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Little Hucklow
Little Hucklow is a village and civil parish in Derbyshire. Whilst it is a separate civil parish in the Derbyshire Dales District, the Parish Council is joint with Great Hucklow, and Grindlow. The parish consists of the village of Little Hucklow and the hamlets of Coplow Dale and Windmill. The population of the parish is about 120 reducing to less than 100 at the 2011 Census. The population is now included in the civil parish of Great Hucklow. It lies within the Peak District National Park, under Hucklow Edge. The neighbouring villages are Bradwell, Derbyshire to the north, Great Hucklow to the east and Tideswell to the south. The village lies just west of the B6049 about a mile and a half north of where it crosses the A623 at the Anchor Inn. The village is linear and is aligned east–west. The sole public house in Little Hucklow village, the Old Bulls Head, closed in the 2000s but reopened as the Blind Bull in 2020. Adjoining the pub is the Manor House, a Grade II* listed ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Derbyshire Dales
Derbyshire Dales ( ) is a local government district in Derbyshire, England. The population at the 2011 Census was 71,116. Much of it is in the Peak District, although most of its population lies along the River Derwent. The borough borders the districts of High Peak, Amber Valley, North East Derbyshire and South Derbyshire in Derbyshire, Staffordshire Moorlands and East Staffordshire in Staffordshire and Sheffield in South Yorkshire. The district also lies within the Sheffield City Region, and the district council is a non-constituent partner member of the Sheffield City Region Combined Authority. A significant amount of the working population is employed in Sheffield and Chesterfield. The district offices are at Matlock Town Hall in Matlock. It was formed on 1 April 1974, originally under the name of West Derbyshire. The district adopted its current name on 1 January 1987. The district was a merger of Ashbourne, Bakewell, Matlock and Wirksworth urban distri ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Derbyshire
Derbyshire ( ) is a ceremonial county in the East Midlands, England. It includes much of the Peak District National Park, the southern end of the Pennine range of hills and part of the National Forest. It borders Greater Manchester to the north-west, West Yorkshire to the north, South Yorkshire to the north-east, Nottinghamshire to the east, Leicestershire to the south-east, Staffordshire to the west and south-west and Cheshire to the west. Kinder Scout, at , is the highest point and Trent Meadows, where the River Trent leaves Derbyshire, the lowest at . The north–south River Derwent is the longest river at . In 2003, the Ordnance Survey named Church Flatts Farm at Coton in the Elms, near Swadlincote, as Britain's furthest point from the sea. Derby is a unitary authority area, but remains part of the ceremonial county. The county was a lot larger than its present coverage, it once extended to the boundaries of the City of Sheffield district in South Yorkshire ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Derbyshire Dales (UK Parliament Constituency)
Derbyshire Dales ( ) is a constituency that has been represented in the House of Commons of the UK Parliament since 2019 by Sarah Dines of the Conservative Party. The constituency was created for the 2010 general election. History Following their review of parliamentary representation in Derbyshire, the Boundary Commission for England created a new constituency of Derbyshire Dales which is almost coterminous with the previous seat of West Derbyshire. Constituency profile The constituency is geographically large and mostly within the Peak District The Peak District is an upland area in England at the southern end of the Pennines. Mostly in Derbyshire, it extends into Cheshire, Greater Manchester, Staffordshire, West Yorkshire and South Yorkshire. It includes the Dark Peak, where moorl ... National Park. Its main settlements are Ashbourne, Bakewell and Matlock. Boundaries The District of Derbyshire Dales, and the Borough of Amber Valley wards of Alport, Crich, an ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Civil Parish
In England, a civil parish is a type of Parish (administrative division), administrative parish used for Local government in England, local government. It is a territorial designation which is the lowest tier of local government below districts of England, districts and metropolitan and non-metropolitan counties of England, counties, or their combined form, the Unitary authorities of England, unitary authority. Civil parishes can trace their origin to the ancient system of Parish (Church of England), ecclesiastical parishes, which historically played a role in both secular and religious administration. Civil and religious parishes were formally differentiated in the 19th century and are now entirely separate. Civil parishes in their modern form came into being through the Local Government Act 1894, which established elected Parish councils in England, parish councils to take on the secular functions of the vestry, parish vestry. A civil parish can range in size from a sparsely ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Great Hucklow
Great Hucklow ( Old English ''Hucca's burial mound'') is a small village and civil parish in the Derbyshire Peak District which nestles under Hucklow Edge between the villages of Tideswell and Bradwell. It has a population of about 100, including Foolow , Grindlow plus Little Hucklow and being measured at 427 in the 2011 Census. In the village, there is a thriving primary school, which is located up a short lane (School Lane), under the edge, and a pub, the Queen Anne. It had a theatre for 40 years, which was run by L. du Garde Peach and the actors and staff were from the local area. The first production (The Merchant of Venice, Shakespeare) was in 1927 staged in the Hucklow Holiday Homes. The first set of plays in the New Play House was in 1938, with four one act plays written by Peach. The New Play House was in a converted lead mining building (known locally as cupolas from the lead smelting furnace). The first 200-second hand seats cost 1 shilling and 9 pence each. The st ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Coplow Dale
Coplow Dale (or Coplowdale) is a small settlement in the civil parish of Little Hucklow, Derbyshire Derbyshire ( ) is a ceremonial county in the East Midlands, England. It includes much of the Peak District National Park, the southern end of the Pennine range of hills and part of the National Forest. It borders Greater Manchester to the nor ..., England. External linksCoplow Dale at Streetmap.co.uk Hamlets in Derbyshire Derbyshire Dales {{Derbyshire-geo-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Peak District National Park
Peak or The Peak may refer to: Basic meanings Geology * Mountain peak ** Pyramidal peak, a mountaintop that has been sculpted by erosion to form a point Mathematics * Peak hour or rush hour, in traffic congestion * Peak (geometry), an (''n''-3)-dimensional element of a polytope * Peak electricity demand or peak usage * Peak-to-peak, the highest (or sometimes the highest and lowest) points on a varying waveform * Peak (pharmacology), the time at which a drug reaches its maximum plasma concentration * Peak experience, psychological term for a euphoric mental state Resource production In terms of resource production, the peak is the moment when the production of a resource reaches a maximum level, after which it declines; in particular see: * Peak oil * Peak car * Peak coal * Peak copper * Peak farmland * Peak gas * Peak gold * Peak minerals * Peak phosphorus * Peak uranium * Peak water * Peak wheat * Peak wood Other basic meanings * Visor, a part of a hat, known as a "p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bradwell, Derbyshire
Bradwell is a village and civil parish in the Derbyshire Peak District of England. The population of the civil parish taken at the 2011 Census was 1,416. It lies south of the main body of the Hope Valley but is usually included among its settlements. Toponymy The name Bradwell is thought to be a corruption of ''Broadwell'', a reference to the Grey Ditch. Some locals cite an alternative derivation from a well at the village's centre known as Brad's Well. It is unclear whether the village's name came from the well or vice versa. History Pre-history A Mesolithic pebble mace-head was found in Smalldale and a Mesolithic lithic working site was discovered when a site near Bradwell Moor Barn was excavated. A number of Neolithic axes have been found in the village. A Bronze Age barrow and the remains of a cist with a skeleton was found in 1891. A possible Bronze Age round barrow 19 m in diameter has been found near to Minchlow Lane. A Late Bronze Age socketed bronze axehead was ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tideswell
Tideswell is a village and civil parish in the Peak District of Derbyshire, England. It lies east of Buxton on the B6049, in a wide valley on a limestone plateau, at an altitude of above sea level, and is within the District of Derbyshire Dales. The population (including Wheston) was 1,820 in 2001, increasing slightly to 1,827 at the 2011 Census, making it the second-largest settlement within the National Park, after Bakewell. Tideswell Dale is a short limestone valley leading south from the village to the River Wye valley. Name There is some debate as to how the village got its name. The English Place Name Society accepts it as being named after a Saxon chieftain named Tidi, others that the name comes from a "tiding well" situated in the north of the village. This 'ebbing and flowing' well was declared to be one of the Seven Wonders of the Peak by Thomas Hobbes in his 1636 book ''De Mirabilibus Pecci.'' Tideswell is known locally as ''Tidza'' or ''Tidsa''. In addition, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
B6049
B6 often refers to: * Vitamin B6 B6 may also refer to: Transportation Automobiles * A generation of Audi A4, manufactured from 2001 to 2005 * A fully armoured version of the Bentley Arnage Series Two RL * A member of the Mazda B engine series Aircraft * Blackburn B.6 Shark, a British 1930s torpedo bomber *Keystone B-6, a United States Army Air Corps bomber *Lohner B.VI, an Austro-Hungarian World War 1 reconnaissance biplane * Nakajima B-6, Nakajima designation for Bréguet 14 built under licence in Japan * Republic B 6, Swedish designation for Republic 2PA fighter Other vehicles * B6 (New York City bus), serving Brooklyn * Bavarian B VI, an 1863 German steam locomotive model * , a submarine of the Royal Navy * , a submarine of Norway Roads * B6 road (Cyprus), a road on the island of Cyprus * B6 (Zimbabwe), a road in Zimbabwe * Bundesstraße 6, a national highway in Germany Life sciences * Vitamin B6, a water-soluble compound pyridoxine which takes several forms * ATC cod ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
A623
Blisibimod (also known as A-623, formerly AMG 623) is a selective antagonist of B-cell activating factor (BAFF, also known as B-lymphocyte stimulator or BLyS), being developed by Anthera Pharmaceuticals as a treatment for systemic lupus erythematosus. It is currently under active investigation in clinical trials. Mechanism of action Blisibimod is a fusion protein consisting of four BAFF binding domains fused to the N-terminus of the fragment crystallizable region (Fc) of a human antibody. BAFF is involved in B-cell survival, activation, and differentiation. Elevated levels of BAFF have been associated with several B-cell mediated autoimmune diseases, including systemic lupus erythematosus, lupus nephritis, rheumatoid arthritis, multiple sclerosis, Sjögren syndrome, Graves' disease, and Hashimoto's thyroiditis. Blisibimod binds to BAFF and inhibits interaction with BAFF receptors, thus decreasing B-cell survival and proliferation throughout the body. Improvements in disease a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Derbyshire Lead Mining History
This article details some of the history of lead mining in Derbyshire, England. Background It has been claimed that Odin Mine, near Castleton, one of the oldest lead mines in England, may have been worked in the tenth century or even as early as Roman Britain, but it was certainly productive in the 1200s. Derbyshire lead mines are mentioned in the Pipe Rolls. Recent analysis of a Swiss ice-core extracted in 2013 indicates that levels of lead in atmospheric pollution between 1170 and 1216 were as high as those during the Industrial Revolution and correlate accurately with lead production from Peak District mines, the main European source at the time. On one of the walls in Wirksworth Church is a crude stone carving, found nearby at Bonsall and placed in the church in the 1870s. Probably executed in Anglo-Saxon times, it shows a man carrying a kibble or basket in one hand and a pick in the other. He is a lead miner. The north choir aisle of Wirksworth church is dominated by ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
