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Michel Sadelain
Michel Sadelain (born 1960) is a genetic engineer and cell therapist at Columbia University New York, New York. He is the Director of the Columbia Initiative in Cell Engineering and Therapy (CICET). Sadelain also serves as the Director of Columbia University Irving Medical Center’s Cancer Cell Therapy Initiative in the Herbert Irving Comprehensive Cancer Center. Sadelain was previously the Steve and Barbara Friedman Chair, founding director of the Center for Cell Engineering, and the head of the Gene Transfer and Gene Expression Laboratory at Memorial Sloan Kettering Cancer Center. He is best known for his major contributions to T cell engineering and chimeric antigen receptor (CAR) therapy, an immunotherapy based on the genetic engineering of a patient's own T cells to treat cancer. Dr. Sadelain is an elected member of the National Academy of Medicine of France and the American Academy of Arts & Sciences. Education and career Sadelain was born in 1960 in Paris, France, whe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Breakthrough Prize In Life Sciences
The Breakthrough Prize in Life Sciences is a scientific award, funded by internet entrepreneurs Mark Zuckerberg and Priscilla Chan of Facebook; Sergey Brin of Google; entrepreneur and venture capitalist Yuri Milner; and Anne Wojcicki, one of the founders of the genetics company 23andMe. The award of $3 million, the largest award in the sciences, is given to researchers who have made discoveries that extend human life. The Prize is awarded annually, beginning in 2013, with six awards given in each subsequent year. Winners are expected to give public lectures and form the committee to decide future winners. The ceremony takes place in the San Francisco Bay Area, with the symposiums alternating between University of California, Berkeley, University of California, San Francisco, and Stanford University. Laureates See also * Breakthrough Prize in Mathematics * Breakthrough Prize in Fundamental Physics * List of biology awards * List of medicine awards This list of medicine aw ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Memorial Sloan Kettering Cancer Center
Memorial Sloan Kettering Cancer Center (MSK or MSKCC) is a cancer treatment and research institution in Manhattan in New York City. MSKCC is one of 72 National Cancer Institute– designated Comprehensive Cancer Centers. Its main campus is located at 1275 York Avenue between 67th and 68th Streets in Manhattan. It was formed in 1980 from the merger of the ''Memorial Hospital for the Treatment of Cancer and Allied Diseases'', founded in 1884, and the adjacent ''Sloan-Kettering Institute for Cancer Research'', founded in 1945. The two medical entities had formally coordinated their operations since 1960. History Early history of Memorial Hospital (1884–1934) The hospital was founded in its original building on the Upper West Side of Manhattan in 1884 as ''New York Cancer Hospital'' by a group that included John Jacob Astor III and his wife Charlotte. The hospital appointed as an attending surgeon William B. Coley, who pioneered an early form of immunotherapy to erad ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Single-chain Variable Fragment
A single-chain variable fragment (scFv) is not actually a fragment of an antibody, but instead is a fusion protein of the variable regions of the heavy (VH) and light chains (VL) of immunoglobulins, connected with a short linker peptide of ten to about 25 amino acids. The linker is usually rich in glycine for flexibility, as well as serine or threonine for solubility, and can either connect the N-terminus of the VH with the C-terminus of the VL, or ''vice versa''. This protein retains the specificity of the original immunoglobulin, despite removal of the constant regions and the introduction of the linker. The image to the right shows how this modification usually leaves the specificity unaltered. These molecules were created to facilitate phage display, where it is highly convenient to express the antigen-binding domain as a single peptide. As an alternative, scFv can be created directly from subcloned heavy and light chains derived from a hybridoma. ScFvs have many uses, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Clarivate Citation Laureates
Clarivate Citation Laureates, formerly Thomson Reuters Citation Laureates, is a list of candidates considered likely to win the Nobel Prize in their respective field. The candidates are so named based on the citation impact of their published research.The list of awardees is announced annually prior to the Nobel Prize ceremonies of that year. In October 2016, Thomson Reuters Intellectual Property and Science Business was acquired by Onex and Baring Asia and the newly independent company was named as Clarivate. Thomson Reuters Citation Laureates was established in 1989. The list pertains to likely Nobel Prize winners in medicine, chemistry, physics, and economics. There appears to be a correlation between high citation rates for a published researcher and the award of prestigious accolades. Furthermore, citation rates disclose researchers furnishing instrumental contributions that advance the science of their respective field. Finally, choosing one tenth of one percent (0.1%) of th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Passano Laureate
The Passano Foundation, established in 1945, provides an annual award to a research scientist whose work – done in the United States – is thought to have immediate practical benefits. Many Passano laureates have subsequently won the Nobel Prize. Selection of award winners Passano Laureates * 2024 K. Christopher Garcia * 2023 Se-Jin Lee * 2022 Duojia Pan * 2021 Alfred Goldberg * 2020 David Eisenberg * 2019 Robert Fettiplace, James Hudspeth * 2018 Carl June, Michel Sadelain * 2017 Yuan Chang, Patrick S. Moore * 2016 , Helen Hobbs * 2015 James P. Allison (2018 Nobel Prize in Physiology or Medicine) * 2014 Jeffrey I. Gordon * 2013 Rudolf Jaenisch * 2012 Eric N. Olson * 2011 Elaine Fuchs * 2010 David Julius (2021 Nobel Prize in Physiology or Medicine) * 2009 Irving Weissman * 2008 Thomas Südhof (2013 Nobel Prize in Physiology or Medicine) * 2007 Joan Massagué Solé * 2006 Napoleone Ferrara * 2005 Jeffrey M. Friedman * 2003 Andrew Z. Fire (2006 Nobel Prize in P ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
William B
William is a masculine given name of Germanic origin. It became popular in England after the Norman conquest in 1066,All Things William"Meaning & Origin of the Name"/ref> and remained so throughout the Middle Ages and into the modern era. It is sometimes abbreviated "Wm." Shortened familiar versions in English include Will or Wil, Wills, Willy, Willie, Bill, Billie, and Billy. A common Irish form is Liam. Scottish diminutives include Wull, Willie or Wullie (as in Oor Wullie). Female forms include Willa, Willemina, Wilma and Wilhelmina. Etymology William is related to the German given name ''Wilhelm''. Both ultimately descend from Proto-Germanic ''*Wiljahelmaz'', with a direct cognate also in the Old Norse name ''Vilhjalmr'' and a West Germanic borrowing into Medieval Latin ''Willelmus''. The Proto-Germanic name is a compound of *''wiljô'' "will, wish, desire" and *''helmaz'' "helm, helmet".Hanks, Hardcastle and Hodges, ''Oxford Dictionary of First Names'', Oxfor ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
American Society Of Hematology
The American Society of Hematology (ASH) is a professional organization representing hematologists, founded in 1958. Its annual meeting is held in December of every year and has attracted more than 30,000 attendees. The society publishes the medical journal ''Blood'', the most cited peer-reviewed publication in the field, and ''Blood Advances'', an online, peer-reviewed open-access journal. The first official ASH meeting was held in Atlantic City, New Jersey, in April 1958. More than 300 hematologists met together to discuss the key research and clinical issues related to blood and blood diseases. Since the first gathering, ASH has been an important member in the development of hematology as a discipline. For more than six decades, ASH has sponsored its annual meeting. Today, ASH has more than 17,000 members, many of whom have made major advancements in understanding and treating blood diseases. Annual meeting Held each year in December, the annual meeting brings together hema ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
American Society Of Gene And Cell Therapy
American Society of Gene & Cell Therapy (ASGCT) is a professional non-profit medical and scientific organization based in Milwaukee, dedicated to understanding, development and application of gene, related cell and nucleic acid Nucleic acids are large biomolecules that are crucial in all cells and viruses. They are composed of nucleotides, which are the monomer components: a pentose, 5-carbon sugar, a phosphate group and a nitrogenous base. The two main classes of nuclei ... therapies, as well as promotion of professional and public education on gene therapy. With more than 4,800 members in the United States and worldwide, today ASGCT is the largest association of individuals involved in gene and cell therapy research. '' Molecular Therapy'' is the official journal of the ASGCT. References External links American Society of Gene & Cell TherapyOfficial site Medical and health organizations based in Wisconsin {{genetics-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
American Association For Cancer Research
The American Association for Cancer Research (AACR) is the world's oldest and largest professional association related to cancer research. Based in Philadelphia, the AACR focuses on all aspects of cancer research, including Basic research, basic, clinical, and translational research into the etiology (medicine), etiology, Preventive medicine, prevention, diagnosis, and therapy, treatment of cancer. Founded in 1907 by 11 physicians and scientists, the organization now has more than 58,000 members in 142 countries and territories. The mission of the AACR is to prevent and cure cancer through research, education, communication, collaboration, science policy and advocacy, and funding for cancer research. History The AACR was founded on May 7, 1907, in Washington, D.C., as the "Association for Cancer Research" by a group of scientists consisting of four surgeons, five pathologists, and two biochemists. The founding members were Silas P. Beebe, George H. A. Clowes, William Coley, Jame ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
American Society For Clinical Investigation
The American Society for Clinical Investigation (ASCI), established in 1908, is one of the oldest and most respected medical honor societies in the United States. Organization and purpose The ASCI is an honorary society to which more than 2,800 physician-scientists from all medical specialties belong. Prospective members are proposed by standing members of the society and elected to ASCI on the basis of an outstanding record of scholarly achievement in biomedical research. The ASCI includes physician-scientists who are active clinically, in basic research, or in teaching. Many of its senior members are widely recognized leaders in academic medicine. As of 2015 the membership of ASCI has included 417 members of the National Academy of Medicine, 191 members of the National Academies of Sciences, Engineering, and Medicine The National Academies of Sciences, Engineering, and Medicine (NASEM), also known as the National Academies, is a Congressional charter, congressionally charte ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
PubMed Identifier
PubMed is an openly accessible, free database which includes primarily the MEDLINE database of references and abstracts on life sciences and biomedical topics. The United States National Library of Medicine (NLM) at the National Institutes of Health maintains the database as part of the Entrez system of information retrieval. From 1971 to 1997, online access to the MEDLINE database was provided via computer and phone lines primarily through institutional facilities, such as university libraries. PubMed, first released in January 1996, ushered in the era of private, free, home- and office-based MEDLINE searching. The PubMed system was offered free to the public starting in June 1997. Content In addition to MEDLINE, PubMed provides access to: * older references from the print version of ''Index Medicus'', back to 1951 and earlier * references to some journals before they were indexed in Index Medicus and MEDLINE, for instance ''Science'', '' BMJ'', and ''Annals of Surgery'' ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
International Standard Serial Number
An International Standard Serial Number (ISSN) is an eight-digit to uniquely identify a periodical publication (periodical), such as a magazine. The ISSN is especially helpful in distinguishing between serials with the same title. ISSNs are used in ordering, cataloging, interlibrary loans, and other practices in connection with serial literature. The ISSN system was first drafted as an International Organization for Standardization (ISO) international standard in 1971 and published as ISO 3297 in 1975. ISO subcommittee TC 46/SC 9 is responsible for maintaining the standard. When a serial with the same content is published in more than one media type, a different ISSN is assigned to each media type. For example, many serials are published both in print and electronic media. The ISSN system refers to these types as print ISSN (p-ISSN) and electronic ISSN (e-ISSN). Consequently, as defined in ISO 3297:2007, every serial in the ISSN system is also assigned a linking ISSN ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
