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Marian Koshland
Marian Elliott "Bunny" Koshland (October 25, 1921 – October 28, 1997) was an American immunologist who discovered that the differences in amino acid composition of antibodies explain the efficiency and effectiveness with which they combat a huge range of foreign invaders. Biography Marian Elliott was born on October 25, 1921, in New Haven, Connecticut, to Margrethe Schmidt Elliott and Walter Elliott. Her mother was a teacher who had emigrated from Denmark and her father was a hardware salesman of Southern Baptist background. When she was four, her younger brother contracted typhoid fever, and she was tutored by two neighbor girls. After her brother's recovery and return from the hospital, the siblings spent a year quarantined inside to protect the immunocompromised boy. During that period, Marian's father dedicated his time to tutoring her, leading to her being advanced compared to many of her peers when she did enter school. She was something of a tomboy, befriending t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
New Haven, Connecticut
New Haven is a city of the U.S. state of Connecticut. It is located on New Haven Harbor on the northern shore of Long Island Sound. With a population of 135,081 as determined by the 2020 United States census, 2020 U.S. census, New Haven is List of municipalities in Connecticut, the third largest city in Connecticut after Bridgeport, Connecticut, Bridgeport and Stamford, Connecticut, Stamford, the largest city in the South Central Connecticut Planning Region, Connecticut, South Central Connecticut Planning Region, and the principal municipality of Greater New Haven metropolitan area, which had a total population of 864,835 in 2020. New Haven was one of the first Planned community, planned cities in the U.S. A year after its founding by English Puritans in 1638, eight streets were laid out in a four-by-four Grid plan, grid, creating the "Nine Square Plan". The central common block is New Haven Green, the New Haven Green, a square at the center of Downtown New Haven. The Green is n ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tomboy
A tomboy is a girl or young woman who generally expresses masculine traits. Such traits may include wearing androgynous or unfeminine clothing and engaging in activities and behaviors traditionally associated with boys or men. Origins The word "tomboy" is a compound word which combines "tom" with "boy". Though this word is now used to refer to "boy-like girls", the etymology suggests the meaning of tomboy has changed drastically over time. In 1533, according to the ''Oxford Dictionary of English'', "tomboy" was used to mean a "rude, boisterous or forward boy". By the 1570s, however, "tomboy” had taken on the meaning of a "bold or immodest woman", finally, in the late 1590s and early 1600s, the term morphed into its current meaning: "a girl who behaves like a spirited or boisterous boy; a wild romping girl." History In the United States 19th century Before the mid-19th century, femininity was equated with emotional fragility, physical vulnerability, hesitation, and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Molecular Biology
Molecular biology is a branch of biology that seeks to understand the molecule, molecular basis of biological activity in and between Cell (biology), cells, including biomolecule, biomolecular synthesis, modification, mechanisms, and interactions. Though cells and other microscopic structures had been observed in living organisms as early as the 18th century, a detailed understanding of the mechanisms and interactions governing their behavior did not emerge until the 20th century, when technologies used in physics and chemistry had advanced sufficiently to permit their application in the biological sciences. The term 'molecular biology' was first used in 1945 by the English physicist William Astbury, who described it as an approach focused on discerning the underpinnings of biological phenomena—i.e. uncovering the physical and chemical structures and properties of biological molecules, as well as their interactions with other molecules and how these interactions explain observ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hapten
Haptens (derived from the Greek ''haptein'', meaning “to fasten”) are small molecules that elicit an immune response only when attached to a large carrier such as a protein; the carrier may be one that also does not elicit an immune response by itself. The mechanisms of absence of immune response may vary and involve complex immunological interactions, but can include absent or insufficient co-stimulatory signals from antigen-presenting cells. Haptens have been used to study allergic contact dermatitis (ACD) and the mechanisms of inflammatory bowel disease (IBD) to induce autoimmune-like responses. The concept of haptens emerged from the work of Austrian immunologist Karl Landsteiner, who also pioneered the use of synthetic haptens to study immunochemical phenomena. Immune reaction on a hapten-carrier adduct Haptens applied on skin, when conjugate with a carrier, could induce contact hypersensitivity, which is a type IV delayed hypersensitivity reaction mediated by T cel ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Polyclonal Antibodies
Polyclonal antibodies (pAbs) are antibodies that are secreted by different B cell lineages within the body (whereas monoclonal antibodies come from a single cell lineage). They are a collection of immunoglobulin molecules that react against a specific antigen, each identifying a different epitope. Production The general procedure to produce polyclonal antibodies is as follows: # Antigen preparation # Adjuvant selection and preparation # Animal selection # Injection process # Blood serum extraction An antigen/adjuvant conjugate is injected into an animal of choice to initiate an amplified immune response. After a series of injections over a specific length of time, the animal is expected to have created antibodies against the conjugate. Blood is then extracted from the animal and then purified to obtain the antibody of interest. Inoculation is performed on a suitable mammal, such as a mouse, rabbit or goat. Larger mammals are often preferred as the amount of serum that can ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Brookhaven National Laboratory
Brookhaven National Laboratory (BNL) is a United States Department of Energy national laboratories, United States Department of Energy national laboratory located in Upton, New York, a hamlet of the Brookhaven, New York, Town of Brookhaven. It was formally established in 1947 at the site of Camp Upton, a former List of United States Army installations, U.S. Army base on Long Island. Located approximately 60 miles east of New York City, it is managed by Stony Brook University and Battelle Memorial Institute. Research at BNL includes nuclear and high energy physics, energy science and technology, environmental and bioscience, nanoscience, and national security. The 5,300 acre campus contains several large research facilities, including the Relativistic Heavy Ion Collider and National Synchrotron Light Source II. Seven Nobel Prizes have been awarded for work conducted at Brookhaven Lab. Overview BNL operations are overseen by a Department of Energy Site office, is staffed by approx ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Harvard Medical School
Harvard Medical School (HMS) is the medical school of Harvard University and is located in the Longwood Medical and Academic Area, Longwood Medical Area in Boston, Massachusetts. Founded in 1782, HMS is the third oldest medical school in the United States. It provides patient care, medical education, and research training through its 15 clinical affiliates and research institutes, including Massachusetts General Hospital (MGH), Boston Children's Hospital, Dana–Farber Cancer Institute, Brigham and Women's Hospital, Beth Israel Deaconess Medical Center, Mount Auburn Hospital, McLean Hospital, Cambridge Health Alliance, The Baker Center for Children and Families, Spaulding Rehabilitation Hospital, and others. Harvard Medical School also partners with newer entities such as Harvard Catalyst, Broad Institute , Broad Institute of MIT and Harvard, Harvard Stem Cell Institute, the Center for Primary Care, and Wyss Institute for Biologically Inspired Engineering. History Harvard ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Manhattan Project
The Manhattan Project was a research and development program undertaken during World War II to produce the first nuclear weapons. It was led by the United States in collaboration with the United Kingdom and Canada. From 1942 to 1946, the project was directed by Major General Leslie Groves of the United States Army Corps of Engineers, U.S. Army Corps of Engineers. Nuclear physicist J. Robert Oppenheimer was the director of the Los Alamos Laboratory that designed the bombs. The Army program was designated the Manhattan District, as its first headquarters were in Manhattan; the name gradually superseded the official codename, Development of Substitute Materials, for the entire project. The project absorbed its earlier British counterpart, Tube Alloys, and subsumed the program from the American civilian Office of Scientific Research and Development. The Manhattan Project employed nearly 130,000 people at its peak and cost nearly US$2 billion (equivalent to about $ b ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Oak Ridge, Tennessee
Oak Ridge is a city in Anderson County, Tennessee, Anderson and Roane County, Tennessee, Roane counties in the East Tennessee, eastern part of the U.S. state of Tennessee, about west of downtown Knoxville, Tennessee, Knoxville. Oak Ridge's population was 31,402 at the 2020 census. It is part of the Knoxville Metropolitan Area. Oak Ridge's nicknames include ''the Atomic City'', ''the Secret City'', and ''the City Behind a Fence''. In 1942, the United States federal government forcibly purchased nearly of farmland in the Clinch River valley for the development of a Planned community, planned city supporting 75,000 residents. It was constructed with assistance from architectural and engineering firm Skidmore, Owings & Merrill, from 1942 to 1943. Oak Ridge was established in 1942 as a production site for the Manhattan Project—the massive American, British, and Canadian operation that developed the Nuclear weapon, atomic bomb. Being the site of Oak Ridge National Laboratory, Y-1 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Levi Strauss
Levi Strauss ( ; born Löb Strauß, ; February 26, 1829 – September 26, 1902) was a German-born American businessman who founded the first company to manufacture blue jeans. His firm of Levi Strauss & Co. (Levi's) began in 1853 in San Francisco, California. Early life Levi Strauss was born to a Jewish family in Buttenheim on February 26, 1829, in the Franconia region of the Kingdom of Bavaria in the German Confederation. He was the son of Hirsch Strauss and Hirsch’s second wife, Rebecca Strauss (née Haas). In 1847, aged 18, Strauss travelled with his mother and two sisters to the United States to join his brothers Jonas and Louis, who had begun a wholesale dry goods business in New York City called J. Strauss Brother & Co., at 108 Liberty Street in Manhattan. After arriving in New York, Strauss worked as an itinerant peddler of goods from his brother's store: kettles, blankets and sewing goods. Business career Levi's sister Fanny and her husband David Stern moved to ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cholera
Cholera () is an infection of the small intestine by some Strain (biology), strains of the Bacteria, bacterium ''Vibrio cholerae''. Symptoms may range from none, to mild, to severe. The classic symptom is large amounts of watery diarrhea lasting a few days. Vomiting and muscle cramps may also occur. Diarrhea can be so severe that it leads within hours to severe dehydration and electrolyte imbalance. This can in turn result in Enophthalmia, sunken eyes, cold or cyanotic skin, decreased skin elasticity, wrinkling of the hands and feet, and, in severe cases, death. Symptoms start two hours to five days after exposure. Cholera is caused by a number of Serotype, types of ''Vibrio cholerae'', with some types producing more severe disease than others. It is spread mostly by Waterborne diseases, unsafe water and Foodborne illness, unsafe food that has been contaminated with human feces containing the bacteria. Undercooked shellfish is a common source. Humans are the only known host fo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cholera Vaccine
A cholera vaccine is a vaccine that is effective at reducing the risk of contracting cholera. The recommended cholera vaccines are administered orally to elicit local immune responses in the gut, where the intestinal cells produce antibodies against ''Vibrio cholerae'', the bacteria responsible for the illness. This immune response was poorly achieved with the injectable vaccines that were used until the 1970s. The first effective oral cholera vaccine was Dukoral, developed in Sweden in the 1980s. For the first six months after vaccination it provides about 85% protection, which decreases to approximately 60% during the first two years. When enough of the population is immunized, it may protect those who have not been immunized thereby increasing the total protective impact to more than 90 % (known as herd immunity). The World Health Organization (WHO) recommends the use of three oral cholera vaccines – Dukoral, Shanchol, and Euvichol-Plus – in combination with other mea ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
