically since at least the time of Hippocrates, over 2,000 years ago. The cervix is approximately 4 cm long with a diameter of approximately 3 cm and tends to be described as a cylindrical shape, although the front and back walls of the cervix are contiguous. The size of the cervix changes throughout a woman's life cycle. For example, women in the fertile years of their reproductive cycle tend to have larger cervixes than postmenopausal women; likewise, women who have produced offspring have a larger cervix than those who have not. In relation to the vagina, the part of the cervix that opens to the uterus is called the ''internal os'' and the opening of the cervix in the vagina is called the ''external os''. Between them is a conduit commonly called the cervic ...
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Gland
A gland is a Cell (biology), cell or an Organ (biology), organ in an animal's body that produces and secretes different substances that the organism needs, either into the bloodstream or into a body cavity or outer surface. A gland may also function to remove unwanted substances such as urine from the body. There are two types of gland, each with a different method of secretion. Endocrine glands are ductless and secrete their products, hormones, directly into interstitial spaces to be taken up into the bloodstream. Exocrine glands secrete their products through a duct into a body cavity or outer surface. Glands are mostly composed of epithelium, epithelial tissue, and typically have a supporting framework of connective tissue, and a capsule. Structure Development Every gland is formed by an ingrowth from an epithelium, epithelial surface. This ingrowth may in the beginning possess a tubular structure, but in other instances glands may start as a solid column of cells which ...
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Inheritance
Inheritance is the practice of receiving private property, titles, debts, entitlements, privileges, rights, and obligations upon the death of an individual. The rules of inheritance differ among societies and have changed over time. Officially bequeathing private property and/or debts can be performed by a testator via will, as attested by a notary or by other lawful means. Terminology In law, an "heir" ( heiress) is a person who is entitled to receive a share of property from a decedent (a person who died), subject to the rules of inheritance in the jurisdiction where the decedent was a citizen, or where the decedent died or owned property at the time of death. The inheritance may be either under the terms of a will or by intestate laws if the deceased had no will. However, the will must comply with the laws of the jurisdiction at the time it was created or it will be declared invalid (for example, some states do not recognise handwritten wills as valid, or only in ...
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McKusick–Kaufman Syndrome
McKusick–Kaufman syndrome (MKS) is a rare genetic condition caused by mutations in the '' MKKS'' gene, which affect how cells develop and function. It is named after Dr. Robert L. Kaufman and Victor McKusick, who studied the condition and helped identify key features. MKS can be difficult to recognize in infancy because it resembles Bardet–Biedl syndrome (BBS). While MKS mainly causes extra fingers or toes (postaxial polydactyly), fluid buildup in the vagina (hydrometrocolpos), and heart defects, BBS has more severe symptoms such as vision loss and obesity that usually appear later in life. MKS is most common in the Old Order Amish population, where it affects about 1 in 10,000 people. The syndrome was first discovered in this group through a genetic method called positional cloning, which helped scientists identify the ''MKKS'' gene as the cause of this condition. Its prevalence outside the Amish population remains unknown. Presentation Clinically, McKusick–Kaufman syndr ...
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Polydactyly
Polydactyly is a birth defect that results in extra fingers or toes. The hands are more commonly involved than the feet. Extra fingers may be painful, affect self-esteem, or result in clumsiness. It is associated with at least 39 genetic mutations. It may either present alone or with other defects. Cases may run in families. The underlying mechanism involves an error in limb bud formation during early development. Diagnosis may occur before birth via prenatal ultrasound as early as nine weeks. X-rays may be useful after a child is a year old. The opposite is oligodactyly (fewer fingers or toes). Treatment varies from removal by cautery to more involved surgery. While putting a tight band around the base has been carried out, this is not typically recommended. If surgery is required, this is often done around two years of age. Occasionally multiple surgeries are required. Polydactyly is present in about 4 to 12 per 10,000 newborns. It is the most common defect of the ha ...
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Cardiovascular Disease
Cardiovascular disease (CVD) is any disease involving the heart or blood vessels. CVDs constitute a class of diseases that includes: coronary artery diseases (e.g. angina, heart attack), heart failure, hypertensive heart disease, rheumatic heart disease, cardiomyopathy, arrhythmia, congenital heart disease, valvular heart disease, carditis, aortic aneurysms, peripheral artery disease, thromboembolic disease, and venous thrombosis. The underlying mechanisms vary depending on the disease. It is estimated that dietary risk factors are associated with 53% of CVD deaths. Coronary artery disease, stroke, and peripheral artery disease involve atherosclerosis. This may be caused by high blood pressure, smoking, diabetes mellitus, lack of exercise, obesity, high blood cholesterol, poor diet, excessive alcohol consumption, and poor sleep, among other things. High blood pressure is estimated to account for approximately 13% of CVD deaths, while tobacco accounts for 9%, di ...
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Syndrome
A syndrome is a set of medical signs and symptoms which are correlated with each other and often associated with a particular disease or disorder. The word derives from the Greek language, Greek σύνδρομον, meaning "concurrence". When a syndrome is paired with a definite cause this becomes a disease. In some instances, a syndrome is so closely linked with a pathogenesis or cause that disease#Terminology, the words ''syndrome'', ''disease'', and ''disorder'' end up being used interchangeably for them. This substitution of terminology often confuses the reality and meaning of medical diagnoses. This is especially true of heredity, inherited syndromes. About one third of all phenotypes that are listed in Online Mendelian Inheritance in Man, OMIM are described as dysmorphic, which usually refers to the facial gestalt. For example, Down syndrome, Wolf–Hirschhorn syndrome, and Andersen–Tawil syndrome are disorders with known pathogeneses, so each is more than just a set of sig ...
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Menstruation
Menstruation (also known as a period, among other colloquial terms) is the regular discharge of blood and Mucous membrane, mucosal tissue from the endometrium, inner lining of the uterus through the vagina. The menstrual cycle is characterized by the rise and fall of hormones. Menstruation is triggered by falling progesterone levels, and is a sign that pregnancy has not occurred. Women use feminine hygiene products to maintain hygiene during menses. The first period, a point in time known as menarche, usually begins during puberty, between the ages of 11 and 13. However, menstruation starting as young as 8 years would still be considered normal. The average age of the first period is generally later in the developing world, and earlier in the developed world. The typical length of time between the first day of one period and the first day of the next is 21 to 45 days in young women; in adults, the range is between 21 and 35 days with the average often cited as 28 days. In the b ...
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