|
Michael Rudolf Stratton
Sir Michael Rudolf Stratton (born 22 June 1957) is a British clinical scientist and the third director of the Wellcome Trust Sanger Institute. He currently heads the Cancer Genome Project and is a leader of the International Cancer Genome Consortium.Patterns of mutation in human cancer genomes' – video of a seminar given by Stratton at the Royal Society.Every human 'could get their own genome sequence'' – Interview with Stratton on BBC's the Today Programme Education Stratton was educated at the independent Haberdashers' Aske's Boys' School and obtained a Bachelor of Medicine, Bachelor of Surgery degree from the University of Oxford where he was a student of Brasenose College, Oxford. He completed his clinical training at Guy's Hospital before training as a histopathologist at the Hammersmith and Maudsley Hospitals in London. He obtained a PhD while working on Medulloblastomas in the molecular biology of cancer at the Institute of Cancer Research, awarded by the Universit ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biomedical Scientist
A biomedical scientist is a scientist trained in biology, particularly in the context of medical laboratory sciences or laboratory medicine. These scientists work to gain knowledge on the main principles of how the human body works and to find new ways to cure or treat disease by developing advanced diagnostic tools or new therapeutic strategies. The research of biomedical scientists is referred to as biomedical research. Description The specific activities of the biomedical scientist can differ in various parts of the world and vary with the level of education. Generally speaking, biomedical scientists conduct research in a laboratory setting, using living organisms as models to conduct experiments. These can include cultured human or animal cells grown outside of the whole organism, small animals such as flies, worms, fish, mice, and rats, or, rarely, larger animals and primates. Biomedical scientists may also work directly with human tissue specimens to perform experiments ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nature Genetics
''Nature Genetics'' is a peer-reviewed scientific journal published by Nature Portfolio. It was established in 1992. It covers research in genetics. The chief editor is Tiago Faial. The journal encompasses genetic and functional genomic studies on human traits and on other model organisms, including mouse, fly, nematode and yeast. Current emphasis is on the genetic basis for common and complex diseases and on the functional mechanism, architecture and evolution of gene networks, studied by experimental perturbation. According to the ''Journal Citation Reports'', the journal has a 2023 impact factor The impact factor (IF) or journal impact factor (JIF) of an academic journal is a type of journal ranking. Journals with higher impact factor values are considered more prestigious or important within their field. The Impact Factor of a journa ... of 31.7, ranking it 2nd out of 175 journals in the category "Genetics & Heredity". Further evaluation metrics from Scopus and Journal ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CHEK2
CHEK2 (Checkpoint kinase 2) is a tumor suppressor gene that encodes the protein CHK2, a serine-threonine kinase. CHK2 is involved in DNA repair, cell cycle arrest or apoptosis in response to DNA damage. Mutations to the CHEK2 gene have been linked to a wide range of cancers. Gene location The CHEK2 gene is located on the long (q) arm of chromosome 22 at position 12.1. Its location on chromosome 22 stretches from base pair 28,687,742 to base pair 28,741,904. Protein structure The CHEK2 protein encoded by the CHEK2 gene is a serine threonine kinase. The protein consists of 543 amino acids and the following domains: * N-terminal SQ/TQ cluster domain (SCD) * Central forkhead-associated (FHA) domain * C-terminal serine/threonine kinase domain (KD) The SCD domain contains multiple SQ/TQ motifs that serve as sites for phosphorylation in response to DNA damage. The most notable and frequently phosphorylated site being Thr68. CHK2 appears as a monomer in its inactive state. H ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chromosome 13
Chromosome 13 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 13 spans about 113 million base pairs (the building material of DNA) and represents between 3.5 and 4% of the total DNA in cell (biology), cells. Genes Number of genes The following are some of the gene count estimates of human chromosome 13. Because researchers use different approaches to genome annotation their predictions of the number of genes on each chromosome varies (for technical details, see gene prediction). Among various projects, the collaborative consensus coding sequence project (Consensus CDS Project, CCDS) takes an extremely conservative strategy. So CCDS's gene number prediction represents a lower bound on the total number of human protein-coding genes. Gene list The following is a partial list of genes on human chromosome 13. For complete list, see the link in the infobox on the right. Diseases and disorders The following diseases ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Allan Bradley
Allan Bradley FRS is a British geneticist at the Wellcome Trust Sanger Institute. Education Bradley was educated at the University of Cambridge where he earned Bachelor of Arts, Master of Arts and PhD degrees in genetics from Trinity College, Cambridge gained while working in the laboratory of Martin Evans. Career Following his PhD, Bradley was appointed assistant professor at Baylor College of Medicine, beginning in 1987 where he was also a Searle Scholar in 1988. Bradley was appointed a Howard Hughes Medical Institute Investigator in 1993 and director of the Wellcome Trust Sanger Institute, from October 2000 (preceded by John Sulston Sir John Edward Sulston (27 March 1942 – 6 March 2018) was a British biologist and academic who won the Nobel Prize in Physiology or Medicine for his work on the cell lineage and genome of the worm ''Caenorhabditis elegans'' in 2002 with ...) to April 2010, succeeded by Michael Stratton. Awards and honours Bradley won a 1994 DeBak ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Royal Marsden NHS Foundation Trust
The Royal Marsden Hospital is a specialist National Health Service oncology hospital in London based at two sites in Brompton, in Kensington and Chelsea, and Belmont in Sutton. It is managed by The Royal Marsden NHS Foundation Trust and supported by The Royal Marsden Cancer Charity. In addition to providing cancer diagnosis, treatment and care, The Royal Marsden is a major centre for cancer research and teaching. It has a close affiliation with the Institute of Cancer Research, which originated as the hospital's research department and is located alongside the hospital in Brompton and Belmont. Through its subsidiary The Royal Marsden School, it offers undergraduate and postgraduate degrees in cancer care validated by the University of East Anglia. Sites The Royal Marsden's Brompton site is adjacent to the Royal Brompton Hospital, in Fulham Road. , this site had 112 inpatient beds and 7 operating theatres. The Belmont site is in the far south of Greater London, adjacent to t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hammersmith Hospital
Hammersmith Hospital, formerly the Military Orthopaedic Hospital, and later the Special Surgical Hospital, is a major teaching hospital in White City, London, White City, West London. It is part of Imperial College Healthcare NHS Trust in the London Borough of Hammersmith and Fulham, and is associated with the Imperial College School of Medicine, Imperial College Faculty of Medicine. Confusingly the hospital is not in Hammersmith but is located in White City adjacent to Wormwood Scrubs and East Acton. History Origins The hospital's origins begin in 1902, when the Hammersmith Poor Law Guardians decided to erect a new workhouse and Hospital, infirmary on a site at the north side of Du Cane Road somewhat to the north of Shepherd's Bush. The land, adjacent to HM Prison Wormwood Scrubs, Wormwood Scrubs Prison, was purchased for £14,500 from the Ecclesiastical Commissioners. A temporary corrugated iron building was erected on the site in 1902 to provide care for victims of a smal ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Westminster Hospital
Westminster Hospital was a hospital in London, England, founded in 1719. In 1834 a medical school attached to the hospital was formally founded. In 1939 a newly built hospital and medical school opened in Horseferry Road, Westminster. In 1994 the hospital closed, and its resources were moved to the new Chelsea and Westminster Hospital at the old St Stephen's Hospital site on Fulham Road. History Foundation The Westminster Hospital was established in 1719 as a charitable society "for relieving the sick and needy at the Public Infirmary in Westminster", and promoted by Henry Hoare (1677–1725), otherwise "Good Henry", son of Sir Richard Hoare and a partner in Hoare's Bank, and his associates the writer William Wogan, a vintner called Robert Witham, and the Reverend Patrick Cockburn. In 1719, a house was rented in Petty France, to accommodate the new Infirmary for the Sick and Needy, which opened in 1720 with 10 beds. The following document, which may be styled the f ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Medulloblastoma
Medulloblastoma is a common type of primary brain cancer in children. It originates in the part of the brain that is towards the back and the bottom, on the floor of the skull, in the cerebellum, or posterior fossa. The brain is divided into two main parts, the larger cerebrum on top and the smaller cerebellum below towards the back. They are separated by a membrane called the tentorium. Tumors that originate in the cerebellum or the surrounding region below the tentorium are, therefore, called infratentorial. Historically, medulloblastomas have been classified as a primitive neuroectodermal tumor (PNET), but it is now known that medulloblastoma is distinct from supratentorial PNETs and they are no longer considered similar entities. Medulloblastomas are invasive, rapidly growing tumors that, unlike most brain tumors, spread through the cerebrospinal fluid and frequently metastasize to different locations along the surface of the brain and spinal cord. Metastasis all the way d ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Brasenose College, Oxford
Brasenose College (BNC) is one of the Colleges of the University of Oxford, constituent colleges of the University of Oxford in the United Kingdom. It began as Brasenose Hall in the 13th century, before being founded as a college in 1509. The library and chapel were added in the mid-17th century and the new quadrangle in the late 19th and early 20th centuries. For 2020–21, Brasenose placed 4th in the Norrington Table (an unofficial measure of performance in undergraduate degree examinations). In a recent Oxford Barometer Survey, Brasenose's undergraduates registered 98% overall satisfaction. In recent years, around 80% of the UK undergraduate intake have been from state schools. Brasenose is home to one of the oldest rowing (sport), rowing clubs in the world, Brasenose College Boat Club. History Foundation The history of Brasenose College, Oxford stretches back to 1509, when the college was founded on the site of Brasenose Hall, a medieval Academic halls of the Universit ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bachelor Of Medicine, Bachelor Of Surgery
A Bachelor of Medicine, Bachelor of Surgery (; MBBS, also abbreviated as BM BS, MB ChB, MB BCh, or MB BChir) is a medical degree granted by medical schools or universities in countries that adhere to the United Kingdom's higher education tradition. Despite the historical distinction in nomenclature, these degrees are typically combined and conferred together. This degree is usually awarded as an undergraduate degree, but it can also be awarded at graduate-level medical institutions. The typical duration for completion is five to six years. A Bachelor of Medicine (BMed, BM, or MB) is an undergraduate medical degree awarded by medical schools in countries following the tradition of China. The completion period for this degree is generally five to six years. The term 'Medicine' in this context encompasses the broader field of medical science and practice, rather than specifically internal medicine. Consequently, graduates with a BMed degree are qualified to practise surgery. T ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
