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James L. Manley
James Manley is the Julian Clarence Levi Professor of Life Sciences at Columbia University, where his laboratory studies gene expression in mammalian cells. Manley and colleagues identified and characterized the key factors responsible for polyadenylation of mRNA precursors, and elucidated how this remarkably complex machinery functions in gene regulation, for example during cell growth and differentiation. He has also studied the mechanism and regulation of the process by which introns are removed from mRNA precursors, mRNA splicing. Manley and his coworkers codiscovered the first alternative splicing factor (SR protein), characterized how this and other splicing regulatory proteins function and are themselves regulated, showed how alternative splicing can become deregulated in disease, and with respect to mechanism demonstrated that two spliceosomal small nuclear RNAs by themselves have catalytic activity. Finally, he elucidated unexpected links between these mRNA processing r ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Minneapolis, Minnesota
Minneapolis () is the largest city in Minnesota, United States, and the county seat of Hennepin County. The city is abundant in water, with thirteen lakes, wetlands, the Mississippi River, creeks and waterfalls. Minneapolis has its origins in timber and as the flour milling capital of the world. It occupies both banks of the Mississippi River and adjoins Saint Paul, the state capital of Minnesota. Prior to European settlement, the site of Minneapolis was inhabited by Dakota people. The settlement was founded along Saint Anthony Falls on a section of land north of Fort Snelling; its growth is attributed to its proximity to the fort and the falls providing power for industrial activity. , the city has an estimated 425,336 inhabitants. It is the most populous city in the state and the 46th-most-populous city in the United States. Minneapolis, Saint Paul and the surrounding area are collectively known as the Twin Cities. Minneapolis has one of the most extensive public ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
United States Of America
The United States of America (U.S.A. or USA), commonly known as the United States (U.S. or US) or America, is a country primarily located in North America. It consists of 50 states, a federal district, five major unincorporated territories, nine Minor Outlying Islands, and 326 Indian reservations. The United States is also in free association with three Pacific Island sovereign states: the Federated States of Micronesia, the Marshall Islands, and the Republic of Palau. It is the world's third-largest country by both land and total area. It shares land borders with Canada to its north and with Mexico to its south and has maritime borders with the Bahamas, Cuba, Russia, and other nations. With a population of over 333 million, it is the most populous country in the Americas and the third most populous in the world. The national capital of the United States is Washington, D.C. and its most populous city and principal financial center is New York City. Paleo-Am ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Americans
Americans are the citizens and nationals of the United States of America.; ; Although direct citizens and nationals make up the majority of Americans, many dual citizens, expatriates, and permanent residents could also legally claim American nationality. The United States is home to people of many racial and ethnic origins; consequently, American culture and law do not equate nationality with race or ethnicity, but with citizenship and an oath of permanent allegiance. Overview The majority of Americans or their ancestors immigrated to the United States or are descended from people who were brought as slaves within the past five centuries, with the exception of the Native American population and people from Hawaii, Puerto Rico, Guam, and the Philippine Islands, who became American through expansion of the country in the 19th century, additionally America expanded into American Samoa, the U.S. Virgin Islands and Northern Mariana Islands in the 20th century. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biology
Biology is the scientific study of life. It is a natural science with a broad scope but has several unifying themes that tie it together as a single, coherent field. For instance, all organisms are made up of cells that process hereditary information encoded in genes, which can be transmitted to future generations. Another major theme is evolution, which explains the unity and diversity of life. Energy processing is also important to life as it allows organisms to move, grow, and reproduce. Finally, all organisms are able to regulate their own internal environments. Biologists are able to study life at multiple levels of organization, from the molecular biology of a cell to the anatomy and physiology of plants and animals, and evolution of populations.Based on definition from: Hence, there are multiple subdisciplines within biology, each defined by the nature of their research questions and the tools that they use. Like other scientists, biologists use t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Columbia University
Columbia University (also known as Columbia, and officially as Columbia University in the City of New York) is a private research university in New York City. Established in 1754 as King's College on the grounds of Trinity Church in Manhattan, Columbia is the oldest institution of higher education in New York and the fifth-oldest institution of higher learning in the United States. It is one of nine colonial colleges founded prior to the Declaration of Independence. It is a member of the Ivy League. Columbia is ranked among the top universities in the world. Columbia was established by royal charter under George II of Great Britain. It was renamed Columbia College in 1784 following the American Revolution, and in 1787 was placed under a private board of trustees headed by former students Alexander Hamilton and John Jay. In 1896, the campus was moved to its current location in Morningside Heights and renamed Columbia University. Columbia scientists and scholars hav ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Stony Brook University
Stony Brook University (SBU), officially the State University of New York at Stony Brook, is a public research university in Stony Brook, New York. Along with the University at Buffalo, it is one of the State University of New York system's two flagship institutions. Its campus consists of 213 buildings on over of land in Suffolk County and it is the largest public university (by area) in the state of New York. Opened in 1957 in Oyster Bay as the State University College on Long Island, the institution moved to Stony Brook in 1962. In 2001, Stony Brook was elected to the Association of American Universities, a selective group of major research universities in North America. It is also a member of the larger Universities Research Association. It is classified among "R1: Doctoral Universities – Very high research activity". Stony Brook University, in partnership with Battelle, manages Brookhaven National Laboratory, a national laboratory of the United States De ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Julian Clarence Levi
Julian Clarence Levi (December 8, 1874 – August 23, 1971) was an American architect, watercolor painter, and philanthropist. Biography Levi was born on December 8, 1874, on West 51st Street in Midtown Manhattan. His father, Albert Augustus Levi, was an investment banker originally from Germany and was one of the trustees of the Society for Ethical Culture upon its founding in 1877. The elder Levi was also a brother-in-law of the Seligman brothers who founded J. & W. Seligman & Co. Levi helped found the San Francisco branch of the family business, J. Seligman & Co. Two of his aunts married into the Seligman family and his uncles-in-law included prominent investment bankers Isaac Seligman and Joseph Seligman. He attended Columbia College, graduating in 1896, and attended the Columbia School of Architecture for two years before moving to Paris to study at the Beaux-Arts de Paris. He joined the practice of Francis H. Kimball upon finishing his studies and designed the J. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Columbia College, Columbia University
Columbia College is the oldest undergraduate college of Columbia University, situated on the university's main campus in Morningside Heights in the borough of Manhattan in New York City. It was founded by the Church of England in 1754 as King's College, receiving a royal charter from King George II of Great Britain. It is the oldest institution of higher learning in the state of New York and the fifth oldest in the United States. Columbia College (along with Columbia Engineering) is distinctive for its comprehensive Core Curriculum and is among the most selective colleges in its admissions. History Columbia College was founded as King's College, by royal charter of King George II of Great Britain, in the Province of New York in 1754. Due in part to the influence of Church of England religious leaders, a site in New York City in the Trinity Church yard, Wall Street on the island of Manhattan was selected, however it would only remain at this site for less than a decade. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gene Expression
Gene expression is the process by which information from a gene is used in the synthesis of a functional gene product that enables it to produce end products, protein or non-coding RNA, and ultimately affect a phenotype, as the final effect. These products are often proteins, but in non-protein-coding genes such as transfer RNA (tRNA) and small nuclear RNA (snRNA), the product is a functional non-coding RNA. Gene expression is summarized in the central dogma of molecular biology first formulated by Francis Crick in 1958, further developed in his 1970 article, and expanded by the subsequent discoveries of reverse transcription and RNA replication. The process of gene expression is used by all known life— eukaryotes (including multicellular organisms), prokaryotes (bacteria and archaea), and utilized by viruses—to generate the macromolecular machinery for life. In genetics, gene expression is the most fundamental level at which the genotype gives rise to the phen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
NIH MERIT Award
The NIH MERIT award (Method To Extend Research in Time) Award (R37) was created by the National Institutes of Health The National Institutes of Health, commonly referred to as NIH (with each letter pronounced individually), is the primary agency of the United States government The federal government of the United States (U.S. federal government or U ... in 1986. It is a prestigious award designed to provide stable, long-term funding support to outstanding, experienced investigators whose productivity is distinctly superior and who are deemed highly likely to continue to perform their research activities in an outstanding manner. The MERIT award provided funding for 5 years and could be renewed for up to 10 years. Unlike most NIH grant awards, the MERIT award can not be applied for by the investigator. Researchers submitting an R01 that receives a fundable score are considered for the award. In 2018, the NIH began awarding MERIT awards to "Early Stage Investigators", ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
National Academy Of Sciences
The National Academy of Sciences (NAS) is a United States nonprofit, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the National Academy of Medicine (NAM). As a national academy, new members of the organization are elected annually by current members, based on their distinguished and continuing achievements in original research. Election to the National Academy is one of the highest honors in the scientific field. Members of the National Academy of Sciences serve '' pro bono'' as "advisers to the nation" on science, engineering, and medicine. The group holds a congressional charter under Title 36 of the United States Code. Founded in 1863 as a result of an Act of Congress that was approved by Abraham Lincoln, the NAS is charged with "providing independent, objective advice to the nation on matters related to science and technology. ... to provide sci ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
21st-century American Biologists
The 1st century was the century spanning AD 1 (Roman numerals, I) through AD 100 (Roman numerals, C) according to the Julian calendar. It is often written as the or to distinguish it from the 1st century BC (or BCE) which preceded it. The 1st century is considered part of the Classical era, epoch, or History by period, historical period. The 1st century also saw the Christianity in the 1st century, appearance of Christianity. During this period, Europe, North Africa and the Near East fell under increasing domination by the Roman Empire, which continued expanding, most notably conquering Britain under the emperor Claudius (AD 43). The reforms introduced by Augustus during his long reign stabilized the empire after the turmoil of the previous century's civil wars. Later in the century the Julio-Claudian dynasty, which had been founded by Augustus, came to an end with the suicide of Nero in AD 68. There followed the famous Year of Four Emperors, a brief period of civil war and inst ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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