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Jerzy Jurka
Jerzy Władysław Jurka (June 4, 1950 – July 19, 2014) was a Polish-American computational and molecular biologist. He served as the assistant director of research at the Linus Pauling Institute prior to founding the Genetic Information Research Institute. He collaborated with several notable scientists including Linus Pauling, George Irving Bell, Roy Britten, Temple Smith, and Emile Zuckerkandl. His Erdős number is 3, using the path through Temple Smith and Stanislaw Ulam. Research Dr. Jurka is best known for his work on eukaryotic transposable elements (TEs), including the discovery of the major families of Alu elements. He also proposed the mechanism of Alu proliferation and discovered their paternal transmission. The majority of known types of class II TEs, or DNA transposons, were discovered or co-discovered by his team at the Genetic Information Research Institute, based on DNA sequence analysis. The first one, reported in 2001 with Vladimir Kapitonov, beca ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ponikiew, Lesser Poland Voivodeship
Ponikiew is a village in the administrative district of Gmina Wadowice, within Wadowice County, Lesser Poland Voivodeship, in southern Poland. It lies approximately south-west of Wadowice and south-west of the regional capital Kraków Kraków (), or Cracow, is the second-largest and one of the oldest cities in Poland. Situated on the Vistula River in Lesser Poland Voivodeship, the city dates back to the seventh century. Kraków was the official capital of Poland until 1596 .... The village has a population of 1,237. References Villages in Wadowice County {{Wadowice-geo-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genetic Information Research Institute
The Genetic Information Research Institute (GIRI) is a non-profit institution that was founded in 1994 by Jerzy Jurka. The mission of the institute "is to understand biological processes which alter the genetic makeup of different organisms, as a basis for potential gene therapy and genome engineering techniques." The institute specializes in applying computer tools to analysis of DNA and protein sequence information. GIRI develops and maintains Repbase Update, a database of prototypic sequences representing repetitive DNA from different eukaryotic species, and Repbase Reports, an electronic journal established in 2001. Repetitive DNA is primarily derived from transposable elements (TEs), which include DNA transposons belonging to around 20 superfamilies and retrotransposons that can also be sub-classified into subfamilies . The majority of known superfamilies of DNA transposons were discovered or co-discovered at GIRI, including Helitron, ''Academ, Dada, Ginger, Kolobok, Novosi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Evolution
Evolution is change in the heritable characteristics of biological populations over successive generations. These characteristics are the expressions of genes, which are passed on from parent to offspring during reproduction. Variation tends to exist within any given population as a result of genetic mutation and recombination. Evolution occurs when evolutionary processes such as natural selection (including sexual selection) and genetic drift act on this variation, resulting in certain characteristics becoming more common or more rare within a population. The evolutionary pressures that determine whether a characteristic is common or rare within a population constantly change, resulting in a change in heritable characteristics arising over successive generations. It is this process of evolution that has given rise to biodiversity at every level of biological organisation, including the levels of species, individual organisms, and molecules. The theory of evol ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Helitron (biology)
Helitrons are one of the three groups of eukaryotic class 2 transposable elements (TEs) so far described. They are the eukaryotic rolling-circle transposable elements which are hypothesized to transpose by a rolling circle replication mechanism via a single-stranded DNA intermediate. They were first discovered in plants (''Arabidopsis thaliana'' and ''Oryza sativa'') and in the nematode ''Caenorhabditis elegans'', and now they have been identified in a diverse range of species, from protists to mammals. Helitrons make up a substantial fraction of many genomes where non-autonomous elements frequently outnumber the putative autonomous partner. Helitrons seem to have a major role in the evolution of host genomes. They frequently capture diverse host genes, some of which can evolve into novel host genes or become essential for Helitron transposition. History Helitrons were the first group of TEs to be discovered by computational analysis of whole genome sequences. The first Helitrons d ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Transposons
A transposable element (TE, transposon, or jumping gene) is a nucleic acid sequence in DNA that can change its position within a genome, sometimes creating or reversing mutations and altering the cell's genetic identity and genome size. Transposition often results in duplication of the same genetic material. Barbara McClintock's discovery of them earned her a Nobel Prize in 1983. Its importance in personalized medicine is becoming increasingly relevant, as well as gaining more attention in data analytics given the difficulty of analysis in very high dimensional spaces. Transposable elements make up a large fraction of the genome and are responsible for much of the mass of DNA in a eukaryotic cell. Although TEs are selfish genetic elements, many are important in genome function and evolution. Transposons are also very useful to researchers as a means to alter DNA inside a living organism. There are at least two classes of TEs: Class I TEs or retrotransposons generally fu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Theoretical Population Biology
''Theoretical Population Biology'' is a peer-reviewed scientific journal covering research on theoretical aspects population biology in its widest sense, including mathematical modelling of populations, ecology, evolution, genetics, demography, and epidemiology. The editor-in-chief is Noah A. Rosenberg (Stanford University), who in January 2013 succeeded the founding editor Marcus Feldman (Stanford University). The journal has a partnership with the journal ''Genetics'', exchanging manuscripts in between the two if they are a better fit of the other journal's scope. Abstracting and indexing The journal is abstracted and indexed in: According to the ''Journal Citation Reports'', the journal has a 2020 impact factor The impact factor (IF) or journal impact factor (JIF) of an academic journal is a scientometric index calculated by Clarivate that reflects the yearly mean number of citations of articles published in the last two years in a given journal, as i ... of 1.57. Ref ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Proceedings Of The National Academy Of Sciences
''Proceedings of the National Academy of Sciences of the United States of America'' (often abbreviated ''PNAS'' or ''PNAS USA'') is a peer-reviewed multidisciplinary scientific journal. It is the official journal of the National Academy of Sciences, published since 1915, and publishes original research, scientific reviews, commentaries, and letters. According to ''Journal Citation Reports'', the journal has a 2021 impact factor of 12.779. ''PNAS'' is the second most cited scientific journal, with more than 1.9 million cumulative citations from 2008 to 2018. In the mass media, ''PNAS'' has been described variously as "prestigious", "sedate", "renowned" and "high impact". ''PNAS'' is a delayed open access journal, with an embargo period of six months that can be bypassed for an author fee ( hybrid open access). Since September 2017, open access articles are published under a Creative Commons license. Since January 2019, ''PNAS'' has been online-only, although print issues are ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alu Element
An Alu element is a short stretch of DNA originally characterized by the action of the '' Arthrobacter luteus (Alu)'' restriction endonuclease. ''Alu'' elements are the most abundant transposable elements, containing over one million copies dispersed throughout the human genome. ''Alu'' elements were thought to be selfish or parasitic DNA, because their sole known function is self reproduction. However, they are likely to play a role in evolution and have been used as genetic markers. They are derived from the small cytoplasmic 7SL RNA, a component of the signal recognition particle. ''Alu'' elements are highly conserved within primate genomes and originated in the genome of an ancestor of Supraprimates. ''Alu'' insertions have been implicated in several inherited human diseases and in various forms of cancer. The study of Alu elements has also been important in elucidating human population genetics and the evolution of primates, including the evolution of humans. Alu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Stanislaw Ulam
Stanisław Marcin Ulam (; 13 April 1909 – 13 May 1984) was a Polish-American scientist in the fields of mathematics and nuclear physics. He participated in the Manhattan Project, originated the Teller–Ulam design of thermonuclear weapons, discovered the concept of the cellular automaton, invented the Monte Carlo method of computation, and suggested nuclear pulse propulsion. In pure and applied mathematics, he proved some theorems and proposed several conjectures. Born into a wealthy Polish Jewish family, Ulam studied mathematics at the Lwów Polytechnic Institute, where he earned his PhD in 1933 under the supervision of Kazimierz Kuratowski and Włodzimierz Stożek. In 1935, John von Neumann, whom Ulam had met in Warsaw, invited him to come to the Institute for Advanced Study in Princeton, New Jersey, for a few months. From 1936 to 1939, he spent summers in Poland and academic years at Harvard University in Cambridge, Massachusetts, where he worked to establish im ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Erdős Number
The Erdős number () describes the "collaborative distance" between mathematician Paul Erdős and another person, as measured by authorship of mathematical papers. The same principle has been applied in other fields where a particular individual has collaborated with a large and broad number of peers. Overview Paul Erdős (1913–1996) was an influential Hungarian mathematician who in the latter part of his life spent a great deal of time writing papers with a large number of colleagues, working on solutions to outstanding mathematical problems. He published more papers during his lifetime (at least 1,525) than any other mathematician in history. (Leonhard Euler published more total pages of mathematics but fewer separate papers: about 800.) Erdős spent a large portion of his later life living out of a suitcase, visiting over 500 collaborators around the world. The idea of the Erdős number was originally created by the mathematician's friends as a tribute to his enormous o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Emile Zuckerkandl
Émile Zuckerkandl (July 4, 1922 – November 9, 2013) was an Austrian-born French biologist considered one of the founders of the field of molecular evolution. He introduced, with Linus Pauling, the concept of the "molecular clock", which enabled the neutral theory of molecular evolution. Life and work Zuckerkandl was raised in Vienna, Austria in a household of intellectuals, but his family relocated in 1938 to Paris, and later Algiers, to escape the racial policy of Nazi Germany with respect to Jews. At the end of World War II, he spent one year at the University of Paris (Sorbonne), then came to the United States to study physiology—earning a master's degree in 1947 from the University of Illinois, under C. Ladd Prosser—then returned to the Sorbonne to complete a Ph.D. in biology. Zuckerkandl developed a strong interest in molecular problems; his early research at a marine biology lab in Roscoff emphasized the roles of copper oxidases and hemocyanin in the molting cycle ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Temple Smith
Temple Ferris Smith (born March 7, 1939) is an emeritus professor in biomedical engineering who helped to develop the Smith-Waterman algorithm with Michael Waterman in 1981. The Smith-Waterman algorithm serves as the basis for multi sequence comparisons, identifying the segment with the maximum local sequence similarity, see sequence alignment. This algorithm is used for identifying similar DNA, RNA and protein segments. He was director of the BioMolecular Engineering Research Center at Boston University for twenty years and is now professor emeritus. Education Smith obtained his bachelor's degree in 1963 from the Physics Department, Purdue University, followed by a PhD in 1969 in the Physics Department, University of Colorado at Boulder. Research and career After his PhD, smith did postdoctoral research from March 1969 to August 1971 in the Department of Biophysics and Genetics, University of Colorado Medical School, Boulder. His research is centered on the application of va ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
