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Modoc Virus
Modoc virus (MODV) is a rodent-associated orthoflavivirus. Small and enveloped, MODV contains positive single-stranded RNA. Taxonomically, MODV is part of the ''Flavivirus'' genus and ''Flaviviridae'' family. The Flavivirus genus includes nearly 80 viruses, both vector-borne and no known vector (NKV) species. Known flavivirus vector-borne viruses include Dengue virus, Yellow fever, Yellow Fever virus, tick-borne encephalitis virus, and West Nile virus. In 1958, MODV was first isolated from the mammary gland tissue of a white-footed deer mouse (''Peromyscus maniculatus'') captured in Modoc County, California. Since the first isolation, the MODV has also been isolated from deer mice in Oregon, Colorado, and Montana. There are other anti-genetically and genetically related viruses which also have no known vector such as Jutiapa virus, the Cowbone Ridge virus, the Sal Vieja virus, and the San Perlita virus. Little information is known about these viruses as well. Structure The MODV ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Orthoflavivirus
''Flavivirus'', renamed ''Orthoflavivirus'' in 2023, is a genus of positive-strand RNA viruses in the family ''Flaviviridae''. The genus includes the West Nile virus, dengue virus, tick-borne encephalitis virus, yellow fever virus, Zika virus and several other viruses which may cause encephalitis, as well as insect-specific flaviviruses (ISFs) such as cell fusing agent virus (CFAV), Palm Creek virus (PCV), and Parramatta River virus (PaRV). While dual-host flaviviruses can infect vertebrates as well as arthropods, insect-specific flaviviruses are restricted to their competent arthropods. The means by which flaviviruses establish persistent infection in their competent vectors and cause disease in humans depends upon several virus-host interactions, including the intricate interplay between flavivirus-encoded immune antagonists and the host antiviral innate immune effector molecules. Flaviviruses are named for the yellow fever virus; the word ''flavus'' means 'yellow' in Latin, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
