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John Gofman
John William Gofman (21 September 1918 – 15 August 2007) was an American scientist and advocate. He was Professor Emeritus of Molecular and Cell Biology at the University of California at Berkeley. Gofman pioneered the field of clinical lipidology, and in 2007 was honored by the '' Journal of Clinical Lipidology'' with the title of "Father of Clinical Lipidology". With Frank T. Lindgren and other research associates, Gofman discovered and described three major classes of plasma lipoproteins, fat molecules that carry cholesterol in the blood. The team he led at the Donner Laboratory went on to demonstrate the role of lipoproteins in the causation of heart disease. Gofman advocated for the adoption of the Linear No-Threshold (LNT) model as a means of estimating actual cancer risks from low-level radiation and as the foundation of the international guidelines for radiation protection. Gofman's earliest research was in nuclear physics and chemistry, in close connection with t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cleveland, Ohio
Cleveland is a city in the U.S. state of Ohio and the county seat of Cuyahoga County, Ohio, Cuyahoga County. Located along the southern shore of Lake Erie, it is situated across the Canada–United States border, Canada–U.S. maritime border and approximately west of the Ohio-Pennsylvania state border. Cleveland is the most populous city on Lake Erie, the list of cities in Ohio, second-most populous city in Ohio, and the List of United States cities by population, 53rd-most populous city in the U.S. with a population of 372,624 in 2020. The city anchors the Greater Cleveland, Cleveland metropolitan area, the Metropolitan statistical area, 33rd-largest in the U.S. at 2.18 million residents, as well as the larger Cleveland–Akron, Ohio, Akron–Canton, Ohio, Canton combined statistical area with 3.63 million residents. Cleveland was founded in 1796 near the mouth of the Cuyahoga River as part of the Connecticut Western Reserve in modern-day Northeast Ohio by General Moses Clea ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Manhattan Project
The Manhattan Project was a research and development program undertaken during World War II to produce the first nuclear weapons. It was led by the United States in collaboration with the United Kingdom and Canada. From 1942 to 1946, the project was directed by Major General Leslie Groves of the United States Army Corps of Engineers, U.S. Army Corps of Engineers. Nuclear physicist J. Robert Oppenheimer was the director of the Los Alamos Laboratory that designed the bombs. The Army program was designated the Manhattan District, as its first headquarters were in Manhattan; the name gradually superseded the official codename, Development of Substitute Materials, for the entire project. The project absorbed its earlier British counterpart, Tube Alloys, and subsumed the program from the American civilian Office of Scientific Research and Development. The Manhattan Project employed nearly 130,000 people at its peak and cost nearly US$2 billion (equivalent to about $ b ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ernest Lawrence
Ernest Orlando Lawrence (August 8, 1901 – August 27, 1958) was an American accelerator physicist who received the Nobel Prize in Physics in 1939 for his invention of the cyclotron. He is known for his work on uranium-isotope separation for the Manhattan Project, as well as for founding the Lawrence Berkeley National Laboratory and the Lawrence Livermore National Laboratory. A graduate of the University of South Dakota and University of Minnesota, Lawrence obtained a PhD in physics at Yale in 1925. In 1928, he was hired as an associate professor of physics at the University of California, Berkeley, becoming the youngest full professor there two years later. In its library one evening, Lawrence was intrigued by a diagram of an accelerator that produced high-energy particles. He contemplated how it could be made compact, and came up with an idea for a circular accelerating chamber between the poles of an electromagnet. The result was the first cyclotron. Lawrence went on t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metabolic reactions, DNA replication, Cell signaling, responding to stimuli, providing Cytoskeleton, structure to cells and Fibrous protein, organisms, and Intracellular transport, transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the Nucleic acid sequence, nucleotide sequence of their genes, and which usually results in protein folding into a specific Protein structure, 3D structure that determines its activity. A linear chain of amino acid residues is called a polypeptide. A protein contains at least one long polypeptide. Short polypeptides, containing less than 20–30 residues, are rarely considered to be proteins and are commonly called pep ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lipoprotein
A lipoprotein is a biochemical assembly whose primary function is to transport hydrophobic lipid (also known as fat) molecules in water, as in blood plasma or other extracellular fluids. They consist of a triglyceride and cholesterol center, surrounded by a phospholipid outer shell, with the hydrophilic portions oriented outward toward the surrounding water and lipophilic portions oriented inward toward the lipid center. A special kind of protein, called apolipoprotein, is embedded in the outer shell, both stabilising the complex and giving it a functional identity that determines its role. Plasma lipoprotein particles are commonly divided into five main classes, based on size, lipid composition, and apolipoprotein content. They are, in increasing size order: HDL, LDL, IDL, VLDL and chylomicrons. Subgroups of these plasma particles are primary drivers or modulators of atherosclerosis. Many enzymes, transporters, structural proteins, antigens, adhesins, and toxins are some ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Uranium-232
Uranium-232 () is an isotope of uranium. It has a half-life of around 69 years and is a side product in the thorium cycle. It has been cited as an obstacle to nuclear proliferation using 233U as the fissile material, because the intense gamma radiation emitted by 208Tl (a daughter of 232U, produced relatively quickly) makes the 233U contaminated with it more difficult to handle. Production of 233U (through the neutron irradiation of 232Th) invariably produces small amounts of 232U as an impurity, because of parasitic (n,2n) reactions on uranium-233 itself, or on protactinium-233, or on thorium-232: :232Th (n,γ) 233Th (β−) 233Pa (β−) 233U (n,2n) 232U :232Th (n,γ) 233Th (β−) 233Pa (n,2n) 232Pa (β−) 232U :232Th (n,2n) 231Th (β−) 231Pa (n,γ) 232Pa (β−) 232U Another channel involves neutron capture reaction on small amounts of thorium-230, which is a tiny fraction of natural thorium present due to the decay of uranium-238: :230Th (n,γ) 231Th (β−) 231Pa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protactinium
Protactinium is a chemical element; it has symbol Pa and atomic number 91. It is a dense, radioactive, silvery-gray actinide metal which readily reacts with oxygen, water vapor, and inorganic acids. It forms various chemical compounds, in which protactinium is usually present in the oxidation state +5, but it can also assume +4 and even +3 or +2 states. Concentrations of protactinium in the Earth's crust are typically a few parts per trillion, but may reach up to a few parts per million in some uraninite ore deposits. Because of its scarcity, high radioactivity, and high toxicity, there are currently no uses for protactinium outside scientific research, and for this purpose, protactinium is mostly extracted from spent nuclear fuel. The element was first identified in 1913 by Kazimierz Fajans and Oswald Helmuth Göhring and named "brevium" because of the short half-life of the specific isotope studied, 234mPa. A more stable isotope of protactinium, 231Pa, was discovered in 191 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mammography
Mammography (also called mastography; DICOM modality: MG) is the process of using low-energy X-rays (usually around 30 kVp) to examine the human breast for diagnosis and screening. The goal of mammography is the early detection of breast cancer, typically through detection of characteristic masses, microcalcifications, asymmetries, and distortions. As with all X-rays, mammograms use doses of ionizing radiation to create images. These images are then analyzed for abnormal findings. It is usual to employ lower-energy X-rays, typically Mo (K-shell X-ray energies of 17.5 and 19.6 keV) and Rh (20.2 and 22.7 keV) than those used for radiography of bones. Mammography may be 2D or 3D ( tomosynthesis), depending on the available equipment or purpose of the examination. Ultrasound, ductography, positron emission mammography (PEM), and magnetic resonance imaging (MRI) are adjuncts to mammography. Ultrasound is typically used for further evaluation of masses found on mammography or palp ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chernobyl Disaster
On 26 April 1986, the no. 4 reactor of the Chernobyl Nuclear Power Plant, located near Pripyat, Ukrainian Soviet Socialist Republic, Ukrainian SSR, Soviet Union (now Ukraine), exploded. With dozens of direct casualties, it is one of only two nuclear energy accidents rated at the maximum severity on the International Nuclear Event Scale, the other being the 2011 Fukushima nuclear accident. The response involved more than Chernobyl liquidators, 500,000 personnel and cost an estimated 18billion Soviet ruble, rubles (about $84.5billion USD in 2025). It remains the worst nuclear disaster and the List of disasters by cost, most expensive disaster in history, with an estimated cost of US$700 billion. The disaster occurred while running a test to simulate cooling the reactor during an accident in blackout conditions. The operators carried out the test despite an accidental drop in reactor power, and due to a design issue, attempting to shut down the reactor in those conditio ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Committee For Nuclear Responsibility
The Committee for Nuclear Responsibility was formed as a "political and educational organization to disseminate anti-nuclear views and information to the public". The goals of the organization were a moratorium on nuclear power and the commercialization of alternative energy sources. John Gofman founded the Committee for Nuclear Responsibility in 1971, as a small non-profit, public interest association with four Nobel Laureates on its board.John W. Gofman, "Irrevy" - An irreverent illustrated view of nuclear power, Committee for Nuclear Responsibility, 1979 These Nobel scientists were Linus Pauling Linus Carl Pauling ( ; February 28, 1901August 19, 1994) was an American chemist and peace activist. He published more than 1,200 papers and books, of which about 850 dealt with scientific topics. ''New Scientist'' called him one of the 20 gre ..., Harold Urey, George Wald and James D. Watson. Other scientists who were involved included Paul Ehrlich, John Edsall, and Richard ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chromosomal Abnormalities
A chromosomal abnormality, chromosomal anomaly, chromosomal aberration, chromosomal mutation, or chromosomal disorder is a missing, extra, or irregular portion of chromosomal DNA. These can occur in the form of numerical abnormalities, where there is an atypical number of chromosomes, or as structural abnormalities, where one or more individual chromosomes are altered. Chromosome mutation was formerly used in a strict sense to mean a change in a chromosomal segment, involving more than one gene. Chromosome anomalies usually occur when there is an error in cell division following meiosis or mitosis. Chromosome abnormalities may be detected or confirmed by comparing an individual's karyotype, or full set of chromosomes, to a typical karyotype for the species via genetic testing. Sometimes chromosomal abnormalities arise in the early stages of an embryo, sperm, or infant. They can be caused by various environmental factors. The implications of chromosomal abnormalities depend on the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Livermore National Laboratory
Lawrence Livermore National Laboratory (LLNL) is a federally funded research and development center in Livermore, California, United States. Originally established in 1952, the laboratory now is sponsored by the United States Department of Energy and administered privately by Lawrence Livermore National Security, LLC. The lab was originally established as the University of California Radiation Laboratory, Livermore Branch in 1952 in response to the detonation of the Soviet Union's first atomic bomb during the Cold War. It later became autonomous in 1971 and was designated a national laboratory in 1981. Lawrence Livermore Lab is primarily funded by the U.S. Department of Energy and it is managed privately and operated by Lawrence Livermore National Security, LLC (a partnership of the University of California, Bechtel, BWX Technologies, Amentum, and Battelle Memorial Institute in affiliation with the Texas A&M University System). In 2012, the synthetic chemical element livermori ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
