|
Jamestown Canyon Virus
Jamestown Canyon encephalitis is an infectious disease caused by the Jamestown Canyon virus, an orthobunyavirus of the California serogroup. It is mainly spread during the summer by different mosquito species in the United States and Canada. The virus is one of a group of mosquito-borne or arthropod-borne viruses, also called arboviruses, that can cause fever and meningitis or meningoencephalitis, mostly in adults. Jamestown Canyon virus disease is relatively rare; in the United States, the CDC found only 31 disease cases from 2000 to 2013, but it is likely under-recognized and probably endemic throughout most of the United States and parts of Canada. Signs and symptoms About 2 days to 2 weeks after the bite of an infected mosquito, disease symptoms of a nonspecific summertime illness with sore throat, runny nose and cough, followed by fever, headache, nausea and vomiting can develop. Many cases are asymptomatic, although the ratio of symptomatic to asymptomatic cases is unkno ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Infectious Disease (medical Speciality)
Infectious diseases (ID), also known as infectiology, is a medical specialty dealing with the diagnosis and treatment of infections. An infectious diseases specialist's practice consists of managing nosocomial ( healthcare-acquired) infections or community-acquired infections. An ID specialist investigates and determines the cause of a disease (bacteria, virus, parasite, fungus or prions). Once the cause is known, an ID specialist can then run various tests to determine the best drug to treat the disease. While infectious diseases have always been around, the infectious disease specialty did not exist until the late 1900s after scientists and physicians in the 19th century paved the way with research on the sources of infectious disease and the development of vaccines. Scope Infectious diseases specialists typically serve as consultants to other physicians in cases of complex infections, and often manage patients with HIV/AIDS and other forms of immunodeficiency. Although many co ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
White-tailed Deer
The white-tailed deer (''Odocoileus virginianus''), also known Common name, commonly as the whitetail and the Virginia deer, is a medium-sized species of deer native to North America, North, Central America, Central and South America. It is the most widely-distributed mainland ungulate herbivore in the Americas; coupled with its natural predator, the Cougar, mountain lion (''Puma concolor''), it is one of the most widely-distributed terrestrial mammal species in the Americas and the world. Highly adaptable, the various subspecies of white-tailed deer inhabit many different ecosystems, from arid grasslands to the Amazon basin, Amazon and Orinoco Basin, Orinoco basins; from the Pantanal and the Llanos to the high-elevation terrain of the Andes. Globally, the white-tailed deer has been introduced (primarily for Trophy hunting, sport hunting) to New Zealand, the Greater Antilles of the Caribbean (Cuba, Jamaica, Hispaniola, and Puerto Rico), and some countries in Europe (mainly the Cz ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Complement-fixation Test
The complement fixation test is an immunological medical test that can be used to detect the presence of either specific antibody or specific antigen in a patient's serum, based on whether complement fixation occurs. It was widely used to diagnose infections, particularly with microbes that are not easily detected by culture methods, and in rheumatic diseases. However, in clinical diagnostics labs it has been largely superseded by other serological methods such as ELISA and by DNA-based methods of pathogen detection, particularly PCR. Process The complement system is a system of serum proteins that react with antigen-antibody complexes. If this reaction occurs on a cell surface, it will result in the formation of trans-membrane pores and therefore destruction of the cell. The basic steps of a complement fixation test are as follows: # Serum is separated from the patient. # Patients naturally have different levels of complement proteins in their serum. To negate any effects th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Immunofluorescence Assay
Immunofluorescence (IF) is a light microscopy-based technique that allows detection and localization of a wide variety of target biomolecules within a cell or tissue at a quantitative level. The technique utilizes the binding specificity of antibodies and antigens. The specific region an antibody recognizes on an antigen is called an epitope. Several antibodies can recognize the same epitope but differ in their binding affinity. The antibody with the higher affinity for a specific epitope will surpass antibodies with a lower affinity for the same epitope. By conjugating the antibody to a fluorophore, the position of the target biomolecule is visualized by exciting the fluorophore and measuring the emission of light in a specific predefined wavelength using a fluorescence microscope. It is imperative that the binding of the fluorophore to the antibody itself does not interfere with the immunological specificity of the antibody or the binding capacity of its antigen. Immunofluoresc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
ELISA
The enzyme-linked immunosorbent assay (ELISA) (, ) is a commonly used analytical biochemistry assay, first described by Eva Engvall and Peter Perlmann in 1971. The assay is a solid-phase type of enzyme immunoassay (EIA) to detect the presence of a ligand (commonly an amino acid) in a liquid sample using antibodies directed against the ligand to be measured. ELISA has been used as a medical diagnosis, diagnostic tool in medicine, plant pathology, and biotechnology, as well as a quality control check in various industries. In the most simple form of an ELISA, antigens from the sample to be tested are attached to a surface. Then, a matching antibody is applied over the surface so it can bind the antigen. This antibody is linked to an enzyme, and then any unbound antibodies are removed. In the final step, a substance containing the enzyme's Enzyme substrate, substrate is added. If there was binding, the subsequent reaction produces a detectable signal, most commonly a color change. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Plaque Reduction Neutralization Test
The plaque reduction neutralization test is used to quantify the titer of neutralizing antibody for a virus. The serum sample or solution of antibody to be tested is diluted and mixed with a viral suspension. This is incubated to allow the antibody to react with the virus. This is poured over a confluent monolayer of host cells. The surface of the cell layer is covered in a layer of agar or carboxymethyl cellulose to prevent the virus from spreading indiscriminately. The concentration of plaque forming units can be estimated by the number of plaques (regions of infected cells) formed after a few days. Depending on the virus, the plaque forming units are measured by microscopic observation, fluorescent antibodies or specific dyes that react with infected cells. The concentration of serum to reduce the number of plaques by 50% compared to the serum free virus gives the measure of how much antibody is present or how effective it is. This measurement is denoted as the PRNT50 value. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
New York State Department Of Health
The New York State Department of Health is the department of the Government of New York (state), New York state government responsible for public health. Its regulations are compiled in title 10 of the ''New York Codes, Rules and Regulations''. Public health infrastructure New York State relies on a county-based system for delivery of public health services. The Department of Health promotes the prevention and control of disease, environmental health, healthy lifestyles, and emergency preparedness and response; supervises local health boards; oversees reporting and vital records; conducts surveillance of hospitals; does research at the Wadsworth Center; and administers several other health insurance programs and institutions. 58 local health departments offer core services including assessing community health, disease control and prevention, family health, and health education; 37 localities provide environmental health services, while the other 21 rely on the state's Departm ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Convalescent
Convalescence is the gradual recovery of health and strength after illness or injury. Details It refers to the later stage of an infectious disease or illness when the patient recovers and returns to previous health, but may continue to be a source of infection to others even if feeling better. In this sense, " recovery" can be considered a synonymous term. This also sometimes includes patient care after a major surgery, under which they are required to visit the doctor for regular check-up In a physical examination, medical examination, clinical examination, or medical checkup, a medical practitioner examines a patient for any possible medical signs or symptoms of a medical condition. It generally consists of a series of questio ...s. Convalescent care facilities are sometimes recognized by the acronym TCF (Transitional Convalescent Facilities). Traditionally, time has been allowed for convalescence to happen. Nowadays, in some instances, where there is a shortage of h ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neutralizing Antibody
A neutralizing antibody (NAb) is an antibody that defends a cell from a pathogen or infectious particle by neutralizing any effect it has biologically. Neutralization renders the particle no longer infectious or pathogenic. Neutralizing antibodies are part of the humoral response of the adaptive immune system against viruses, bacteria and microbial toxin. By binding specifically to surface structures (antigen) on an infectious particle, neutralizing antibodies prevent the particle from interacting with its host cells it might infect and destroy. Mechanism In order to enter cells, pathogens, such as circulating viral particles or extracellular bacteria, use molecules on their surfaces to interact with the cell surface receptors of their target cell which allows them to enter the cell and start their replication cycle. Neutralizing antibodies can inhibit infectivity by binding to the pathogen and blocking the molecules needed for cell entry. This can be due to the antibodies s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Centers For Disease Control And Prevention
The Centers for Disease Control and Prevention (CDC) is the National public health institutes, national public health agency of the United States. It is a Federal agencies of the United States, United States federal agency under the United States Department of Health and Human Services, Department of Health and Human Services (HHS), and is headquartered in Atlanta, Georgia. The CDC's current nominee for director is Susan Monarez. She became acting director on January 23, 2025, but stepped down on March 24, 2025 when nominated for the director position. On May 14, 2025, Robert F. Kennedy Jr. stated that lawyer Matthew Buzzelli is acting CDC director. However, the CDC web site does not state the acting director's name. The agency's main goal is the protection of public health and safety through the control and prevention of disease, injury, and disability in the US and worldwide. The CDC focuses national attention on developing and applying disease control and prevention. It e ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ingå
Ingå (; , ) is a municipality in Finland, located in the southern coast of the country. Ingå is situated in the western part of the Uusimaa region. The population of Ingå is approximately , while the Raseborg sub-region, sub-region has a population of approximately . It is the most populous Municipalities of Finland, municipality in Finland. Ingå is located east of Ekenäs, Finland, Ekenäs, the town centre of Raseborg. Ingå covers an area of of which is water. The population density is . Ingå is a bilingual municipality with Finnish language, Finnish and Swedish language, Swedish as its official languages. The population consists of Finnish speakers, Swedish speakers, and speakers of other languages. Finnish national road 51 goes right through the southern part of Ingå. The centre consists mainly of the road ''Bollstavägen'' that cuts through the Ingå centrum. Along the road are most of the major buildings and shops of the small municipality. A few grocery store ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sequence Conservation
In evolutionary biology, conserved sequences are identical or similar sequences in nucleic acids (DNA and RNA) or proteins across species ( orthologous sequences), or within a genome ( paralogous sequences), or between donor and receptor taxa ( xenologous sequences). Conservation indicates that a sequence has been maintained by natural selection. A highly conserved sequence is one that has remained relatively unchanged far back up the phylogenetic tree, and hence far back in geological time. Examples of highly conserved sequences include the RNA components of ribosomes present in all domains of life, the homeobox sequences widespread amongst eukaryotes, and the tmRNA in bacteria. The study of sequence conservation overlaps with the fields of genomics, proteomics, evolutionary biology, phylogenetics, bioinformatics and mathematics. History The discovery of the role of DNA in heredity, and observations by Frederick Sanger of variation between animal insulins in 1949, promp ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
