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Leonard W. Seymour
Leonard W. Seymour is a Professor of Gene Therapy at the University of Oxford's oncology department. As a cancer-oriented translational researcher, he investigates technologies utilised to enhance targeted therapy's (e.g. drugs, genes, oncolytic virus) delivery and develops related biological therapeutics under the support of Cancer Research UK. Early life and education Professor Seymour was born in Plymouth, United Kingdom, in 1958, and was educated at Plymouth College. He later read Biochemistry at the University of Manchester and obtained his PhD from Keele University, submitting a thesis on "The mechanism of transcellular transport of immunoglobulin G in yolk-sac tissue" in 1985. Career He later formed a research group focused on gene delivery at the Cancer Research UK Institute in Birmingham, and then relocated to the University of Oxford in 2003 as Gene Therapy lead for the National Translational Cancer Research Network (NTRAC). There, he took part in forming the British ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Plymouth
Plymouth ( ) is a port city status in the United Kingdom, city and unitary authority in Devon, South West England. It is located on Devon's south coast between the rivers River Plym, Plym and River Tamar, Tamar, about southwest of Exeter and southwest of London. It is the most populous city in Devon. Plymouth's history extends back to the Bronze Age, evolving from a trading post at Mount Batten into the thriving market town of Sutton, which was formally re-named as Plymouth in 1439 when it was made a borough status in the United Kingdom, borough. The settlement has played a significant role in English history, notably in 1588 when an English fleet based here defeated the Spanish Armada, and in 1620 as the departure point for the Pilgrim Fathers to the New World. During the English Civil War, the town was held by the Roundhead, Parliamentarians and was besieged between 1642 and 1646. In 1690 a dockyard was established on the River Tamar for the Royal Navy and Plymouth grew as ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
ESGCT
European Society of Gene & Cell Therapy (ESGCT) formerly European Society of Gene Therapy (ESGT) is a legally registered professional body which emerged from a small working group in 1992 that focused on human gene therapy. The objectives of the ESGT include the following: * promote basic and clinical research in gene therapy; * facilitate education (and the exchange of information and technologies) related to gene transfer and therapy; * serve as a professional adviser to the gene therapy community and various regulatory bodies in Europe. The official journal of the ESGT is '' The Journal of Gene Medicine''. Collaborations The ESGT works with other entities in the scientific communities in the event that an adverse effect to a specific gene therapy is discovered. Investigations the ESGT has been involved with include the adverse effects discovered during the French X-SCID gene therapy trial. The ESGT hosted a forum of 500 researchers from various facilities around the world, incl ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Scientists From Plymouth, Devon
A scientist is a person who Scientific method, researches to advance knowledge in an Branches of science, area of the natural sciences. In classical antiquity, there was no real ancient analog of a modern scientist. Instead, philosophers engaged in the philosophical study of nature called natural philosophy, a precursor of natural science. Though Thales ( 624–545 BC) was arguably the first scientist for describing how cosmic events may be seen as natural, not necessarily caused by gods,Frank N. Magill''The Ancient World: Dictionary of World Biography'', Volume 1 Routledge, 2003 it was not until the 19th century in science, 19th century that the term ''scientist'' came into regular use after it was coined by the theologian, philosopher, and historian of science William Whewell in 1833. History The roles of "scientists", and their predecessors before the emergence of modern scientific disciplines, have evolved considerably over time. Scientists of different er ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Living People
Purpose: Because living persons may suffer personal harm from inappropriate information, we should watch their articles carefully. By adding an article to this category, it marks them with a notice about sources whenever someone tries to edit them, to remind them of WP:BLP (biographies of living persons) policy that these articles must maintain a neutral point of view, maintain factual accuracy, and be properly sourced. Recent changes to these articles are listed on Special:RecentChangesLinked/Living people. Organization: This category should not be sub-categorized. Entries are generally sorted by family name In many societies, a surname, family name, or last name is the mostly hereditary portion of one's personal name that indicates one's family. It is typically combined with a given name to form the full name of a person, although several give .... Maintenance: Individuals of advanced age (over 90), for whom there has been no new documentation in the last ten ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1958 Births
Events January * January 1 – The European Economic Community (EEC) comes into being. * January 3 – The West Indies Federation is formed. * January 4 ** Edmund Hillary's Commonwealth Trans-Antarctic Expedition completes the third overland journey to the South Pole, the first to use powered vehicles. ** Sputnik 1 (launched on October 4, 1957) falls towards Earth from its orbit and burns up. * January 13 – Battle of Edchera: The Moroccan Army of Liberation ambushes a Spanish patrol. * January 27 – A Soviet-American executive agreement on cultural, educational and scientific exchanges, also known as the "Lacy-Zarubin Agreement, Lacy–Zarubin Agreement", is signed in Washington, D.C. February * February 1 – Egypt and Syria unite to form the United Arab Republic. * February 2 – The ''Falcons'' aerobatic team of the Pakistan Air Force led by Wg Cdr Zafar Masud (air commodore), Mitty Masud set a World record loop, world record performing a 16 aircraft diamon ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Academics Of The University Of Oxford , a person who is a researcher or has expertise in an academic discipline
{{Disambiguation ...
Academic means of or related to an academy, an institution learning. Academic or academics may also refer to: * Academic staff, or faculty, teachers or research staff * school of philosophers associated with the Platonic Academy in ancient Greece * The Academic, Irish indie rock band * "Academic", song by New Order from the 2015 album ''Music Complete'' Other uses *Academia (other) *Academy (other) *Faculty (other) *Scholar A scholar is a person who is a researcher or has expertise in an academic discipline. A scholar can also be an academic, who works as a professor, teacher, or researcher at a university. An academic usually holds an advanced degree or a termina ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Princeton University
Princeton University is a private university, private Ivy League research university in Princeton, New Jersey, United States. Founded in 1746 in Elizabeth, New Jersey, Elizabeth as the College of New Jersey, Princeton is the List of Colonial Colleges, fourth-oldest institution of higher education in the United States and one of the nine colonial colleges chartered before the American Revolution. The institution moved to Newark, New Jersey, Newark in 1747 and then to its Mercer County, New Jersey, Mercer County campus in Princeton nine years later. It officially became a university in 1896 and was subsequently renamed Princeton University. The university is governed by the Trustees of Princeton University and has an endowment of $37.7 billion, the largest List of colleges and universities in the United States by endowment, endowment per student in the United States. Princeton provides undergraduate education, undergraduate and graduate education, graduate instruction in the hu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Paul Seymour (mathematician)
Paul D. Seymour is a British mathematician known for his work in discrete mathematics, especially graph theory. He (with others) was responsible for important progress on regular matroids and totally unimodular matrices, the four colour theorem, linkless embeddings, graph minors and structure, the perfect graph conjecture, the Hadwiger conjecture, claw-free graphs, χ-boundedness, and the Erdős–Hajnal conjecture. Many of his recent papers are available from his website. Seymour is currently the Albert Baldwin Dod Professor of Mathematics at Princeton University. He won a Sloan Fellowship in 1983, and the Ostrowski Prize in 2003; and (sometimes with others) won the Fulkerson Prize in 1979, 1994, 2006 and 2009, and the Pólya Prize in 1983 and 2004. He received an honorary doctorate from the University of Waterloo in 2008, one from the Technical University of Denmark in 2013, and one from the École normale supérieure de Lyon in 2022. He was an invited speaker i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
WuXi AppTec
WuXi AppTec (WuXi is pronounced as ''Wu-shee'') is a global pharmaceutical, biopharmaceutical, and medical device company. History WuXi PharmaTech was founded in December 2000 in Shanghai by organic chemist Ge Li. The company opened chemistry facilities in Tianjin in 2007. In 2008, WuXi PharmaTech acquired AppTec Laboratory Services Inc., a US-based company founded in 2001 with expertise in medical-device and biologics testing and with facilities in St. Paul, MN; Philadelphia, PA; and Atlanta, GA. In the same year the company was renamed WuXi AppTec. WuXi AppTec opened a toxicology facility in Suzhou in 2009. WuXi AppTec's subsidiary, WuXi STA, opened a large-scale manufacturing facility in Jinshan in 2010. The company began a biologics discovery, development, and manufacturing operation in Shanghai and Wuxi City in 2011. At the same year, WuXi AppTec acquired MedKey, a China-based clinical research company, and Abgent, a San Diego company and one of the world's largest manu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Oncolytic Adenovirus
Adenovirus varieties have been explored extensively as a viral vector for gene therapy and also as an oncolytic virus. Of the many different viruses being explored for oncolytic potential, an adenovirus was the first to be approved by a regulatory agency, the genetically modified H101 strain. It gained regulatory approval in 2005 from China's State Food and Drug Administration (SFDA) for the treatment of head and neck cancer. Engineering of oncolytic adenovirus Adenoviruses have so far been through three generations of development. Some of the strategies for modification of adenoviruses are described below. Attenuation For adenovirus replication to occur, the host cell must be induced into S phase by viral proteins interfering with cell cycle proteins. The adenoviral E1A gene is responsible for inactivation of several proteins, including retinoblastoma, allowing entry into S-phase. The adenovirus E1B55kDa gene cooperates with another adenoviral product, E4ORF6, to inactivate p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Birmingham
Birmingham ( ) is a City status in the United Kingdom, city and metropolitan borough in the metropolitan county of West Midlands (county), West Midlands, within the wider West Midlands (region), West Midlands region, in England. It is the List of English districts by population, largest local authority district in England by population and the second-largest city in Britain – commonly referred to as the second city of the United Kingdom – with a population of million people in the city proper in . Birmingham borders the Black Country to its west and, together with the city of Wolverhampton and towns including Dudley and Solihull, forms the West Midlands conurbation. The royal town of Sutton Coldfield is incorporated within the city limits to the northeast. The urban area has a population of 2.65million. Located in the West Midlands (region), West Midlands region of England, Birmingham is considered to be the social, cultural, financial and commercial centre of the Midland ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gene Therapy
Gene therapy is Health technology, medical technology that aims to produce a therapeutic effect through the manipulation of gene expression or through altering the biological properties of living cells. The first attempt at modifying human DNA was performed in 1980, by Martin Cline, but the first successful nuclear gene transfer in humans, approved by the National Institutes of Health, was performed in May 1989. The first therapeutic use of gene transfer as well as the first direct insertion of human DNA into the nuclear genome was performed by French Anderson in a trial starting in September 1990. Between 1989 and December 2018, over 2,900 clinical trials were conducted, with more than half of them in Phases of clinical research, phase I. In 2003, Gendicine became the first gene therapy to receive regulatory approval. Since that time, further gene therapy drugs were approved, such as alipogene tiparvovec (2012), Strimvelis (2016), tisagenlecleucel (2017), voretigene neparvovec ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
