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Jack D. Keene
Jack D. Keene (born June 22, 1947, Jacksonville, Florida) is a James B. Duke Professor of Molecular Genetics and Microbiology at Duke University. Keene studies the regulation of RNA and the mechanisms of RNA-protein interactions. He identified RNA recognition motif (RRM) proteins, which are the largest family of RNA-binding proteins. He isolated the first human autoimmune antigen. He formalized the posttranscriptional operon and regulon (PTRO) model to describe global gene regulation, and proposed the RNA regulon hypothesis to better understand post-transcriptional regulation of mRNAs encoding proteins. Keene introduced the RIP (ribonucleoprotein immunoprecipitation) protocol for isolating specific mRNPs, which has become a tool for the mapping of mRNA targets of specific RBPs. Early life and education Jack Donald Keene was born in Jacksonville, Florida on June 22, 1947. His father worked for the RAND Corporation. Keene attended Redlands High School in Redlands, California, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Jacksonville, Florida
Jacksonville ( ) is the most populous city proper in the U.S. state of Florida, located on the Atlantic coast of North Florida, northeastern Florida. It is the county seat of Duval County, Florida, Duval County, with which the City of Jacksonville Jacksonville Consolidation, consolidated in 1968. It was the List of United States cities by area, largest city by area in the contiguous United States as of 2020, and became the 10th List of United States cities by population, largest U.S. city by population in 2023. Jacksonville straddles the St. Johns River in the First Coast region of northeastern Florida, about south of the Georgia state line ( to the urban core/downtown) and north of Miami. The Jacksonville Beaches communities are along the adjacent Atlantic coast. The area was originally inhabited by the Timucua people, and in 1564 was the site of the French colony of Fort Caroline, one of the earliest European settlements in what is now the continental United States. Under B ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bethesda, Maryland
Bethesda () is an unincorporated, census-designated place in southern Montgomery County, Maryland, United States. Located just northwest of Washington, D.C., it is a major business and government center of the Washington metropolitan region and a national center for medical research. According to the 2020 census, the community had a population of 68,056. Etymology It takes its name from a local church, the Bethesda Meeting House (1820, rebuilt 1849), which in turn took its name from Jerusalem's Pool of Bethesda. History Bethesda is located in the traditional territory of the indigenous Native Piscataway and Nacotchtank at the time of European colonization. Fur trader Henry Fleet became the first European to visit the area, reaching it by sailing up the Potomac River. He stayed with the Piscataway tribe from 1623 to 1627, either as a guest or prisoner (historical accounts differ). Fleet eventually secured funding for another expedition to the region and was later gra ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cytokines
Cytokines () are a broad and loose category of small proteins (~5–25 kDa) important in cell signaling. Cytokines are produced by a broad range of cells, including immune cells like macrophages, B cell, B lymphocytes, T cell, T lymphocytes and mast cells, as well as Endothelium, endothelial cells, fibroblasts, and various stromal cells; a given cytokine may be produced by more than one type of cell. Due to their size, cytokines cannot cross the lipid bilayer of cells to enter the cytoplasm and therefore typically exert their functions by interacting with specific cytokine receptor, cytokine receptors on the target cell surface. Cytokines are especially important in the immune system; cytokines modulate the balance between humoral immunity, humoral and cell-mediated immunity, cell-based immune responses, and they regulate the maturation, growth, and responsiveness of particular cell populations. Some cytokines enhance or inhibit the action of other cytokines in complex way ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Systemic Lupus Erythematosus
Lupus, formally called systemic lupus erythematosus (SLE), is an autoimmune disease in which the body's immune system mistakenly attacks healthy tissue in many parts of the body. Symptoms vary among people and may be mild to severe. Common symptoms include painful and swollen joints, fever, chest pain, hair loss, mouth ulcers, swollen lymph nodes, feeling tired, and a red rash which is most commonly on the face. Often there are periods of illness, called flares, and periods of remission during which there are few symptoms. Children up to 18 years old develop a more severe form of SLE termed childhood-onset systemic lupus erythematosus. The cause of SLE is not clear. It is thought to involve a combination of genetics and environmental factors. Among identical twins, if one is affected there is a 24% chance the other one will also develop the disease. Female sex hormones, sunlight, smoking, vitamin D deficiency, and certain infections are also believed to increa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
SnRNP70
snRNP70 also known as U1 small nuclear ribonucleoprotein 70 kDa is a protein that in humans is encoded by the ''SNRNP70'' gene. snRNP70 is a small nuclear ribonucleoprotein that associates with U1 spliceosomal RNA, forming the U1snRNP a core component of the spliceosome. The U1-70K protein and other components of the spliceosome complex form detergent-insoluble aggregates in both sporadic and familial human cases of Alzheimer's disease. U1-70K co-localizes with Tau in neurofibrillary tangles in Alzheimer's disease. Interactions snRNP70 has been shown to interact with ASF/SF2, SRPK1, and ZRANB2. Role in autoimmunity Antibodies towards snRNP70 are associated with mixed connective tissue disease Mixed connective tissue disease (MCTD) is a systemic autoimmune disease that shares characteristics with at least two other systemic autoimmune diseases, including Systemic scleroderma, systemic sclerosis (Ssc), systemic lupus erythematosus (SLE), .... References Further re ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Epitope
An epitope, also known as antigenic determinant, is the part of an antigen that is recognized by the immune system, specifically by antibodies, B cells, or T cells. The part of an antibody that binds to the epitope is called a paratope. Although epitopes are usually non-self proteins, sequences derived from the host that can be recognized (as in the case of autoimmune diseases) are also epitopes. The epitopes of protein antigens are divided into two categories, conformational epitopes and linear epitopes, based on their structure and interaction with the paratope. Conformational and linear epitopes interact with the paratope based on the 3-D conformation adopted by the epitope, which is determined by the surface features of the involved epitope residues and the shape or tertiary structure of other segments of the antigen. A conformational epitope is formed by the 3-D conformation adopted by the interaction of discontiguous amino acid residues. In contrast, a linear epitope i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Defective Interfering Particle
Defective interfering particles (DIPs), also known as defective interfering viruses, are spontaneously generated virus mutants in which a critical portion of the particle's genome has been lost due to defective replication or non-homologous recombination. The mechanism of their formation is presumed to be as a result of template-switching during replication of the viral genome, although non-replicative mechanisms involving direct ligation of genomic RNA fragments have also been proposed. DIPs are derived from and associated with their parent virus, and particles are classed as DIPs if they are rendered non-infectious due to at least one essential gene of the virus being lost or severely damaged as a result of the defection. A DIP can usually still penetrate host cells, but requires another fully functional virus particle (the 'helper' virus) to co-infect a cell with it, in order to provide the lost factors. DIPs were first observed as early as the 1950s by Von Magnus and Schlesin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Marburg Virus
Marburg virus (MARV) is a hemorrhagic fever virus of the '' Filoviridae'' family of viruses and a member of the species '' Marburg marburgvirus'', genus '' Marburgvirus''. It causes Marburg virus disease in primates, a form of viral hemorrhagic fever. The World Health Organization (WHO) rates it as a Risk Group 4 Pathogen (requiring biosafety level 4-equivalent containment). In the United States, the National Institute of Allergy and Infectious Diseases ranks it as a Category A Priority Pathogen and the Centers for Disease Control and Prevention lists it as a Category A Bioterrorism Agent. It is also listed as a biological agent for export control by the Australia Group. The virus can be transmitted by exposure to one species of fruit bats or it can be transmitted between people via body fluids through unprotected sex and broken skin. The disease can cause haemorrhage, fever, and other symptoms similar to Ebola, which belongs to the same family of viruses. According to t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ebola Virus
''Orthoebolavirus zairense'' or Zaire ebolavirus, more commonly known as Ebola virus (; EBOV), is one of six known species within the genus ''Ebolavirus''. Four of the six known ebolaviruses, including EBOV, cause a severe and often fatal viral hemorrhagic fever, hemorrhagic fever in humans and other mammals, known as Ebola virus disease (EVD). Ebola virus has caused the majority of human deaths from EVD, and was the cause of the Western African Ebola virus epidemic, 2013–2016 epidemic in western Africa, which resulted in at least suspected cases and confirmed deaths. Ebola virus and its genus were both originally named for Zaire (now the Democratic Republic of the Congo), the country where it was List of Ebola outbreaks, first described, and was at first suspected to be a new "strain" of the closely related Marburg virus. The virus was renamed "Ebola virus" in 2010 to avoid confusion. Ebola virus is the single member of the species ''Zaire ebolavirus'', which is assigned t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rhabdoviridae
''Rhabdoviridae'' is a family of negative-strand RNA viruses in the order ''Mononegavirales''. Vertebrates (including mammals and humans), invertebrates, plants, fungi and protozoans serve as natural hosts. Diseases associated with member viruses include Rabies, rabies encephalitis caused by the rabies virus, and flu-like symptoms in humans caused by vesiculoviruses. The name is derived from Ancient Greek , meaning rod, referring to the shape of the viral particles. The family has 62 genera, most assigned to four subfamilies. Structure The individual virus particles (virions) of rhabdoviruses are composed of RNA, protein, carbohydrate and lipid. They have complex bacilliform or bullet-like shapes. All these viruses have structural similarities and have been classified as a single family. The virions are about 75 nm wide and 180 nm long. Rhabdoviruses are Viral envelope, enveloped and have helical Capsid, nucleocapsids and their genomes are linear, around 11–15 kb ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rabies Virus
Rabies virus (''Lyssavirus rabies'') is a neurotropic virus that causes rabies in animals, including humans. It can cause violence, hydrophobia, and fever. Rabies transmission can also occur through the saliva of animals and less commonly through contact with human saliva. Rabies virus, like many Rhabdoviridae, rhabdoviruses, has an extremely wide host range. In the wild it has been found infecting many mammalian species, while in the laboratory it has been found that birds can be infected, as well as cell cultures from mammals, birds, reptiles and insects. Rabies is reported in more than 150 countries and on all continents except Antarctica. The main burden of disease is reported in Asia and Africa, but some cases have been reported also in Europe in the past 10 years, especially in returning travellers. Rabies virus has a cylindrical morphology and is a member of the ''Lyssavirus'' genus of the ''Rhabdoviridae'' family. These viruses are Viral envelope, enveloped and have a Ne ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Vesicular Stomatitis Virus
''Indiana vesiculovirus'', formerly ''Vesicular stomatitis Indiana virus'' (VSIV or VSV) is a virus in the family ''Rhabdoviridae''; the well-known '' Rabies lyssavirus'' belongs to the same family. VSIV can infect insects, cattle, horses and pigs. It has particular importance to farmers in certain regions of the world where it infects cattle. This is because its clinical presentation is identical to the very important foot and mouth disease virus. reviewed and published by WikiVet, accessed 12 October 2011. The virus is zoonotic and leads to a flu-like illness in infected humans. It is also a common laboratory virus used to study the properties of viruses in the family ''Rhabdoviridae'', as well as to study viral evolution. Properties ''Indiana vesiculovirus'' is the prototypic member of the genus ''Vesiculovirus'' of the family ''Rhabdoviridae''. VSIV is an arbovirus, and its replication occurs in the cytoplasm. Natural VSIV infections encompass two steps, cytolytic infections ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
