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Marie Jakus
Marie Agnes Jakus (born ) was an American biologist and microscopist specialized in electron microscopic studies of the fine structure of eye tissues. She was a researcher at the Massachusetts Institute of Technology, Retina Foundation, and the National Institute of Neurological Diseases and Blindness before becoming a science administrator at the Center for Scientific Review. Early life and education Jakus was born in Ohio to Hungarian immigrants, Anna H. Vintila (née Hovancsik) and Anton Jakus. She had a sister, Florence A. Frash. Jakus completed a B.A. from Oberlin College where she was a student assistant for 5 years. She was a member of Phi Beta Kappa and Sigma Xi. Jakus received a fellowship from Oberlin College in 1938 to study marine invertebrate zoology at Woods Hole Oceanographic Institution. She later worked as a graduate assistant at Washington University in St. Louis between 1938 and 1941, during which she received a fellowship in 1941 to return to Woods Hole ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biomedical Research
Medical research (or biomedical research), also known as experimental medicine, encompasses a wide array of research, extending from " basic research" (also called ''bench science'' or ''bench research''), – involving fundamental scientific principles that may apply to a ''preclinical'' understanding – to clinical research, which involves studies of people who may be subjects in clinical trials. Within this spectrum is applied research, or translational research, conducted to expand knowledge in the field of medicine. Both clinical and preclinical research phases exist in the pharmaceutical industry's drug development pipelines, where the clinical phase is denoted by the term ''clinical trial''. However, only part of the clinical or preclinical research is oriented towards a specific pharmaceutical purpose. The need for fundamental and mechanism-based understanding, diagnostics, medical devices, and non-pharmaceutical therapies means that pharmaceutical res ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Physiology
Physiology (; ) is the scientific study of functions and mechanisms in a living system. As a sub-discipline of biology, physiology focuses on how organisms, organ systems, individual organs, cells, and biomolecules carry out the chemical and physical functions in a living system. According to the classes of organisms, the field can be divided into medical physiology, animal physiology, plant physiology, cell physiology, and comparative physiology. Central to physiological functioning are biophysical and biochemical processes, homeostatic control mechanisms, and communication between cells. ''Physiological state'' is the condition of normal function. In contrast, '' pathological state'' refers to abnormal conditions, including human diseases. The Nobel Prize in Physiology or Medicine is awarded by the Royal Swedish Academy of Sciences for exceptional scientific achievements in physiology related to the field of medicine. Foundations Cells Although there are ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
American Association Of Anatomists
The American Association for Anatomy (AAA), based in Rockville, MD, was founded in Washington, D.C. in 1888 as the Association of American Anatomists for the "advancement of anatomical science." AAA later changed its name to the American Association of Anatomists, and then became the American Association for Anatomy in 2019. AAA is an international membership organization of biomedical researchers and educators specializing in the structural foundation of health and disease. In addition to being the primary educators of healthcare profession students in their first year of training, AAA members work in imaging, cell biology, genetics, molecular development, endocrinology, histology, neuroscience, forensics, microscopy, physical anthropology, and numerous other developing areas. AAA holds an annual meeting (part of Experimental Biology through 2022); offers a wide range or awards, grants, scholarships, and fellowships; provides a variety of professional development programs a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Grant Application
In the United States, federal grants are economic aid issued by the United States government out of the general federal revenue. A federal grant is an award of financial assistance from a federal agency to a recipient to carry out a public purpose of support or stimulation authorized by a law of the United States. Grants are federal assistance to individuals, benefits or entitlements. A grant is not used to acquire property or services for the federal government's direct benefit. Grants may also be issued by private non-profit organizations such as foundations, not-for-profit corporations or charitable trusts which are all collectively referred to as charities. Outside the United States grants, subventions or subsidies are used to in similar fashion by government or private charities to subsidize programs and projects that fit within the funding criteria of the grant-giving entity or donor. Grants can be unrestricted, to be used by the recipient in any fashion within the p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cornea
The cornea is the transparent front part of the eye that covers the iris, pupil, and anterior chamber. Along with the anterior chamber and lens, the cornea refracts light, accounting for approximately two-thirds of the eye's total optical power. In humans, the refractive power of the cornea is approximately 43 dioptres. The cornea can be reshaped by surgical procedures such as LASIK. While the cornea contributes most of the eye's focusing power, its focus is fixed. Accommodation (the refocusing of light to better view near objects) is accomplished by changing the geometry of the lens. Medical terms related to the cornea often start with the prefix "'' kerat-''" from the Greek word κέρας, ''horn''. Structure The cornea has unmyelinated nerve endings sensitive to touch, temperature and chemicals; a touch of the cornea causes an involuntary reflex to close the eyelid. Because transparency is of prime importance, the healthy cornea does not have or need blood vess ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Descemet's Membrane
Descemet's membrane ( or the Descemet membrane) is the basement membrane that lies between the corneal proper substance, also called stroma, and the endothelial layer of the cornea. It is composed of different kinds of collagen (Type IV and VIII) than the stroma. The endothelial layer is located at the posterior of the cornea. Descemet's membrane, as the basement membrane for the endothelial layer, is secreted by the single layer of squamous epithelial cells that compose the endothelial layer of the cornea. Structure Its thickness ranges from 3 μm at birth to 8–10 μm in adults.Johnson DH, Bourne WM, Campbell RJ: The ultrastructure of Descemet's membrane. I. Changes with age in normal cornea. Arch Ophthalmol 100:1942, 1982 The corneal endothelium is a single layer of squamous cells covering the surface of the cornea that faces the anterior chamber. Clinical significance Significant damage to the membrane may require a corneal transplant. Damage caused by the hereditary co ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Trichocyst
A trichocyst is an organelle found in certain ciliates and dinoflagellates. A trichocyst can be found in tetrahymena ''Tetrahymena'', a unicellular eukaryote, is a genus of free-living ciliates. The genus Tetrahymena is the most widely studied member of its phylum. It can produce, store and react with different types of hormones. Tetrahymena cells can recogn ... and along cila pathways of several metabolic systems. It is also a structure in the cortex of certain ciliate and flagellate protozoans consisting of a cavity and long, thin threads that can be ejected in response to certain stimuli. Trichocysts may be widely distributed over an organism or restricted to certain areas (e.g., tentacles, papillae, around the mouth). There are several types. Mucoid trichocysts are elongated inclusions that may be ejected as visible bodies after artificial stimulation. Filamentous trichocysts in Paramecium and other ciliates are discharged as filaments composed of a cross-striated shaft ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Paramyosin
Myosins () are a superfamily of motor proteins best known for their roles in muscle contraction and in a wide range of other motility processes in eukaryotes. They are ATP-dependent and responsible for actin-based motility. The first myosin (M2) to be discovered was in 1864 by Wilhelm Kühne. Kühne had extracted a viscous protein from skeletal muscle that he held responsible for keeping the tension state in muscle. He called this protein ''myosin''. The term has been extended to include a group of similar ATPases found in the cells of both striated muscle tissue and smooth muscle tissue. Following the discovery in 1973 of enzymes with myosin-like function in ''Acanthamoeba castellanii'', a global range of divergent myosin genes have been discovered throughout the realm of eukaryotes. Although myosin was originally thought to be restricted to muscle cells (hence ''myo-''(s) + '' -in''), there is no single "myosin"; rather it is a very large superfamily of genes whose protein pro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Collagen
Collagen () is the main structural protein in the extracellular matrix found in the body's various connective tissues. As the main component of connective tissue, it is the most abundant protein in mammals, making up from 25% to 35% of the whole-body protein content. Collagen consists of amino acids bound together to form a triple helix of elongated fibril known as a collagen helix. It is mostly found in connective tissue such as cartilage, bones, tendons, ligaments, and skin. Depending upon the degree of mineralization, collagen tissues may be rigid (bone) or compliant (tendon) or have a gradient from rigid to compliant (cartilage). Collagen is also abundant in corneas, blood vessels, the gut, intervertebral discs, and the dentin in teeth. In muscle tissue, it serves as a major component of the endomysium. Collagen constitutes one to two percent of muscle tissue and accounts for 6% of the weight of the skeletal muscle tissue. The fibroblast is the most common cell tha ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Micrograph
A micrograph or photomicrograph is a photograph or digital image taken through a microscope or similar device to show a magnify, magnified image of an object. This is opposed to a macrograph or photomacrograph, an image which is also taken on a microscope but is only slightly magnified, usually less than 10 times. Micrography is the practice or art of using microscopes to make photographs. A micrograph contains extensive details of microstructure. A wealth of information can be obtained from a simple micrograph like behavior of the material under different conditions, the phases found in the system, failure analysis, grain size estimation, elemental analysis and so on. Micrographs are widely used in all fields of microscopy. Types Photomicrograph A light micrograph or photomicrograph is a micrograph prepared using an optical microscope, a process referred to as ''photomicroscopy''. At a basic level, photomicroscopy may be performed simply by connecting a camera to a micros ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Karolinska Institute
The Karolinska Institute (KI; sv, Karolinska Institutet; sometimes known as the (Royal) Caroline Institute in English) is a research-led medical university in Solna within the Stockholm urban area of Sweden. The Karolinska Institute is consistently ranked amongst the world's best medical schools, ranking 6th worldwide for medicine in 2021. The Nobel Assembly at the Karolinska Institute awards the Nobel Prize in Physiology or Medicine. The assembly consists of fifty professors from various medical disciplines at the university. The current rector of Karolinska Institute is Ole Petter Ottersen, who took office in August 2017. The Karolinska Institute was founded in 1810 on the island of Kungsholmen on the west side of Stockholm; the main campus was relocated decades later to Solna, just outside Stockholm. A second campus was established more recently in Flemingsberg, Huddinge, south of Stockholm. The Karolinska Institute is Sweden's third oldest medical school, after Upp ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rockefeller Foundation
The Rockefeller Foundation is an American private foundation and philanthropic medical research and arts funding organization based at 420 Fifth Avenue, New York City. The second-oldest major philanthropic institution in America, after the Carnegie Corporation, the foundation was ranked as the 39th largest U.S. foundation by total giving as of 2015. By the end of 2016, assets were tallied at $4.1 billion (unchanged from 2015), with annual grants of $173 million. According to the OECD, the foundation provided US$103.8 million for development in 2019. The foundation has given more than $14 billion in current dollars. The foundation was started by Standard Oil magnate John D. Rockefeller ("Senior") and son " Junior", and their primary business advisor, Frederick Taylor Gates, on May 14, 1913, when its charter was granted by New York. The foundation has had an international reach since the 1930s and major influence on global non-governmental organizations. The World Health ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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