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Michael Stratton
Sir Michael Rudolf Stratton, (born 22 June 1957) is a British clinical scientist and the third director of the Wellcome Trust Sanger Institute. He currently heads the Cancer Genome Project and is a leader of the International Cancer Genome Consortium.Patterns of mutation in human cancer genomes' – video of a seminar given by Stratton at the Royal Society.Every human 'could get their own genome sequence'' – Interview with Stratton on BBC's the Today Programme Education Stratton was educated at the independent Haberdashers' Aske's Boys' School and obtained a Bachelor of Medicine, Bachelor of Surgery degree from the University of Oxford where he was a student of Brasenose College, Oxford. He completed his clinical training at Guy's Hospital before training as a histopathologist at the Hammersmith and Maudsley Hospitals in London. He obtained a PhD while working on Medulloblastomas in the molecular biology of cancer at the Institute of Cancer Research, awarded by the Univer ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
International Cancer Genome Consortium
The International Cancer Genome Consortium (ICGC) is a voluntary scientific organization that provides a forum for collaboration among the world's leading cancer and genomic researchers. The ICGC was launched in 2008 to coordinate large-scale cancer genome studies in tumours from 50 cancer types and/or subtypes that are of main importance across the globe. Systematic studies of more than 25,000 cancer genomes at the genomic, epigenomic and transcriptomic levels will reveal the repertoire of oncogenic mutations, uncover traces of the mutagenic influences, define clinically relevant subtypes for prognosis and therapeutic management, and enable the development of new cancer therapies. The ICGC incorporates data from The Cancer Genome Atlas (TCGA) and the Sanger Cancer Genome Project. Professor Andrew Biankin AO, Regius Professor and Director of the Wolfson Wohl Cancer Research Centre at the University of Glasgow has been Executive Director and Chairman from 2018. Goals The ICGC ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Automated Teller Machine
An automated teller machine (ATM) or cash machine (in British English) is an electronic telecommunications device that enables customers of financial institutions to perform financial transactions, such as cash withdrawals, deposits, funds transfers, balance inquiries or account information inquiries, at any time and without the need for direct interaction with bank staff. ATMs are known by a variety of names, including automatic teller machine (ATM) in the United States (sometimes redundantly as "ATM machine"). In Canada, the term ''automated banking machine'' (ABM) is also used, although ATM is also very commonly used in Canada, with many Canadian organizations using ATM over ABM. In British English, the terms ''cashpoint'', ''cash machine'' and ''hole in the wall'' are most widely used. Other terms include ''any time money'', ''cashline'', ''tyme machine'', ''cash dispenser'', ''cash corner'', ''bankomat'', or ''bancomat''. ATMs that are not operated by a financial ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nature Genetics
''Nature Genetics'' is a peer-reviewed scientific journal published by Nature Portfolio. It was established in 1992. It covers research in genetics. The chief editor is Tiago Faial. The journal encompasses genetic and functional genomic studies on human traits and on other model organisms, including mouse, fly, nematode and yeast. Current emphasis is on the genetic basis for common and complex diseases and on the functional mechanism, architecture and evolution of gene networks, studied by experimental perturbation. According to the ''Journal Citation Reports'', the journal has a 2021 impact factor The impact factor (IF) or journal impact factor (JIF) of an academic journal is a scientometric index calculated by Clarivate that reflects the yearly mean number of citations of articles published in the last two years in a given journal, as ... of 41.379, ranking it 2nd out of 175 journals in the category "Genetics & Heredity". References External links Official website ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CHEK2
CHEK2 (Checkpoint kinase 2) is a tumor suppressor gene that encodes the protein CHK2, a serine-threonine kinase. CHK2 is involved in DNA repair, cell cycle arrest or apoptosis in response to DNA damage. Mutations to the CHEK2 gene have been linked to a wide range of cancers. Gene location The CHEK2 gene is located on the long (q) arm of chromosome 22 at position 12.1. Its location on chromosome 22 stretches from base pair 28,687,742 to base pair 28,741,904. Protein structure The CHEK2 protein encoded by the CHEK2 gene is a serine threonine kinase. The protein consists of 543 amino acids and the following domains: * N-terminal SQ/TQ cluster domain (SCD) * Central forkhead-associated (FHA) domain * C-terminal serine/threonine kinase domain (KD) The SCD domain contains multiple SQ/TQ motifs that serve as sites for phosphorylation in response to DNA damage. The most notable and frequently phosphorylated site being Thr68. CHK2 appears as a monomer in its inactive state. H ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chromosome 13
Chromosome 13 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 13 spans about 114 million base pairs (the building material of DNA) and represents between 3.5 and 4% of the total DNA in cells. Genes Number of genes The following are some of the gene count estimates of human chromosome 13. Because researchers use different approaches to genome annotation their predictions of the number of genes on each chromosome varies (for technical details, see gene prediction). Among various projects, the collaborative consensus coding sequence project ( CCDS) takes an extremely conservative strategy. So CCDS's gene number prediction represents a lower bound on the total number of human protein-coding genes. Gene list The following is a partial list of genes on human chromosome 13. For complete list, see the link in the infobox on the right. Diseases and disorders The following diseases and disorders are some of those ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Allan Bradley
Allan Bradley FRS is a British geneticist at the Wellcome Trust Sanger Institute. Education Bradley was educated at the University of Cambridge where he earned Bachelor of Arts, Master of Arts and PhD degrees in genetics from Trinity College, Cambridge gained while working in the laboratory of Martin Evans. Career Following his PhD, Bradley was appointed assistant professor at Baylor College of Medicine, beginning in 1987 where he was also a Searle Scholar in 1988. Bradley was appointed a Howard Hughes Medical Institute Investigator in 1993 and director of the Wellcome Trust Sanger Institute, from October 2000 (preceded by John Sulston) to April 2010, succeeded by Michael Stratton Sir Michael Rudolf Stratton, (born 22 June 1957) is a British clinical scientist and the third director of the Wellcome Trust Sanger Institute. He currently heads the Cancer Genome Project and is a leader of the International Cancer Genome Co .... Awards and honours Bradley won a 1994 DeBakey ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Royal Marsden NHS Foundation Trust
The Royal Marsden NHS Foundation Trust is an NHS Foundation Trust which operates the Royal Marsden Hospital facilities on two sites: *The Chelsea, London, Chelsea site in Brompton, Kensington, Brompton, next to the Royal Brompton Hospital, in Fulham Road *The Sutton, London, Sutton site in Belmont, Sutton, Belmont, close to Sutton Hospital, High Down (HM Prison), High Down and Downview (HM Prison), Downview Prisons Private patients The trust hopes to raise 45% of its income from private patients and other non-NHS sources in 2016/7 and is trying to raise its income from paying patients from £90m to £100m. According to LaingBuisson it is the most commercially orientated NHS hospital. It increased private patient income by 13% from 2014 to 2016 to £77 million. In 2018-19 it made £121 million through its private patient units, more than a quarter of its total income, and about 18% of all the private healthcare carried out in England by the NHS. This growth was led by imag ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hammersmith Hospital
Hammersmith Hospital, formerly the Military Orthopaedic Hospital, and later the Special Surgical Hospital, is a major teaching hospital in White City, West London. It is part of Imperial College Healthcare NHS Trust in the London Borough of Hammersmith and Fulham, and is associated with the Imperial College Faculty of Medicine. Confusingly the hospital is not in Hammersmith but is located in White City adjacent to Wormwood Scrubs and East Acton. History Origins The hospital's origins begin in 1902, when the Hammersmith Poor Law Guardians decided to erect a new workhouse and infirmary on a site at the north side of Du Cane Road somewhat to the north of Shepherd's Bush. The land, adjacent to Wormwood Scrubs Prison, was purchased for £14,500 from the Ecclesiastical Commissioners. A temporary corrugated iron building was erected on the site in 1902 to provide care for victims of a smallpox epidemic that had taken place in the winter of 1901–2. The buildings were designed b ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Westminster Hospital
Westminster Hospital was a hospital in London, England, founded in 1719. In 1834 a medical school attached to the hospital was formally founded. In 1939 a newly built hospital and medical school opened in Horseferry Road, Westminster. In 1994 the hospital closed, and its resources were moved to the new Chelsea and Westminster Hospital at the old St Stephen's Hospital site in Fulham Road. History Foundation The Westminster Hospital was established in 1719 as a charitable society "for relieving the sick and needy at the Public Infirmary in Westminster", and promoted by Henry Hoare (1677–1725), otherwise "Good Henry", son of Sir Richard Hoare and a partner in Hoare's Bank, and his associates the writer William Wogan, a vintner called Robert Witham, and the Reverend Patrick Cockburn. In 1719, a house was rented in Petty France, to accommodate the new Infirmary for the Sick and Needy, which opened in 1720 with 10 beds. The following document, which may be styled the fi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Medulloblastoma
Medulloblastoma is a common type of primary brain cancer in children. It originates in the part of the brain that is towards the back and the bottom, on the floor of the skull, in the cerebellum, or posterior fossa. The brain is divided into two main parts, the larger cerebrum on top and the smaller cerebellum below towards the back. They are separated by a membrane called the tentorium. Tumors that originate in the cerebellum or the surrounding region below the tentorium are, therefore, called infratentorial. Historically medulloblastomas have been classified as a primitive neuroectodermal tumor (PNET), but it is now known that medulloblastoma is distinct from supratentorial PNETs and they are no longer considered similar entities. Medulloblastomas are invasive, rapidly growing tumors that, unlike most brain tumors, spread through the cerebrospinal fluid and frequently metastasize to different locations along the surface of the brain and spinal cord. Metastasis all the way ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Brasenose College, Oxford
Brasenose College (BNC) is one of the constituent colleges of the University of Oxford in the United Kingdom. It began as Brasenose Hall in the 13th century, before being founded as a college in 1509. The library and chapel were added in the mid-17th century and the new quadrangle in the late 19th and early 20th centuries. For 2020–21, Brasenose placed 4th in the Norrington Table (an unofficial measure of performance in undergraduate degree examinations). In a recent Oxford Barometer Survey, Brasenose's undergraduates registered 98% overall satisfaction. In recent years, around 80% of the UK undergraduate intake have been from state schools. Brasenose is home to one of the oldest rowing clubs in the world, Brasenose College Boat Club. History Foundation The history of Brasenose College, Oxford stretches back to 1509, when the college was founded on the site of Brasenose Hall, a medieval academic hall whose name is first mentioned in 1279. Its name is believed to deri ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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