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Marburgvirus
The genus ''Marburgvirus'' is the taxonomic home of ''Marburg marburgvirus'', whose members are the two known marburgviruses, Marburg virus (MARV) and Ravn virus (RAVV). Both viruses cause Marburg virus disease in humans and nonhuman primates, a form of viral hemorrhagic fever. Both are Select agents, World Health Organization Risk Group 4 Pathogens (requiring Biosafety Level 4-equivalent containment), National Institutes of Health/ National Institute of Allergy and Infectious Diseases Category A Priority Pathogens, Centers for Disease Control and Prevention Category A Bioterrorism Agents, and are listed as Biological Agents for Export Control by the Australia Group. Use of term The genus ''Marburgvirus'' is a virological taxon included in the family '' Filoviridae'', order '' Mononegavirales''. The genus currently includes a single virus species, ''Marburg marburgvirus''. The members of the genus (i.e. the actual physical entities) are called marburgviruses ...
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Marburg Virus Disease
Marburg virus disease (MVD; formerly Marburg hemorrhagic fever) is a viral hemorrhagic fever in humans and primates caused by either of the two Marburgviruses: Marburg virus (MARV) and Ravn virus (RAVV). Its clinical symptoms are very similar to those of Ebola virus disease (EVD). Egyptian fruit bats are believed to be the normal carrier in nature and Marburg virus RNA has been isolated from them. Signs and symptoms The most detailed study on the frequency, onset, and duration of MVD clinical signs and symptoms was performed during the 1998–2000 mixed MARV/RAVV disease outbreak. A maculopapular rash, petechiae, purpura, ecchymoses, and hematomas (especially around needle injection sites) are typical hemorrhagic manifestations. However, contrary to popular belief, hemorrhage does not lead to hypovolemia and is not the cause of death (total blood loss is minimal except during labor). Instead, death occurs due to multiple organ dysfunction syndrome (MODS) due to fluid redistr ...
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Marburg Marburgvirus
The genus ''Marburgvirus'' is the taxonomic home of ''Marburg marburgvirus'', whose members are the two known marburgviruses, Marburg virus (MARV) and Ravn virus (RAVV). Both viruses cause Marburg virus disease in humans and nonhuman primates, a form of viral hemorrhagic fever. Both are Select agents, World Health Organization Risk Group 4 Pathogens (requiring Biosafety Level 4-equivalent containment), National Institutes of Health/National Institute of Allergy and Infectious Diseases Category A Priority Pathogens, Centers for Disease Control and Prevention Category A Bioterrorism Agents, and are listed as Biological Agents for Export Control by the Australia Group. Use of term The genus ''Marburgvirus'' is a virological taxon included in the family ''Filoviridae'', order ''Mononegavirales''. The genus currently includes a single virus species, '' Marburg marburgvirus''. The members of the genus (i.e. the actual physical entities) are called marburgviruses. The name ''M ...
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Marburg Virus
Marburg virus (MARV) is a hemorrhagic fever virus of the '' Filoviridae'' family of viruses and a member of the species ''Marburg marburgvirus'', genus ''Marburgvirus''. It causes Marburg virus disease in primates, a form of viral hemorrhagic fever. The virus is considered to be extremely dangerous. The World Health Organization (WHO) rates it as a Risk Group 4 Pathogen (requiring biosafety level 4-equivalent containment). In the United States, the National Institute of Allergy and Infectious Diseases ranks it as a Category A Priority Pathogen and the Centers for Disease Control and Prevention lists it as a Category A Bioterrorism Agent. It is also listed as a biological agent for export control by the Australia Group. The virus can be transmitted by exposure to one species of fruit bats or it can be transmitted between people via body fluids through unprotected sex and broken skin. The disease can cause haemorrhage, fever, and other symptoms similar to Ebola, which belong ...
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Ravn Virus
Ravn virus (; RAVV) is a close relative of Marburg virus (MARV). RAVV causes Marburg virus disease in humans and nonhuman primates, a form of viral hemorrhagic fever. RAVV is a Select agent, World Health Organization Risk Group 4 Pathogen (requiring Biosafety Level 4-equivalent containment), National Institutes of Health/National Institute of Allergy and Infectious Diseases Category A Priority Pathogen, Centers for Disease Control and Prevention Category A Bioterrorism Agent, and listed as a Biological Agent for Export Control by the Australia Group. Use of term Ravn virus (today abbreviated RAVV, but then considered identical to Marburg virus) was first described in 1987 and is named after a 15-year old Danish boy who fell ill and died from it. Today, the virus is classified as one of two members of the species ''Marburg marburgvirus'', which is included into the genus ''Marburgvirus'', family ''Filoviridae'', order ''Mononegavirales''. The name Ravn virus is derived from ' ...
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Filoviridae
''Filoviridae'' () is a family of single-stranded negative-sense RNA viruses in the order '' Mononegavirales''. Two members of the family that are commonly known are Ebola virus and Marburg virus. Both viruses, and some of their lesser known relatives, cause severe disease in humans and nonhuman primates in the form of viral hemorrhagic fevers. All filoviruses are classified by the US as select agents, by the World Health Organization as Risk Group 4 Pathogens (requiring Biosafety Level 4-equivalent containment), by the National Institutes of Health/ National Institute of Allergy and Infectious Diseases as Category A Priority Pathogens, and by the Centers for Disease Control and Prevention as Category A Bioterrorism Agents, and are listed as Biological Agents for Export Control by the Australia Group. Use of term The family ''Filoviridae'' is a virological taxon that was defined in 1982 and emended in 1991, 1998, 2000, 2005, 2010 and 2011. The family currently includes the ...
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Hesse
Hesse (, , ) or Hessia (, ; german: Hessen ), officially the State of Hessen (german: links=no, Land Hessen), is a state in Germany. Its capital city is Wiesbaden, and the largest urban area is Frankfurt. Two other major historic cities are Darmstadt and Kassel. With an area of 21,114.73 square kilometers and a population of just over six million, it ranks seventh and fifth, respectively, among the sixteen German states. Frankfurt Rhine-Main, Germany's second-largest metropolitan area (after Rhine-Ruhr), is mainly located in Hesse. As a cultural region, Hesse also includes the area known as Rhenish Hesse (Rheinhessen) in the neighbouring state of Rhineland-Palatinate. Name The German name '' Hessen'', like the names of other German regions (''Schwaben'' "Swabia", ''Franken'' "Franconia", ''Bayern'' "Bavaria", ''Sachsen'' "Saxony"), derives from the dative plural form of the name of the inhabitants or eponymous tribe, the Hessians (''Hessen'', singular ''Hesse''). The g ...
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Virus
A virus is a wikt:submicroscopic, submicroscopic infectious agent that replicates only inside the living Cell (biology), cells of an organism. Viruses infect all life forms, from animals and plants to microorganisms, including bacteria and archaea. Since Dmitri Ivanovsky's 1892 article describing a non-bacterial pathogen infecting tobacco plants and the discovery of the tobacco mosaic virus by Martinus Beijerinck in 1898,Dimmock p. 4 more than 9,000 virus species have been described in detail of the millions of types of viruses in the environment. Viruses are found in almost every ecosystem on Earth and are the most numerous type of biological entity. The study of viruses is known as virology, a subspeciality of microbiology. When infected, a host cell is often forced to rapidly produce thousands of copies of the original virus. When not inside an infected cell or in the process of infecting a cell, viruses exist in the form of independent particles, or ''virions'', consisti ...
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Viral Hemorrhagic Fever
Viral hemorrhagic fevers (VHFs) are a diverse group of animal and human illnesses in which fever and hemorrhage are caused by a viral infection. VHFs may be caused by five distinct families of RNA viruses: the families ''Filoviridae'', ''Flaviviridae'', ''Rhabdoviridae'', and several member families of the ''Bunyavirales'' order such as '' Arenaviridae'', and ''Hantaviridae''. All types of VHF are characterized by fever and bleeding disorders and all can progress to high fever, shock and death in many cases. Some of the VHF agents cause relatively mild illnesses, such as the Scandinavian '' nephropathia epidemica'' (a hantavirus), while others, such as Ebola virus, can cause severe, life-threatening disease. Signs and symptoms Signs and symptoms of VHFs include (by definition) fever and bleeding: * Flushing of the face and chest, small red or purple spots (petechiae), bleeding, swelling caused by edema, low blood pressure (hypotension), and circulatory shock. * Malaise, muscle ...
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Mononegavirales
''Mononegavirales'' is an order of negative-strand RNA viruses which have nonsegmented genomes. Some common members of the order are Ebola virus, human respiratory syncytial virus, measles virus, mumps virus, Nipah virus, and rabies virus. All of these viruses cause significant disease in humans. Many other important pathogens of nonhuman animals and plants are also in the group. The order includes eleven virus families: ''Artoviridae'', '' Bornaviridae'', ''Filoviridae'', ''Lispiviridae'', '' Mymonaviridae'', '' Nyamiviridae'', ''Paramyxoviridae'', ''Pneumoviridae'', ''Rhabdoviridae'', ''Sunviridae'', and ''Xinmoviridae''. Use of term The order ''Mononegavirales'' (pronounced: ) According to the rules for taxon naming established by the International Committee on Taxonomy of Viruses (ICTV), the name ''Mononegavirales'' is always to be capitalized, italicized, and never abbreviated. The names of the order's physical members ("mononegaviruses" or "mononegavirads") are to be wri ...
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Italic Type
In typography, italic type is a cursive font based on a stylised form of calligraphic handwriting. Owing to the influence from calligraphy, italics normally slant slightly to the right. Italics are a way to emphasise key points in a printed text, to identify many types of creative works, to cite foreign words or phrases, or, when quoting a speaker, a way to show which words they stressed. One manual of English usage described italics as "the print equivalent of Underline, underlining"; in other words, underscore in a manuscript directs a typesetter to use italic. The name comes from the fact that calligraphy-inspired typefaces were first designed in Italy, to replace documents traditionally written in a handwriting style called chancery hand. Aldus Manutius and Ludovico Arrighi (both between the 15th and 16th centuries) were the main type designers involved in this process at the time. Along with blackletter and Roman type, it served as one of the major typefaces in the history ...
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Belgrade
Belgrade ( , ;, ; Names of European cities in different languages: B, names in other languages) is the Capital city, capital and List of cities in Serbia, largest city in Serbia. It is located at the confluence of the Sava and Danube rivers and the crossroads of the Pannonian Basin, Pannonian Plain and the Balkan Peninsula. Nearly 1,166,763 million people live within the administrative limits of the City of Belgrade. It is the third largest of all List of cities and towns on Danube river, cities on the Danube river. Belgrade is one of the List of oldest continuously inhabited cities, oldest continuously inhabited cities in Europe and the world. One of the most important prehistoric cultures of Europe, the Vinča culture, evolved within the Belgrade area in the 6th millennium BC. In antiquity, Thracians, Thraco-Dacians inhabited the region and, after 279 BC, Celts settled the city, naming it ''Singidunum, Singidūn''. It was Roman Serbia, conquered by the Romans under the reign ...
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Suffix
In linguistics, a suffix is an affix which is placed after the stem of a word. Common examples are case endings, which indicate the grammatical case of nouns, adjectives, and verb endings, which form the conjugation of verbs. Suffixes can carry grammatical information ( inflectional suffixes) or lexical information ( derivational/lexical suffixes'').'' An inflectional suffix or a grammatical suffix. Such inflection changes the grammatical properties of a word within its syntactic category. For derivational suffixes, they can be divided into two categories: class-changing derivation and class-maintaining derivation. Particularly in the study of Semitic languages, suffixes are called affirmatives, as they can alter the form of the words. In Indo-European studies, a distinction is made between suffixes and endings (see Proto-Indo-European root). Suffixes can carry grammatical information or lexical information. A word-final segment that is somewhere between a free morpheme ...
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