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Low-density Lipoprotein Receptor Gene Family
The low-density lipoprotein receptor gene family codes for a class of structurally related cell surface receptors that fulfill diverse biological functions in different organs, tissues, and cell types. The role that is most commonly associated with this evolutionarily ancient family is cholesterol homeostasis (maintenance of appropriate concentration of cholesterol). In humans, excess cholesterol in the blood is captured by low-density lipoprotein (LDL) and removed by the liver via endocytosis of the LDL receptor. Recent evidence indicates that the members of the LDL receptor gene family are active in the cell signalling pathways between specialized cells in many, if not all, multicellular organisms. There are seven members of the LDLR family in mammals, namely: * LDLR * VLDL receptor ( VLDLR) * ApoER2, or LRP8 * Low density lipoprotein receptor-related protein 4 ** also known as multiple epidermal growth factor (EGF) repeat-containing protein (MEGF7) * LDLR-related protein ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genetic Code
Genetic code is a set of rules used by living cell (biology), cells to Translation (biology), translate information encoded within genetic material (DNA or RNA sequences of nucleotide triplets or codons) into proteins. Translation is accomplished by the ribosome, which links proteinogenic amino acids in an order specified by messenger RNA (mRNA), using transfer RNA (tRNA) molecules to carry amino acids and to read the mRNA three nucleotides at a time. The genetic code is highly similar among all organisms and can be expressed in a simple table with 64 entries. The codons specify which amino acid will be added next during protein biosynthesis. With some exceptions, a three-nucleotide codon in a nucleic acid sequence specifies a single amino acid. The vast majority of genes are encoded with a single scheme (see the Codon tables, RNA codon table). That scheme is often called the canonical or standard genetic code, or simply ''the'' genetic code, though #Variations, variant codes (suc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Complement Component 7
Complement component 7 is a protein involved in the complement system of the innate immune system. C7 is part of the membrane attack complex (MAC) which creates a hole on pathogen surfaces, leading to cell lysis and death. Its primary task is to bind the C5bC6 complex together. This junction alters the configuration of the protein molecules, exposing a hydrophobic site on C7 that allows the C7 to insert into the phospholipid bilayer The lipid bilayer (or phospholipid bilayer) is a thin polar membrane made of two layers of lipid molecules. These membranes form a continuous barrier around all cells. The cell membranes of almost all organisms and many viruses are made of a l ... of the pathogen. See also * Terminal complement pathway deficiency External links * * References Complement system {{gene-5-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
LRP12
Low density lipoprotein receptor-related protein 1 (LRP1), also known as alpha-2-macroglobulin receptor (A2MR), apolipoprotein E receptor (APOER) or cluster of differentiation 91 (CD91), is a protein forming a receptor found in the plasma membrane of cells involved in receptor-mediated endocytosis. In humans, the LRP1 protein is encoded by the ''LRP1'' gene. LRP1 is also a key signalling protein and, thus, involved in various biological processes, such as lipoprotein metabolism and cell motility, and diseases, such as neurodegenerative diseases, atherosclerosis, and cancer. Structure The ''LRP1'' gene encodes a 600 kDa precursor protein that is processed by furin in the trans-Golgi complex, resulting in a 515 kDa alpha-chain and an 85 kDa beta-chain associated noncovalently. As a member of the LDLR family, LRP1 contains cysteine-rich complement-type repeats, EGF (gene) repeats, β-propeller domains, a transmembrane domain, and a cytoplasmic domain. The extracellular domain of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
LRP11
Low density lipoprotein receptor-related protein 11 is a protein in humans that is encoded by the LRP11 gene In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei .... References Further reading Genes on human chromosome 6 {{gene-6-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
LRP10
Low-density lipoprotein receptor-related protein 10 is a protein that in humans is encoded by the ''LRP10'' gene In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei .... References Further reading * * * * * * * * {{gene-14-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
LDLR
The low-density lipoprotein receptor (LDL-R) is a mosaic protein of 839 amino acids (after removal of 21-amino acid signal peptide) that mediates the endocytosis of cholesterol-rich low-density lipoprotein (LDL). It is a cell-surface receptor that recognizes apolipoprotein B100 (ApoB100), which is embedded in the outer phospholipid layer of very low-density lipoprotein (VLDL), their remnants—i.e. intermediate-density lipoprotein (IDL), and LDL particles. The receptor also recognizes apolipoprotein E (ApoE) which is found in chylomicron remnants and IDL. In humans, the LDL receptor protein is encoded by the gene on chromosome 19. It belongs to the low density lipoprotein receptor gene family. It is most significantly expressed in bronchial epithelial cells and adrenal gland and cortex tissue. Michael S. Brown and Joseph L. Goldstein were awarded the 1985 Nobel Prize in Physiology or Medicine for their identification of LDL-R and its relation to cholesterol metabolism and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
HSPG2
Perlecan (PLC) also known as basement membrane-specific heparan sulfate proteoglycan core protein (HSPG) or heparan sulfate proteoglycan 2 (HSPG2), is a protein that in humans is encoded by the ''HSPG2'' gene. The HSPG2 gene codes for a 4,391 amino acid protein with a molecular weight of 468,829. It is one of the largest known proteins. The name perlecan comes from its appearance as a "string of pearls" in rotary shadowed images. Perlecan was originally isolated from a tumor cell line and shown to be present in all native basement membranes. Perlecan is a large multidomain (five domains, labeled I-V) proteoglycan that binds to and cross-links many extracellular matrix (ECM) components and cell-surface molecules. Perlecan is synthesized by both vascular endothelial and smooth muscle cells and deposited in the extracellular matrix of parahoxozoans. Perlecan is highly conserved across species and the available data indicate that it has evolved from ancient ancestors by gene dupli ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
DGCR2
The ''DGCR2'' gene encodes the protein integral membrane protein DGCR2/IDD in humans. Deletions of the 22q11.2 have been associated with a wide range of developmental defects (notably DiGeorge syndrome, velocardiofacial syndrome, conotruncal anomaly face syndrome and isolated conotruncal cardiac defects) classified under the acronym CATCH 22. The ''DGCR2'' gene encodes a novel putative adhesion receptor protein, which could play a role in neural crest cells migration, a process which has been proposed to be altered in DiGeorge syndrome. DGCR2 is thought to interact with the Reelin Reelin, encoded by the ''RELN'' gene, is a large secreted extracellular matrix glycoprotein that helps regulate processes of neuronal migration and positioning in the developing brain by controlling cell–cell interactions. Besides this importa ... complex to regulate corticogenesis. References Further reading * * * * * * * External links * * {{gene-22-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CORIN
Corin is a given name in English deriving from the Latin Quirinus, a Roman god. The meaning is unclear but is probably associated with "spear". It is used as a masculine or feminine given name, and also as a surname. Given name * Corin Braga (born 1961), Romanian writer and academic * Corin Hewitt (born 1971), American sculptor and photographer * Corin Ileto, stage name CORIN, Filipina-Australian electronic producer, composer and performer, performed at 2023 Unsound Adelaide * Corin Mellor (born 1966), British designer * Corin Nemec (born 1971), American actor * Corin Redgrave (1939–2010), British actor and political activist * Corin Tucker (born 1972), American singer and guitarist Surname * Jaclyn Corin (born 2000), American activist and advocate for gun control *Lucy Corin, American writer * William Corin (1867–1929), Australian electrical engineer Fictional characters * Corin, a character in William Shakespeare's play ''As You Like It'' * Corin Thunderfist, fictiona ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CD320
CD3 or CD-3 may refer to: * CD3, or 2020 CD3, a small minimoon of Earth * CD3 (immunology), an antigen, cluster of differentiation protein (immunology), part of the T cell receptor (TCR) complex on a mature T lymphocyte * Cost of delay (CD3 Prioritisation), an approach for scheduling work through a scarce resource that maximises Return on Investment. (CD3 = CDx3 from Cost of Delay Divided by Duration). * Ford CD3 platform * MediaMax CD-3, copy protection scheme * MiniCD, a ''3-inch CD'' ** 3-inch CD single * Color Developing Agent 3 The third in the series of color developing agents used in developing color films, commonly known as CD-3, is chemically known as N- 4-Amino-3-methylphenyl)ethylamino.html" ;"title="- -[(4-Amino-3-methylphenyl)e ..., the color developer for E-6 process">4-Amino-3-methylphenyl)ethylamino">-[(4-Amino-3-methylphenyl)e ..., the color developer for E-6 process and VNF-1 process. {{Letter-NumberCombDisambig ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
