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Jak 25
Jak or JAK may refer to: People * JAK, pen name of British cartoonist Raymond Jackson (1927–1997) * Jak Airport (c. 1955–2004), English guitarist born Jack Stafford * Jak Alnwick (born 1993), English football goalkeeper * Jak Crawford (born 2005) an American racing driver * Jak Jones (born 1993), Welsh professional snooker player * Jak Knight (1993–2022), American actor, comedian and writer * Jak Orion, stage name used by Australian musician Jack Moffitt in 2010 * José Antonio Kast (born 1966), Chilean politician also known by his initials JAK Fictional characters * Jak (''Jak and Daxter''), in ''Jak and Daxter'' video games * Jak (comics), in the UK comic book ''The Dandy'' Other uses * Ják, a village in Hungary * JAK members bank, a Swedish interest-free bank * Janus kinase, a family of intracellular, nonreceptor tyrosine kinases including ** Janus kinase 1 (JAK1) ** Janus kinase 2 (JAK2) ** Janus kinase 3 (JAK3) See also * Jack (other) * Jaks Jaks, Jåks ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Raymond Jackson ("JAK")
Raymond Jackson, best known by his pen-name JAK (11 March 1927 in Marylebone – 27 July 1997 in Wimbledon) was one of Britain's best-known newspaper cartoonists, working for the London Evening Standard from 1952 onwards. Life JAK was born Raymond Allen Jackson on 11 March 1927 in Marylebone, London. He trained as a commercial artist at Willesden School of Art after a period in the Army Education Corps where he taught painting "in the style of Jackson Pollock". After working for an advertising agency and various magazines including Punch and Lilliput he joined the ''Evening Standard'' in 1952. Starting as a general artist and illustrator on the television page, he eventually in 1965 succeeded " Vicky" as the ''Standard'' 's Political Cartoonist. His predecessors were " Vicky" and " Low". As such, the views expressed in his cartoons were sometimes highly controversial; one 1970 cartoon that nearly led to the Evening Standard being closed by industrial action caricatured p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Jak (comics)
Jak Hurley and Todd Nolan are two fictional comic strip characters from the UK comic book, comic ''The Dandy'' who rose to popularity as the comic's main strip after its re-launch in 2004. Originally known as simply ''Jak'', both characters received equal billing after the popularity of Todd from readership. Character history Early strips (1997–2004) Jak's first incarnation was drawn by Jimmy Hansen starting from issue 2924, dated 6 December 1997. The strip played mostly on his relationship with his father (though not to the same extent as Molly (comic strip), Molly and Beryl the Peril from that time). The second incarnation in the early 2000s (decade) was drawn by David Sutherland (comics artist), David Sutherland, who drew Jak's dad with black hair and a beard, and introduced a cat called Spike. Both strips portrayed Jak as younger than his modern-day counterpart and Todd was absent. Dandy re-launches (2004–2010) Finally, Jak was reincarnated with the ''Dandy'' from issu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Janus Kinase 3
Tyrosine-protein kinase JAK3 is a tyrosine kinase enzyme that in humans is encoded by the ''JAK3'' gene. Janus kinases Janus kinase 3 is a tyrosine kinase that belongs to the janus family of kinases. Other members of the Janus family include JAK1, JAK2 and TYK2. Janus kinases (JAKs) are relatively large kinases of approximately 1150 amino acids with apparent molecular weights of 120-130 kDa. They are cytosolic tyrosine kinases that are specifically associated with cytokine receptors. Since cytokine receptor proteins lack enzymatic activity, they are dependent upon JAKs to initiate signaling upon binding of their ligands (e.g. cytokines). The cytokine receptors can be divided into five major subgroups based on their different domains and activation motifs. JAK3 is required for signaling of the type I receptors that use the common gamma chain (γc). Studies suggest Jak3 plays essential roles in immune and nonimmune cell physiology. Epithelial Jak3 is important for the regulat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Janus Kinase 2
Janus kinase 2 (commonly called JAK2) is a non-receptor tyrosine kinase. It is a member of the Janus kinase family and has been implicated in signaling by members of the type II cytokine receptor family (e.g. interferon receptors), the GM-CSF receptor family ( IL-3R, IL-5R and GM-CSF-R), the gp130 receptor family (e.g., IL-6R), and the single chain receptors (e.g. Epo-R, Tpo-R, GH-R, PRL-R). The distinguishing feature between janus kinase 2 and other JAK kinases is the lack of Src homology binding domains ( SH2/ SH3) and the presence of up to seven JAK homology domains (JH1-JH7). Nonetheless the terminal JH domains retain a high level of homology to tyrosine kinase domains. An interesting note is that only one of these carboxy-terminal JH domains retains full kinase function (JH1) while the other (JH2), previously thought to have no kinase functionality and accordingly termed a pseudokinase domain, has since been found to be catalytically active, albeit at only 10% ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Janus Kinase 1
Janus kinase 1 (JAK1) is a human tyrosine kinase protein essential for signaling for certain type I and type II cytokines. It interacts with the common gamma chain (γc) of type I cytokine receptors, to elicit signals from the IL-2 receptor family (e.g. IL-2R, IL-7R, IL-9R and IL-15R), the IL-4 receptor family (e.g. IL-4R and IL-13R), the gp130 receptor family (e.g. IL-6R, IL-11R, LIF-R, OSM-R, cardiotrophin-1 receptor (CT-1R), ciliary neurotrophic factor receptor (CNTF-R), neurotrophin-1 receptor (NNT-1R) and Leptin-R). It is also important for transducing a signal by type I ( IFN-α/ β) and type II ( IFN-γ) interferons, and members of the IL-10 family via type II cytokine receptors. Jak1 plays a critical role in initiating responses to multiple major cytokine receptor families. Loss of Jak1 is lethal in neonatal mice, possibly due to difficulties suckling. Expression of JAK1 in cancer cells enables individual cells to contract, potentially allowing them to ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Janus Kinase
Janus kinase (JAK) is a family of intracellular, non-receptor tyrosine kinases that transduce cytokine-mediated signals via the JAK-STAT pathway. They were initially named "just another kinase" 1 and 2 (since they were just two of many discoveries in a PCR-based screen of kinases), but were ultimately published as "Janus kinase". The name is taken from the two-faced Roman god of beginnings, endings and duality, Janus, because the JAKs possess two near-identical phosphate-transferring domains. One domain exhibits the kinase activity, while the other negatively regulates the kinase activity of the first. Family The four JAK family members are: * Janus kinase 1 (JAK1) * Janus kinase 2 (JAK2) * Janus kinase 3 (JAK3) * Tyrosine kinase 2 (TYK2) Transgenic mice that do not express JAK1 have defective responses to some cytokines, such as interferon-gamma. JAK1 and JAK2 are involved in type II interferon (interferon-gamma) signalling, whereas JAK1 and TYK2 are involved in type I ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ják
Ják is a village in Vas County, on the western boundary of Hungary. Church of Saint George The parish church of Ják is the best preserved Romanesque church in Hungary. It was originally built as the church of a Benedictine monastery. The village church at that time was a rotunda in front of the façade of the main doorway of Ják church. Both outside and inside the church is adorned with rich sculptures. The 3 naves and 3 apses are formed in a basilica structure. Columnar capitals are sculptured by plant and some animal ornamentation. The rotunda has been built with 4 apses and 2 floors. Photo gallery File:Jákitemplom-34.JPG File:Apátsági templom (8941. számú műemlék) 9.jpg File:Apátsági templom (8941. számú műemlék) 10.jpg File:Apátsági templom (8941. számú műemlék) 3.jpg, Saint George's Abbey, Ják Image:Jaki templomcivertanlegi3.jpg File:Jákitemplom-16.JPG File:San Mateo en la Iglesia de Ják.jpg, Medieval relief of Saint Matthew Matthew th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Jak (Jak And Daxter)
Jak or JAK may refer to: People * JAK, pen name of British cartoonist Raymond Jackson (1927–1997) * Jak Airport (c. 1955–2004), English guitarist born Jack Stafford * Jak Alnwick (born 1993), English football goalkeeper * Jak Crawford (born 2005) an American racing driver * Jak Jones (born 1993), Welsh professional snooker player * Jak Knight (1993–2022), American actor, comedian and writer * Jak Orion, stage name used by Australian musician Jack Moffitt in 2010 * José Antonio Kast (born 1966), Chilean politician also known by his initials JAK Fictional characters * Jak (''Jak and Daxter''), in ''Jak and Daxter'' video games * Jak (comics), in the UK comic book ''The Dandy'' Other uses * Ják, a village in Hungary * JAK members bank, a Swedish interest-free bank * Janus kinase, a family of intracellular, nonreceptor tyrosine kinases including ** Janus kinase 1 (JAK1) ** Janus kinase 2 (JAK2) ** Janus kinase 3 (JAK3) See also * Jack (other) Jack may re ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Jak Airport
Jak Airport (born Jack Stafford; 22 February 1958 – 13 August 2004) was the guitarist of 1970s punk band X-Ray Spex and new wave band Classix Nouveaux. Born and raised in Catford, London, Jak Airport is best known and remembered for being a member of punk rock band X-Ray Spex, contributing with songs like " Oh Bondage Up Yours!" and " The Day The World Turned Day-Glo". The beginning riff of the latter song was considered a classic by the band's singer Poly Styrene. He joined the band after leaving another punk group called Puncture. When X-Ray Spex disbanded in 1979, he and the group's bassist Paul Dean formed Airport and Dean. In 1979, he and fellow X-Ray Spex member, drummer BP Hurding formed, alongside singer Sal Solo, the new wave band Classix Nouveaux, but he had left the band by the end of the year. He retired from the music industry then worked at VVL London and also in the BBC The British Broadcasting Corporation (BBC) is a British public service broadcast ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
José Antonio Kast
José Antonio Kast Rist (born 18 January 1966), also known by his initials JAK, is a Chilean lawyer and politician. He is running for president in the 2025 Chilean general election, for the third time. Part of the prominent Kast family, he served as a member of the Chamber of Deputies of Chile, Chamber of Deputies from 2002 to 2018, representing District 24 of Peñalolén and La Reina. Kast was a member of the Independent Democratic Union until 2016, becoming an independent politician until 2019 when he formed the conservative Republican Party (Chile, 2019), Chilean Republican Party and the think tank ''Republican Ideas''. He previously ran for president as an independent candidate in the 2017 Chilean general election, and founded the of Republican Action Movement () in 2018. Kast ran for president of Chile, president in 2021, 2021 Chilean general election#President, winning the first round and losing in the second round run-off to Gabriel Boric. He served as the president of t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Jak Orion
Jack Moffitt is an Australian musician. He is known for his work as a member of indie rock band ''The Preatures'' (2010-2021), in which he worked as guitarist, vocalist, and producer. He used the alias Jak Orion on a 2010 release. Early life and education Jack Moffitt attended Newington College in Sydney, New South Wales, graduating high school in 2007. Along with his Preatures bandmate Tom Champion, he studied the Music 1 course in Years 11 and 12, and was also active in promoting and developing the contemporary music program. He was 2nd Captain of Music in his final year of school. In 2008 Moffitt and Champion both attended the Australian Institute of Music, where they met Isabella Manfredi, another future member of The Preatures. Career The Preatures Moffitt, Champion, and Manfredi formed a band together first, before meeting vocalist and guitarist Gideon Bensen at the Lansdowne Hotel, and asking him to write songs for them. In 2010, they met Luke Davison and invited him t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
