|
Life Extension Advocacy Foundation
The Lifespan Extension Advocacy Foundation (LEAF) also known as Lifespan.io is a non-profit organization with mission to support fundamental research on the main mechanisms of aging and Aging-associated diseases, age-related diseases and educate the public on the possibility of bringing aging under medical control in order to prevent, postpone and cure age-related diseases. It was founded in 2014 and is based in New York City, New York (state), New York, United States, USA. Its activities include a news outlet covering aging research, an annual scientific conference on aging in New York City, and the non-profit crowdfunding platform ''Lifespan.io''. As of 2020, the platform has hosted eight successful campaigns, including three research projects by SENS Research Foundation. The organization also operates the largest investor network platform for longevity related startups and investors. In October 2024, LEAF completed a merger with SENS Research Foundation. The newly merged organ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
501(c)
A 501(c) organization is a nonprofit organization in the federal law of the United States according to Internal Revenue Code (26 U.S.C. § 501(c)). Such organizations are exempt from some federal income taxes. Sections 503 through 505 set out the requirements for obtaining such exemptions. Many states refer to Section 501(c) for definitions of organizations exempt from state taxation as well. 501(c) organizations can receive unlimited contributions from individuals, corporations, and unions. For example, a nonprofit organization may be tax-exempt under section 501(c)(3) if its primary activities are charitable, religious, educational, scientific, literary, testing for public safety, fostering amateur sports competition, or preventing cruelty to children or animals. Types According to the IRS Publication 557, in the ''Organization Reference Chart'' section, the following is an exact list of 501(c) organization types (29 in total) and their corresponding descriptions. G ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Jeanne Calment
Jeanne Louise Calment (; 21 February 1875 – 4 August 1997) was a French supercentenarian. With a documented lifespan of 122 years and 164 days, she was the oldest people, oldest person in history whose age has been verified. Her longevity attracted media attention and medical studies of her health and lifestyle. Calment is the only person in history who has been verified to have reached the age of 120. According to census records, Calment outlived both her daughter and her grandson. In January 1988, she was widely reported to be the oldest living person in the world. In 1995, at age 120, she was declared to be the oldest person in history with a verified date of birth. Early life Calment was born on 21 February 1875 in Arles, Bouches-du-Rhône, Provence. Some of her close family members also had above-average lifespans. Her older brother, François (1865–1962), lived to the age of 97; her father, Nicolas (1837–1931), who was a shipbuilding, shipbuilder, lived to be 93 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Life Extension
Life extension is the concept of extending the human lifespan, either modestly through improvements in medicine or dramatically by increasing the maximum lifespan beyond its generally-settled biological limit of around 125 years. Several researchers in the area, along with "life extensionists", " immortalists", or " longevists" (those who wish to achieve longer lives themselves), postulate that future breakthroughs in tissue rejuvenation, stem cells, regenerative medicine, molecular repair, gene therapy, pharmaceuticals, and organ replacement (such as with artificial organs or xenotransplantations) will eventually enable humans to have indefinite lifespans through complete rejuvenation to a healthy youthful condition (agerasia). The ethical ramifications, if life extension becomes a possibility, are debated by bioethicists. The sale of purported anti-aging products such as supplements and hormone replacement is a lucrative global industry. For example, the industry that ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Immortality
Immortality is the concept of eternal life. Some species possess "biological immortality" due to an apparent lack of the Hayflick limit. From at least the time of the Ancient Mesopotamian religion, ancient Mesopotamians, there has been a conviction that gods may be physically immortal, and that this is also a state that the gods at times offer humans. In Christianity, the conviction that God may offer physical immortality with the resurrection of the flesh at the end of time has traditionally been at the center of its beliefs. What form an unending human life would take, or whether an immaterial soul exists and possesses immortality, has been a major point of focus of religion, as well as the subject of speculation and debate. In religious contexts, immortality is often stated to be one of the promises of divinities to human beings who perform virtue or follow divine law. Some scientists, futurists and philosophers have theorized about the immortality of the human body, with ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Geroprotector
A geroprotector aims to affect the root cause of aging and age-related diseases, and thus prolong the life span of animals. Some possible geroprotectors include melatonin, carnosine, metformin, rapamycin, nicotinamide mononucleotide (NMN), delta sleep-inducing peptide and glycine. Geroprotectors could belong to multiple classes, depending on which of the ''hallmarks of aging'' they influence. The distinction between geroprotectors and senotherapeutics is an evolving area of aging research. Geroprotectors broadly aim to target multiple mechanisms of aging, prolonging lifespan and healthspan by addressing the fundamental causes of aging. Senotherapeutics, on the other hand, are a subset of therapies that specifically target ''senescent cells'', which are dysfunctional cells that accumulate with age and contribute to inflammation and age-related diseases. See also * Anti-aging product * Growth hormone * Senolytic A senolytic (from the words ''senescence'' and ''-lytic'', "d ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genetics Of Aging
Genetics of aging is generally concerned with life extension associated with genetic alterations, rather than with accelerated aging diseases leading to reduction in lifespan. The first mutation found to increase longevity in an animal was the '' age-1'' gene in ''Caenorhabditis elegans''. Michael Klass discovered that lifespan of ''C. elegans'' could be altered by mutations, but Klass believed that the effect was due to reduced food consumption (calorie restriction). Thomas Johnson later showed that life extension of up to 65% was due to the mutation itself rather than due to calorie restriction, and he named the gene ''age-1'' in the expectation that other genes that control aging would be found. The '' age-1'' gene encodes the catalytic subunit of class-I phosphatidylinositol 3-kinase (PI3K). A decade after Johnson's discovery '' daf-2'', one of the two genes that are essential for dauer larva formation, was shown by Cynthia Kenyon to double ''C. elegans'' lifes ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Eternal Youth
Eternal youth is the concept of human physical immortality free of ageing. The youth referred to is usually meant to be in contrast to the depredations of aging, rather than a specific age of the human lifespan. Eternal youth is common in mythology, and is a popular theme in fiction. Religion and mythology Eternal youth is a characteristic of the inhabitants of Paradise in Abrahamic religions. The Hindus believe that the Vedic and the post-Vedic rishis have attained immortality, which implies the ability to change one's body's age or even shape at will. These are some of the siddhas in Yoga. Markandeya is said to always stay at the age of 16. The difference between eternal life and the more specific eternal youth is a recurrent theme in Greek and Roman mythology. The mytheme of requesting the boon of immortality from a god, but forgetting to ask for eternal youth appears in the story of Tithonus. A similar theme is found in Ovid regarding the Cumaean Sibyl. In Norse mytholo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biological Immortality
Biological immortality (sometimes referred to as bio-indefinite mortality) is a state in which the rate of mortality from senescence (or aging) is stable or decreasing, thus decoupling it from chronological age. Various unicellular and multicellular species, including some vertebrates, achieve this state either throughout their existence or after living long enough. A biologically immortal living being can still die from means other than senescence, such as through injury, poison, disease, predation, lack of available resources, or changes to environment. This definition of immortality has been challenged in the ''Handbook of the Biology of Aging'', because the increase in rate of mortality as a function of chronological age may be negligible at extremely old ages, an idea referred to as the late-life mortality plateau. The rate of mortality may cease to increase in old age, but in most cases that rate is typically very high. Cell lines Biologists chose the word "immortal" to ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CGP Grey
CGP Grey is an American educational entertainment, educational YouTuber, podcaster, and Online streamer, live streamer based in the United Kingdom who creates explanatory videos on subjects including politics, geography, economics, sociology, history, philosophy, and culture. In addition to video production, he is known for creating and hosting the podcasts ''Hello Internet'' with Brady Haran and ''Cortex'' with Myke Hurley. Early life and career Grey grew up on Staten Island, a suburban borough of New York City. He went to college in upstate New York, earning two degrees: one in physics and another in sociology. When Grey was a child, his father applied for Irish nationality law, Irish citizenship on his behalf, and he gained Dual Citizenship in United States, dual American–Irish citizenship. Grey's Irish citizenship allowed him to move to the United Kingdom. He attended a masters program in economics in London. He became a physics teacher while in London. Content Grey's p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Life Noggin
Life, also known as biota, refers to matter that has biological processes, such as signaling and self-sustaining processes. It is defined descriptively by the capacity for homeostasis, organisation, metabolism, growth, adaptation, response to stimuli, and reproduction. All life over time eventually reaches a state of death, and none is immortal. Many philosophical definitions of living systems have been proposed, such as self-organizing systems. Viruses in particular make definition difficult as they replicate only in host cells. Life exists all over the Earth in air, water, and soil, with many ecosystems forming the biosphere. Some of these are harsh environments occupied only by extremophiles. Life has been studied since ancient times, with theories such as Empedocles's materialism asserting that it was composed of four eternal elements, and Aristotle's hylomorphism asserting that living things have souls and embody both form and matter. Life originated at least 3.5&nbs ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Kurzgesagt
Kurzgesagt (, ; German language, German for "In a nutshell", "in short", or literally "shortly said"; ) is a German animation studio, animation and design studio founded by Philipp Dettmer. The studio is best known for its YouTube, YouTube channel, which focuses on Minimalism, minimalistic animated educational content using a Flat design, flat and 3D computer graphics, 3D design style. It discusses Science, scientific, Technology, technological, Politics, political, Philosophy, philosophical, and Psychology, psychological subjects. Narrated in English by Steve Taylor, videos on the channel are normally four to sixteen minutes. Many videos are also available through other language-specific channels, such as in German through the channel ''Dinge Erklärt – Kurzgesagt'', and in Spanish language, Spanish through ''En Pocas Palabras – Kurzgesagt''. Some of their videos are also available in French language, French, Hindi, Arabic, Brazilian Portuguese, Japanese language, Japanese ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Longevity
Longevity may refer to especially long-lived members of a population, whereas ''life expectancy'' is defined Statistics, statistically as the average number of years remaining at a given age. For example, a population's life expectancy at birth is the same as the average age at death for all people born in the same year (in the case of Cohort (statistics), cohorts). Longevity studies may involve putative methods to extend life. Longevity has been a topic not only for the scientific community but also for writers of Hyperborei, travel, science fiction, and utopian novels. The legendary fountain of youth appeared in the work of the Ancient Greek historian Herodotus. There are difficulties in authenticating the longest human maximum life span, life span, owing to inaccurate or incomplete birth statistics. Fiction, legend, and folklore have proposed or claimed life spans in the past or future vastly longer than those verified by modern standards, and longevity narratives and unverif ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
