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Magainin
The magainins are a class of antimicrobial peptides found in the African clawed frog (''Xenopus laevis''). The peptides are cationic, generally lack a stable conformation in water but form amphipathic α-helix in membranes; their mechanism against micro-organisms is unclear but they disrupt the cell membranes of a broad spectrum of bacteria, protozoa, and fungi. They were independently discovered at around the same time by the labs of Michael Zasloff at the NIH and Dudley H. Williams at the University of Cambridge. They were named by Zasloff, after the Hebrew word for "shield," מגן māgēn (Ashkenazi pronunciation: magain). Zasloff helped found a company, Magainin Pharmaceuticals (subsequently called Genaera) to develop magainins into drugs. One candidate was an analog of magainin called pexiganan (MSI-78) that the company developed as a topical agent for infected diabetic foot ulcer Diabetic foot ulcer is a breakdown of the skin and sometimes deeper tissues of the foot ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Michael Zasloff
Michael A. Zasloff (born July 2, 1946) is an American physician, medical researcher, and entrepreneur. Zasloff is primarily known for his work on antimicrobial peptides. Early life Michael Alan Zasloff was born to a Jewish family, the son a dentist and an artist. Growing up on Manhattan's West Side, he studied at the Bronx High School of Science. Education Zasloff did his undergraduate work at Columbia University and earned his M.D. and Ph.D. from the New York University School of Medicine. He did his residency training in pediatrics at the Boston Children's Hospital and a research fellowship at Johns Hopkins University. In 1975 he joined the National Institutes of Health (NIH) as a postdoc. Professional career Zasloff stayed at the NIH after he finished his postdoc, and in 1981 he was made the Chief of the Human Genetics Branch of the National Institutes of Child Health and Human Development. In 1986 he discovered magainin The magainins are a class of antimicrobial peptid ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Antimicrobial Peptides
Antimicrobial peptides (AMPs), also called host defence peptides (HDPs) are part of the innate immune response found among all classes of life. Fundamental differences exist between Prokaryote, prokaryotic and eukaryota, eukaryotic cells that may represent targets for antimicrobial peptides. These peptides are potent, broad spectrum antimicrobials which demonstrate potential as novel therapeutic agents. Antimicrobial peptides have been demonstrated to kill Gram negative and Gram positive bacteria, enveloped viruses, fungi and even transformed or cancerous cells. Unlike the majority of conventional antibiotics it appears that antimicrobial peptides frequently destabilize biological membranes, can form transmembrane channels, and may also have the ability to enhance immunity by functioning as immunomodulators. Structure Antimicrobial peptides are a unique and diverse group of molecules, which are divided into subgroups on the basis of their amino acid composition and structure. A ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
African Clawed Frog
The African clawed frog (''Xenopus laevis''), also known as simply xenopus, African clawed toad, African claw-toed frog or the ''platanna'') is a species of African Aquatic animal, aquatic frog of the family Pipidae. Its name is derived from the short black claws on its feet. The word ''Xenopus'' means 'strange foot' and ''laevis'' means 'smooth'. The species is found throughout much of Sub-Saharan Africa (Nigeria and Sudan to South Africa), and in isolated, Introduced species, introduced populations in North America, South America, Europe, and Asia. All species of the family Pipidae are tongueless, toothless and completely aquatic. They use their hands to shove food in their mouths and down their throats and a hyobranchial pump to draw or suck things in their mouth. Pipidae have powerful legs for swimming and lunging after food. They also use the claws on their feet to tear pieces of large food. They have no external eardrums, but instead subcutaneous cartilaginous disks that se ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dudley H
Dudley ( , ) is a market town in the West Midlands, England, southeast of Wolverhampton and northwest of Birmingham. Historically part of Worcestershire, the town is the administrative centre of the Metropolitan Borough of Dudley. In the 2011 census, it had a population of 79,379. The wider Metropolitan Borough had a population of 312,900. In 2014, the borough council adopted a slogan describing Dudley as the capital of the Black Country, a title by which it had long been informally known. Originally a market town, Dudley was one of the birthplaces of the Industrial Revolution and grew into an industrial centre in the 19th century with its iron, coal, and limestone industries before their decline and the relocation of its commercial centre to the nearby Merry Hill Shopping Centre in the 1980s. Tourist attractions include Dudley Zoo and Castle, the 12th century priory ruins, and the Black Country Living Museum. History Early history Dudley has a history dating back to ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hebrew
Hebrew (; ''ʿÎbrit'') is a Northwest Semitic languages, Northwest Semitic language within the Afroasiatic languages, Afroasiatic language family. A regional dialect of the Canaanite languages, it was natively spoken by the Israelites and remained in regular use as a first language until after 200 CE and as the Sacred language, liturgical language of Judaism (since the Second Temple period) and Samaritanism. The language was Revival of the Hebrew language, revived as a spoken language in the 19th century, and is the only successful large-scale example of Language revitalization, linguistic revival. It is the only Canaanite language, as well as one of only two Northwest Semitic languages, with the other being Aramaic, still spoken today. The earliest examples of written Paleo-Hebrew alphabet, Paleo-Hebrew date back to the 10th century BCE. Nearly all of the Hebrew Bible is written in Biblical Hebrew, with much of its present form in the dialect that scholars believe flourish ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ashkenazi Hebrew
Ashkenazi Hebrew (, ) is the pronunciation system for Biblical and Mishnaic Hebrew favored for Jewish liturgical use and Torah study by Ashkenazi Jewish practice. Features As it is used parallel with Modern Hebrew, its phonological differences are clearly recognized: * ''aleph'' and '' ayin'' are completely silent at all times in most forms of Ashkenazi Hebrew. In other dialects of Hebrew, they can be pronounced as a glottal stop. Compare ''Yisroeil'' (Lithuanian) or ''Yisruayl'' (Polish-Galician) vs. ''Yisra'el'' (Israeli). An earlier pronunciation of ''ayin'' as a velar nasal () is attested most prominently in Dutch Hebrew (and historically also the Hebrew of Frankfurt am Main). Vestiges of this earlier pronunciation are still found throughout the Yiddish-speaking world in names like ''Yankev'' (יעקבֿ) and words like ''manse'' (מעשׂה, more commonly pronounced ''mayse''), but are otherwise marginal. * ungeminated '' '' is pronounced in Ashkenazi Hebrew. It is always ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Diabetic Foot Ulcer
Diabetic foot ulcer is a breakdown of the skin and sometimes deeper tissues of the foot that leads to sore formation. It is thought to occur due to abnormal pressure or mechanical stress chronically applied to the foot, usually with concomitant predisposing conditions such as peripheral sensory neuropathy, motor neuropathy, peripheral motor neuropathy, autonomic neuropathy or peripheral arterial disease. It is a major complication of diabetes mellitus, and it is a type of diabetic foot, diabetic foot disease. Secondary complications to the ulcer, such as infection of the skin or subcutaneous tissue, osteomyelitis, bone infection, gangrene or sepsis are possible, often leading to amputation. A key feature of wound healing is stepwise repair of lost extracellular matrix (ECM), the largest component of the dermal skin layer. However, in some cases, physiological insult or disorder - in this case, diabetes mellitus - impedes the wound healing process. In diabetic wounds, the inflamm ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
