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Mammalian Genetics Unit
The Mammalian Genetics Unit was a genetics and genomics research institute in Oxfordshire. History Earlier research on the same site at the Radiobiology Research Unit, which opened in 1954, in the 1950s was into cytogenetics, where Charles Edmund Ford and John Hamerton confirmed on 12 January 1956 the size of the human genome. In the early 1970s this unit led research into mutagenic effects of radiation on the human chromosome. In the mid-1980s, important early work was done in genomic imprinting. From 2007, the site no longer carried work into the effects of radiation on genes (radiobiology). From April 2022, the site closed as the Mammalian Genetics Unit and was merged with the neighboring Mary Lyons Centre. MGU The MGU is largely derived from the earlier Radiobiology Unit (RBU). In 2010, work at the unit discovered that overexpression of the FTO gene led to obesity. Structure The unit is in Oxfordshire. Function The unit carries out work into genetics and genome enginee ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Research Institute
A research institute, research centre, research center or research organization, is an establishment founded for doing research. Research institutes may specialize in basic research or may be oriented to applied research. Although the term often implies natural science research, there are also many research institutes in the social science as well, especially for sociological and historical research purposes. Famous research institutes In the early medieval period, several astronomical observatories were built in the Islamic world. The first of these was the 9th-century Baghdad observatory built during the time of the Abbasid caliph al-Ma'mun, though the most famous were the 13th-century Maragheh observatory, and the 15th-century Ulugh Beg Observatory. The Kerala School of Astronomy and Mathematics was a school of mathematics and astronomy founded by Madhava of Sangamagrama in Kerala, India. The school flourished between the 14th and 16th centuries and the original disc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genome Engineering
Genome editing, or genome engineering, or gene editing, is a type of genetic engineering in which DNA is inserted, deleted, modified or replaced in the genome of a living organism. Unlike early genetic engineering techniques that randomly inserts genetic material into a host genome, genome editing targets the insertions to site-specific locations. The basic mechanism involved in genetic manipulations through programmable nucleases is the recognition of target genomic loci and binding of effector DNA-binding domain (DBD), double-strand breaks (DSBs) in target DNA by the restriction endonucleases (FokI and CRISPR associated protein, Cas), and the repair of DSBs through homology-directed recombination (HDR) or non-homologous end joining (NHEJ). History Genome editing was pioneered in the 1990s, before the advent of the common current nuclease-based gene editing platforms, however, its use was limited by low efficiencies of editing. Genome editing with engineered nucleases, i.e. all t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Research Institutes Established In 1995
Research is "creative and systematic work undertaken to increase the stock of knowledge". It involves the collection, organization and analysis of evidence to increase understanding of a topic, characterized by a particular attentiveness to controlling sources of bias and error. These activities are characterized by accounting and controlling for biases. A research project may be an expansion on past work in the field. To test the validity of instruments, procedures, or experiments, research may replicate elements of prior projects or the project as a whole. The primary purposes of basic research (as opposed to applied research) are documentation, discovery, interpretation, and the research and development (R&D) of methods and systems for the advancement of human knowledge. Approaches to research depend on epistemologies, which vary considerably both within and between humanities and sciences. There are several forms of research: scientific, humanities, artistic, economic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mammal Genetics
Mammals () are a group of vertebrate animals constituting the class Mammalia (), characterized by the presence of mammary glands which in females produce milk for feeding (nursing) their young, a neocortex (a region of the brain), fur or hair, and three middle ear bones. These characteristics distinguish them from reptiles (including birds) from which they diverged in the Carboniferous, over 300 million years ago. Around 6,400 extant species of mammals have been described divided into 29 orders. The largest orders, in terms of number of species, are the rodents, bats, and Eulipotyphla (hedgehogs, moles, shrews, and others). The next three are the Primates (including humans, apes, monkeys, and others), the Artiodactyla (cetaceans and even-toed ungulates), and the Carnivora (cats, dogs, seals, and others). In terms of cladistics, which reflects evolutionary history, mammals are the only living members of the Synapsida (synapsids); this clade, together with Saurop ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genetics Or Genomics Research Institutions
Genetics is the study of genes, genetic variation, and heredity in organisms.Hartl D, Jones E (2005) It is an important branch in biology because heredity is vital to organisms' evolution. Gregor Mendel, a Moravian Augustinian friar working in the 19th century in Brno, was the first to study genetics scientifically. Mendel studied "trait inheritance", patterns in the way traits are handed down from parents to offspring over time. He observed that organisms (pea plants) inherit traits by way of discrete "units of inheritance". This term, still used today, is a somewhat ambiguous definition of what is referred to as a gene. Trait inheritance and molecular inheritance mechanisms of genes are still primary principles of genetics in the 21st century, but modern genetics has expanded to study the function and behavior of genes. Gene structure and function, variation, and distribution are studied within the context of the cell, the organism (e.g. dominance), and within the context o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genetic Engineering In The United Kingdom
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Genetic may refer to: *Genetics, in biology, the science of genes, heredity, and the variation of organisms **Genetic, used as an adjective, refers to genes ***Genetic disorder, any disorder caused by a genetic mutation, whether inherited or de novo ***Genetic mutation, a change in a gene ****Heredity, genes and their mutations being passed from parents to offspring **Genetic recombination, refers to the recombining of alleles resulting in a new molecule of DNA *Genetic relationship (linguistics), in linguistics, a relationship between two languages with a common ancestor language *Genetic algorithm, in computer science, a kind of search technique modeled on evolutionary biology See also *Genetic memory (other) Genetic memory may refer to: *Genetic memory (psychology) In psychology, genetic memory is a theorized phenomenon in which certain kinds of memories could be inherited, being present at birth in the absence of any associated sensory experience, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1995 Establishments In England
File:1995 Events Collage V2.png, From left, clockwise: O.J. Simpson is acquitted of the murders of Nicole Brown Simpson and Ronald Goldman from the year prior in "The Trial of the Century" in the United States; The Great Hanshin earthquake strikes Kobe, Japan, killing 5,000-6,000 people; The Unabomber Manifesto is published in several U.S. newspapers; Gravestones mark the victims of the Srebrenica massacre near the end of the Bosnian War; Windows 95 is launched by Microsoft for PC; The first exoplanet, 51 Pegasi b, is discovered; Space Shuttle Atlantis docks with the Space station Mir in a display of U.S.-Russian cooperation; The Alfred P. Murrah Federal Building in Oklahoma City is bombed by domestic terrorists, killing 168., 300x300px, thumb rect 0 0 200 200 O. J. Simpson murder case rect 200 0 400 200 Kobe earthquake rect 400 0 600 200 Unabomber Manifesto rect 0 200 300 400 Oklahoma City bombing rect 300 200 600 400 Srebrenica massacre rect 0 400 200 600 Space Shuttle Atlanti ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Environmental Mutagenesis And Genomics Society
The Environmental Mutagenesis and Genomics Society (EMGS) is a scientific society "for the promotion of critical scientific knowledge and research into the causes and consequences of damage to the genome and epigenome in order to inform and support national and international efforts to ensure a healthy, sustainable environment for future generations." The society promotes scientific research into the causes of DNA damage and repair and the relevance of these to disease. It also promotes the application and communication of this knowledge, especially through education, to help protect human health and the environment. History The society, originally founded as the Environmental Mutagen Society (EMS) was formed in the USA in 1969 by Drs. Alexander Hollaender, Joshua Lederberg, James Crow, Ernst Freese, James Neel, William Russell, Heinrich Malling, Frederick J. de Serres, Matthew Meselson, and others. The initial aim was to support the study of environmental mutagenesis, ori ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
List Of Geneticists
This is a list of people who have made notable contributions to genetics. The growth and development of genetics represents the work of many people. This list of geneticists is therefore by no means complete. Contributors of great distinction to genetics are not yet on the list. __NOTOC__ A *Dagfinn Aarskog (1928–2014), Norwegian pediatrician and geneticist, described Aarskog–Scott syndrome * Jon Aase (born 1936), US dysmorphologist, described Aase syndrome, expert on fetal alcohol syndrome * John Abelson (born c. 1939), US biochemist, studies of machinery and mechanism of RNA splicing *Susan L. Ackerman, US neurogeneticist, genes controlling brain development and neuron survival *Jerry Adams (born 1940), US molecular biologist in Australia, hematopoietic genetics and cancer *Bruce Alberts (born 1938), US biochemist, phage worker, studied DNA replication and cell division * William Allan (1881–1943), US country doctor, pioneered human genetics * C. David Allis (born ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
FTO Gene
Fat mass and obesity-associated protein also known as alpha-ketoglutarate-dependent dioxygenase FTO is an enzyme that in humans is encoded by the ''FTO'' gene located on Chromosome 16 (human), chromosome 16. As one homolog in the AlkB family proteins, it is the first mRNA demethylase that has been identified. Certain alleles of the FTO gene appear to be correlated with obesity in humans. Function The amino acid sequence (biology), sequence of the transcription (genetics), transcribed FTO protein shows high similarity with the enzyme AlkB which oxidatively demethylation, demethylates DNA. FTO is a member of the superfamily of alpha-ketoglutarate-dependent hydroxylase, which are non-heme iron-containing proteins. Recombinant FTO protein was first discovered to catalyze demethylation of 3-methylthymine in single-stranded DNA, and 3-methyluridine in single-stranded RNA, with low efficiency. The nucleoside N6-methyladenosine (m6A), an abundant modification in RNA, was then found to ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genetics
Genetics is the study of genes, genetic variation, and heredity in organisms.Hartl D, Jones E (2005) It is an important branch in biology because heredity is vital to organisms' evolution. Gregor Mendel, a Moravian Augustinian friar working in the 19th century in Brno, was the first to study genetics scientifically. Mendel studied "trait inheritance", patterns in the way traits are handed down from parents to offspring over time. He observed that organisms (pea plants) inherit traits by way of discrete "units of inheritance". This term, still used today, is a somewhat ambiguous definition of what is referred to as a gene. Trait inheritance and molecular inheritance mechanisms of genes are still primary principles of genetics in the 21st century, but modern genetics has expanded to study the function and behavior of genes. Gene structure and function, variation, and distribution are studied within the context of the cell, the organism (e.g. dominance), and within the con ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Radiobiology
Radiobiology (also known as radiation biology, and uncommonly as actinobiology) is a field of clinical and basic medical sciences that involves the study of the action of ionizing radiation on living things, especially health effects of radiation. Ionizing radiation is generally harmful and potentially lethal to living things but can have health benefits in radiation therapy for the treatment of cancer and thyrotoxicosis. Its most common impact is the induction of cancer with a latent period of years or decades after exposure. High doses can cause visually dramatic radiation burns, and/or rapid fatality through acute radiation syndrome. Controlled doses are used for medical imaging and radiotherapy. Health effects In general, ionizing radiation is harmful and potentially lethal to living beings but can have health benefits in radiation therapy for the treatment of cancer and thyrotoxicosis. Most adverse health effects of radiation exposure may be grouped in two general c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
_Protein.png "Click for more on -> FTO Gene")
