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Knemometry
Knemometry () is the medical term for measuring the distance between knee and heel of a sitting child or adolescent using a technical device, the knemometer. Knemometric measurements show a measurement error of less than 160 μm (0.16 mm) and enable illustrating growth at intervals of few weeks (short-term growth). The device Ignaz Maria Valk developed this technique in 1983 in Nijmegen/Netherlands. It is being practiced since and used for basic research in growth and the treatment of growth disorders. Hermanussen introduced the mini-knemometer for accurate growth measurements of prematures and newborn infants. Mini-knemometry determines the lower leg length with an accuracy of less than 100 μm (0.1 mm). This enables substantiating growth within 24 hours. In an animal model, the technique was used to investigate the effects of steroids and growth hormone Growth hormone (GH) or somatotropin, also known as human growth hormone (hGH or HGH) in its human form, i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Michael Hermanussen
Michael Hermanussen (born 26 April 1955 in Hamburg) is a German pediatrician and professor at the University of Kiel. He is known for his work on growth and nutrition. Life Hermanussen studied medicine and worked as a pediatrician at the University of Kiel from 1982 until 1989. He investigated growth and child development ( auxology) and first described mini growth spurts. Since 1990 he cooperates in international joint projects with scientists and also works in a general pediatric office. He organizes national and international meetings on growth and nutrition. From 2003 to 2011 he was a member of the scientific board of the German society for Anthropology and he is chief editor of ”Human Biology and Public Health”. He is the founder and head of the Auxological Society. Scientific Work Hermanussen developed new mathematical methods for improved diagnostics of growth disorders and a new technique for estimating final adult height. He developed mini-knemometry, a new and accur ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lower Leg
The leg is the entire lower limb (anatomy), limb of the human body, including the foot, thigh or sometimes even the hip or Gluteal muscles, buttock region. The major bones of the leg are the femur (thigh bone), tibia (shin bone), and adjacent fibula. There are 30 bones in each leg. The thigh is located in between the hip and knee. The calf (leg), calf (rear) and Tibia#Structure, shin (front), or shank, are located between the knee and ankle. Legs are used for standing, many forms of human movement, recreation such as dancing, and constitute a significant portion of a person's mass. Evolution has led to the human leg's development into a mechanism specifically adapted for efficient bipedalism, bipedal gait. While the capacity to walk upright is not unique to humans, other primates can only achieve this for short periods and at a great expenditure of energy. In humans, female legs generally have greater hip anteversion and tibiofemoral angles, while male legs have longer femur a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Growth Disorders
Growth hormone therapy refers to the use of growth hormone (GH) as a prescription medication—it is one form of hormone therapy. Growth hormone is a peptide hormone secreted by the pituitary gland that stimulates growth and cell reproduction. In the past, growth hormone was extracted from human pituitary glands. Growth hormone is now produced by recombinant DNA technology and is prescribed for a variety of reasons. GH therapy has been a focus of social and ethical controversies for 50 years. This article describes the history of GH treatment and the current uses and risks arising from GH use. Other articles describe GH physiology, diseases of GH excess (acromegaly and pituitary gigantism), deficiency, the recent phenomenon of HGH controversies, growth hormone in sports, and growth hormone for cows. Medical uses HGH deficiency in children Growth hormone deficiency is treated by replacing growth hormone. Lonapegsomatropin was approved for medical use in the United State ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Catch-up Growth
Compensatory growth, known as catch-up growth and compensatory gain, is an accelerated growth of an organism following a period of slowed development, particularly as a result of nutrient deprivation. The growth may be with respect to weight or length (or height in humans). For example, the body weights of animals who experience nutritional restriction will often over time become similar to those of animals who did not experience such stress. It is possible for high compensatory growth rates to result in overcompensation, where the organism exceeds normal weight and often has excessive fat deposition. An organism can recover to normal weight without additional time. Sometimes when the nutrient restriction is severe, the growth period is extended to reach the normal weight. If the nutrient restriction is severe enough, the organism may have permanent stunted growth where it does not ever reach normal weight. Usually in animals, complete recovery from carbohydrate and protein rest ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Auxology
Auxology (from Greek , ''auxō'', or , ''auxanō'' 'grow'; and , ''-logia'') is a meta-term covering the study of all aspects of human physical growth. (Although, it is also fundamental of biology.) Auxology is a multi-disciplinary science involving health sciences/medicine (pediatrics, general practice, endocrinology, neuroendocrinology, physiology, epidemiology), and to a lesser extent: nutrition science, genetics, anthropology, anthropometry, ergonomics, history, economic history, economics, socio-economics, sociology, public health, and psychology, among others. History of auxology ''""Ancient Babylonians and Egyptians left some writings on child growth and variation in height between ethnic groups. In the late 18th century, scattered documents of child growth started to appear in the scientific literature, the studies of Jamberts in 1754 and the annual measurements of the son of Montbeillard published by Buffon in 1777 being the most cited ones Louis René Villermé (18 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Growth Hormone
Growth hormone (GH) or somatotropin, also known as human growth hormone (hGH or HGH) in its human form, is a peptide hormone that stimulates growth, cell reproduction, and cell regeneration in humans and other animals. It is thus important in human development. GH also stimulates production of insulin-like growth factor 1 (IGF-1) and increases the concentration of glucose and free fatty acids. It is a type of mitogen which is specific only to the receptors on certain types of cells. GH is a 191-amino acid, single-chain polypeptide that is synthesized, stored and secreted by somatotropic cells within the lateral wings of the anterior pituitary gland. A recombinant form of HGH called somatropin ( INN) is used as a prescription drug to treat children's growth disorders and adult growth hormone deficiency. In the United States, it is only available legally from pharmacies by prescription from a licensed health care provider. In recent years in the United States, some health ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Steroids
A steroid is an organic compound with four fused rings (designated A, B, C, and D) arranged in a specific molecular configuration. Steroids have two principal biological functions: as important components of cell membranes that alter membrane fluidity; and as signaling molecules. Examples include the lipid cholesterol, sex hormones estradiol and testosterone, anabolic steroids, and the anti-inflammatory corticosteroid drug dexamethasone. Hundreds of steroids are found in fungi, plants, and animals. All steroids are manufactured in cells from a sterol: cholesterol (animals), lanosterol ( opisthokonts), or cycloartenol (plants). All three of these molecules are produced via cyclization of the triterpene squalene. Structure The steroid nucleus ( core structure) is called gonane (cyclopentanoperhydrophenanthrene). It is typically composed of seventeen carbon atoms, bonded in four fused rings: three six-member cyclohexane rings (rings A, B and C in the first illus ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Infants
In common terminology, a baby is the very young offspring of adult human beings, while infant (from the Latin word ''infans'', meaning 'baby' or 'child') is a formal or specialised synonym. The terms may also be used to refer to juveniles of other organisms. A newborn is, in colloquial use, a baby who is only hours, days, or weeks old; while in medical contexts, a newborn or neonate (from Latin, ''neonatus'', newborn) is an infant in the first 28 days after birth (the term applies to premature, full term, and postmature infants). Infants born prior to 37 weeks of gestation are called "premature", those born between 39 and 40 weeks are "full term", those born through 41 weeks are "late term", and anything beyond 42 weeks is considered "post term". Before birth, the offspring is called a fetus. The term ''infant'' is typically applied to very young children under one year of age; however, definitions may vary and may include children up to two years of age. When a human child ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Basic Research
Basic research, also called pure research, fundamental research, basic science, or pure science, is a type of scientific research with the aim of improving scientific theories for better understanding and prediction of natural or other phenomena. In contrast, applied research uses scientific theories to develop technology or techniques, which can be used to intervene and ''alter'' natural or other phenomena. Though often driven simply by curiosity,"Curiosity creates cures: The value and impact of basic research , National Institute of General Medical Sciences, |
Distance
Distance is a numerical or occasionally qualitative measurement of how far apart objects, points, people, or ideas are. In physics or everyday usage, distance may refer to a physical length or an estimation based on other criteria (e.g. "two counties over"). The term is also frequently used metaphorically to mean a measurement of the amount of difference between two similar objects (such as statistical distance between probability distributions or edit distance between string (computer science), strings of text) or a degree of separation (as exemplified by distance (graph theory), distance between people in a social network). Most such notions of distance, both physical and metaphorical, are formalized in mathematics using the notion of a metric space. In the social sciences, distance can refer to a qualitative measurement of separation, such as social distance or psychological distance. Distances in physics and geometry The distance between physical locations can be defined ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Netherlands
, Terminology of the Low Countries, informally Holland, is a country in Northwestern Europe, with Caribbean Netherlands, overseas territories in the Caribbean. It is the largest of the four constituent countries of the Kingdom of the Netherlands. The Netherlands consists of Provinces of the Netherlands, twelve provinces; it borders Germany to the east and Belgium to the south, with a North Sea coastline to the north and west. It shares Maritime boundary, maritime borders with the United Kingdom, Germany, and Belgium. The official language is Dutch language, Dutch, with West Frisian language, West Frisian as a secondary official language in the province of Friesland. Dutch, English_language, English, and Papiamento are official in the Caribbean Netherlands, Caribbean territories. The people who are from the Netherlands is often referred to as Dutch people, Dutch Ethnicity, Ethnicity group, not to be confused by the language. ''Netherlands'' literally means "lower countries" i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nijmegen
Nijmegen ( , ; Nijmeegs: ) is the largest city in the Dutch province of Gelderland and the ninth largest of the Netherlands as a whole. Located on the Waal River close to the German border, Nijmegen is one of the oldest cities in the Netherlands and the first to be recognized as such in Roman times. In 2005, it celebrated 2,000 years of existence. Nijmegen became a free imperial city in 1230 and in 1402 a Hanseatic city. Since 1923 it has been a university city with the opening of a Catholic institution now known as the Radboud University Nijmegen. The city is well known for the annual International Four Days Marches Nijmegen event. Its population as of 2024 was 187,011. Population centres The municipality is formed by the city of Nijmegen, incorporating the former villages of Hatert, Hees and Neerbosch, as well as the urban expansion projects in Veur-Lent, Nijmegen-Oosterhout and Nijmegen–Ressen, all situated north of the river Waal. Proximity of border ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
