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List Of Miscellaneous 5-HT2A Receptor Agonists
This is a list of miscellaneous agonists of the serotonin receptor subtype 5-HT2A (and other 5-HT2 subtypes to a varying extent) that fall outside the common structural classes. Most agonists at this receptor are either substituted phenethylamine derivatives from the 2C, DOx and 25-NB groups, or substituted tryptamines and related compounds along with more complex derivatives of these such as lysergamides and iboga-type alkaloids. There are however numerous 5-HT2A receptor agonists which do not fall within any of these groups, some representative examples of which are listed below. Ki and EC50 values vary depending on the assay conditions used and so may not be directly comparable between sources. Many of these compounds have been designed to be non-psychoactive derivatives for medical applications, and it should not be assumed that a compound which acts as a 5-HT2A agonist will necessarily be psychedelic in nature. See also * Partial lysergamide * DPCPX * LY-341,495 * Ro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Agonist
An agonist is a chemical that activates a Receptor (biochemistry), receptor to produce a biological response. Receptors are Cell (biology), cellular proteins whose activation causes the cell to modify what it is currently doing. In contrast, an Receptor antagonist, antagonist blocks the action of the agonist, while an inverse agonist causes an action opposite to that of the agonist. Etymology The word originates from the Ancient Greek, Greek word (''agōnistēs''), "contestant; champion; rival" < (''agōn''), "contest, combat; exertion, struggle" < (''agō''), "I lead, lead towards, conduct; drive." Types of agonists Receptor (biochemistry), Receptors can be activated by either endogenous agonists (such as hormones and neurotransmitters) or exogenous agonists (such as medication, drugs), resulting in a biological response. A physiological agonism an ...[...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
DEIMDHPCA
DEIMDHPCA, also known as 3,5-seco-LSD, is an indole chemical derivative, derivative and a "partial" or simplified ergoline which is closely related to the highly potency (pharmacology), potent serotonergic psychedelic lysergic acid diethylamide (LSD). It is specifically the structural analogue, analogue of LSD in which one of LSD's carbon atoms in the ergoline ring system (chemistry), ring system, the carbon at position 4, has been removed. This in turn renders the DEIMDHPCA molecule more flexible and makes it a partially rigid structure, rigid indole, indolic substituted phenethylamine, phenethylamine-containing chemical compound, compound rather than an ergoline. DEIMDHPCA is known to be a highly potent serotonin 5-HT2 receptor, 5-HT2 receptor agonist similarly to LSD and to produce psychoplastogenic effects. Pharmacology Like LSD, the drug is known to be a highly potent serotonin 5-HT2A receptor, 5-HT2A and 5-HT2C receptor, 5-HT2C receptor agonist ''in vitro''. Its affinity ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
2C-B-morpholine
2C-B-morpholine, also known as 2C-B-norphenmetrazine or as 2-(4-bromo-2,5-dimethoxyphenyl)morpholine, is a serotonin receptor modulator of the phenylmorpholine (phenmetrazine) and cyclized phenethylamine groups. It is a ligand of the serotonin 5-HT2A receptor, with an affinity of 20.6nM and an of 4%. The drug showed 103-fold lower affinity for this receptor than ''R''(–)-DOB and had minimal agonist activity (with ''R''(–)-DOB having an of 51% in the assay), so for practical purposes would act as an antagonist at the 5-HT2A receptor under most circumstances, despite being technically classified as a partial agonist. 2C-B-morpholine was first described in the scientific literature by Richard Glennon and colleagues by 2004. See also * Substituted phenethylamine § Cyclized phenethylamines * Substituted phenylmorpholine * 2C-B-aminorex * 2C-B-BZP * 2C-B-PP 2,5-dimethoxy-4-bromophenylpiperazine (2C-B-PP) is a drug of the phenylpiperazine class. It acts as an agonist at s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
2C-B-aminorex
2C-B-aminorex (2C-B-AR) is a recreational designer drug with psychedelic effects. It is a substituted aminorex derivative which was first identified in Sweden in June 2019. Structurally, it is a hybrid of 4-bromo-2,5-dimethoxyphenethylamine (2C-B) and aminorex. See also * 2C-B * 2C-B-morpholine * 2C-B-PP * BOB (psychedelic) * 4,4'-DMAR * 4'-Fluoro-4-methylaminorex * 4B-MAR * 4C-MAR * List of aminorex analogues This is a list of aminorex analogues, also known as substituted 2-amino-5-aryloxazolines. Aminorex itself is a stimulant drug with a 5-phenyl-2-amino-oxazoline structure. It was developed in the 1960s as an anorectic, but withdrawn from sale after ... References 2,5-Dimethoxyphenethylamines Aminorexes Bromoarenes Designer drugs Psychedelic phenethylamines {{hallucinogen-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
ZC-B
ZC-B (3-(4-bromo-2,5-dimethoxyphenyl)azetidine) is a phenethylamine derivative which acts as a serotonin receptor agonist selective for the 5-HT2 subtypes, with an EC50 of 1.6nM at 5-HT2A, vs 5.8nM at 5-HT2C. It is structurally related to the psychedelic phenethylamines 2C-B and DOB, but with the amine side chain conformationally restricted as an azetidine ring. See also * DOB * β-Methyl-2C-B * 4C-B * TCB-2 TCB-2 is a hallucinogen discovered in 2006 by Thomas McLean working in the lab of David Nichols at Purdue University. It is a conformationally-restricted derivative of the phenethylamine 2C-B, also a hallucinogen, and acts as a potent agonis ... * LPH-5 * LSZ References {{Phenethylamines 2,5-Dimethoxyphenethylamines Designer drugs Serotonin receptor agonists Azetidines Bromoarenes ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
6c From J Med Chem 2023, 66, 11536 Structure
6C or VI-C may refer to : * Sixth Cambridge Survey of radio sources * Alfa Romeo 6C, a road, race and sports car * Keratin 6C in biochemistry * Stalag VI-C, a German prisoner of war camp * Carbon (6C), a chemical element * 6C, the production code for the 1982 ''Doctor Who'' serial ''Time-Flight ''Time-Flight'' is the seventh and final serial of the Doctor Who (season 19), 19th season of the British science fiction television series ''Doctor Who'', which was first broadcast in four twice-weekly parts on BBC One, BBC1 from 22 to 30 March ...'' See also * C6 (other) {{Letter-NumberCombDisambig ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
106 From ACS Med Chem Lett 2022, 13, 4, 648 Structure
1 (one, unit, unity) is a number, numeral, and glyph. It is the first and smallest positive integer of the infinite sequence of natural numbers. This fundamental property has led to its unique uses in other fields, ranging from science to sports, where it commonly denotes the first, leading, or top thing in a group. 1 is the unit of counting or measurement, a determiner for singular nouns, and a gender-neutral pronoun. Historically, the representation of 1 evolved from ancient Sumerian and Babylonian symbols to the modern Arabic numeral. In mathematics, 1 is the multiplicative identity, meaning that any number multiplied by 1 equals the same number. 1 is by convention not considered a prime number. In digital technology, 1 represents the "on" state in binary code, the foundation of computing. Philosophically, 1 symbolizes the ultimate reality or source of existence in various traditions. In mathematics The number 1 is the first natural number after 0. Each natural number, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
