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Leptosidin
Leptosidin was the first aurone to be isolated in ''Coreopsis grandiflora'' by Geissman T.A. and Heaton C.D. in 1943. Leptosidin blocks the active residues of PRKACA The catalytic subunit α of protein kinase A is a key regulatory enzyme that in humans is encoded by the ''PRKACA'' gene. This enzyme is responsible for phosphorylating other proteins and substrates, changing their activity. Protein kinase A cata .... References Aurones Catechols Phenol ethers {{Aromatic-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Aurones
An aurone is a heterocyclic chemical compound which is a type of flavonoid. There are two isomers of the molecule, with (''E'')- and (''Z'')-configurations. The molecule contains a benzofuran element associated with a benzylidene linked in position 2. In aurone, a chalcone-like group is closed into a 5-membered ring instead of the 6-membered ring more typical of flavonoids. Aurone derivatives Aurone forms the core for a family of derivatives which are known collectively as aurones. Aurones are plant flavonoids that provide yellow color to the flowers of some popular ornamental plants, such as snapdragon and cosmos. Aurones including 4'-chloro-2-hydroxyaurone (C15H11O3Cl) and 4'-chloroaurone (C15H9O2Cl) can also be found in the brown alga '' Spatoglossum variabile''. Most aurones are in a (''Z'')-configuration, which is the more stable configuration according to Austin Model 1 computation, but there are also some in the (''E'')-configurations such as (E)-3'-O-β-d-g ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Coreopsis Grandiflora
''Coreopsis grandiflora'' is a North American species of perennial plant in the family Asteraceae. The common name is large-flowered tickseed. It is found in eastern Canada (Quebec, Ontario, New Brunswick) and much of the United States, especially the south-central part of the country ( Oklahoma, Arkansas, etc.). The species is widely cultivated in China and naturalized there. ''Coreopsis grandiflora'' is a perennial herb sometimes greater than 60 cm (2 feet) tall. It produces yellow ray and disc flowers. Its native habitats include prairies, glades, open woods, thickets, roadsides and open ground. The Latin specific epithet ''grandiflora'' means large-flowered. The plant attracts bees and butterflies. In the UK the cultivar 'Early Sunrise' has received the Royal Horticultural Society's Award of Garden Merit The Award of Garden Merit (AGM) is a long-established annual award for plants by the British Royal Horticultural Society (RHS). It is based on assessment of the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
PRKACA
The catalytic subunit α of protein kinase A is a key regulatory enzyme that in humans is encoded by the ''PRKACA'' gene. This enzyme is responsible for phosphorylating other proteins and substrates, changing their activity. Protein kinase A catalytic subunit (PKA Cα) is a member of the AGC kinase family (protein kinases A, G, and C), and contributes to the control of cellular processes that include glucose metabolism, cell division, and contextual memory. PKA Cα is part of a larger protein complex that is responsible for controlling when and where proteins are phosphorylated. Defective regulation of PKA holoenzyme activity has been linked to the progression of cardiovascular disease, certain endocrine disorders and cancers. Discovery Edmond H. Fischer and Edwin G. Krebs at the University of Washington discovered PKA in the late 1950s while working through the mechanisms that govern glycogen phosphorylase. They realized that a key metabolic enzyme called phosphorylase k ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Catechols
Catechol ( or ), also known as pyrocatechol or 1,2-dihydroxybenzene, is a toxic organic compound with the molecular formula . It is the ''ortho'' isomer of the three isomeric benzenediols. This colorless compound occurs naturally in trace amounts. It was first discovered by destructive distillation of the plant extract catechin. About 20,000 tonnes of catechol are now synthetically produced annually as a commodity organic chemical, mainly as a precursor to pesticides, flavors, and fragrances. Catechol occurs as feathery white crystals that are very rapidly soluble in water. Isolation and synthesis Catechol was first isolated in 1839 by Edgar Hugo Emil Reinsch (1809–1884) by distilling it from the solid tannic preparation catechin, which is the residuum of catechu, the boiled or concentrated juice of ''Mimosa catechu'' ('' Acacia catechu''). Upon heating catechin above its decomposition point, a substance that Reinsch first named ''Brenz-Katechusäure'' (burned catechu a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
