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List Of Unsolved Problems In Medicine
This article discusses notable Lists of unsolved problems, unsolved problems in medicine. Many of the problems relate to how drugs work (the so-called mechanism of action), and to diseases with an unknown cause, the so-called idiopathic diseases. Definition of "disease" There is no overarching, clear definition of what a disease is. On one hand, there is a scientific definition which is tied to a Physiology, physiological process, and on the other hand, there is the subjective suffering of a patient and the loss of their life quality. Both approaches do not need to match, and they can even be contradictory. For example, when a patient seeks medical help because of a severe influenza, flu, the doctor will not care about the specific virological and immunological process behind the clearly visible suffering. This is contrasted by many hemochromatosis patients who will neither see suffering nor a change in their life quality, while the disease-causing process is severe and often de ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lists Of Unsolved Problems
List of unsolved problems may refer to several notable conjectures or open problems in various academic fields: Natural sciences, engineering and medicine * Unsolved problems in astronomy * Unsolved problems in biology * Unsolved problems in chemistry * Unsolved problems in geoscience * Unsolved problems in medicine * Unsolved problems in neuroscience * Unsolved problems in physics Mathematics, statistics and information sciences * Unsolved problems in mathematics * Unsolved problems in statistics * Unsolved problems in computer science * Unsolved problems in information theory Social sciences and humanities * Problems in philosophy * Unsolved problems in economics * Unsolved problems in fair division See also * Cold case (unsolved crimes) * List of ciphertexts * List of hypothetical technologies * List of NP-complete problems * List of paradoxes * List of PSPACE-complete problems * List of undecidable problems * List of unsolved deaths This list of unsolved death ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Autism Spectrum Disorder
Autism, also known as autism spectrum disorder (ASD), is a neurodevelopmental disorder characterized by differences or difficulties in social communication and interaction, a preference for predictability and routine, sensory processing differences, Special interest (autism), focused interests, and repetitive behaviors, which may include stimming. Formal Diagnosis of autism, diagnosis requires significant challenges in multiple domains of life, with characteristics that are atypical or more pronounced than expected for one's age and sociocultural context.(World Health Organization: International Classification of Diseases version 11 (ICD-11)): https://icd.who.int/browse/2024-01/mms/en#437815624 Motor coordination difficulties are common but not required for diagnosis. Autism is a spectrum disorder, resulting in wide variations in presentation and support needs, such as that between speaking and Nonverbal autism, non-speaking populations. Increased estimates of Epidemiology ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pedophilia
Pedophilia ( alternatively spelled paedophilia) is a psychiatric disorder in which an adult or older adolescent experiences a primary or exclusive sexual attraction to prepubescent children. Although girls typically begin the process of puberty at age 10 or 11, and boys at age 11 or 12, psychiatric diagnostic criteria for pedophilia extend the cut-off point for prepubescence to age 13. People with the disorder are often referred to as pedophiles (or paedophiles). Pedophilia is a paraphilia. In recent versions of formal diagnostic coding systems such as the DSM-5 and ICD-11, "pedophilia" is distinguished from "pedophilic disorder". Pedophilic disorder is defined as a pattern of pedophilic arousal accompanied by either subjective distress or interpersonal difficulty, or having acted on that arousal. The DSM-5 requires that a person must be at least 16 years old, and at least five years older than the prepubescent child or children they are aroused by, for the attraction to be d ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Richard Green (sexologist)
Richard Green (6 June 1936 – 6 April 2019) was an American-born British sexologist, psychiatrist, lawyer, and author known for his research on homosexuality and transsexualism, specifically gender identity disorder in children. He is known for his behaviorism experiment in which he attempted to prevent male homosexuality and transsexuality by extinguishing feminine behavior in young boys. He later came to favor biological explanations for male homosexuality. Green was the founding editor of the ''Archives of Sexual Behavior'' (1971) and served as Editor until 2001. He was also the founding president of the International Academy of Sex Research (1975), which made the ''Archives'' its official publication. He served on the American Psychiatric Association DSM-IV Subcommittee on Gender Identity Disorders. Early life and education Green was born on 6 June 1936, in Crown Heights, Brooklyn, New York, to parents Rose (née Ingber) a teacher, and Leo Green, accountant.Peacock S, Ed ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
American Psychiatric Association
The American Psychiatric Association (APA) is the main professional organization of psychiatrists and trainee psychiatrists in the United States, and the largest psychiatric organization in the world. It has more than 39,200 members who are involved in psychiatric practice, research, and academia representing a diverse population of patients in more than 100 countries. The association publishes various journals and pamphlets, as well as the ''Diagnostic and Statistical Manual of Mental Disorders'' (DSM). The DSM codifies psychiatric conditions and is used mostly in the United States as a guide for diagnosing mental disorders. The organization has its headquarters in Washington, D.C. History At a meeting in 1844 in Philadelphia, thirteen superintendents and organizers of insane asylums and hospitals formed the Association of Medical Superintendents of American Institutions for the Insane (AMSAII). The group included Thomas Kirkbride, creator of the asylum model which was ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Homosexuality
Homosexuality is romantic attraction, sexual attraction, or Human sexual activity, sexual behavior between people of the same sex or gender. As a sexual orientation, homosexuality is "an enduring pattern of emotional, romantic, and/or sexual attractions" exclusively to people of the same sex or gender. It also denotes Sexual identity, identity based on attraction, related behavior, and community affiliation. Along with bisexuality and heterosexuality, homosexuality is one of the three main categories of sexual orientation within the heterosexual–homosexual continuum. Although no single theory on the cause of sexual orientation has yet gained widespread support, scientists favor Biology and sexual orientation, biological theories. There is considerably more evidence supporting nonsocial, biological causes of sexual orientation than social ones, especially for males. A major hypothesis implicates the Prenatal development, prenatal environment, specifically the organizationa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Personality Disorders
Personality disorders (PD) are a class of mental health conditions characterized by enduring maladaptive patterns of behavior, cognition, and inner experience, exhibited across many contexts and deviating from those accepted by the culture. These patterns develop early, are inflexible, and are associated with significant distress or disability. The definitions vary by source and remain a matter of controversy. Official criteria for diagnosing personality disorders are listed in the sixth chapter of the ''International Classification of Diseases'' (ICD) and in the American Psychiatric Association's ''Diagnostic and Statistical Manual of Mental Disorders'' (DSM). Personality, defined psychologically, is the set of enduring behavioral and mental traits that distinguish individual humans. Hence, personality disorders are characterized by experiences and behaviors that deviate from social norms and expectations. Those diagnosed with a personality disorder may experience difficultie ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Compulsive Sexual Behavior
Sexual addiction is a state characterized by compulsive participation or engagement in sexual activity, particularly sexual intercourse, despite negative consequences. The concept is contentious; sexual addiction is not a clinical diagnosis in either the DSM or ICD medical classifications of diseases and medical disorders, the latter of which instead classifying such behaviors as a part of compulsive sexual behaviour disorder (CSBD). There is considerable debate among psychiatrists, psychologists, sexologists, and other specialists whether compulsive sexual behavior constitutes an addiction – in this instance a behavioral addiction – and therefore its classification and possible diagnosis. Animal research has established that compulsive sexual behavior arises from the same transcriptional and epigenetic mechanisms that mediate drug addiction in laboratory animals. Some argue that applying such concepts to normal behaviors such as sex can be problematic, and suggest that ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Major Depressive Disorder
Major depressive disorder (MDD), also known as clinical depression, is a mental disorder characterized by at least two weeks of pervasive depression (mood), low mood, low self-esteem, and anhedonia, loss of interest or pleasure in normally enjoyable activities. Introduced by a group of US clinicians in the mid-1970s, the term was adopted by the American Psychiatric Association for this syndrome, symptom cluster under mood disorders in the 1980 version of the ''Diagnostic and Statistical Manual of Mental Disorders'' (DSM-III), and has become widely used since. The disorder causes the second-most years lived with disability, after low back pain, lower back pain. The diagnosis of major depressive disorder is based on the person's reported experiences, behavior reported by family or friends, and a mental status examination. There is no laboratory test for the disorder, but testing may be done to rule out physical conditions that can cause similar symptoms. The most common time o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cohen's Kappa
Cohen's kappa coefficient ('κ', lowercase Greek kappa) is a statistic that is used to measure inter-rater reliability (and also intra-rater reliability) for qualitative (categorical) items. It is generally thought to be a more robust measure than simple percent agreement calculation, as κ takes into account the possibility of the agreement occurring by chance. There is controversy surrounding Cohen's kappa due to the difficulty in interpreting indices of agreement. Some researchers have suggested that it is conceptually simpler to evaluate disagreement between items. History The first mention of a kappa-like statistic is attributed to Galton in 1892. The seminal paper introducing kappa as a new technique was published by Jacob Cohen (statistician), Jacob Cohen in the journal ''Educational and Psychological Measurement'' in 1960. Definition Cohen's kappa measures the agreement between two raters who each classify ''N'' items into ''C'' mutually exclusive categories. The definit ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dementia
Dementia is a syndrome associated with many neurodegenerative diseases, characterized by a general decline in cognitive abilities that affects a person's ability to perform activities of daily living, everyday activities. This typically involves problems with memory, thinking, behavior, and motor control. Aside from memory impairment and a thought disorder, disruption in thought patterns, the most common symptoms of dementia include emotional problems, difficulties with language, and decreased motivation. The symptoms may be described as occurring in a continuum (measurement), continuum over several stages. Dementia is a life-limiting condition, having a significant effect on the individual, their caregivers, and their social relationships in general. A diagnosis of dementia requires the observation of a change from a person's usual mental functioning and a greater cognitive decline than might be caused by the normal aging process. Several diseases and injuries to the brain, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Inter-rater Reliability
In statistics, inter-rater reliability (also called by various similar names, such as inter-rater agreement, inter-rater concordance, inter-observer reliability, inter-coder reliability, and so on) is the degree of agreement among independent observers who rate, code, or assess the same phenomenon. Assessment tools that rely on ratings must exhibit good inter-rater reliability, otherwise they are not test validity, valid tests. There are a number of statistics that can be used to determine inter-rater reliability. Different statistics are appropriate for different types of measurement. Some options are joint-probability of agreement, such as Cohen's kappa, Scott's pi and Fleiss' kappa; or inter-rater correlation, concordance correlation coefficient, intra-class correlation, and Krippendorff's alpha. Concept There are several operational definitions of "inter-rater reliability," reflecting different viewpoints about what is a reliable agreement between raters. There are three oper ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
