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Jeff W. Lichtman
Jeff W. Lichtman (born 1951) is an American neuroscientist. He is the Jeremy R. Knowles Professor of Molecular and Cellular Biology and Santiago Ramón y Cajal Professor of Arts and Sciences at Harvard University. He is best known for his pioneering work developing the neuroimaging connectomic technique known as Brainbow. Education and career Lichtman was born in Salt Lake City, Utah in 1951. He grew up in the Northeastern United States. Lichtman received a BA from Bowdoin College in 1973. In 1980, he received both MD and PhD from Washington University in St. Louis, where he was advised by Dale Purves. After completing postdoctoral work at Harvard Medical School, he established his lab at Washington University School of Medicine and conducted research there for 30 years. In 2004, he was appointed Jeremy R. Knowles Professor of Molecular and Cellular Biology at Harvard University. In 2013, he was named the inaugural Santiago Ramón y Cajal Professor, a five-year appointment ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Salt Lake City
Salt Lake City, often shortened to Salt Lake or SLC, is the capital and most populous city of the U.S. state of Utah. It is the county seat of Salt Lake County, the most populous county in the state. The city is the core of the Salt Lake City Metropolitan Statistical Area (MSA), which had a population of 1,257,936 at the 2020 census. Salt Lake City is further situated within a larger metropolis known as the Salt Lake City–Ogden–Provo Combined Statistical Area, a corridor of contiguous urban and suburban development stretched along a segment of the Wasatch Front, comprising a population of 2,746,164 (as of 2021 estimates), making it the 22nd largest in the nation. With a population of 199,723 in 2020, it is the 111th most populous city in the United States. It is also the central core of the larger of only two major urban areas located within the Great Basin (the other being Reno, Nevada). Salt Lake City was founded on July 24, 1847 by settlers led by Brigham Young ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Northeastern United States
The Northeastern United States (also referred to as the Northeast, the East Coast, or the American Northeast) is List of regions of the United States, census regions United States Census Bureau. Located on the East Coast of the United States, Atlantic coast of North America, the region borders Canada to its north, the Southern United States to its south, the Midwestern United States to its west, and the Atlantic Ocean to its east. The Northeast is one of the four regions defined by the U.S. Census Bureau for the collection and analysis of statistics. The Census Bureau defines the region as including the six New England states of Connecticut, Maine, Massachusetts, New Hampshire, Rhode Island, and Vermont, and three lower North-Eastern states of New Jersey, New York (state), New York, and Pennsylvania. Some expanded definitions of the region include Mid-Atlantic (United States), Mid-Atlantic locations such as Delaware, Maryland, Northern Virginia, and Washington, D.C. The regio ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nervous System
In biology, the nervous system is the complex system, highly complex part of an animal that coordinates its behavior, actions and sense, sensory information by transmitting action potential, signals to and from different parts of its body. The nervous system detects environmental changes that impact the body, then works in tandem with the endocrine system to respond to such events. Nervous tissue first arose in Ediacara biota, wormlike organisms about 550 to 600 million years ago. In Vertebrate, vertebrates, it consists of two main parts, the central nervous system (CNS) and the peripheral nervous system (PNS). The CNS consists of the brain and spinal cord. The PNS consists mainly of nerves, which are enclosed bundles of the long fibers, or axons, that connect the CNS to every other part of the body. Nerves that transmit signals from the brain are called motor nerves (efferent), while those nerves that transmit information from the body to the CNS are called sensory nerves (aff ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Joshua R
Joshua ( ), also known as Yehoshua ( ''Yəhōšuaʿ'', Tiberian: ''Yŏhōšuaʿ,'' lit. 'Yahweh is salvation'), Jehoshua, or Josue, functioned as Moses' assistant in the books of Exodus and Numbers, and later succeeded Moses as leader of the Israelite tribes in the Book of Joshua of the Hebrew Bible. His name was Hoshea ( ''Hōšēaʿ'', lit. 'Save') the son of Nun, of the tribe of Ephraim, but Moses called him "Yehoshua" (translated as "Joshua" in English),''Bible'' the name by which he is commonly known in English. According to the Bible, he was born in Egypt prior to the Exodus. The Hebrew Bible identifies Joshua as one of the twelve spies of Israel sent by Moses to explore the land of Canaan. In and after the death of Moses, he led the Israelite tribes in the conquest of Canaan, and allocated lands to the tribes. According to biblical chronology, Joshua lived some time in the Bronze Age. According to Joshua died at the age of 110. Joshua holds a position of respect ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genetically Modified Mouse
A genetically modified mouse, genetically engineered mouse model (GEMM) or transgenic mouse is a mouse (''Mus musculus'') that has had its genome altered through the use of genetic engineering techniques. Genetically modified mice are commonly used for research or as animal models of human diseases and are also used for research on genes. Together with patient-derived xenografts (PDXs), GEMMs are the most common '' in vivo'' models in cancer research. The two approaches are considered complementary and may be used to recapitulate different aspects of disease. GEMMs are also of great interest for drug development, as they facilitate target validation and the study of response, resistance, toxicity and pharmacodynamics. History In 1974 Beatrice Mintz and Rudolf Jaenisch created the first genetically modified animal by inserting a DNA virus into an early-stage mouse embryo and showing that the inserted genes were present in every cell. However, the mice did not pass the transgene ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Synaptic Plasticity
In neuroscience, synaptic plasticity is the ability of synapses to Chemical synapse#Synaptic strength, strengthen or weaken over time, in response to increases or decreases in their activity. Since memory, memories are postulated to be represented by vastly interconnected neural circuits in the brain, synaptic plasticity is one of the important neurochemical foundations of learning and memory (''see Hebbian theory''). Plastic change often results from the alteration of the number of neurotransmitter receptors located on a synapse. There are several underlying mechanisms that cooperate to achieve synaptic plasticity, including changes in the quantity of neurotransmitters released into a synapse and changes in how effectively cells respond to those neurotransmitters. Synaptic plasticity in both Excitatory synapse, excitatory and Inhibitory synapse, inhibitory synapses has been found to be dependent upon postsynaptic calcium release. Historical discoveries In 1973, Terje Lømo and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Synaptic Pruning
Synaptic pruning is the process of synapse elimination or weakening. Though it occurs throughout the lifespan of a mammal, the most active period of synaptic pruning in the development of the nervous system occurs between early childhood and the onset of puberty in many mammals, including humans. Pruning starts near the time of birth and continues into the late-20s. During elimination of a synapse, the axon withdraws or dies off, and the dendrite decays and die off. Synaptic pruning was traditionally considered to be complete by the time of sexual maturation, but magnetic resonance imaging studies have discounted this idea. The infant brain will increase in size by a factor of up to 5 by adulthood. Two factors contribute to this growth: the growth of synaptic connections between neurons and the myelination of nerve fibers. The total number of neurons, however, remains approximately the same, containing approximately 86 (± 8) billion neurons. After adolescence, the volume of the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Axon
An axon (from Greek ἄξων ''áxōn'', axis) or nerve fiber (or nerve fibre: see American and British English spelling differences#-re, -er, spelling differences) is a long, slender cellular extensions, projection of a nerve cell, or neuron, in Vertebrate, vertebrates, that typically conducts electrical impulses known as action potentials away from the Soma (biology), nerve cell body. The function of the axon is to transmit information to different neurons, muscles, and glands. In certain sensory neurons (pseudounipolar neurons), such as those for touch and warmth, the axons are called afferent nerve fibers and the electrical impulse travels along these from the peripheral nervous system, periphery to the cell body and from the cell body to the spinal cord along another branch of the same axon. Axon dysfunction can be the cause of many inherited and acquired neurological disorders that affect both the Peripheral nervous system, peripheral and Central nervous system, central ne ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Autonomic Nervous System
The autonomic nervous system (ANS), sometimes called the visceral nervous system and formerly the vegetative nervous system, is a division of the nervous system that operates viscera, internal organs, smooth muscle and glands. The autonomic nervous system is a control system that acts largely unconsciously and regulates bodily functions, such as the heart rate, its Myocardial contractility, force of contraction, digestion, respiratory rate, pupillary dilation, pupillary response, Micturition, urination, and Animal sexual behaviour, sexual arousal. The fight-or-flight response, also known as the acute stress response, is set into action by the autonomic nervous system. The autonomic nervous system is regulated by integrated reflexes through the brainstem to the spinal cord and organ (anatomy), organs. Autonomic functions include control of respiration, heart rate, cardiac regulation (the cardiac control center), vasomotor activity (the vasomotor center), and certain reflex, reflex ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Motor System
The motor system is the set of central nervous system, central and peripheral nervous system, peripheral structures in the nervous system that support motor functions, i.e. movement. Peripheral structures may include skeletal muscles and Efferent nerve fiber#Motor nerve, neural connections with muscle tissues. Central structures include cerebral cortex, brainstem, spinal cord, pyramidal system including the upper motor neurons, extrapyramidal system, cerebellum, and the lower motor neurons in the brainstem and the spinal cord. The motor system is a biological system with close ties to the muscular system and the circulatory system. To achieve motor skill, the motor system must accommodate the working state of the muscles, whether hot or cold, stiff or loose, as well as physiological fatigue. Pyramidal motor system The pyramidal tracts, pyramidal motor system, also called the pyramidal tract or the corticospinal tract, start in the motor center of the cerebral cortex.Rizzolatti ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Activity-dependent Plasticity
Activity-dependent plasticity is a form of functional and structural neuroplasticity that arises from the use of cognitive functions and personal experience. Hence, it is the biological basis for learning and the formation of new memory, memories. Activity-dependent plasticity is a form of neuroplasticity that arises from intrinsic or endogenous activity, as opposed to forms of neuroplasticity that arise from extrinsic or exogenous factors, such as electrical brain stimulation- or drug-induced neuroplasticity. The brain's ability to remodel itself forms the basis of the brain's capacity to retain memories, improve motor function, and enhance comprehension and speech amongst other things. It is this trait to retain and form memories that is associated with neural plasticity and therefore many of the functions individuals perform on a daily basis. This plasticity occurs as a result of changes in gene expression which are triggered by signaling cascades that are activated by various s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
