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John H. Gaddum
Sir John Henry Gaddum (31 March 1900 – 30 June 1965) was an English pharmacologist who, along with Ulf von Euler, co-discovered the neuropeptide Substance P in 1931. He was a founder member of the British Pharmacological Society and first editor of the ''British Journal of Pharmacology''. Early life and education He was born in Hale (now part of Manchester) the son of silk merchant, Henry Edwin Gaddum and his wife Phyllis Mary Barratt. He was educated at Moorland House School, Heswall, Cheshire; Rugby School; and Trinity College, Cambridge. He completed his BSc in Physiology at the University of Cambridge in 1922, and his MD at University College London in 1925. His first role was to assist J. W. Trevan at the Wellcome Physiological Research Laboratories. Career From 1927–33, Gaddum worked under Henry Dale at the National Institute for Medical Research, and helped develop the classical laws of drug antagonism. He showed that sympathetic nerves release adrenaline. To ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pharmacology
Pharmacology is the science of drugs and medications, including a substance's origin, composition, pharmacokinetics, pharmacodynamics, therapeutic use, and toxicology. More specifically, it is the study of the interactions that occur between a living organism and chemicals that affect normal or abnormal biochemical function. If substances have medicinal properties, they are considered pharmaceuticals. The field encompasses drug composition and properties, functions, sources, synthesis and drug design, molecular and cellular mechanisms, organ/systems mechanisms, signal transduction/cellular communication, molecular diagnostics, interactions, chemical biology, therapy, and medical applications and antipathogenic capabilities. The two main areas of pharmacology are pharmacodynamics and pharmacokinetics. Pharmacodynamics studies the effects of a drug on biological systems, and pharmacokinetics studies the effects of biological systems on a drug. In broad terms, pharmacod ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Heswall
Heswall () is a coastal town in the Metropolitan Borough of Wirral in Merseyside, England. It was historically part of Cheshire and became part of Merseyside in 1974. It is located on the Wirral Peninsula. At the 2021 United Kingdom census, 2021 census, the population of the built up area as defined by the Office for National Statistics was 29,075. History Early history Before the Norman Conquest, Heswall has been cited as a possible location for Dingesmere, mentioned with regard to the Battle of Brunanburh, in ''Egil's Saga''. Heswall was recorded in the Domesday Book of 1086 as ''Eswelle'', owned by Robert de Rodelent, who also owned much of the land on the eastern side of the River Dee. In 1277, it became the property of Patrick de Haselwall, who was Sheriff of Cheshire. Development In 1801, the population was recorded as 168. By the census in 1841, it had grown to 398. Before 1897 it was known as ''Hestlewelle'' or ''Hesselwelle''. Its growth was started by wealthy merchant ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
James Ritchie (naturalist)
James Ritchie CBE PRSE (27 May 1882 – 19 October 1958) was a Scottish naturalist and archaeologist, who was Professor of Natural History at the University of Edinburgh 1936–52 and President of the Royal Society of Edinburgh 1952–1958. Life He was born on 27 May 1882 in Port Elphinstone in Aberdeenshire the son of James Ritchie, the local schoolmaster. He was educated at Gordon's College in Aberdeen then studied Science at Aberdeen University. In 1916 he was elected a Fellow of the Royal Society of Edinburgh. His proposers were Sir Thomas Carlaw Martin, James Cossar Ewart, James Hartley Ashworth and Cargill Gilston Knott. He won the Society's Keith Prize for the period 1941–43. He served as Secretary 1928–31; Vice President 1931–34, 1940–43 and 1951–54; and President 1954–58. From 1921 to 1930 he was Keeper of Natural History at the Royal Scottish Museum on Chambers Street in Edinburgh. In 1930 he left Edinburgh to take up a post of Regius Professor o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Thomas J
Clarence Thomas (born June 23, 1948) is an American lawyer and jurist who has served since 1991 as an associate justice of the Supreme Court of the United States. President George H. W. Bush Clarence Thomas Supreme Court nomination, nominated him to succeed Thurgood Marshall. After Marshall, Thomas is the second African Americans, African American to serve on the U.S. Supreme Court and has been its List of United States Supreme Court justices by time in office, longest-serving member since Anthony Kennedy's retirement in 2018. He has also been the Court's oldest member since Stephen Breyer retired in 2022. Thomas was born in Pin Point, Georgia. After his father abandoned the family, he was raised by his grandfather in a poor Gullah community near Savannah, Georgia. Growing up as a devout Catholic, Thomas originally intended to be a priest in the Catholic Church but became dissatisfied with its efforts to combat racism and abandoned his aspiration to join the clergy. He gradua ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
James Couper Brash
James Couper Brash, MC, FRCSE, FRSE (24 October 1886 in Cathcart – 19 January 1958 in Edinburgh) was a leading anatomist and embryologist in Britain. Early life and family James Couper Brash was born in Cathcart in Scotland, the son of James Brash, J.P. He was educated at George Watson's College and the University of Edinburgh. Brash graduated B.Sc. in 1908 and M.B., Ch.B. in 1910. In 1912 Brash married Margaret Henderson, daughter of William Henderson, of Leslie, Fife, and she survived him together with one son, James Couper Henderson Brash (d.1990) and one daughter, Nancy Brash. Neither had children, ending the line. Career After holding the post of resident physician at the Royal Infirmary and working as a demonstrator of anatomy at Edinburgh, he became an assistant in the anatomical department in the University of Leeds. During the First World War he served as a Major in the Royal Army Medical Corps in France and Belgium and was awarded the Military Cross for h ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
James Pickering Kendall
James Pickering Kendall FRS FRSE (30 July 1889, in Chobham, Surrey – 14 June 1978, in Edinburgh) was a British chemist. Life Kendall was born in Chobham, Surrey to soldier William Henry Kendall of the Royal Horse Artillery, and his second wife Rebecca Pickering. He attended the local village school and then, from 1900, Farnham Grammar School. From 1907 to 1910, he studied at the University of Edinburgh graduating with both a BSc and MA. In 1912, with the support of a scholarship, he went to the Nobel Institute for Physical Chemistry in Stockholm to work with Arrhenius on electrolytes. In 1913, he accepted the position as Professor of Chemistry at Columbia University, New York. Two years later he was awarded the degree of Doctor of Science (DSc) by the University of Edinburgh. He also served in 1917 as a Lieutenant Commander in the United States Naval Reserve, acting as Liaison Officer with Allied Services on Chemical Warfare. His candidacy for the Royal Society of Londo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Royal Society Of Edinburgh
The Royal Society of Edinburgh (RSE) is Scotland's national academy of science and letters. It is a registered charity that operates on a wholly independent and non-partisan basis and provides public benefit throughout Scotland. It was established in 1783. , there are around 1,800 Fellows. The Society covers a broader range of fields than the Royal Society of London, including literature and history. The Fellowship includes people from a wide range of disciplines: science and technology, arts, humanities, medicine, social science, business, and public service. History At the start of the 18th century, Edinburgh's intellectual climate fostered many clubs and societies (see Scottish Enlightenment). Though there were several that treated the arts, sciences and medicine, the most prestigious was the Society for the Improvement of Medical Knowledge, commonly referred to as the Medical Society of Edinburgh, co-founded by the mathematician Colin Maclaurin in 1731. Maclaurin was u ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Second World War
World War II or the Second World War (1 September 1939 – 2 September 1945) was a World war, global conflict between two coalitions: the Allies of World War II, Allies and the Axis powers. World War II by country, Nearly all of the world's countries participated, with many nations mobilising all resources in pursuit of total war. Tanks in World War II, Tanks and Air warfare of World War II, aircraft played major roles, enabling the strategic bombing of cities and delivery of the Atomic bombings of Hiroshima and Nagasaki, first and only nuclear weapons ever used in war. World War II is the List of wars by death toll, deadliest conflict in history, causing World War II casualties, the death of 70 to 85 million people, more than half of whom were civilians. Millions died in genocides, including the Holocaust, and by massacres, starvation, and disease. After the Allied victory, Allied-occupied Germany, Germany, Allied-occupied Austria, Austria, Occupation of Japan, Japan, a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Autonomic Ganglia
An autonomic ganglion is a cluster of neuron, nerve cell Cell body, bodies (a ganglion) in the autonomic nervous system. The two types are the sympathetic ganglion and the parasympathetic ganglion. References Autonomic ganglia, Autonomic nervous system {{neuroanatomy-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Acetylcholine
Acetylcholine (ACh) is an organic compound that functions in the brain and body of many types of animals (including humans) as a neurotransmitter. Its name is derived from its chemical structure: it is an ester of acetic acid and choline. Parts in the body that use or are affected by acetylcholine are referred to as cholinergic. Acetylcholine is the neurotransmitter used at the neuromuscular junction. In other words, it is the chemical that motor neurons of the nervous system release in order to activate muscles. This property means that drugs that affect cholinergic systems can have very dangerous effects ranging from paralysis to convulsions. Acetylcholine is also a neurotransmitter in the autonomic nervous system, both as an internal transmitter for both the sympathetic nervous system, sympathetic and the parasympathetic nervous system, and as the final product released by the parasympathetic nervous system. Acetylcholine is the primary neurotransmitter of the parasympathet ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sympathetic Nerves
The sympathetic nervous system (SNS or SANS, sympathetic autonomic nervous system, to differentiate it from the somatic nervous system) is one of the three divisions of the autonomic nervous system, the others being the parasympathetic nervous system and the enteric nervous system. The enteric nervous system is sometimes considered part of the autonomic nervous system, and sometimes considered an independent system. The autonomic nervous system functions to regulate the body's unconscious actions. The sympathetic nervous system's primary process is to stimulate the body's fight or flight response. It is, however, constantly active at a basic level to maintain homeostasis. The sympathetic nervous system is described as being antagonistic to the parasympathetic nervous system. The latter stimulates the body to "feed and breed" and to (then) "rest-and-digest". The SNS has a major role in various physiological processes such as blood glucose levels, body temperature, cardiac output, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Receptor Antagonist
A receptor antagonist is a type of receptor ligand or drug that blocks or dampens a biological response by binding to and blocking a receptor rather than activating it like an agonist. Antagonist drugs interfere in the natural operation of receptor proteins.Pharmacology Guide: In vitro pharmacology: concentration-response curves ." '' GlaxoWellcome.'' Retrieved on December 6, 2007. They are sometimes called blockers; examples include alpha blockers, beta b ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
