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John Westley (biochemist)
John W. Westley (1927–) was an enzymologist at the University of Chicago The University of Chicago (UChicago, Chicago, or UChi) is a Private university, private research university in Chicago, Illinois, United States. Its main campus is in the Hyde Park, Chicago, Hyde Park neighborhood on Chicago's South Side, Chic ..., best known for his research on rhodanese and other sulfurtransferases. Education and employment John Westley obtained his Ph.D. in 1954 at the University of Chicago on the basis of a thesis entitled "Studies on the synthesis of histidine by ''Escherichia coli''". He subsequently worked in the Department of Biochemistry (now Department of Biochemistry & Molecular Biology) of the University of Chicago. Research John Westley's doctoral research concerned the biosynthesis of histidine in ''Escherichia coli''. Subsequently he became an enzymologist and worked principally on rhodanese (thiosulfate sulfurtransferase, EC 2.8.1.1), starting with a comparison o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Chicago
The University of Chicago (UChicago, Chicago, or UChi) is a Private university, private research university in Chicago, Illinois, United States. Its main campus is in the Hyde Park, Chicago, Hyde Park neighborhood on Chicago's South Side, Chicago, South Side, near the shore of Lake Michigan about from Chicago Loop, the Loop. The university is composed of an College of the University of Chicago, undergraduate college and four graduate divisions: Biological Science, Arts & Humanities, Physical Science, and Social Science, which include various organized departments and institutes. In addition, the university operates eight professional schools in the fields of University of Chicago Booth School of Business, business, Crown Family School of Social Work, Policy, and Practice, social work, University of Chicago Divinity School, divinity, Graham School of Continuing Liberal and Professional Studies, continuing studies, Harris School of Public Policy, public policy, University of Chi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rhodanese
Rhodanese is a mitochondrial enzyme that detoxifies cyanide (CN−) by converting it to thiocyanate (SCN−, also known as "rhodanate"). In enzymatology, the common name is listed as thiosulfate sulfurtransferase (). The diagram on the right shows the crystallographically-determined structure of rhodanese. It catalyzes the following reaction: :thiosulfate + cyanide \rightleftharpoons sulfite + thiocyanate Structure and mechanism This reaction takes place in two steps. In the first step, thiosulfate is reduced by the thiol group on cysteine-247 1, to form a persulfide and a sulfite 2. In the second step, the persulfide reacts with cyanide to produce thiocyanate, re-generating the cysteine thiol 1. Rhodanese shares evolutionary relationship with a large family of proteins, including: * Cdc25 phosphatase catalytic domain * non-catalytic domains of eukaryotic dual-specificity MAPK-phosphatases * non-catalytic domains of yeast PTP-type MAPK-phosphatases * non-catalytic doma ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Enzyme Memory
Enzyme memory is a concept in enzyme kinetics based on the idea that the kinetic properties of an enzyme may vary according to conditions in its previous catalytic cycle. It can occur both in ternary-complex mechanisms and in substituted-enzyme Enzyme kinetics#Multi-substrate reactions, ("ping-pong") mechanisms, with very different consequences. Ternary-complex mechanism A mnemonical mechanism for a reaction A + B → products that proceeds through a ternary complex EAB is shown in the illustration at the right. The essential characteristic, that makes this different from any mechanism in which substrate binding is at or close to equilibrium, is that it contains both slow and fast steps, with the fast step preventing the binding from reaching equilibrium, because release of products is too rapid to allow this. The enzyme exists in two forms: as a free enzyme it exists as E′, but the form released at the end of the catalytic cycle is E. E′ is the form that exists during the c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Enzyme Kinetics
Enzyme kinetics is the study of the rates of enzyme catalysis, enzyme-catalysed chemical reactions. In enzyme kinetics, the reaction rate is measured and the effects of varying the conditions of the reaction are investigated. Studying an enzyme's chemical kinetics, kinetics in this way can reveal the catalytic mechanism of this enzyme, its role in metabolism, how its activity is controlled, and how a drug or a modifier (Enzyme inhibitor, inhibitor or Enzyme activator, activator) might affect the rate. An enzyme (E) is a protein molecule that serves as a biological catalyst to facilitate and accelerate a chemical reaction in the body. It does this through binding of another molecule, its Substrate (biochemistry), substrate (S), which the enzyme acts upon to form the desired product. The substrate binds to the active site of the enzyme to produce an enzyme-substrate complex ES, and is transformed into an enzyme-product complex EP and from there to product P, via a transition state ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1927 Births
Events January * January 1 – The British Broadcasting ''Company'' becomes the BBC, British Broadcasting ''Corporation'', when its Royal Charter of incorporation takes effect. John Reith, 1st Baron Reith, John Reith becomes the first Director-General. * January 7 ** The first transatlantic telephone call is made ''via radio'' from New York City, United States, to London, United Kingdom. ** The Harlem Globetrotters exhibition basketball team play their first ever road game in Hinckley, Illinois. * January 9 – The Laurier Palace Theatre fire at a movie theatre in Montreal, Quebec, Canada, kills 78 children. * January 10 – Fritz Lang's futuristic film ''Metropolis (1927 film), Metropolis'' is released in Germany. * January 11 – Louis B. Mayer, head of film studio Metro-Goldwyn-Mayer (MGM), announces the creation of the Academy of Motion Picture Arts and Sciences, at a banquet in Los Angeles, California. * January 24 – U.S. Marines United States occ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
American Biochemists
American(s) may refer to: * American, something of, from, or related to the United States of America, commonly known as the "United States" or "America" ** Americans, citizens and nationals of the United States of America ** American ancestry, people who self-identify their ancestry as "American" ** American English, the set of varieties of the English language native to the United States ** Native Americans in the United States, indigenous peoples of the United States * American, something of, from, or related to the Americas, also known as "America" ** Indigenous peoples of the Americas * American (word), for analysis and history of the meanings in various contexts Organizations * American Airlines, U.S.-based airline headquartered in Fort Worth, Texas * American Athletic Conference, an American college athletic conference * American Recordings (record label), a record label that was previously known as Def American * American University, in Washington, D.C. Sports teams S ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Scientists From Chicago
A scientist is a person who Scientific method, researches to advance knowledge in an Branches of science, area of the natural sciences. In classical antiquity, there was no real ancient analog of a modern scientist. Instead, philosophers engaged in the philosophical study of nature called natural philosophy, a precursor of natural science. Though Thales ( 624–545 BC) was arguably the first scientist for describing how cosmic events may be seen as natural, not necessarily caused by gods,Frank N. Magill''The Ancient World: Dictionary of World Biography'', Volume 1 Routledge, 2003 it was not until the 19th century in science, 19th century that the term ''scientist'' came into regular use after it was coined by the theologian, philosopher, and historian of science William Whewell in 1833. History The roles of "scientists", and their predecessors before the emergence of modern scientific disciplines, have evolved considerably over time. Scientists of different er ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
