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Mark Batshaw
Mark Levitt Batshaw (born 19 September 1945) is a Canadian-born physician, medical researcher and academic administrator. He was a professor in the department of pediatrics and an associate dean at the George Washington University School of Medicine & Health Sciences and was the physician-in-chief and chief academic officer at Children's National Hospital in Washington, D.C. He is known for his research into urea cycle disorders and gene therapy, and is the author of the classic textbook "Children with Disabilities". Biography Batshaw was born in Montreal, Canada, in 1945 and is a United States citizen. His father, Manuel G. Batshaw, was a social worker. Batshaw manifested dyslexia and attention deficit hyperactivity disorder as a child at a time where there were limited special education services or medication for treatment. It was this experience that led him to the fields of developmental pediatrics and genetics. Batshaw received his M.D. from the University of Chicago Prit ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Montreal
Montreal is the List of towns in Quebec, largest city in the Provinces and territories of Canada, province of Quebec, the List of the largest municipalities in Canada by population, second-largest in Canada, and the List of North American cities by population, ninth-largest in North America. It was founded in 1642 as ''Fort Ville-Marie, Ville-Marie'', or "City of Mary", and is now named after Mount Royal, the triple-peaked mountain around which the early settlement was built. The city is centred on the Island of Montreal and a few, much smaller, peripheral islands, the largest of which is Île Bizard. The city is east of the national capital, Ottawa, and southwest of the provincial capital, Quebec City. the city had a population of 1,762,949, and a Census geographic units of Canada#Census metropolitan areas, metropolitan population of 4,291,732, making it the List of census metropolitan areas and agglomerations in Canada, second-largest metropolitan area in Canada. French l ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Toronto
The University of Toronto (UToronto or U of T) is a public university, public research university whose main campus is located on the grounds that surround Queen's Park (Toronto), Queen's Park in Toronto, Ontario, Canada. It was founded by royal charter in 1827 as King's College, the first institution of higher learning in Upper Canada. Originally controlled by the Church of England, the university assumed its present name in 1850 upon becoming a secular institution. It has three campuses: University of Toronto Mississauga, Mississauga, #St. George campus, St. George, and University of Toronto Scarborough, Scarborough. Its main campus, St. George, is the oldest of the three and located in Downtown Toronto. U of T operates as a collegiate university, comprising 11 #Colleges, colleges, each with substantial autonomy on financial and institutional affairs and significant differences in character and history. The University of Toronto is the largest university in Canada with a t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
American Geneticists
American(s) may refer to: * American, something of, from, or related to the United States of America, commonly known as the "United States" or "America" ** Americans, citizens and nationals of the United States of America ** American ancestry, people who self-identify their ancestry as "American" ** American English, the set of varieties of the English language native to the United States ** Native Americans in the United States, indigenous peoples of the United States * American, something of, from, or related to the Americas, also known as "America" ** Indigenous peoples of the Americas * American (word), for analysis and history of the meanings in various contexts Organizations * American Airlines, U.S.-based airline headquartered in Fort Worth, Texas * American Athletic Conference, an American college athletic conference * American Recordings (record label), a record label that was previously known as Def American * American University The American University (AU or A ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
George Washington University Faculty
George may refer to: Names * George (given name) * George (surname) People * George (singer), American-Canadian singer George Nozuka, known by the mononym George * George Papagheorghe, also known as Jorge / GEØRGE * George, stage name of Giorgio Moroder * George, son of Andrew I of Hungary Places South Africa * George, South Africa, a city ** George Airport United States * George, Iowa, a city * George, Missouri, a ghost town * George, Washington, a city * George County, Mississippi * George Air Force Base, a former U.S. Air Force base located in California Computing * George (algebraic compiler) also known as 'Laning and Zierler system', an algebraic compiler by Laning and Zierler in 1952 * GEORGE (computer), early computer built by Argonne National Laboratory in 1957 * GEORGE (operating system), a range of operating systems (George 1–4) for the ICT 1900 range of computers in the 1960s * GEORGE (programming language), an autocode system invented by Charles L ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1945 Births
1945 marked the end of World War II, the fall of Nazi Germany, and the Empire of Japan. It is also the year concentration camps were liberated and the only year in which atomic weapons have been used in combat. Events World War II will be abbreviated as “WWII” January * January 1 – WWII: ** Germany begins Operation Bodenplatte, an attempt by the ''Luftwaffe'' to cripple Allied air forces in the Low Countries. ** Chenogne massacre: German prisoners are allegedly killed by American forces near the village of Chenogne, Belgium. * January 6 – WWII: A German offensive recaptures Esztergom, Hungary from the Soviets. * January 9 – WWII: American and Australian troops land at Lingayen Gulf on western coast of the largest Philippine island of Luzon, occupied by Japan since 1942. * January 12 – WWII: The Soviet Union begins the Vistula–Oder Offensive in Eastern Europe, against the German Army. * January 13 – WWII: The Soviet Union begins the East Prussia ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Living People
Purpose: Because living persons may suffer personal harm from inappropriate information, we should watch their articles carefully. By adding an article to this category, it marks them with a notice about sources whenever someone tries to edit them, to remind them of WP:BLP (biographies of living persons) policy that these articles must maintain a neutral point of view, maintain factual accuracy, and be properly sourced. Recent changes to these articles are listed on Special:RecentChangesLinked/Living people. Organization: This category should not be sub-categorized. Entries are generally sorted by family name In many societies, a surname, family name, or last name is the mostly hereditary portion of one's personal name that indicates one's family. It is typically combined with a given name to form the full name of a person, although several give .... Maintenance: Individuals of advanced age (over 90), for whom there has been no new documentation in the last ten ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Jesse Gelsinger
Jesse Gelsinger (June 18, 1981 – September 17, 1999) was the first person publicly identified as having died in a clinical trial for gene therapy. Gelsinger suffered from ornithine transcarbamylase deficiency, an X-linked genetic disease of the liver, the symptoms of which include an inability to metabolize ammonia – a byproduct of protein breakdown. The disease is usually fatal at birth, but Gelsinger had a milder form of the disease, in which the ornithine transcarbamylase gene is mutated in only part of the patient's cells, a condition known as somatic mosaicism. As his deficiency was partial, Gelsinger managed to survive on a restricted diet and special medications. Gelsinger joined a clinical trial run by the University of Pennsylvania that aimed at developing a treatment for infants born with the severe form of the disease. On September 13, 1999, Gelsinger was injected with an adenoviral vector carrying a corrected gene to test the safety of the procedure. He died four d ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Viral Vector
A viral vector is a modified virus designed to gene delivery, deliver genetic material into cell (biology), cells. This process can be performed inside an organism or in cell culture. Viral vectors have widespread applications in basic research, agriculture, and medicine. Viruses have evolved specialized molecular mechanisms to transport their genomes into infected hosts, a process termed transduction (genetics), transduction. This capability has been exploited for use as viral vectors, which may integrate their genetic cargo—the transgene—into the host genome, although non-integrative vectors are also commonly used. In addition to agriculture and laboratory research, viral vectors are widely applied in gene therapy: as of 2022, all approved gene therapies were viral vector-based. Further, compared to traditional vaccines, the intracellular antigen expression enabled by viral vector vaccines offers more robust immune activation. Many types of viruses have been developed into ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
James Wilson (scientist)
James M. Wilson (born 1954 or 1955) is an American biomedical researcher and CEO of two biotech companies, Gemma Biotherapeutics and Franklin Biolabs, focused on gene therapies. He previously served as the Director of the Gene Therapy Program, Rose H. Weiss Professor and Director of the Orphan Disease Center, and Professor of Medicine and Pediatrics at the Perelman School of Medicine at the University of Pennsylvania. Previously, he held the John Herr Musser endowed professorship at the Perelman School of Medicine. Education Wilson graduated from Albion College (B.A., Chemistry) and the University of Michigan (MD, PhD). He completed residency training in Internal Medicine at the Massachusetts General Hospital followed by a postdoctoral fellowship at the Whitehead Institute. Career Wilson's research involves the development of viral-based gene therapies for genetic diseases. A major research focus is the generation of novel vectors for improved transduction efficiencies and re ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Glycerol Phenylbutyrate
Glycerol phenylbutyrate, sold under the brand name Ravicti, is a nitrogen-binding agent medication used in the treatment of certain inborn urea cycle disorders. The medication works by preventing the harmful buildup of ammonia in the body. It is an FDA-approved prescription drug in the US. It was developed by Hyperion Therapeutics based on the existing medication sodium phenylbutyrate, and received approval in February 2013. Medical uses Glycerol phenylbutyrate is indicated In medicine, an indication is a valid reason to use a certain test, medication, procedure, or surgery. There can be multiple indications to use a procedure or medication. An indication can commonly be confused with the term diagnosis. A diagnosis ... for chronic management of people with urea cycle disorders who cannot be managed by dietary protein restriction and/or amino acid supplementation alone. Society and culture Economics Hyperion has been criticized for setting a high price for the drug. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sodium Phenylbutyrate
Sodium phenylbutyrate, sold under the brand name Buphenyl among others, is a salt of an aromatic fatty acid, 4-phenylbutyrate (4-PBA) or 4-phenylbutyric acid. The compound is used to treat urea cycle disorders, because its metabolites offer an alternative pathway to the urea cycle to allow excretion of excess nitrogen. Sodium phenylbutyrate is also a histone deacetylase inhibitor and chemical chaperone, leading respectively to research into its use as an anti-cancer agent and in protein misfolding diseases such as cystic fibrosis. Structure and properties Sodium phenylbutyrate is a sodium salt of an aromatic fatty acid, made up of an aromatic ring and butyric acid. The chemical name for sodium phenylbutyrate is 4-phenylbutyric acid, sodium salt. It forms water-soluble off-white crystals. Uses Medical uses Sodium phenylbutyrate is taken orally or by nasogastric intubation as a tablet or powder, and tastes very salty and bitter. It treats urea cycle disorders, genetic diseases ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Saul Brusilow
Saul (; , ; , ; ) was a monarch of ancient Israel and Judah and, according to the Hebrew Bible and Old Testament, the first king of the United Monarchy, a polity of uncertain historicity. His reign, traditionally placed in the late eleventh century BCE, according to the Bible, marked the transition of the Israelites from a scattered tribal society ruled by various judges to organized statehood. The historicity of Saul and the United Kingdom of Israel is not universally accepted, as what is known of both comes exclusively from the Hebrew Bible. According to the text, he was anointed as king of the Israelites by Samuel, and reigned from Gibeah. Saul is said to have committed suicide when he fell on his sword during a battle with the Philistines at Mount Gilboa, in which three of his sons were also killed. Saul's son Ish-bosheth succeeded him to the throne, reigning for only two years before being murdered by his own military leaders. Saul's son-in-law David then became king. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
