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James Homer Wright
James Homer Wright (April 8, 1869 – January 3, 1928) was an early and influential American pathologist, who was chief of pathology at Massachusetts General Hospital from 1896 to 1926. Wright was born in Pittsburgh, Pennsylvania. In 1915, he joined with Richard C. Cabot to begin publication of the ''Case Records of the Massachusetts General Hospital''. These began regular publication as the ''Boston Medical and Surgical Journal'' which later became the ''New England Journal of Medicine''. In 1924, Wright, along with Frank B. Mallory, published ''Pathological Technique: A Practical Manual for the Pathological Laboratory''. The book saw eight editions and for many years was the standard textbook in the field. He is the Wright in Wright's stain, and the Homer Wright rosettes associated with neuroblastoma Neuroblastoma (NB) is a type of cancer that forms in certain types of nerve tissue. It most frequently starts from one of the adrenal glands but can also develop in the hea ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pittsburgh, Pennsylvania
Pittsburgh ( ) is a city in Allegheny County, Pennsylvania, United States, and its county seat. It is the List of municipalities in Pennsylvania#Municipalities, second-most populous city in Pennsylvania (after Philadelphia) and the List of United States cities by population, 67th-most populous city in the U.S., with a population of 302,971 as of the 2020 United States census, 2020 census. The city is located in Western Pennsylvania, southwestern Pennsylvania at the confluence of the Allegheny River and Monongahela River, which combine to form the Ohio River. It anchors the Greater Pittsburgh, Pittsburgh metropolitan area, which had a population of 2.457 million residents and is the largest metro area in both the Ohio Valley and Appalachia, the Pennsylvania metropolitan areas, second-largest in Pennsylvania, and the List of metropolitan statistical areas, 26th-largest in the U.S. Pittsburgh is the principal city of the greater Pittsburgh–New Castle–Weirton combined statistic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Google Books
Google Books (previously known as Google Book Search, Google Print, and by its code-name Project Ocean) is a service from Google that searches the full text of books and magazines that Google has scanned, converted to text using optical character recognition (OCR), and stored in its digital database.The basic Google book link is found at: https://books.google.com/ . The "advanced" interface allowing more specific searches is found at: https://books.google.com/advanced_book_search Books are provided either by publishers and authors through the Google Books Partner Program, or by Google's library partners through the Library Project. Additionally, Google has partnered with a number of magazine publishers to digitize their archives. The Publisher Program was first known as Google Print when it was introduced at the Frankfurt Book Fair in October 2004. The Google Books Library Project, which scans works in the collections of library partners and adds them to the digital inventory, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pathologist
Pathology is the study of disease. The word ''pathology'' also refers to the study of disease in general, incorporating a wide range of biology research fields and medical practices. However, when used in the context of modern medical treatment, the term is often used in a narrower fashion to refer to processes and tests that fall within the contemporary medical field of "general pathology", an area that includes a number of distinct but inter-related medical specialties that diagnose disease, mostly through analysis of tissue and human cell samples. Idiomatically, "a pathology" may also refer to the predicted or actual progression of particular diseases (as in the statement "the many different forms of cancer have diverse pathologies", in which case a more proper choice of word would be " pathophysiologies"). The suffix ''pathy'' is sometimes used to indicate a state of disease in cases of both physical ailment (as in cardiomyopathy) and psychological conditions (such as ps ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Massachusetts General Hospital
Massachusetts General Hospital (Mass General or MGH) is a teaching hospital located in the West End neighborhood of Boston, Massachusetts. It is the original and largest clinical education and research facility of Harvard Medical School/Harvard University, and houses the world's largest hospital-based research program with an annual research budget of more than $1.2 billion in 2021. It is the third-oldest general hospital in the United States with a patient capacity of 999 beds. Along with Brigham and Women's Hospital, Mass General is a founding member of Mass General Brigham, formerly known as Partners HealthCare, the largest healthcare provider in Massachusetts. History Founded in 1811, the original hospital was designed by the famous American architect Charles Bulfinch. It is the third-oldest general hospital in the United States; only Pennsylvania Hospital (1751) and NewYork-Presbyterian Hospital's predecessor New York Hospital (1771) are older. John Warren, Profess ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neuroblastoma
Neuroblastoma (NB) is a type of cancer that forms in certain types of nerve tissue. It most frequently starts from one of the adrenal glands but can also develop in the head, neck, chest, abdomen, or Vertebral column, spine. Symptoms may include bone pain, a lump in the abdomen, neck, or chest, or a painless bluish lump under the skin. Typically, neuroblastoma occurs due to a genetic mutation occurring in the first trimester of pregnancy. Rarely, it may be due to a mutation heredity, inherited. Environmental factors have not been found to be involved. Diagnosis is based on a tissue biopsy. Occasionally, it may be found in a baby by ultrasound during pregnancy. At diagnosis, the cancer has usually already Metastasis, spread. The cancer is divided into low-, intermediate-, and high-risk groups based on a child's age, cancer stage, and what the cancer looks like. Treatment and outcomes depends on the risk group a person is in. Treatments may include observation, surgery, radiatio ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Newspapers
A newspaper is a Periodical literature, periodical publication containing written News, information about current events and is often typed in black ink with a white or gray background. Newspapers can cover a wide variety of fields such as politics, business, sports, art, and science. They often include materials such as opinion columns, weather forecasts, reviews of local services, Obituary, obituaries, birth notices, crosswords, editorial cartoons, comic strips, and advice columns. Most newspapers are businesses, and they pay their expenses with a mixture of Subscription business model, subscription revenue, Newsagent's shop, newsstand sales, and advertising revenue. The journalism organizations that publish newspapers are themselves often Metonymy, metonymically called newspapers. Newspapers have traditionally been published Printing, in print (usually on cheap, low-grade paper called newsprint). However, today most newspapers are also Electronic publishing, published on webs ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Richard Clarke Cabot
Richard Clarke Cabot (May 21, 1868 – May 7, 1939) was an American physician who advanced clinical hematology, was an innovator in teaching methods, and was a pioneer in social work. Early life and education Richard Clarke Cabot was born May 21, 1868, in Brookline, Massachusetts, one of five sons of James Elliot Cabot and Elizabeth (Dwight) Cabot."Cabot, Richard C. (Richard Clarke), 1868-1939. Papers of Richard Clarke Cabot : an inventory," Harvard University archives. Accessed Jan. 5, 2016. James Cabot was a philosopher and professor who also trained as a lawyer and biographer, and was a friend of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
New England Journal Of Medicine
''The New England Journal of Medicine'' (''NEJM'') is a weekly medical journal published by the Massachusetts Medical Society. Founded in 1812, the journal is among the most prestigious peer-reviewed medical journals. Its 2023 impact factor was 96.2, ranking it 2nd out of 168 journals in the category "Medicine, General & Internal". History In September 1811, Boston physician John Collins Warren, along with James Jackson, submitted a formal prospectus to establish the ''New England Journal of Medicine and Surgery and Collateral Branches of Science'' as a medical and philosophical journal. Subsequently, the first issue of the ''New England Journal of Medicine and Surgery and the Collateral Branches of Medical Science'' was published in January 1812. The journal was published quarterly. In 1823, another publication, the ''Boston Medical Intelligencer'', appeared under the editorship of Jerome V. C. Smith. The editors of the ''New England Journal of Medicine and Surgery and the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Frank Burr Mallory
Frank Burr Mallory (November 12, 1862 – September 27, 1941) was an American pathologist at the Boston City Hospital and professor of pathology at Harvard Medical School, after whom the Mallory body is named. The Pathology Department at Boston City Hospital, the Mallory Institute of Pathology, was named after him. The Mallory Institute of Pathology was operational from 1933 to 2006. Early life and career Mallory was born in Cleveland, Ohio on November 12, 1862 to George Burr and Anne (Faragher) Mallory, and received his medical degree in 1890 from Harvard Medical School. He became an assistant pathologist at Boston City Hospital in 1891, working under William Thomas Councilman. He married Persis McClain Tracy of Chautauqua, New York in 1893.Haythorn, Samuel R."Frank Burr Mallory. 1862–1941" ''The Journal of Pathology and Bacteriology'', Volume 54, Issue 2, pages 263–267, April 1942 In 1893 Mallory traveled to Europe to train under Hans Chiari in Prague and Ern ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Wright's Stain
Wright's stain is a hematologic stain that facilitates the differentiation of blood cell types. It is classically a mixture of eosin (red) and methylene blue dyes. It is used primarily to stain peripheral blood smears, urine samples, and bone marrow needle aspiration biopsy, aspirates, which are examined under a light microscope. In cytogenetics, it is used to stain chromosomes to facilitate diagnosis of syndromes and diseases. It is named for James Homer Wright, who devised the stain, a modification of the Romanowsky stain, in 1902. Because it distinguishes easily between blood cells, it became widely used for performing differential white blood cell counts, which are routinely ordered when conditions such as infection or leukemia are suspected. The related stains are known as the buffered Wright stain, the Wright-Giemsa stain (a combination of Wright and Giemsa stain, Giemsa stains), and the buffered Wright-Giemsa stain, and specific instructions depend on the solutions being us ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Homer Wright Rosettes
In histopathology, a palisade is a single layer of relatively long cells, arranged loosely perpendicular to a surface and parallel to each other. A rosette is a palisade in a halo or spoke-and-wheel arrangement, surrounding a central core or hub. A pseudorosette is a perivascular radial arrangement of neoplastic cells around a small blood vessel. Rosettes are characteristic of tumors. Rosette A ''rosette'' is a cell formation in a halo or spoke-and-wheel arrangement, surrounding a central core or hub. The central hub may consist of an empty-appearing lumen or a space filled with cytoplasmic processes. The cytoplasm of each of the cells in the rosette is often wedge-shaped with the apex directed toward the central core: the nuclei of the cells participating in the rosette are peripherally positioned and form a ring or halo around the hub. Pathogenesis Rosettes may be considered primary or secondary manifestations of tumor architecture. Primary rosettes form as a characteristic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Romanowsky Stain
Romanowsky staining is a prototypical staining technique that was the forerunner of several distinct but similar stains widely used in hematology (the study of blood) and cytopathology (the study of diseased cells). Romanowsky-type stains are used to differentiate cells for microscopic examination in pathological specimens, especially blood and bone marrow films, and to detect parasites such as malaria within the blood. The staining technique is named after the Russian physician Dmitri Leonidovich Romanowsky (1861–1921), who was one of the first to recognize its potential for use as a blood stain. Stains that are related to or derived from the Romanowsky-type stains include Giemsa, Jenner, Wright, Field, May–Grünwald, Pappenheim and Leishman stains. They differ in protocols and additives and their names are often confused with one another in practice. Mechanism The value of Romanowsky staining lies in its ability to produce a wide range of hues, allowing cellular comp ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
