|
Machine Perfusion
Machine perfusion (MP) is an artificial perfusion technique often used for organ preservation to help facilitate organ transplantation. MP works by continuously pumping a specialized solution through Organ donation, donor organs, mimicking the body's natural Hemodynamics, blood flow while actively controlling Thermoregulation, temperature, Oxygen saturation, oxygen levels, Composition of the human body, chemical composition, and mechanical stress within the organ. By maintaining organ viability outside the body for extended periods, machine perfusion addresses critical challenges in organ transplantation, such as limited preservation times. Machine perfusion has various forms and can be categorised according to the temperature of the perfusate: cold (4 °C) and warm (37 °C). Machine perfusion has been applied to kidney transplantation, renal transplantation, liver transplantation and lung transplantation. It is an alternative to static Refrigeration, cold storage (SCS). ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Perfusion
Perfusion is the passage of fluid through the circulatory system or lymphatic system to an organ (anatomy), organ or a tissue (biology), tissue, usually referring to the delivery of blood to a capillary bed in tissue. Perfusion may also refer to fixation via perfusion, used in histological studies. Perfusion is measured as the rate at which blood is delivered to tissue, or volume of blood per unit time (blood volumetric flow rate, flow) per unit tissue mass. The SI unit is m3/(s·kg), although for human organs perfusion is typically reported in ml/min/g. The word is derived from the French verb ''perfuser'', meaning to "pour over or through". All animal tissues require an adequate blood supply for health and life. Poor perfusion (malperfusion), that is, ischemia, causes health problems, as seen in cardiovascular disease, including coronary artery disease, cerebrovascular disease, peripheral artery disease, and many other conditions. Tests verifying that adequate perfusion exists ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alexis Carrel
Alexis Carrel (; 28 June 1873 – 5 November 1944) was a French surgeon and biologist who spent most of his scientific career in the United States. He was awarded the Nobel Prize in Physiology or Medicine in 1912 for pioneering vascular suturing techniques. He invented the first perfusion pump with Charles Lindbergh opening the way to organ transplantation. Carrel was also a pioneer in tissue culture, transplantology and thoracic surgery. He is known for his leading role in implementing eugenic policies in Vichy France.Sade, Robert M. MD''Alexis Carrel, Pioneer Surgeon''Medical University of South Carolina, Charleston, South Carolina.(see Reggiano (2002) as well as Caillois, p. 107) Biography Born in Sainte-Foy-lès-Lyon, Rhône, Carrel was raised in a devout Catholic family and was educated by Jesuits, though he had become an agnostic by the time he became a university student. He studied medicine at the University of Lyon. Working as an intern at a Lyon hospital, he dev ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Membrane Oxygenator
A membrane oxygenator is a device used to add oxygen to, and remove carbon dioxide from the blood. It can be used in two principal modes: to imitate the function of the lungs in cardiopulmonary bypass (CPB), and to oxygenate blood in longer term life support, termed extracorporeal membrane oxygenation (ECMO). A membrane oxygenator consists of a thin gas-permeable membrane separating the blood and gas flows in the CPB circuit; oxygen diffuses from the gas side into the blood, and carbon dioxide diffuses from the blood into the gas for disposal. History The history of the oxygenator, or artificial lung, dates back to 1885, with the first demonstration of a disc oxygenator, on which blood was exposed to the atmosphere on rotating discs by Von Frey and Gruber. These pioneers noted the dangers of blood streaming, foaming and clotting. In the 1920s and 30s, research into developing extracorporeal oxygenation continued. Working independently, Brukhonenko in the USSR and John Heysh ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Metabolism
Metabolism (, from ''metabolē'', "change") is the set of life-sustaining chemical reactions in organisms. The three main functions of metabolism are: the conversion of the energy in food to energy available to run cellular processes; the conversion of food to building blocks of proteins, lipids, nucleic acids, and some carbohydrates; and the elimination of metabolic wastes. These enzyme-catalyzed reactions allow organisms to grow and reproduce, maintain their Structures#Biological, structures, and respond to their environments. The word ''metabolism'' can also refer to the sum of all chemical reactions that occur in living organisms, including digestion and the transportation of substances into and between different cells, in which case the above described set of reactions within the cells is called intermediary (or intermediate) metabolism. Metabolic reactions may be categorized as ''catabolic''—the ''breaking down'' of compounds (for example, of glucose to pyruvate by c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dextran
Dextran is a complex branched glucan (polysaccharide derived from the condensation of glucose), originally derived from wine. IUPAC defines dextrans as "Branched poly-α-d-glucosides of microbial origin having glycosidic bonds predominantly C-1 → C-6". Dextran chains are of varying lengths (from 3 to 2000 kilodaltons). The polymer main chain consists of α-1,6 glycosidic linkages between glucose monomers, with branches from α-1,3 linkages. This characteristic branching distinguishes a dextran from a dextrin, which is a straight chain glucose polymer tethered by α-1,4 or α-1,6 linkages. Occurrence Dextran was discovered by Louis Pasteur as a microbial product in wine, but mass production was only possible after the development by Allene Jeanes of a process using bacteria. Dental plaque is rich in dextrans. Dextran is a complicating contaminant in the refining of sugar because it elevates the viscosity of sucrose solutions and fouls plumbing. Dextran is now produced f ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hyperbaric Oxygen
Hyperbaric medicine is medical treatment in which an increase in barometric pressure of typically air or oxygen is used. The immediate effects include reducing the size of gas emboli and raising the partial pressures of the gases present. Initial uses were in decompression sickness, and it also effective in certain cases of gas gangrene and carbon monoxide poisoning. There are potential hazards. Injury can occur at pressures as low as 2 psig (13.8 kPa) if a person is rapidly decompressed. If oxygen is used in the hyperbaric therapy, this can increase the fire hazard. Hyperbaric oxygen therapy (HBOT), is the medical use of greater than 99% oxygen at an ambient pressure higher than atmospheric pressure, and therapeutic recompression. The equipment required consists of a pressure vessel for human occupancy (hyperbaric chamber), which may be of rigid or flexible construction, and a means of a controlled atmosphere supply. Treatment gas may be the ambient chamber gas, or delivered via ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Arterial Thrombosis
Thrombosis () is the formation of a blood clot inside a blood vessel, obstructing the flow of blood through the circulatory system. When a blood vessel (a vein or an artery) is injured, the body uses platelets (thrombocytes) and fibrin to form a blood clot to prevent blood loss. Even when a blood vessel is not injured, blood clots may form in the body under certain conditions. A clot, or a piece of the clot, that breaks free and begins to travel around the body is known as an embolus. Thrombosis can cause serious conditions such as stroke and heart attack. Thrombosis may occur in veins (venous thrombosis) or in arteries ( arterial thrombosis). Venous thrombosis (sometimes called DVT, deep vein thrombosis) leads to a blood clot in the affected part of the body, while arterial thrombosis (and, rarely, severe venous thrombosis) affects the blood supply and leads to damage of the tissue supplied by that artery (ischemia and necrosis). A piece of either an arterial or a venous thr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nephrectomy
A nephrectomy is the surgical removal of a kidney, performed to treat a number of kidney diseases including kidney cancer. It is also done to remove a normal healthy kidney from a living or deceased donor, which is part of a kidney transplant procedure. History The first recorded nephrectomy was performed in 1861 by Erastus B. Wolcott in Wisconsin. The patient had had a large tumor and the operation was initially successful, but the patient died fifteen days later. The first planned nephrectomy was performed by the German surgeon Gustav Simon (surgeon), Gustav Simon on August 2, 1869, in Heidelberg. Simon practiced the operation beforehand in animal experiments. He proved that one healthy kidney can be sufficient for urine excretion in humans. Indications There are various indications for this procedure, including renal cell carcinoma, a non-functioning kidney (which may cause arterial hypertension, high blood pressure) and a congenitally small kidney (in which the kidney is sw ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Vascular Occlusion
Vascular occlusion is a blockage of a blood vessel, usually with a clot. It differs from thrombosis in that it can be used to describe any form of blockage, not just one formed by a clot. When it occurs in a major vein, it can, in some cases, cause deep vein thrombosis. The condition is also relatively common in the retina, and can cause partial or total loss of vision. An occlusion can often be diagnosed using Doppler sonography (a form of ultrasound). Some medical procedures, such as embolisation, involve occluding a blood vessel to treat a particular condition. This can be to reduce pressure on aneurysms (weakened blood vessels) or to restrict a haemorrhage. It can also be used to reduce blood supply to tumours or growths in the body, and therefore restrict their development. Occlusion can be carried out using a ligature; by implanting small coils which stimulate the formation of clots; or, particularly in the case of cerebral aneurysms, by clipping. See also * Cent ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Thoracic Aorta
The thoracic aorta is a part of the aorta located in the thorax. It is a continuation of the aortic arch. It is located within the posterior mediastinal cavity, but frequently bulges into the left pleural cavity. The descending thoracic aorta begins at the lower border of the fourth thoracic vertebra and ends in front of the lower border of the twelfth thoracic vertebra, at the aortic hiatus in the diaphragm where it becomes the abdominal aorta. At its commencement, it is situated on the left of the vertebral column; it approaches the median line as it descends; and, at its termination, lies directly in front of the column. The thoracic aorta has a curved shape that faces forward, and has small branches. It has a radius of approximately 1.16 cm. Structure The thoracic aorta is part of the descending aorta, which has different parts named according to their structure or location. The thoracic aorta is a continuation of the descending aorta and becomes the abdominal aorta ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
