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MindMed
Mind Medicine Inc., also known as MindMed, is a New York-based psychedelic medicine biotech company that develops psychedelic-inspired medicines known as psychoplastogens and therapies to address addiction and mental illness. History MindMed was founded in May 2019 by Jamon A. Rahn, an entrepreneur, Y-Combinator alumnus, and former Uber executive, and Stephen Hurst, a 35-year veteran of the pharmaceutical industry. Rahn, who was interested in the Silicon Valley trend of psychedelic microdosing to improve focus after struggling with his own mental health and addiction issues, spent two years researching the therapeutic potential of psychedelics prior to meeting Hurst. MindMed initially focused on developing treatments for opioid withdrawal and opioid use disorder with 18-MC, a non-hallucinogenic molecule based on the psychedelic substance Ibogaine. In June 2019 it acquired the 18-MC drug development program, previously funded by the National Institute on Drug Abuse, and in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
18-Methoxycoronaridine
18-Methoxycoronaridine (18-MC, or MM-110) is a derivative of ibogaine invented in 1996 by the research team around the pharmacologist Stanley D. Glick from the Albany Medical College and the chemists Upul K. Bandarage and Martin E. Kuehne from the University of Vermont. In animal studies it has proved to be effective at reducing self-administration of morphine, cocaine, methamphetamine, nicotine and sucrose. It has also been shown to produce anorectic effects in obese rats, most likely due to the same actions on the reward system which underlie its anti-addictive effects against drug addiction. 18-MC was in the early stages of human testing by the California-based drug development company Savant HWP before being acquired by MindMed, a Canadian pharmaceutical company newly listed on the NASDAQ in April 2021. [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Drug Development
Drug development is the process of bringing a new pharmaceutical drug to the market once a lead compound has been identified through the process of drug discovery. It includes preclinical research on microorganisms and animals, filing for regulatory status, such as via the United States Food and Drug Administration for an investigational new drug to initiate clinical trials on humans, and may include the step of obtaining regulatory approval with a new drug application to market the drug. The entire process – from concept through preclinical testing in the laboratory to clinical trial development, including Phase I–III trials – to approved vaccine or drug typically takes more than a decade. New chemical entity development Broadly, the process of drug development can be divided into preclinical and clinical work. Pre-clinical New chemical entities (NCEs, also known as new molecular entities or NMEs) are compounds that emerge from the process of drug discovery. T ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
National Institute On Drug Abuse
The National Institute on Drug Abuse (NIDA) is a United States federal government research institute whose mission is to "advance science on the causes and consequences of drug use and addiction and to apply that knowledge to improve individual and public health." The institute has conducted an in-depth study of addiction according to its biological, behavioral and social components. It has also supported many treatments such as nicotine patches and gums, and performed research into AIDS and other drug-related diseases. Its monopoly on the supply of research-grade marijuana has proved controversial. History NIDA's roots can be traced back to 1935, when a research facility (named the Addiction Research Center in 1948) was established in Lexington, Kentucky as part of a USPHS hospital. The Drug Abuse Warning Network (DAWN) and National Household Survey on Drug Abuse (NHSDA) were created in 1972. In 1974 NIDA was established as part of the Alcohol, Drug Abuse, and Mental Health A ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Psilocybin
Psilocybin ( , ) is a naturally occurring psychedelic prodrug compound produced by more than 200 species of fungi. The most potent are members of the genus ''Psilocybe'', such as '' P. azurescens'', '' P. semilanceata'', and '' P. cyanescens'', but psilocybin has also been isolated from about a dozen other genera. Psilocybin is itself biologically inactive but is quickly converted by the body to psilocin, which has mind-altering effects similar, in some aspects, to those of LSD, mescaline, and DMT. In general, the effects include euphoria, visual and mental hallucinations, changes in perception, a distorted sense of time, and perceived spiritual experiences. It can also cause adverse reactions such as nausea and panic attacks. Imagery found on prehistoric murals and rock paintings of modern-day Spain and Algeria suggests that human usage of psilocybin mushrooms predates recorded history. In Mesoamerica, the mushrooms had long been consumed in spiritual ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lysergic Acid Diethylamide
Lysergic acid diethylamide (LSD), also known colloquially as acid, is a potent psychedelic drug. Effects typically include intensified thoughts, emotions, and sensory perception. At sufficiently high dosages LSD manifests primarily mental, visual, as well as auditory, hallucinations. Dilated pupils, increased blood pressure, and increased body temperature are typical. Effects typically begin within half an hour and can last for up to 20 hours. LSD is also capable of causing mystical experiences and ego dissolution. It is used mainly as a recreational drug or for spiritual reasons. LSD is both the prototypical psychedelic and one of the "classical" psychedelics, being the psychedelics with the greatest scientific and cultural significance. LSD is typically either swallowed or held under the tongue. It is most often sold on blotter paper and less commonly as tablets, in a watery solution or in gelatin squares called panes. LSD is considered to be non-addictive with low pote ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neuropsychopharmacology (journal)
''Neuropsychopharmacology'' is a monthly peer-reviewed scientific journal published by Springer Nature. It was established in 1987 and is an official publication of the American College of Neuropsychopharmacology. The journal covers all aspects of neuropsychopharmacology, including clinical and basic science research into the brain and behavior, the properties of agents acting within the central nervous system, and drug targeting and development. Editors-in-chief Over the years, there have been ten editors-in-chief ("principal editors"), including J. Christian Gillin (1987-1993), Ronald D. Ciaranello (1994), Herbert Y. Meltzer (1994-1998), Hans C. Fibiger (1995-1998), Robert H. Lenox (1999-2001), Charles B. Nemeroff (2002-2006), and James H. Meador-Woodruff (2007-2012) and William A. Carlezon, Jr. (2013-2022). Since 2023, Tony P. George (University of Toronto) and Lisa M. Monteggia (Vanderbilt University) have been co-editors. Abstracting and indexing The journal is abs ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
American College Of Neuropsychopharmacology
Founded in 1961, the American College of Neuropsychopharmacology (ACNP) is a professional organization of leading brain and behavior scientists. The principal functions of the college are research and education. Their goals in research are to offer investigators an opportunity for cross-disciplinary communication and to promote the application of various scientific disciplines to the study of the brain's effect on behavior, with a focus on mental illness of all forms. Their educational goals are to encourage young scientists to enter research careers in neuropsychopharmacology and to develop and provide accurate information about behavioral disorders and their pharmacological treatment. Organization The college is an honorific society. Members are selected primarily on the basis of their original research contributions to the broad field of neuroscience. The membership of the college is drawn from scientists in multiple fields including behavioral pharmacology, brain imagin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Hospital Basel
The University Hospital of Basel (German: ''Universitätsspital Basel'', USB), in Basel, is one of the five university hospitals of Switzerland. Since 1842 it is located in a former palace, the Markgräflerhof. USB brings together 50 clinics, units and institutes all working together in an interdisciplinary manner and employs a staff of about 5000. Since the beginning of 2012, the University Hospital has been an independent business. Following its spin-off from the state administration of the Canton of Basel-Stadt, it now has the organisational form of a state-owned enterprise. With its 7,219 employees (as of 31 December 2017), who treat around 38,000 inpatients per year (as of 2017), the University Hospital Basel is one of the largest employers in the region. A characteristic feature is its close relationship with the University of Basel and the life sciences companies based in the region. With an approximate 670 beds, USB is the biggest healthcare facility in north-western ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
OTCQB
OTC Markets Group (previously known as Pink Sheets) is an American financial market providing price and liquidity information for almost 10,000 over-the-counter (OTC) securities. The group has its headquarters in New York City. OTC-traded securities are organized into three markets to inform investors of opportunities and risks: OTCQX, OTCQB and Pink. History The company was first established in 1913 as the National Quotation Bureau (NQB). For decades, the NQB reported quotations for both stocks and bonds, publishing the quotations in the paper-based Pink Sheets and Yellow Sheets respectively. The publications were named for the color of paper on which they were printed. NQB was owned by CCH from 1963 to 1993. In September 1999, the NQB introduced the real-time Electronic Quotation Service. The National Quotation Bureau changed its name to Pink Sheets LLC in 2000 and subsequently to Pink OTC Markets in 2008. The company eventually changed to its current name, OTC Markets ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Food And Drug Administration
The United States Food and Drug Administration (FDA or US FDA) is a federal agency of the Department of Health and Human Services. The FDA is responsible for protecting and promoting public health through the control and supervision of food safety, tobacco products, caffeine products, dietary supplements, prescription and over-the-counter pharmaceutical drugs (medications), vaccines, biopharmaceuticals, blood transfusions, medical devices, electromagnetic radiation emitting devices (ERED), cosmetics, animal foods & feed and veterinary products. The FDA's primary focus is enforcement of the Federal Food, Drug, and Cosmetic Act (FD&C), but the agency also enforces other laws, notably Section 361 of the Public Health Service Act, as well as associated regulations. Much of this regulatory-enforcement work is not directly related to food or drugs, but involves such things as regulating lasers, cellular phones, and condoms, as well as control of disease in contexts v ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ibogaine
Ibogaine is a naturally occurring psychoactive substance found in plants in the family Apocynaceae such as '' Tabernanthe iboga'', '' Voacanga africana'', and '' Tabernaemontana undulata''. It is a psychedelic with dissociative properties. Preliminary research indicates that it may help counter drug addiction. Its use has been associated with serious side effects and death. Between the years 1990 and 2008, a total of 19 fatalities temporally associated with the ingestion of ibogaine were reported, from which six subjects died of acute heart failure or cardiopulmonary arrest. The total number of subjects who have used it without major side effects during this period remains unknown. It is used as an alternative medicine treatment for drug addiction in some countries. Its prohibition in other countries has slowed scientific research. Ibogaine is also used to facilitate psychological introspection and spiritual exploration. Various derivatives of ibogaine designed to lack psyched ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Psychedelic Research
Psychedelic therapy (or psychedelic-assisted therapy) refers to the proposed use of psychedelic drugs, such as psilocybin, MDMA, LSD, and ayahuasca, to treat mental disorders. As of 2021, psychedelic drugs are controlled substances in most countries and psychedelic therapy is not legally available outside clinical trials, with some exceptions. The procedure for psychedelic therapy differs from that of therapies using conventional psychiatric medications. While conventional medications are usually taken without supervision at least once daily, in contemporary psychedelic therapy the drug is administered in a single session (or sometimes up to three sessions) in a therapeutic context. The therapeutic team prepares the patient for the experience beforehand and helps them integrate insights from the drug experience afterwards. After ingesting the drug, the patient normally wears eyeshades and listens to music to facilitate focus on the psychedelic experience, with the therapeutic team i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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