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Metallome
In biochemistry, the metallome is the distribution of metal ions in a cellular compartment. The term was coined in analogy with proteome, as metallomics is the study of metallome: the "comprehensive analysis of the entirety of metal and metalloid species within a cell or tissue type". Therefore, metallomics can be considered a branch of metabolomics, even though the metals are not typically considered as metabolites. An alternative definition of "metallomes" as metalloproteins or any other metal-containing biomolecules, and "metallomics" as a study of such biomolecules. Metallointeractome In the study of metallomes the transcriptome, proteome and the metabolome constitutes the whole metallome. A study of the metallome is done to arrive at the metallointeractome. Metallotranscriptome The metallotranscriptome can be defined as the map of the entire transcriptome in the presence of biologically or environmentally relevant concentrations of an essential or toxic metal, respectivel ...
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Bioinorganic Chemistry
Bioinorganic chemistry is a field that examines the role of metals in biology. Bioinorganic chemistry includes the study of both natural phenomena such as the behavior of metalloproteins as well as artificially introduced metals, including those that are non-essential, in medicine and toxicology. Many biological processes such as respiration depend upon molecules that fall within the realm of inorganic chemistry. The discipline also includes the study of inorganic models or mimics that imitate the behaviour of metalloproteins. As a mix of biochemistry and inorganic chemistry, bioinorganic chemistry is important in elucidating the implications of electron-transfer proteins, substrate bindings and activation, atom and group transfer chemistry as well as metal properties in biological chemistry. The successful development of truly interdisciplinary work is necessary to advance bioinorganic chemistry. Composition of living organisms About 99% of mammals' mass are the elements carb ...
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-omics
Omics is the collective characterization and quantification of entire sets of biological molecules and the investigation of how they translate into the structure, function, and dynamics of an organism or group of organisms. The branches of science known informally as ''omics'' are various disciplines in biology whose names end in the suffix ''wikt:-omics, -omics'', such as genomics, proteomics, metabolomics, metagenomics, phenomics and transcriptomics. The related suffix -ome is used to address the objects of study of such fields, such as the genome, proteome or metabolome respectively. The suffix ''-ome'' as used in molecular biology refers to a ''totality'' of some sort; it is an example of a "neo-suffix" formed by abstraction from various Greek terms in , a sequence that does not form an identifiable suffix in Greek. Functional genomics aims at identifying the functions of as many genes as possible of a given organism. It combines different -omics techniques such as transcr ...
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Metabolism
Metabolism (, from ''metabolē'', "change") is the set of life-sustaining chemical reactions in organisms. The three main functions of metabolism are: the conversion of the energy in food to energy available to run cellular processes; the conversion of food to building blocks of proteins, lipids, nucleic acids, and some carbohydrates; and the elimination of metabolic wastes. These enzyme-catalyzed reactions allow organisms to grow and reproduce, maintain their Structures#Biological, structures, and respond to their environments. The word ''metabolism'' can also refer to the sum of all chemical reactions that occur in living organisms, including digestion and the transportation of substances into and between different cells, in which case the above described set of reactions within the cells is called intermediary (or intermediate) metabolism. Metabolic reactions may be categorized as ''catabolic''—the ''breaking down'' of compounds (for example, of glucose to pyruvate by c ...
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Systems Biology
Systems biology is the computational modeling, computational and mathematical analysis and modeling of complex biological systems. It is a biology-based interdisciplinary field of study that focuses on complex interactions within biological systems, using a holistic approach (holism instead of the more traditional reductionist, reductionism) to biological research. This multifaceted research domain necessitates the collaborative efforts of chemists, biologists, mathematicians, physicists, and engineers to decipher the biology of intricate living systems by merging various quantitative molecular measurements with carefully constructed mathematical models. It represents a comprehensive method for comprehending the complex relationships within biological systems. In contrast to conventional biological studies that typically center on isolated elements, systems biology seeks to combine different biological data to create models that illustrate and elucidate the dynamic interactions with ...
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Applied And Environmental Microbiology
''Applied and Environmental Microbiology'' is a biweekly peer-reviewed scientific journal published by the American Society for Microbiology. It was established in 1953 as ''Applied Microbiology'' and obtained its current name in 1975. Articles older than six months are available free of cost from the website, however, the newly published articles within six months are available to subscribers only. According to the ''Journal Citation Reports'', the journal has a 2023 impact factor of 3.9. The journal has been ranked as one of the top 100 journals over the past 100 years in the fields of biology and medicine. Special Libraries Association100 Journals in last 100 years/ref> The editor-in-chief is Gemma Reguera (Michigan State University Michigan State University (Michigan State or MSU) is a public university, public Land-grant university, land-grant research university in East Lansing, Michigan, United States. It was founded in 1855 as the Agricultural College of the State o ...
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The Analyst
''The Analyst'' (subtitled ''A Discourse Addressed to an Infidel Mathematician: Wherein It Is Examined Whether the Object, Principles, and Inferences of the Modern Analysis Are More Distinctly Conceived, or More Evidently Deduced, Than Religious Mysteries and Points of Faith'') is a book by George Berkeley. It was first published in 1734, first by J. Tonson (London), then by S. Fuller (Dublin). The "infidel mathematician" is believed to have been Edmond Halley, though others have speculated Sir Isaac Newton was intended. The book contains a direct attack on the foundations of calculus, specifically on Isaac Newton's notion of Method of Fluxions, fluxions and on Gottfried Leibniz, Leibniz's notion of infinitesimal change. Background and purpose From his earliest days as a writer, Berkeley had taken up his satirical pen to attack what were then called 'free-thinkers' (secularists, sceptics, agnostics, atheists, etc.—in short, anyone who doubted the truths of received Christi ...
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Metallomics (journal)
''Metallomics'' is a monthly peer-reviewed scientific journal covering the growing research field of metallomics. The journal's scope is aimed at "elucidating the identification, distribution, dynamics, role and impact of metals and metalloids in biological systems". It is published by the Royal Society of Chemistry. The executive editor is Jeanne Andres, while the current chair of the editorial board is David Giedroc at Indiana University Bloomington. Abstracting and indexing The journal is abstracted and indexed in: * Chemical Abstracts Service/ CASSI * PubMed/MEDLINE * Science Citation Index * Scopus According to the ''Journal Citation Reports'', the journal has a 2020 impact factor The impact factor (IF) or journal impact factor (JIF) of an academic journal is a type of journal ranking. Journals with higher impact factor values are considered more prestigious or important within their field. The Impact Factor of a journa ... of 4.526. References External links ...
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Chemical Society Reviews
''Chemical Society Reviews'' is a biweekly peer-reviewed scientific journal published by the Royal Society of Chemistry, for review articles on topics of current interest in chemistry. Its predecessors were ''Quarterly Reviews, Chemical Society'' (1947–1971) and ''Royal Institute of Chemistry, Reviews'' (1968–1971); it maintained its current title since 1972. According to the ''Journal Citation Reports'', the journal has a 2023 impact factor of 40.4. The current editor-in-chief (chair of editorial board) is Jennifer Love (University of Calgary). ''Chemical Society Reviews'' publishes occasional themed issues on new and emerging areas of research in the chemical sciences. These issues are edited by a guest editor who is a specialist in their field. Since 2005, ''Chemical Society Reviews'' has published reviews on topics of broad appeal, termed "social interest" reviews, such as articles on art conservation, forensics, and automotive fuels. The journal is abstracted and indexed ...
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Journal Of Analytical Atomic Spectrometry
The ''Journal of Analytical Atomic Spectrometry'' is a peer-reviewed scientific journal publishing original (primary) research and review articles covering all areas of modern spectrometry including fundamental theory, practice and analytical applications. It is published monthly by the Royal Society of Chemistry, the editor-in-chief is May Copsey. The journal replaced ''Annual Reports on Analytical Atomic Spectroscopy'' (1971–1984) in 1986 and has a 2021 impact factor of 4.351. The current editor-in-chief An editor-in-chief (EIC), also known as lead editor or chief editor, is a publication's editorial leader who has final responsibility for its operations and policies. The editor-in-chief heads all departments of the organization and is held accoun ... is Heidi Goenaga-Infante (LGC).Editorial Board ...
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Metal
A metal () is a material that, when polished or fractured, shows a lustrous appearance, and conducts electrical resistivity and conductivity, electricity and thermal conductivity, heat relatively well. These properties are all associated with having electrons available at the Fermi level, as against nonmetallic materials which do not. Metals are typically ductile (can be drawn into a wire) and malleable (can be shaped via hammering or pressing). A metal may be a chemical element such as iron; an alloy such as stainless steel; or a molecular compound such as polythiazyl, polymeric sulfur nitride. The general science of metals is called metallurgy, a subtopic of materials science; aspects of the electronic and thermal properties are also within the scope of condensed matter physics and solid-state chemistry, it is a multidisciplinary topic. In colloquial use materials such as steel alloys are referred to as metals, while others such as polymers, wood or ceramics are nonmetallic ...
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Ions
An ion () is an atom or molecule with a net electrical charge. The charge of an electron is considered to be negative by convention and this charge is equal and opposite to the charge of a proton, which is considered to be positive by convention. The net charge of an ion is not zero because its total number of electrons is unequal to its total number of protons. A cation is a positively charged ion with fewer electrons than protons (e.g. K+ (potassium ion)) while an anion is a negatively charged ion with more electrons than protons (e.g. Cl− (chloride ion) and OH− (hydroxide ion)). Opposite electric charges are pulled towards one another by electrostatic force, so cations and anions attract each other and readily form ionic compounds. Ions consisting of only a single atom are termed ''monatomic ions'', ''atomic ions'' or ''simple ions'', while ions consisting of two or more atoms are termed polyatomic ions or ''molecular ions''. If only a + or − is present, it indicates ...
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Metabolome
The metabolome refers to the complete set of small-molecule chemicals found within a biological sample. The biological sample can be a cell, a cellular organelle, an organ, a tissue, a tissue extract, a biofluid or an entire organism. The small molecule chemicals found in a given metabolome may include both endogenous metabolites that are naturally produced by an organism (such as amino acids, organic acids, nucleic acids, fatty acids, amines, sugars, vitamins, co-factors, pigments, antibiotics, etc.) as well as exogenous chemicals (such as drugs, environmental contaminants, food additives, toxins and other xenobiotics) that are not naturally produced by an organism. In other words, there is both an endogenous metabolome and an exogenous metabolome. The endogenous metabolome can be further subdivided to include a "primary" and a "secondary" metabolome (particularly when referring to plant or microbial metabolomes). A primary metabolite is directly involved in the nor ...
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