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Judah Folkman
Moses Judah Folkman (February 24, 1933 – January 14, 2008) was an American biologist and pediatric surgeon best known for his research on tumor angiogenesis, the process by which a tumor attracts blood vessels to nourish itself and sustain its existence. He founded the field of angiogenesis research, which has led to the discovery of a number of therapies based on inhibiting or stimulating neovascularization. Early life Born in 1933 in Cleveland, Ohio, Judah Folkman accompanied his father, a rabbi, on visits to hospital patients. By age seven, he knew he wanted to be a doctor rather than follow in his father's footsteps, so he could offer cures in addition to comfort. His father replied, "In that case, you can be a rabbi-like doctor," words his son took to heart.Children's Hospital BostoRemembering Judah Folkman: Biography/ref> Folkman graduated from Ohio State University in 1953, and then Harvard Medical School in 1957.Harvard Medical SchooBio at Harvard Medical School/ref> W ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cleveland
Cleveland is a city in the U.S. state of Ohio and the county seat of Cuyahoga County. Located along the southern shore of Lake Erie, it is situated across the Canada–U.S. maritime border and approximately west of the Ohio-Pennsylvania state border. Cleveland is the most populous city on Lake Erie, the second-most populous city in Ohio, and the 53rd-most populous city in the U.S. with a population of 372,624 in 2020. The city anchors the Cleveland metropolitan area, the 33rd-largest in the U.S. at 2.18 million residents, as well as the larger Cleveland– Akron– Canton combined statistical area with 3.63 million residents. Cleveland was founded in 1796 near the mouth of the Cuyahoga River as part of the Connecticut Western Reserve in modern-day Northeast Ohio by General Moses Cleaveland, after whom the city was named. The city's location on the river and the lake shore allowed it to grow into a major commercial and industrial metropolis by the late 19th century, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Artificial Cardiac Pacemaker
A pacemaker, also known as an artificial cardiac pacemaker, is an implanted medical device that generates electrical pulses delivered by electrodes to one or more of the chambers of the heart. Each pulse causes the targeted chamber(s) to contract and pump blood, thus regulating the function of the electrical conduction system of the heart. The primary purpose of a pacemaker is to maintain an even heart rate Heart rate is the frequency of the cardiac cycle, heartbeat measured by the number of contractions of the heart per minute (''beats per minute'', or bpm). The heart rate varies according to the body's Human body, physical needs, including the nee ..., either because the heart's natural cardiac pacemaker provides an inadequate or irregular heartbeat, or because there is a heart block, block in the heart's electrical conduction system. Modern pacemakers are externally programmable and allow a cardiologist to select the optimal pacing modes for individual patients. Most p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Monsanto
The Monsanto Company () was an American agrochemical and agricultural biotechnology corporation founded in 1901 and headquartered in Creve Coeur, Missouri. Monsanto's best-known product is Roundup, a glyphosate-based herbicide, developed in the 1970s. Later, the company became a major producer of genetically engineered crops. In 2018, the company ranked 199th on the Fortune 500 of the largest United States corporations by revenue. Monsanto was one of four groups to introduce genes into plants in 1983, and was among the first to conduct field trials of genetically modified crops in 1987. It was one of the top-ten U.S. chemical companies until it divested most of its chemical businesses between 1997 and 2002, through a process of mergers and spin-offs that focused the company on biotechnology. Monsanto was one of the first companies to apply the biotechnology industry business model to agriculture, using techniques developed by biotech drug companies. In this business m ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fibroblast Growth Factor
Fibroblast growth factors (FGF) are a family of cell signalling proteins produced by the macrophages. They are involved in a wide variety of processes, most notably as crucial elements for normal development in animal cells. Any irregularities in their function will lead to a range of developmental defects. These growth factors typically act as a systemic or locally circulating molecules of extracellular origin that activate cell surface receptors. A defining property of FGFs is that they bind to heparin and to heparan sulfate. Thus, some are sequestered in the extracellular matrix of tissues that contains heparan sulfate proteoglycans, and released locally upon injury or tissue remodeling. Families In humans, 23 members of the FGF family have been identified, all of which are ''structurally'' related signaling molecules: * Members FGF1 through FGF10 all bind fibroblast growth factor receptors (FGFRs). FGF1 is also known as ''acidic fibroblast growth factor'', and FGF2 is al ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bert L
Bert or BERT may refer to: Persons, characters, or animals known as Bert *Bert (name), commonly an abbreviated forename and sometimes a surname *Bert, a character in the poem "Bert the Wombat" by The Wiggles; from their 1992 album ''Here Comes a Song'' *Bert (Sesame Street), fictional character on the TV series ''Sesame Street'' *Bert (horse), foaled 1934 * Bert (Mary Poppins), a Cockney chimney sweep in the book series & Disney film ''Mary Poppins'' * Iron Bert (one half of the two yellow diesels 'Arry and Bert), also in ''Thomas and Friends'' Places *Berd, Armenia, also known as Bert * Bert, Allier, a commune in the French of Allier (pronounced \bɛʁ\) *Bert, West Virginia Electronics and computing *Bit error rate test, a testing method for digital communication circuits *Bit error rate tester, a test equipment used for testing the bit error rate of digital communication circuits *HP Bert, a CPU in certain Hewlett-Packard programmable calculators *BERT (language model) (Bidir ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Solid Tumor
A neoplasm () is a type of abnormal and excessive growth of tissue. The process that occurs to form or produce a neoplasm is called neoplasia. The growth of a neoplasm is uncoordinated with that of the normal surrounding tissue, and persists in growing abnormally, even if the original trigger is removed. This abnormal growth usually forms a mass, which may be called a tumour or tumor.'' ICD-10 classifies neoplasms into four main groups: benign neoplasms, in situ neoplasms, malignant neoplasms, and neoplasms of uncertain or unknown behavior. Malignant neoplasms are also simply known as cancers and are the focus of oncology. Prior to the abnormal growth of tissue, such as neoplasia, cells often undergo an abnormal pattern of growth, such as metaplasia or dysplasia. However, metaplasia or dysplasia does not always progress to neoplasia and can occur in other conditions as well. The word neoplasm is from Ancient Greek 'new' and 'formation, creation'. Types A neoplasm can be ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
New England Journal Of Medicine
''The New England Journal of Medicine'' (''NEJM'') is a weekly medical journal published by the Massachusetts Medical Society. Founded in 1812, the journal is among the most prestigious peer-reviewed medical journals. Its 2023 impact factor was 96.2, ranking it 2nd out of 168 journals in the category "Medicine, General & Internal". History In September 1811, Boston physician John Collins Warren, along with James Jackson, submitted a formal prospectus to establish the ''New England Journal of Medicine and Surgery and Collateral Branches of Science'' as a medical and philosophical journal. Subsequently, the first issue of the ''New England Journal of Medicine and Surgery and the Collateral Branches of Medical Science'' was published in January 1812. The journal was published quarterly. In 1823, another publication, the ''Boston Medical Intelligencer'', appeared under the editorship of Jerome V. C. Smith. The editors of the ''New England Journal of Medicine and Surgery and the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Children's Hospital Boston
Boston Children's Hospital (formerly known as Children's Hospital Boston until 2013) is the main pediatric training and research hospital of Harvard Medical School, Harvard University. It is a nationally ranked, freestanding acute care children's hospital located at the centre of Harvard Longwood Medical and Academic Area in Boston, Massachusetts. The hospital is home to the world's largest pediatric research enterprise, and it is the leading recipient of pediatric research funding from the National Institutes of Health (NIH). It provides comprehensive pediatric specialties and subspecialties to infants, children, teens, and young adults aged 0–21 throughout Massachusetts, the United States, and the world. The hospital also sometimes treats adults that require pediatric care. The hospital uses the Brigham and Women's Hospital's rooftop helipad and is an ACS verified level I pediatric trauma center, one of three in Boston. The hospital features a regional pediatric intensiv ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Population Council
The Population Council is an international, nonprofit, non-governmental organization. The Council conducts research in biomedicine, social science, and public health and helps build research capacities in developing countries. One-third of its research relates to HIV and AIDS; while its other major program areas are still linked to its early foundation in reproductive health and its relation to poverty, youth, and gender. For example, the Population Council strives to teach boys that they can be involved in contraceptive methods regardless of stereotypes that limit male responsibility in child bearing. The organization held the license for Norplant contraceptive implant, and now holds the license for Mirena intrauterine system. The Population Council also publishes the journal '' Population and Development Review'', which reports scientific research on the interrelationships between population and socioeconomic development. It also provides a forum for discussion on related issu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Norplant
Levonorgestrel-releasing implant, sold under the brand name Jadelle among others, are devices that release levonorgestrel for birth control. It is one of the most effective forms of birth control with a one-year failure rate around 0.05%. The device is placed under the skin and lasts for up to five years. It may be used by women who have a history of pelvic inflammatory disease and therefore cannot use an intrauterine device. Following removal, fertility quickly returns. It is generally well tolerated with few significant side effects. Side effects may include irregular menstrual periods, no periods, headaches, and breast pain. Use is not recommended in people with significant liver disease. The levonorgestrel implant is a type of long-acting reversible birth control. It primarily works by stopping ovulation and by thickening the mucus around the cervix. A levonorgestrel-releasing implant was approved for medical use in 1983 in Finland and in the United States in 1990. It i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lipophilic
Lipophilicity (from Greek language, Greek λίπος "fat" and :wikt:φίλος, φίλος "friendly") is the ability of a chemical compound to dissolve in fats, oils, lipids, and non-polar solvents such as hexane or toluene. Such compounds are called lipophilic (translated as "fat-loving" or "fat-liking"). Such non-polar solvents are themselves lipophilic, and the adage "like dissolves like" generally holds true. Thus lipophilic substances tend to dissolve in other lipophilic substances, whereas hydrophilic ("water-loving") substances tend to dissolve in water and other hydrophilic substances. Lipophilicity, hydrophobicity, and non-polarity may describe the same tendency towards participation in the London dispersion force, as the terms are often used interchangeably. However, the terms "lipophilic" and "hydrophobicity, hydrophobic" are not synonymous, as can be seen with silicones and fluorocarbons, which are hydrophobic but not lipophilic. __TOC__ Surfactants Hydrocarbon-based ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Silastic
Silastic (a portmanteau of 'silicone' and 'plastic') is a trademark registered in 1948 by Dow Corning Corporation for flexible, inert silicone elastomer. Composition The Silastic trademark refers to silicone elastomers, silicone tubing and some cross-linked polydimethylsiloxane Polydimethylsiloxane (PDMS), also known as dimethylpolysiloxane or dimethicone, is a silicone polymer with a wide variety of uses, from cosmetics to industrial lubrication and passive daytime radiative cooling. PDMS is particularly known for its ... materials manufactured by Dow Corning,United States Patent and Trademark Office, . Filing date June 15, 1946; registration date April 13, 1948. Owner: Dow Corning Corporation, Midland, Michigan 48686-0994. the owner of the global trademark. Applications Silastic-brand silicone elastomers have a range of applications. In the automotive industry they are used for making gaskets, spark plug boots, hoses and other components that must operate over a broad temp ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
