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Leonurine
Leonurine (also known as SCM-198 in research) is a alkaloid, pseudoalkaloid that has been isolated from ''Leonotis leonurus'', ''Leonotis nepetifolia'', ''Leonurus japonicus'', ''Leonurus cardiaca'' (motherwort), ''Leonurus sibiricus'', as well as other plants of family Lamiaceae. Leonurine is easily extracted into water. Research Leonurine weakly binds to multiple GABA receptor sites including the GABAA receptor, GABAA receptor. However, it shows much higher affinity as a 5-HT3 receptor, 5-HT3A receptor receptor antagonist, antagonist. 5-HT3A antagonists have been shown to help prevent nausea and vomiting as well as the negative effects of serotonin in the gastrointestinal tract. Leonurine can regulate a variety of functions including oxidative stress, inflammation, fibrosis, apoptosis, and metabolic disorder. Leonurine has demonstrated antidepressant-like action and has been shown to increase levels of serotonin, noradrenaline, and dopamine in chronic mild stress studies on ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Leonotis Leonurus
''Leonotis leonurus'', also known as lion's tail and wild dagga, is a plant species in the mint family, Lamiaceae. The plant is a broadleaf evergreen large shrub native to South Africa, where it is very common.MBC-Kemper Center - ''Leonotis leonurus'' . accessed 7.7.2011 It is known for its medicinal properties. The main psychoactive component of ''Leonotis leonurus'' is hypothesized to be related to the presence of leonurine or labdanes; ''Leonotis leonurus'' has been confirmed to contain leonurine according to peer reviewed journal published phytochemical analysis. Like other plants in the mint family, it also contains [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Leonurus Cardiaca
''Leonurus cardiaca'', known as motherwort, is an herbaceous perennial plant in the mint family, Lamiaceae. Other common names include throw-wort, lion's ear, and lion's tail. Lion's tail is also a common name for ''Leonotis leonurus'', and lion's ear, a common name for ''Leonotis nepetifolia''. Originally from Central Asia and southeastern Europe, it is now found worldwide, spread largely due to its use as a herbal remedy. Description ''Leonurus cardiaca'' has a squarish stem which is clad in short hairs and is often purplish, especially near the nodes. The opposite leaves have serrated margins and are palmately lobed with long petioles; basal leaves are wedge shaped with three points while the upper leaves have three to five. They are slightly hairy above and greyish beneath. Flowers appear in leaf axils on the upper part of the plant and have three-lobed bracts. The calyx of each flower is bell-shaped and has five lobes. The corolla is irregular, long, fused, long-tubed wi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alkaloid
Alkaloids are a broad class of natural product, naturally occurring organic compounds that contain at least one nitrogen atom. Some synthetic compounds of similar structure may also be termed alkaloids. Alkaloids are produced by a large variety of organisms including bacteria, fungus, fungi, Medicinal plant, plants, and animals. They can be purified from crude extracts of these organisms by acid-base extraction, or solvent extractions followed by silica-gel column chromatography. Alkaloids have a wide range of pharmacology, pharmacological activities including antimalarial medication, antimalarial (e.g. quinine), asthma, antiasthma (e.g. ephedrine), chemotherapy, anticancer (e.g. omacetaxine mepesuccinate, homoharringtonine), cholinomimetic (e.g. galantamine), vasodilation, vasodilatory (e.g. vincamine), Antiarrhythmic agent, antiarrhythmic (e.g. quinidine), analgesic (e.g. morphine), antibacterial (e.g. chelerythrine), and anti-diabetic, antihyperglycemic activities (e.g. berb ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alkaloids
Alkaloids are a broad class of naturally occurring organic compounds that contain at least one nitrogen atom. Some synthetic compounds of similar structure may also be termed alkaloids. Alkaloids are produced by a large variety of organisms including bacteria, fungi, plants, and animals. They can be purified from crude extracts of these organisms by acid-base extraction, or solvent extractions followed by silica-gel column chromatography. Alkaloids have a wide range of pharmacological activities including antimalarial (e.g. quinine), antiasthma (e.g. ephedrine), anticancer (e.g. homoharringtonine), cholinomimetic (e.g. galantamine), vasodilatory (e.g. vincamine), antiarrhythmic (e.g. quinidine), analgesic (e.g. morphine), antibacterial (e.g. chelerythrine), and antihyperglycemic activities (e.g. berberine). Many have found use in traditional or modern medicine, or as starting points for drug discovery. Other alkaloids possess psychotropic (e.g. psilocin) and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ing–Manske Procedure
The Gabriel synthesis is a chemical reaction that transforms primary alkyl halides into primary amines. Traditionally, the reaction uses potassium phthalimide. The reaction is named after the German chemist Siegmund Gabriel. The Gabriel reaction has been generalized to include the alkylation of sulfonamides and imides, followed by deprotection, to obtain amines (see Gabriel synthesis#Alternative Gabriel reagents, Alternative Gabriel reagents). The alkylation of ammonia is often an unselective and inefficient route to amines. In the Gabriel method, phthalimide anion is employed as a surrogate of H2N−. Traditional Gabriel synthesis In this method, the sodium or potassium salt of phthalimide is ''N''-alkylated with a primary alkyl halide to give the corresponding ''N''-alkylphthalimide. Upon workup by acidic hydrolysis the primary amine is liberated as the amine salt. Alternatively the workup may be via the Ing–Manske procedure, involving reaction with hydrazine. This meth ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Potassium Phthalimide
Potassium phthalimide is a chemical compound of formula C8H4KNO2. It is the potassium salt of phthalimide, and usually presents as fluffy, very pale yellow crystals. It can be prepared by adding a hot solution of phthalimide in ethanol to a solution of potassium hydroxide in ethanol; the desired product precipitates. This compound is a commercially available reagent used in the Gabriel synthesis of amine In chemistry, amines (, ) are organic compounds that contain carbon-nitrogen bonds. Amines are formed when one or more hydrogen atoms in ammonia are replaced by alkyl or aryl groups. The nitrogen atom in an amine possesses a lone pair of elec ...s. References Potassium compounds Phthalimides {{Organic-compound-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gabriel Synthesis
The Gabriel synthesis is a chemical reaction that transforms primary alkyl halides into primary amines. Traditionally, the reaction uses potassium phthalimide. The reaction is named after the German chemist Siegmund Gabriel. The Gabriel reaction has been generalized to include the alkylation of sulfonamides and imides, followed by deprotection, to obtain amines (see Alternative Gabriel reagents). The alkylation of ammonia is often an unselective and inefficient route to amines. In the Gabriel method, phthalimide anion is employed as a surrogate of H2N−. Traditional Gabriel synthesis In this method, the sodium or potassium salt of phthalimide is ''N''-alkylated with a primary alkyl halide to give the corresponding ''N''-alkylphthalimide. Upon workup by acidic hydrolysis the primary amine is liberated as the amine salt. Alternatively the workup may be via the Ing–Manske procedure, involving reaction with hydrazine. This method produces a precipitate of phthalhydrazide ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Amino Group
In chemistry, amines (, ) are organic compounds that contain carbon-nitrogen bonds. Amines are formed when one or more hydrogen atoms in ammonia are replaced by alkyl or aryl groups. The nitrogen atom in an amine possesses a lone pair of electrons. Amines can also exist as hetero cyclic compounds. Aniline is the simplest aromatic amine, consisting of a benzene ring bonded to an amino group. Amines are classified into three types: primary (1°), secondary (2°), and tertiary (3°) amines. Primary amines (1°) contain one alkyl or aryl substituent and have the general formula RNH2. Secondary amines (2°) have two alkyl or aryl groups attached to the nitrogen atom, with the general formula R2NH. Tertiary amines (3°) contain three substituent groups bonded to the nitrogen atom, and are represented by the formula R3N. The functional group present in primary amines is called the amino group. Classification of amines Amines can be classified according to the nature and number o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tetrahydrofuran
Tetrahydrofuran (THF), or oxolane, is an organic compound with the formula (CH2)4O. The compound is classified as heterocyclic compound, specifically a cyclic ether. It is a colorless, water- miscible organic liquid with low viscosity. It is mainly used as a precursor to polymers. Being polar and having a wide liquid range, THF is a versatile solvent. It is an isomer of another solvent, butanone. Production About 200,000 tonnes of tetrahydrofuran are produced annually. The most widely used industrial process involves the acid-catalyzed dehydration of 1,4-Butanediol, 1,4-butanediol. Ashland Inc., Ashland/ISP is one of the biggest producers of this chemical route. The method is similar to the production of diethyl ether from ethanol. The butanediol is derived from Condensation reaction, condensation of acetylene with formaldehyde followed by hydrogenation. DuPont developed a process for producing THF by oxidizing Butane#Isomers, ''n''-butane to crude maleic anhydride, follow ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
