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John Jacob Abel
John Jacob Abel (19 May 1857 – 26 May 1938) was an American biochemist and pharmacologist. He established the pharmacology department at Johns Hopkins University School of Medicine in 1893, and then became America's first full-time professor of pharmacology. During his time at Hopkins, he made several important medical advancements, especially in the field of hormone extraction. In addition to his laboratory work, he founded several significant scientific journals such as the ''Journal of Biological Chemistry'' and the '' Journal of Pharmacology and Experimental Therapeutics''. Early life and education John Jacob Abel was born in 1857 near Cleveland, Ohio, to German immigrants George M. and Mary (Becker) Abel. He earned his Ph.B. (Bachelor of Philosophy) from the University of Michigan where he studied under Henry Sewall in 1883. But, during this time he took several years off to serve as a principal of the high school in La Porte, Indiana. There he taught many subjects rangi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cleveland
Cleveland is a city in the U.S. state of Ohio and the county seat of Cuyahoga County. Located along the southern shore of Lake Erie, it is situated across the Canada–U.S. maritime border and approximately west of the Ohio-Pennsylvania state border. Cleveland is the most populous city on Lake Erie, the second-most populous city in Ohio, and the 53rd-most populous city in the U.S. with a population of 372,624 in 2020. The city anchors the Cleveland metropolitan area, the 33rd-largest in the U.S. at 2.18 million residents, as well as the larger Cleveland– Akron– Canton combined statistical area with 3.63 million residents. Cleveland was founded in 1796 near the mouth of the Cuyahoga River as part of the Connecticut Western Reserve in modern-day Northeast Ohio by General Moses Cleaveland, after whom the city was named. The city's location on the river and the lake shore allowed it to grow into a major commercial and industrial metropolis by the late 19th century, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Adolph Strümpell
Adolf (also spelt Adolph or Adolphe, Adolfo, and when Latinised Adolphus) is a given name with German origins. The name is a compound derived from the Old High German ''Athalwolf'' (or ''Hadulf''), a composition of ''athal'', or ''adal'', meaning "noble" (or '' had(u)''-, meaning "battle, combat"), and ''wolf''. The name is cognate to the Anglo-Saxon name '' Æthelwulf'' (also Eadulf or Eadwulf). The name can also be derived from the ancient Germanic elements "Wald" meaning "power", "brightness" and wolf (Waldwulf). Due to its extremely negative associations with the Nazi leader Adolf Hitler, the name has greatly declined in popularity since the end of World War II. Similar names include Lithuanian Adolfas and Latvian Ādolfs. The female forms Adolphine and Adolpha are far more rare than the male names. Adolphus can also appear as a surname, as in John Adolphus, the English historian. Popularity and usage During the 19th and early 20th centuries, Adolf was a popular na ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Insulin
Insulin (, from Latin ''insula'', 'island') is a peptide hormone produced by beta cells of the pancreatic islets encoded in humans by the insulin (''INS)'' gene. It is the main Anabolism, anabolic hormone of the body. It regulates the metabolism of carbohydrates, fats, and protein by promoting the absorption of glucose from the blood into cells of the liver, fat cell, fat, and skeletal muscles. In these tissues the absorbed glucose is converted into either glycogen, via glycogenesis, or Fatty acid metabolism#Glycolytic end products are used in the conversion of carbohydrates into fatty acids, fats (triglycerides), via lipogenesis; in the liver, glucose is converted into both. Glucose production and secretion by the liver are strongly inhibited by high concentrations of insulin in the blood. Circulating insulin also affects the synthesis of proteins in a wide variety of tissues. It is thus an anabolic hormone, promoting the conversion of small molecules in the blood into large ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Kidney Dialysis
Kidney dialysis is the process of removing excess water, solutes, and toxins from the blood in people whose kidneys can no longer perform these functions naturally. Along with kidney transplantation, it is a type of renal replacement therapy. Dialysis may need to be initiated when there is a sudden rapid loss of kidney function, known as acute kidney injury (previously called acute renal failure), or when a gradual decline in kidney function, chronic kidney failure, reaches stage 5. Stage 5 chronic renal failure is reached when the glomerular filtration rate is less than 15% of the normal, creatinine clearance is less than 10 mL per minute, and uremia is present. Dialysis is used as a temporary measure in either acute kidney injury or in those awaiting kidney transplant and as a permanent measure in those for whom a transplant is not Indication (medicine), indicated or not possible.Pendse S, Singh A, Zawada E. "Initiation of Dialysis". In: ''Handbook of Dialysis''. 4th ed. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Amino Acid
Amino acids are organic compounds that contain both amino and carboxylic acid functional groups. Although over 500 amino acids exist in nature, by far the most important are the 22 α-amino acids incorporated into proteins. Only these 22 appear in the genetic code of life. Amino acids can be classified according to the locations of the core structural functional groups ( alpha- , beta- , gamma- amino acids, etc.); other categories relate to polarity, ionization, and side-chain group type ( aliphatic, acyclic, aromatic, polar, etc.). In the form of proteins, amino-acid '' residues'' form the second-largest component (water being the largest) of human muscles and other tissues. Beyond their role as residues in proteins, amino acids participate in a number of processes such as neurotransmitter transport and biosynthesis. It is thought that they played a key role in enabling life on Earth and its emergence. Amino acids are formally named by the IUPAC- IUBMB Joint Commi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Leonard Rowntree
Leonard George Rowntree (1883–1959) was a Canadians, Canadian physician and medical researcher who was credited with founding the research tradition at the Mayo Clinic. He is most well known for pioneering kidney research including the Rowntree test for kidney function; Kidney dialysis, dialysis; the intravenous pyelogram and plasmapheresis. Rowntree was awarded the Medal for Merit in 1946. Early life Rowntree was born in London, Ontario, on April 10, 1883. He entered University of Western Ontario medical school in 1901, graduating in 1905 with the gold medal. He interned at Victoria Hospital (London, Ontario), Victoria Hospital and then entered general practice in Camden, New Jersey. A year later he attended a lecture given by William Osler in Philadelphia. He approached Osler about his career. Academic career Osler recommended Rowntree to Johns Hopkins Hospital where he worked with John Jacob Abel, John J. Abel, a prominent pharmacologist. Abel introduced him to phthalein, fro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Takamine Jōkichi
was a Japanese chemist. He is known for being the first to isolate epinephrine in 1901. Early life and education Takamine was born in Takaoka, Toyama, Takaoka, Toyama Prefecture, in November 1854. His father was a doctor; his mother a member of a family of ''sake'' brewers. He spent his childhood in Kanazawa, Ishikawa, Kanazawa, capital of present-day Ishikawa Prefecture in central Honshū. He learned English language, English as a child from a Dutch family in Nagasaki, and so always spoke English with a Dutch accent. He was educated in Osaka, Kyoto, and Tokyo, graduating from one of the predecessors of Tokyo Imperial University in 1879. He did postgraduate work at University of Glasgow and Anderson's University, Anderson College in Scotland until 1883. Career Japan In 1883, Takamine returned to Japan and joined the division of chemistry at the newly established Ministry of Agriculture, Forestry and Fisheries (Japan), Department of Agriculture and Commerce until 1887. He then f ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Adrenal Medulla
The adrenal medulla () is the inner part of the adrenal gland. It is located at the center of the gland, being surrounded by the adrenal cortex. It is the innermost part of the adrenal gland, consisting of chromaffin cells that secrete catecholamines, including epinephrine (adrenaline), norepinephrine (noradrenaline), and a small amount of dopamine, in response to stimulation by sympathetic preganglionic neurons. Structure The adrenal medulla consists of irregularly shaped cells grouped around blood vessels. These cells are intimately connected with the sympathetic division of the autonomic nervous system (ANS). These adrenal medullary cells are modified postganglionic neurons, and preganglionic autonomic nerve fibers lead to them directly from the central nervous system. The adrenal medulla affects energy availability, heart rate, and basal metabolic rate. Recent research indicates that the adrenal medulla may receive input from higher-order cognitive centers in the prefron ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Epinephrine
Adrenaline, also known as epinephrine, is a hormone and medication which is involved in regulating visceral functions (e.g., respiration). It appears as a white microcrystalline granule. Adrenaline is normally produced by the adrenal glands and by a small number of neurons in the medulla oblongata. It plays an essential role in the fight-or-flight response by increasing blood flow to muscles, heart output by acting on the SA node, pupil dilation response, and blood sugar level. It does this by binding to alpha and beta receptors. It is found in many animals, including humans, and some single-celled organisms. It has also been isolated from the plant '' Scoparia dulcis'' found in Northern Vietnam. Medical uses As a medication, it is used to treat several conditions, including allergic reaction anaphylaxis, cardiac arrest, and superficial bleeding. Inhaled adrenaline may be used to improve the symptoms of croup. It may also be used for asthma when other treatments are ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Arthur Robertson Cushny
Arthur Robertson Cushny Royal Society, FRS FRSE LLD (6 March 1866 – 25 February 1926), was a Scottish pharmacologist and physiologist who became a Fellow of the Royal Society. Life Cushny was born on 6 March 1866 in Fochabers, Moray, Scotland, the fourth son of Rev John Cushny of Speymouth and his wife, Catherine Ogilvie Brown. He attended a local rural school until he enrolled at the University of Aberdeen and received an Master of Arts (Scotland), M.A. in 1886. Then in 1889, he graduated from medical studies at Marischal College, Aberdeen, receiving C.M., M.B. and Doctor of Medicine, M.D. degrees in 1892. Aroused by interests of physiological drug interaction, he traveled to the European continent and spent a year of associated study under Oswald Schmiedeberg at Straßburg, German Empire and six months in Bern under Hugo Kronecker, from whom he learned elements of physiological technique. Then in 1893, at age 27, he accepted the chairmanship of pharmacology at the Unive ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Oswald Schmiedeberg
Johann Ernst Oswald Schmiedeberg (10 October 1838 – 12 July 1921) was a Baltic German pharmacologist. In 1866 he earned his medical doctorate from the University of Dorpat with a thesis concerning the measurement of chloroform in blood, before becoming the first professor of pharmacology at the University of Strasbourg, where he remained for 46 years. In 1911, he testified in the '' United States v. Forty Barrels and Twenty Kegs of Coca-Cola'' trial, and later, was a major factor in the success of the German pharmaceutical industry prior to the Second World War, having trained most of the European professors at the time. Early life and family Oswald Schmiedeberg was born in Courland, one of the Baltic provinces of Russia. His father Wilhelm Ludwig (1809–1878) was a bailiff in Leidzen and later forester in Paggar (Estonia). His mother Anna Lucie Bernard (1813–1871) was the daughter of a watchmaker from Lausanne. Oswald was the eldest of six siblings of whom a brother Johann ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
