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Klotho (biology)
Klotho is an enzyme that in humans is encoded by the ''KL'' gene. The three subfamilies of klotho are α-klotho, β-klotho, and γ-klotho. α-klotho activates Fibroblast growth factor 23, FGF23, and β-klotho activates FGF19 and FGF21. When the subfamily is not specified, the word "klotho" typically refers to the α-klotho subfamily, because α-klotho was discovered before the other members. α-klotho is highly Gene expression, expressed in the brain, liver and kidney. β-klotho is predominantly expressed in the liver. γ-klotho is expressed in the skin. Klotho can exist in a membrane-bound form or a (hormonal) soluble, circulating form. Proteases can convert the membrane-bound form into the circulating form. The ''KL'' gene encodes a type-I single-pass transmembrane protein that is related to beta-glucuronidase, β-glucuronidases. Reduced production of this protein has been observed in patients with chronic kidney failure (CKF), and this may be one of the factors underlying de ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Enzyme
An enzyme () is a protein that acts as a biological catalyst by accelerating chemical reactions. The molecules upon which enzymes may act are called substrate (chemistry), substrates, and the enzyme converts the substrates into different molecules known as product (chemistry), products. Almost all metabolism, metabolic processes in the cell (biology), cell need enzyme catalysis in order to occur at rates fast enough to sustain life. Metabolic pathways depend upon enzymes to catalyze individual steps. The study of enzymes is called ''enzymology'' and the field of pseudoenzyme, pseudoenzyme analysis recognizes that during evolution, some enzymes have lost the ability to carry out biological catalysis, which is often reflected in their amino acid sequences and unusual 'pseudocatalytic' properties. Enzymes are known to catalyze more than 5,000 biochemical reaction types. Other biocatalysts include Ribozyme, catalytic RNA molecules, also called ribozymes. They are sometimes descr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Kilo-
Kilo is a decimal prefix, decimal metric prefix, unit prefix in the metric system denoting multiplication by one thousand (103). It is used in the International System of Units, where it has the symbol k, in Letter case, lowercase. The prefix ''kilo'' is derived from the Greek language, Greek word (), meaning "thousand". In 19th century English it was sometimes spelled chilio, in line with a Linguistic purism, puristic opinion by Thomas Young (scientist), Thomas Young. As an opponent of suggestions to introduce the metric system in Britain, he qualified the nomenclature adopted in France as barbarous. Examples * one kilogram (kg) is 1000 grams * one kilometre (km) is 1000 metres * one kilojoule (kJ) is 1000 joules * one kilolitre (kL) is 1000 litres * one kilobaud (kBd) is 1000 bauds * one kilohertz (kHz) is 1000 hertz * one kilodalton (kDa) is 1000 Dalton (unit), daltons * one kilobit (kb) is 1000 bits * one kilobyte (kB) is 1000 bytes * one kiloohm is (kΩ) is 1000 ohms * ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Glucuronide
A glucuronide, also known as glucuronoside, is any substance produced by linking glucuronic acid to another substance via a glycosidic bond. The glucuronides belong to the glycosides. Glucuronidation, the conversion of chemical compounds to glucuronides, is a method that animals use to assist in the excretion of toxic substances, drugs or other substances that cannot be used as an energy source. Glucuronic acid is attached via a glycosidic bond to the substance, and the resulting glucuronide, which has a much higher water solubility than the original substance, is eventually excreted by the kidneys. Enzymes that cleave the glycosidic bond of a glucuronide are called glucuronidases. Classes of glucuronides Acyl glucuronide Carboxylic acids are a common functional group in many medications, such as NSAIDS, anticonvulsants, and diuretics. One common pathway for the clearance of carboxylic-acid-containing drugs is via glucuronidation. By conjugating one such drug to a glucur ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Steroid
A steroid is an organic compound with four fused compound, fused rings (designated A, B, C, and D) arranged in a specific molecular configuration. Steroids have two principal biological functions: as important components of cell membranes that alter membrane fluidity; and as signal transduction, signaling molecules. Examples include the lipid cholesterol, sex hormones estradiol and testosterone, anabolic steroids, and the anti-inflammatory corticosteroid drug dexamethasone. Hundreds of steroids are found in Fungus, fungi, plants, and animals. All steroids are manufactured in cells from a sterols, sterol: Cholesterol, cholesterol (animals), lanosterol (opisthokonts), or cycloartenol (plants). All three of these molecules are produced via Cyclic compound, cyclization of the triterpene squalene. Structure The steroid nucleus (parent structure, core structure) is called gonane (cyclopentanoperhydrophenanthrene). It is typically composed of seventeen carbon atoms, bonded in fou ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Enzyme Commission Number
The Enzyme Commission number (EC number) is a numerical classification scheme for enzymes, based on the chemical reactions they catalyze. As a system of enzyme nomenclature, every EC number is associated with a recommended name for the corresponding enzyme-catalyzed reaction. EC numbers do not specify enzymes but enzyme-catalyzed reactions. If different enzymes (for instance from different organisms) catalyze the same reaction, then they receive the same EC number. Furthermore, through convergent evolution, completely different protein folds can catalyze an identical reaction (these are sometimes called non-homologous isofunctional enzymes) and therefore would be assigned the same EC number. By contrast, UniProt identifiers uniquely specify a protein by its amino acid sequence. Format of number Every enzyme code consists of the letters "EC" followed by four numbers separated by periods. Those numbers represent a progressively finer classification of the enzyme. Preliminary ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Greek Mythology
Greek mythology is the body of myths originally told by the Ancient Greece, ancient Greeks, and a genre of ancient Greek folklore, today absorbed alongside Roman mythology into the broader designation of classical mythology. These stories concern the ancient Greek religion's view of the Cosmogony, origin and Cosmology#Metaphysical cosmology, nature of the world; the lives and activities of List of Greek deities, deities, Greek hero cult, heroes, and List of Greek mythological creatures, mythological creatures; and the origins and significance of the ancient Greeks' cult (religious practice), cult and ritual practices. Modern scholars study the myths to shed light on the religious and political institutions of ancient Greece, and to better understand the nature of mythmaking itself. The Greek myths were initially propagated in an oral tradition, oral-poetic tradition most likely by Minoan civilization, Minoan and Mycenaean Greece, Mycenaean singers starting in the 18th century&n ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Moirai
In ancient Greek religion and Greek mythology, mythology, the Moirai ()often known in English as the Fateswere the personifications of fate, destiny. They were three sisters: Clotho (the spinner), Lachesis (mythology), Lachesis (the allotter), and Atropos (the inevitable, a metaphor for death). Their Roman mythology, Roman equivalent is the Parcae. The role of the Moirai was to ensure that every being, mortal and divine, lived out their destiny as it was assigned to them by the laws of the universe. For mortals, this destiny spanned their entire lives and was represented as a thread spun from a spindle. Generally, they were considered to be above even the gods in their role as enforcers of fate, although in some representations, Zeus, the chief of the gods, is able to command them. The concept of a universal principle of natural order and balance has been compared to similar concepts in other cultures such as the Vedic Ṛta, the Avestan Asha (Arta), and the Ancient Egyptian ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Clotho
Clotho (; ) or Klotho, is a mythological figure. She was one of the Three Fates or Moirai. In ancient Greek mythology, she spins the thread of human life, her sisters draw out ( Lachesis) and cut ( Atropos) the thread. She also made major decisions, such as when a person was born, thus in effect controlling people's lives. This power enabled her not only to choose who was born, but also to decide when deities or mortals were to be saved or put to death. For example, Clotho resurrected Pelops when his father killed him. Her Roman equivalent is Nona. As one of the three fates, her influence in Greek mythology was significant. Along with her sisters and Hermes, Clotho was given credit for creating the alphabet for their people. Even though Clotho and her sisters were worshiped as goddesses, their representation of fate is more central to their role in mythology. Thread represented human life and her decisions represented the fate of all people in society. Origin Although the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ageing
Ageing (or aging in American English) is the process of becoming older until death. The term refers mainly to humans, many other animals, and fungi; whereas for example, bacteria, perennial plants and some simple animals are potentially biologically immortal. In a broader sense, ageing can refer to single cells within an organism which have ceased dividing, or to the population of a species. In humans, ageing represents the accumulation of changes in a human being over time and can encompass physical, psychological, and social changes. Reaction time, for example, may slow with age, while memories and general knowledge typically increase. Of the roughly 150,000 people who die each day across the globe, about two-thirds die from age-related causes. Current ageing theories are assigned to the damage concept, whereby the accumulation of damage (such as DNA oxidation) may cause biological systems to fail, or to the programmed ageing concept, whereby the internal processes (e ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Insulin
Insulin (, from Latin ''insula'', 'island') is a peptide hormone produced by beta cells of the pancreatic islets encoded in humans by the insulin (''INS)'' gene. It is the main Anabolism, anabolic hormone of the body. It regulates the metabolism of carbohydrates, fats, and protein by promoting the absorption of glucose from the blood into cells of the liver, fat cell, fat, and skeletal muscles. In these tissues the absorbed glucose is converted into either glycogen, via glycogenesis, or Fatty acid metabolism#Glycolytic end products are used in the conversion of carbohydrates into fatty acids, fats (triglycerides), via lipogenesis; in the liver, glucose is converted into both. Glucose production and secretion by the liver are strongly inhibited by high concentrations of insulin in the blood. Circulating insulin also affects the synthesis of proteins in a wide variety of tissues. It is thus an anabolic hormone, promoting the conversion of small molecules in the blood into large ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Transmembrane Protein
A transmembrane protein is a type of integral membrane protein that spans the entirety of the cell membrane. Many transmembrane proteins function as gateways to permit the transport of specific substances across the membrane. They frequently undergo significant conformational changes to move a substance through the membrane. They are usually highly hydrophobic and aggregate and precipitate in water. They require detergents or nonpolar solvents for extraction, although some of them ( beta-barrels) can be also extracted using denaturing agents. The peptide sequence that spans the membrane, or the transmembrane segment, is largely hydrophobic and can be visualized using the hydropathy plot. Depending on the number of transmembrane segments, transmembrane proteins can be classified as single-pass membrane proteins, or as multipass membrane proteins. Some other integral membrane proteins are called monotopic, meaning that they are also permanently attached to the membrane, b ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
