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MK-7845
MK-7845 is an experimental antiviral medication being studied as a potential treatment for COVID-19. It is believed to work by inhibiting SARS-CoV-2 main protease (3CLpro), a crucial enzyme for viral replication. Mechanism of action MK-7845 functions as a reversible covalent inhibitor of the SARS-CoV-2 main protease (also known as 3CLpro or Mpro). This viral protease enzyme is critical for cleaving viral polyproteins into functional viral proteins necessary for viral replication. The unique cleavage site recognized by 3CLpro features a glutamine residue at the P1 position that is not utilized by human proteases, making it an attractive target for drug development. Unlike other covalent inhibitors that typically utilize an amide group as a glutamine mimic at this position, MK-7845 incorporates a difluorobutyl substituent. Research demonstrates that this modification interacts with the protease's His163 residue, a crucial component for the binding and inhibition of the enzyme. Res ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
By Mouth
Oral administration is a route of administration whereby a substance is taken through the Human mouth, mouth, swallowed, and then processed via the digestive system. This is a common route of administration for many medications. Oral administration can be easier and less painful than other routes of administration, such as Injection (medicine), injection. However, the onset of action is relatively low, and the effectiveness is reduced if it is not absorbed properly in the digestive system, or if it is broken down by digestive enzymes before it can reach the bloodstream. Some medications may cause gastrointestinal side effects, such as nausea or vomiting, when taken orally. Oral administration can also only be applied to conscious patients, and patients able to swallow. Terminology ''Per os'' (; ''P.O.'') is an adverbial phrase meaning literally from Latin "through the mouth" or "by mouth". The expression is used in medicine to describe a treatment that is taken orally (but not ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
