|
Maximum Life Span
Maximum life span (or, for humans, maximum reported age at death) is a measure of the maximum amount of time one or more members of a population have been observed to survive between birth and death. The term can also denote an estimate of the maximum amount of time that a member of a given species could survive between birth and death, provided circumstances that are optimal to that member's longevity. Most living species have an upper limit on the number of times somatic cells not expressing telomerase can divide. This is called the Hayflick limit, although this number of cell divisions does not strictly control lifespan. Definition In animal studies, maximum span is often taken to be the mean life span of the most long-lived 10% of a given cohort. By another definition, however, maximum life span corresponds to the age at which the oldest known member of a species or experimental group has died. Calculation of the maximum life span in the latter sense depends upon the init ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Humans
Humans (''Homo sapiens'') or modern humans are the most common and widespread species of primate, and the last surviving species of the genus ''Homo''. They are Hominidae, great apes characterized by their Prehistory of nakedness and clothing#Evolution of hairlessness, hairlessness, bipedality, bipedalism, and high Human intelligence, intelligence. Humans have large Human brain, brains, enabling more advanced cognitive skills that facilitate successful adaptation to varied environments, development of sophisticated tools, and formation of complex social structures and civilizations. Humans are Sociality, highly social, with individual humans tending to belong to a Level of analysis, multi-layered network of distinct social groups — from families and peer groups to corporations and State (polity), political states. As such, social interactions between humans have established a wide variety of Value theory, values, norm (sociology), social norms, languages, and traditions (co ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Murder
Murder is the unlawful killing of another human without justification (jurisprudence), justification or valid excuse (legal), excuse committed with the necessary Intention (criminal law), intention as defined by the law in a specific jurisdiction (area), jurisdiction. ("The killing of another person without justification or excuse, especially the crime of killing a person with malice aforethought or with recklessness manifesting extreme indifference to the value of human life.") This state of mind may, depending upon the jurisdiction, distinguish murder from other forms of unlawful homicide, such as manslaughter. Manslaughter is killing committed in the absence of Malice (law), ''malice'',This is "malice" in a technical legal sense, not the more usual English sense denoting an emotional state. See malice (law). such as in the case of voluntary manslaughter brought about by reasonable Provocation (legal), provocation, or diminished capacity. Involuntary manslaughter, ''Invol ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Stretched Exponential Function
The stretched exponential function f_\beta (t) = e^ is obtained by inserting a fractional power law into the exponential function. In most applications, it is meaningful only for arguments between 0 and +∞. With , the usual exponential function is recovered. With a ''stretching exponent'' ''β'' between 0 and 1, the graph of log ''f'' versus ''t'' is characteristically ''stretched'', hence the name of the function. The compressed exponential function (with ) has less practical importance, with the notable exceptions of , which gives the normal distribution In probability theory and statistics, a normal distribution or Gaussian distribution is a type of continuous probability distribution for a real-valued random variable. The general form of its probability density function is f(x) = \frac ..., and of compressed exponential relaxation in the dynamics of amorphous solids. In mathematics, the stretched exponential is also known as the Cumulative distribution fun ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biodemography Of Human Longevity
Biodemography is a multidisciplinary approach, integrating biological knowledge (studies on human biology and animal models) with demographic research on human longevity and survival. Biodemographic studies are important for understanding the driving forces of the current longevity revolution (dramatic increase in human life expectancy), forecasting the future of human longevity, and identification of new strategies for further increase in healthy and productive life span. Theory Biodemographic studies have found a remarkable similarity in survival dynamics between humans and laboratory animals. Specifically, three general biodemographic laws of survival are found: # Gompertz–Makeham law of mortality # Compensation law of mortality # Late-life mortality deceleration (now disputed *) The Gompertz–Makeham law states that death rate is a sum of an age-independent component ( Makeham term) and an age-dependent component ( Gompertz function), which increases exponentially with ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
New York City
New York, often called New York City (NYC), is the most populous city in the United States, located at the southern tip of New York State on one of the world's largest natural harbors. The city comprises five boroughs, each coextensive with a respective county. The city is the geographical and demographic center of both the Northeast megalopolis and the New York metropolitan area, the largest metropolitan area in the United States by both population and urban area. New York is a global center of finance and commerce, culture, technology, entertainment and media, academics, and scientific output, the arts and fashion, and, as home to the headquarters of the United Nations, international diplomacy. With an estimated population in 2024 of 8,478,072 distributed over , the city is the most densely populated major city in the United States. New York City has more than double the population of Los Angeles, the nation's second-most populous city. [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Caloric Restriction Mimetic
Calorie restriction mimetics (CRM), also known as energy restriction mimetics, are a hypothetical class of dietary supplements or drug candidates that would, in principle, mimic the substantial anti-aging effects that calorie restriction (CR) has on many laboratory animals and humans. CR is defined as a reduction in calorie intake of 20% (mild CR) to 50% (severe CR) without incurring malnutrition or a reduction in essential nutrients. An effective CRM would alter the key metabolic pathways involved in the effects of CR itself, leading to preserved youthful health and longer lifespan without the need to reduce food intake. The term was coined by Lane, Ingram, Roth of the National Institute on Aging in a seminal 1998 paper in the ''Journal of Anti-Aging Medicine'', the forerunner of ''Rejuvenation Research''. A number of genes and pathways have been shown to be involved with the actions of CR in model organisms and these represent attractive targets for drug discovery and for developin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Senescence
Senescence () or biological aging is the gradual deterioration of Function (biology), functional characteristics in living organisms. Whole organism senescence involves an increase in mortality rate, death rates or a decrease in fecundity with increasing age, at least in the later part of an organism's biological life cycle, life cycle. However, the resulting effects of senescence can be delayed. The 1934 discovery that calorie restriction can Life extension, extend lifespans by 50% in rats, the existence of species having negligible senescence, and the existence of potentially immortal organisms such as members of the genus ''Hydra (genus), Hydra'' have motivated research into Life extension, delaying senescence and thus age-related diseases. Rare human mutations can cause accelerated aging diseases. Environmental Gerontogens, factors may affect aging – for example, overexposure to ultraviolet radiation accelerates skin aging. Different parts of the body may age at different ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
James Vaupel
James W. Vaupel (May 2, 1945 – March 27, 2022) was an American scientist in the fields of aging research, biodemography, and formal demography. He was instrumental in developing and advancing the idea of the plasticity of longevity, and pioneered research on the heterogeneity of mortality risks and on the deceleration of death rates at the highest ages. Later positions Vaupel was the founding director of the Max Planck Institute for Demographic Research in Rostock, Germany in 1996. He was also a research professor at Duke University and the director of its Population, Policy, Aging and Research Center. Vaupel was a member of the German Academy of Sciences Leopoldina, a regular scientific member of the U.S. National Academy of Sciences and fellow of the American Academy of Arts and Sciences. He was involved in many endeavors and published over 20 books. Contributions Convinced that formal demography is the source of the discipline's strength, Vaupel contributed to the me ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mortality Rate
Mortality rate, or death rate, is a measure of the number of deaths (in general, or due to a specific cause) in a particular Statistical population, population, scaled to the size of that population, per unit of time. Mortality rate is typically expressed in units of deaths per 1,000 individuals per year; thus, a mortality rate of 9.5 (out of 1,000) in a population of 1,000 would mean 9.5 deaths per year in that entire population, or 0.95% out of the total. It is distinct from "morbidity", which is either the prevalence or Incidence (epidemiology), incidence of a disease, and also from the incidence rate (the number of newly appearing cases of the disease per unit of time). An important specific mortality rate measure is the crude death rate, which looks at mortality from all causes in a given time interval for a given population. , for instance, the Central Intelligence Agency, CIA estimates that the crude death rate globally will be 7.7 deaths per 1,000 people in a population p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Jiroemon Kimura
Jiroemon Kimura (Japanese: 木村 次郎右衛門, Hepburn: ''Kimura Jirōemon''; 19 April 1897 – 12 June 2013) was a Japanese supercentenarian who was the verified oldest living person between Dina Manfredini's death on 17 December 2012 and his own death at age 116 years and 54 days on 12 June 2013. Kimura became the verified oldest living man on 25 September 2011 at the age of 114, upon the death of Peru's Horacio Celi Mendoza, and later also the oldest man in history whose lifespan is verified on 28 December 2012, when he surpassed the age of Christian Mortensen (1882–1998), as well as the only verified man who has lived to age 116. Kimura was, after 113-year-old James Sisnett's death on 23 May 2013, the last surviving man born in the 19th century. Family According to records, Kimura, then named , was born on 19 April 1897 in the fishing village of Kamiukawa, in the Kyoto Prefecture of the Empire of Japan, as the fifth of eight children to farmers Morizo Miyake (1858� ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Jeanne Calment
Jeanne Louise Calment (; 21 February 1875 – 4 August 1997) was a French supercentenarian. With a documented lifespan of 122 years and 164 days, she was the oldest people, oldest person in history whose age has been verified. Her longevity attracted media attention and medical studies of her health and lifestyle. Calment is the only person in history who has been verified to have reached the age of 120. According to census records, Calment outlived both her daughter and her grandson. In January 1988, she was widely reported to be the oldest living person in the world. In 1995, at age 120, she was declared to be the oldest person in history with a verified date of birth. Early life Calment was born on 21 February 1875 in Arles, Bouches-du-Rhône, Provence. Some of her close family members also had above-average lifespans. Her older brother, François (1865–1962), lived to the age of 97; her father, Nicolas (1837–1931), who was a shipbuilding, shipbuilder, lived to be 93 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gerontology Research Group
The Gerontology Research Group (GRG) based in Los Angeles, California, US, is a global non-profit scientific organization of researchers in various fields of gerontology, primarily concerned with validating the ages of, recording and researching supercentenarians (people who are at least 110 years old). The group endeavors to further gerontology research with a goal of slowing and reversing aging. Many of its worldwide correspondents are respected scientists and PhD holders. History The GRG was founded in 1990 by L. Stephen Coles and Stephen M. Kaye. The original chapter of the LA-GRG holds meetings each month, though the organization has members worldwide who meet via online forums and video meetings. The GRG's current director, upon the death of Dr L. Stephen Coles, is John M. Adams, known as Johnny. Lead in supercentenarian research for the GRG is Robert Douglas Young. The GRG validates the ages of supercentenarians by finding proof-of-age documents. People that have att ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
