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Michael R. Hayden
Michael R. Hayden, . is a Killam Professor of Medical Genetics at the University of British Columbia, the highest honour UBC can confer on any faculty member. Only four such awards have ever been conferred in the Faculty of Medicine. Hayden is best known for his research in Huntington disease (HD). He is a senior scientist and former director of the Centre for Molecular Medicine and Therapeutics (CMMT) in Vancouver, British Columbia, Canada; a genetic research centre within UBC's Faculty of Medicine and affiliated with the BC Children's Hospital Research Institute and the BC Children's Hospital Foundation, which he founded. He was also Canada Research Chair in Human Genetics and Molecular Medicine from 2000-2021 and the Program Director of the Translational Laboratory in Genetic Medicine in Singapore from 2011 to 2020. Dr. Hayden was appointed as the President of Global R&D and Chief Scientific Officer at Teva Pharmaceutical Industries from 2012 to 2017. During this time, he le ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cape Town
Cape Town is the legislature, legislative capital city, capital of South Africa. It is the country's oldest city and the seat of the Parliament of South Africa. Cape Town is the country's List of municipalities in South Africa, second-largest city by population, after Johannesburg, and the largest city in the Western Cape. The city is part of the City of Cape Town metropolitan municipality (South Africa), metropolitan municipality. The city is known for Port of Cape Town, its harbour, its natural setting in the Cape Floristic Region, and for landmarks such as Table Mountain and Cape Point. In 2014, Cape Town was named the best place in the world to visit by ''The New York Times'', and was similarly ranked number one by ''The Daily Telegraph'' in both 2016 and 2023. Located on the shore of Table Bay, the City Bowl area of Cape Town, which contains its Cape Town CBD, central business district (CBD), is History of Cape Town, the oldest urban area in the Western Cape, with a signi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Order Of British Columbia
The Order of British Columbia is a civilian honour for merit in the Canadian province of British Columbia. Instituted in 1989 by Lieutenant Governor David Lam, on the advice of the Cabinet under Premier Bill Vander Zalm, the order is administered by the Governor-in-Council and is intended to honour current or former British Columbia residents for conspicuous achievements in any field, being thus described as the highest honour amongst all others conferred by the British Columbia Crown. Structure and appointment The Order of British Columbia, which evolved out of and replaced the earlier Order of the Dogwood, is intended to honour any current or former longtime resident of British Columbia who has demonstrated a high level of individual excellence and achievement in any field, demonstrating the "greatest distinction and excell ncein any field of endeavour benefiting the people of the Province or elsewhere." Only those who are elected or appointed members of a governmental body ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chorea
Chorea, or (rarely) choreia, () is an abnormal involuntary movement disorder, characterized by quick movements of the hands or feet. It is one of a group of neurological disorders called dyskinesias. The term ''chorea'' is derived , as the movements of the body is comparable to dancing. The term hemichorea refers to chorea of one side of the body, such as chorea of one arm but not both (analogous to hemiballismus). Presentation Chorea is characterized by brief, semi-directed, irregular movements that are not repetitive or rhythmic, but appear to flow from one muscle to the next. These 'dance-like' movements of chorea often occur with athetosis, which adds twisting and writhing movements. Walking may become difficult and include odd postures and leg movements. Unlike ataxia, which affects the quality of voluntary movements, or Parkinsonism, which is a hindrance of voluntary movements, the movements of chorea and ballism occur on their own, without conscious effort. Thus, chorea ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Austedo
Deutetrabenazine (trade name Austedo) is a vesicular monoamine transporter 2 inhibitor which is used for the treatment of chorea associated with Huntington's disease and tardive dyskinesia. Chemically, deutetrabenazine is an isotopic isomer of tetrabenazine in which six hydrogen atoms have been replaced by deuterium atoms. The incorporation of deuterium slows the rate of drug metabolism, allowing less frequent dosing. Efficacy A '' Lancet'' study published on 28 June 2017 carried out a review between 29 October 2014 and 19 August 2016 where 298 patients were randomly assigned to receive at least one of the following: one dose of placebo per day, one dose of deutetrabenazine 12 mg/day, one dose of deutetrabenazine 24 mg/day, or one dose of deutetrabenazine 36 mg/day. From baseline to week 12, the least-squares mean AIMS (Abnormal Involuntary Movement Scale) score improved by −3.3 points in the deutetrabenazine 36 mg/day group, −3.2 points in the 24&nbs ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Central Nervous System
The central nervous system (CNS) is the part of the nervous system consisting primarily of the brain, spinal cord and retina. The CNS is so named because the brain integrates the received information and coordinates and influences the activity of all parts of the bodies of bilateria, bilaterally symmetric and triploblastic animals—that is, all multicellular animals except sponges and Coelenterata, diploblasts. It is a structure composed of nervous tissue positioned along the Anatomical_terms_of_location#Rostral,_cranial,_and_caudal, rostral (nose end) to caudal (tail end) axis of the body and may have an enlarged section at the rostral end which is a brain. Only arthropods, cephalopods and vertebrates have a true brain, though precursor structures exist in onychophorans, gastropods and lancelets. The rest of this article exclusively discusses the vertebrate central nervous system, which is radically distinct from all other animals. Overview In vertebrates, the brain and spinal ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Phila
Phila most often refers to a shortened name for the City of Philadelphia, U.S. It may also refer to: * Phila of Elimeia, sister of Derdas and wife of Philip II of Macedon *Phila (daughter of Antipater), wife of Balacrus, Craterus and significantly Demetrius I of Macedon *Phila (daughter of Seleucus), wife of Antigonus Gonatas *Phila (daughter of Theodorus), daughter of Theodorus of Athamania * Phila of Thebes, courtesan *Phila (Pieria) Phila () was a fortified town of Macedon in Pieria (regional unit), Pieria toward ancient Magnesia, Magnesia, 5 Mille passus, M.P from Herakleion (Pieria), Herakleion on the way toward Tempe Vale. According to Stephanus of Byzantium, it was built by ..., ancient town in Pieria, Macedonia kingdom See also * Fila (other) {{dab, hndis ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Teva Pharmaceutical Industries
Teva Pharmaceutical Industries Ltd. (also known as Teva Pharmaceuticals) is an Israeli multinational pharmaceutical company. Teva specializes primarily in generic drugs, but other business interests include branded-drugs, active pharmaceutical ingredients (APIs) and, to a lesser extent, contract manufacturing services and an out-licensing platform. Teva's primary branded products include Austedo ( deutetrabenazine) which is used for the treatment of chorea associated with Huntington's disease and tardive dyskinesia; and Ajovy ( fremanezumab), used for the preventive treatment of migraine in adults. Additional branded drugs sold by Teva include Copaxone, Bendeka and Treanda, all of which are primarily sold in the United States. Teva is listed on the Tel Aviv Stock Exchange and the New York Stock Exchange. Its manufacturing facilities are located in Israel, North America, Europe, Australia, and South America. The company is a member of the Pharmaceutical Research and Manufact ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Human Genetics
Human genetics is the study of inheritance as it occurs in Human, human beings. Human genetics encompasses a variety of overlapping fields including: classical genetics, cytogenetics, molecular genetics, biochemical genetics, genomics, population genetics, developmental genetics, clinical genetics, and genetic counseling. Genes are the common factor of the qualities of most human-inherited traits. Study of human genetics can answer questions about human nature, can help understand diseases and the development of effective treatment and help us to understand the genetics of human life. This article describes only basic features of human genetics; for the genetics of disorders please see: medical genetics. For information on the genetics of DNA repair defects related to accelerated aging and/or increased risk of cancer please see: DNA repair-deficiency disorder. Genetic differences and inheritance patterns Inheritance of traits for humans are based upon Gregor Mendel's model ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Canada Research Chair
Canada Research Chair (CRC) is a title given to certain Canadian university research professors by the Canada Research Chairs Program. Program goals The Canada Research Chair program was established in 2000 as a part of the Government of Canada wanting to promote research and development excellence in Canadian post-secondary educational institutions. Through the Canada Research Chair program, $300 million is spent annually to attract and retain outstanding scholars and scientists. The program hopes to help chairholders achieve research excellence in natural sciences, engineering, health sciences, humanities, and social sciences, improve Canada's depth of knowledge and quality of life, strengthen the country's international competitiveness, and train personnel through student supervision, teaching, and the coordination of other researchers' work. Types of chairs There are two types of Canada Research Chair: *Tier 1 Chairs – tenable for seven years and renewable once (and twi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
BC Children's Hospital Foundation
BC Children's Hospital Foundation (BCCHF) is a Canadian non-profit registered charity that raises money to support the British Columbia Children's Hospital. The Foundation works with communities to raise funds for essentials including: life-saving equipment, research into childhood diseases, a wide range of medical staff and community child health education programs. Since 1982, BC Children's Hospital Foundation has partnered with children, families, health professionals, and other British Columbia residents to raise funds to support BC Children's Hospital, Sunny Hill Health Centre for Children, and the BC Children's Hospital Research Institute. * References External links BC Children's Hospital Foundation Official website {{DEFAULTSORT:BC Children's Hospital Foundation 1982 establishments in British Columbia Non-profit organizations based in Vancouver Health charities in Canada Medical and health organizations based in British Columbia ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Huntington Disease
Huntington's disease (HD), also known as Huntington's chorea, is an incurable neurodegenerative disease that is mostly inherited. It typically presents as a triad of progressive psychiatric, cognitive, and motor symptoms. The earliest symptoms are often subtle problems with mood or mental/psychiatric abilities, which precede the motor symptoms for many people. The definitive physical symptoms, including a general lack of coordination and an unsteady gait, eventually follow. Over time, the basal ganglia region of the brain gradually becomes damaged. The disease is primarily characterized by a distinctive hyperkinetic movement disorder known as '' chorea.'' Chorea classically presents as uncoordinated, involuntary, "dance-like" body movements that become more apparent as the disease advances. Physical abilities gradually worsen until coordinated movement becomes difficult and the person is unable to talk. Mental abilities generally decline into dementia, depression, apat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
